A combination of Viagra and a flu vaccine could treat cancer, surprising new research suggests.
The team at the University of Ottawa found that erectile dysfunction drugs block suppressor cells, allowing natural killer cells to do their cancer-fighting job. The flu vaccine further invigorates the killer cells.
https://youtube.com/watch?v=vfuHNHLJzoM
Aurora Flight Services’ Autonomous Aerial Cargo Utility System (AACUS) took another step forward as an AACUS-enabled UH-1H helicopter autonomously delivered 520 lb (236 kg) of water, gasoline, MREs, communications gear, and a cooler capable of carrying urgent supplies such as blood to US Marines in the field.
Last week’s demonstration at the Marine Corps Air Ground Combat Center Twentynine Palms in California was the first ever autonomous point-to-point cargo resupply mission to Marines and was carried out as part of an Integrated Training Exercise. The completion of what has been billed as the system’s first closed-loop mission involved the modified helicopter carrying out a full cargo resupply operation that included takeoff and landing with minimal human intervention.
Developed as part of a US$98-million project by the US Office of Naval Research (ONR), AACUS is an autonomous flight system that can be retrofitted to existing helicopters to make them pilot optional. The purpose of AACUS is to provide the US armed forces with logistical support in the field with a minimum of hazard to human crews.
At the cellular level, aging and cancer are two sides of the same coin. The mechanism that limits a cell’s lifespan can be slowed down, but that can turn them cancerous, as they divide unchecked. Now, scientists at EPFL have found a way to manipulate that mechanism to effectively turn off cancer’s immortality, letting it die slowly and naturally.
Every time a cell divides, it consults the blueprints contained in the chromosomes, but some genetic information is lost with every division. To protect the important bits, the tips of the chromosomes are covered with repeating sequences of “junk” DNA known as telomeres. Eventually even they erode away, leaving the cell vulnerable to damage – which we recognize as wrinkles, grey hairs, decreased metabolism, and higher chances of disease. In that way, telomere length is inextricably linked to aging.
Found in turmeric, curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s disease and better cognitive performance.
“Exactly how curcumin exerts its effects is not certain, but it may be due to its ability to reduce brain inflammation, which has been linked to both Alzheimer’s disease and major depression,” said Dr. Gary Small, director of geriatric psychiatry at UCLA’s Longevity Center and of the geriatric psychiatry division at the Semel Institute for Neuroscience and Human Behavior at UCLA, and the study’s first author.
The double-blind, placebo-controlled study involved 40 adults between the ages of 50 and 90 years who had mild memory complaints. Participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months.
Stem cells in the brain can divide and mature into neurons participating in various brain functions, including memory. In a paper scientists have discovered that the flow of cerebrospinal fluid is a key signal for neural stem cell renewal.
The ancient Greek aphorism panta rhei means “everything flows”, a phrase used by philosophers to describe the constant flux and interplay between the past and renewal. A recent paper lends this relationship a whole new meaning: a team of researchers headed by Professor Magdalena Götz and their collaborators from the LMU (Professor Benedikt Grothe, Chair of Neurobiology) and the Henrich-Heine University Düsseldorf have discovered that the flow of cerebrospinal fluid is a key signal for neural stem cell renewal.
“Neural stem cells in the brain can divide and mature into neurons and this process plays important roles in various regions of the brain – including olfactory sense and memory,” explains Magdalena Götz, Head of LMU Department of Physiological Genomics and Director of the Institute for Stem Cell Research at Helmholtz Zentrum München. “These cells are located in what is known as the neurogenic stem cell niche one of which is located at the walls of the lateral ventricles, where they are in contact with circulating cerebrospinal fluid.”
Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine.
The approach works for many different types of cancers, including those that arise spontaneously, the study found.
The researchers believe the local application of very small amounts of the agents could serve as a rapid and relatively inexpensive cancer therapy that is unlikely to cause the adverse side effects often seen with bodywide immune stimulation.
Somewhat paradoxically, euthanasia and life extension share a common goal—ending pointless suffering.
On May 10 this year, Australian ecologist David Goodall took his own life before aging could. The scientist, aged 104, reportedly said he “regretted” having reached that age, because the quality of his life had significantly deteriorated as a consequence of his declining health. Unhappy with his condition, though not suffering from any terminal disease—except for aging itself—Goodall opted to end his life through assisted suicide. As the practice is currently not allowed in Australia, he flew with friends and family all the way to a clinic in Switzerland, where he flipped a switch and administered his own lethal injection while listening to Beethoven’s Ninth Symphony. Interestingly, the cost of his trip to Switzerland was covered with money collected through a crowdfunding campaign.
A matter of rights
Goodall was a lifelong supporter of euthanasia, and both he and his fellows from Exit International—a non-profit organization advocating the legalization of voluntary euthanasia and assisted suicide—said that people should have the right to die with dignity when they feel the time has come.
Researchers from the National Cancer Institute (NCI), the University of Kansas, and the National Center for Advancing Translational Science (NCATS) have discovered a compound that can block the spread of cancer cells.
Preventing cancer metastasis
Metastasis is how cancer spreads from an initial site to a secondary site within the host’s body; the newly pathological sites, then, are metastases. Metastasis is what makes some cancers so lethal and hard to treat unless they are caught before they spread.
In the air, beneath the ocean’s surface, and on land, microbes are the minute but mighty forces regulating much of the planet’s biogeochemical cycles. To better understand their roles, scientists work to identify these microbes and to determine their individual contributions. While advances in sequencing technologies have enabled researchers to access the genomes of thousands of microbes and make them publicly available, no similar shift has occurred with the task of assigning functions to the genes uncovered.
To help overcome this bottleneck, scientists at Lawrence Berkeley National Laboratory (Berkeley Lab), including researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), have developed a workflow that enables large-scale, genome-wide assays of gene importance across many conditions. The study, “Mutant Phenotypes for Thousands of Bacterial Genes of Unknown Function,” has been published in the journal Nature and is by far the largest functional genomics study of bacteria ever published.
“This is the first really large, systematic experimental effort to try to assign functions to bacterial genes of unknown function,” said study senior author and biologist Adam Deutschbauer of Berkeley Lab’s Biosciences Area. “We are tackling the problem that biology is up against and recognizes: It is super easy to sequence, but we cannot currently assign confident functions for the majority of genes identified by sequencing. Our experimental data provides an anchor that other researchers could use to make a more informed inference about protein function.”
