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I’m curious what biomarkers people here currently track? I did some research and came up with these 20 but any you would add/take away? (9 of them were mostly included to be able to use Morgan Levine’s biological age calculator).


This is the first article in a two-part series on the best aging biomarkers to track for longevity. The second article will compare different tests and testing companies on the market and supply a sample testing schedule you can use.

“When you can measure what you are speaking about, and express it in numbers, you know something about it; but when you cannot express it in numbers, your knowledge is of a meagre and unsatisfactory kind; it may be the beginning of knowledge, but you have scarcely, in your thoughts, advanced to the stage of science, whatever the matter may be.”

Homeslice Kelvin here is right.

“The results showed that rat cyborgs could be smoothly and successfully navigated by the human mind to complete a navigation task in a complex maze. Our experiments indicated that the cooperation through transmitting multidimensional information between two brains by computer-assisted BBI is promising.”

(2019)


Brain-machine interfaces (BMIs) provide a promising information channel between the biological brain and external devices and are applied in building brain-to-device control. Prior studies have explored the feasibility of establishing a brain-brain interface (BBI) across various brains via the combination of BMIs. However, using BBI to realize the efficient multidegree control of a living creature, such as a rat, to complete a navigation task in a complex environment has yet to be shown. In this study, we developed a BBI from the human brain to a rat implanted with microelectrodes (i.e., rat cyborg), which integrated electroencephalogram-based motor imagery and brain stimulation to realize human mind control of the rat’s continuous locomotion. Control instructions were transferred from continuous motor imagery decoding results with the proposed control models and were wirelessly sent to the rat cyborg through brain micro-electrical stimulation. The results showed that rat cyborgs could be smoothly and successfully navigated by the human mind to complete a navigation task in a complex maze. Our experiments indicated that the cooperation through transmitting multidimensional information between two brains by computer-assisted BBI is promising.

Among popular public thinkers advocating for the simulation hypothesis is Elon Musk who stated: if you assume any rate of improvement at all, games will eventually be indistinguishable from reality “before concluding ” that its most likely we’re in a simulation.

Elon Musk is known in the philosophical community to make “outrageous” claims, whether its about the advent of digital superintelligence, or in this case, according to some skeptics of the simulation hypothesis, Elon Musk exaggerates the probability that we might be living in a simulation.

Another high-profile proponent to the hypothesis is famous astrophysicist Neil Degrasse Tyson, who said in an NBC news interview that the hypothesis is correct giving better than 50–50 odds and adding: I wish I could summon a strong argument against it, but I can find none.

In a review of the literature on simulated realities, philosopher Nick Bostrom argues that although it is difficult to prove that we are living in a simulation, “It is nevertheless generally considered acceptable philosophy to question the reality of our own existence.

A typical member of an advanced civilization would have a high probability of being among the simulated minds rather than among the original biological ones. Therefore, if we are typical, we should consider that we might be living in a simulation. Thus, the possibility that we are living in a simulation is greater than we might have supposed.

Some hypotheses hold that if it is possible to simulate reality, then it is also possible to leave behind copies of everyone within these simulations. It has further been suggested that these simulated people may be conscious or sentient, although this idea belongs more in the realm of philosophy rather than scientific inquiry.

Engineers at MIT and Imperial College London have developed a new way to generate tough, functional materials using a mixture of bacteria and yeast similar to the “kombucha mother” used to ferment tea.

Using this mixture, also called a SCOBY (symbiotic culture of bacteria and yeast), the researchers were able to produce cellulose embedded with enzymes that can perform a variety of functions, such as sensing environmental pollutants. They also showed that they could incorporate yeast directly into the material, creating “living materials” that could be used to purify water or to make “smart” packaging materials that can detect damage.

“We foresee a future where diverse materials could be grown at home or in local production facilities, using biology rather than resource-intensive centralized manufacturing,” says Timothy Lu, an MIT associate professor of electrical engineering and computer science and of .

Review: Meat Planet (2019) by Benjamin Aldes Wurgaft

In the words of the book’s author, Benjamin Aldes Wurgaft, Meat Planet: Artificial Flesh and the Future of Food (2019) is “not an attempt at prediction but rather a study of cultured meat as a special case of speculation on the future of food, and as a lens through which to view the predictions we make about how technology changes the world.” While not serving as some crystal ball to tell us the future of food, Wurgaft’s book certainly does serve as a kind of lens.

Our very appetites are questioned quite a bit in the book. Wondering about the ever-changing history of food, the author asks, “Will it be an effort to reproduce the industrial meat forms we know, albeit on a novel, and more ethical and sustainable, foundation?” Questioning why hamburgers are automatically the default goal, he points out cultured meat advocates should carefully consider “the question of which human appetite for meat, in historical terms, they wish to satisfy.”

Wurgaft’s question of “which human appetite” – past, present, or future – is an excellent one. If we use his book as a lens to observe other emerging technologies, the question extends well beyond our choices of food. It could even have direct implications for such endeavours as radical life extension. Will we, if we extend our lifetimes, be satisfactory to future people? We already know the kind of clash that persists between different generations, and the blame we often place on previous generations for current social ills, without there also being a group of people who simply refuse to die. We should be wary of basing our future on the present – of attempting to preserve present tastes as somehow immutable and deserving immortality. This may be a problem such futurists as Ray Kurzweil, author of The Singularity is Near (2005) need to respond to.

If we are to justify the singularity at which we or our appetites are immortalized, we should remember technology changes “morality’s horizon”, as Wurgaft observes. If, for example, a new technology arises that can entirely eliminate suffering, our choice to allow suffering is an immoral one. If further technologies then emerge that can eliminate not just suffering but death, it will become immoral on that day to permit someone’s natural death – at least to the extent it is like the crime of manslaughter. I argued in my own book that it will be immoral to withhold novel biotechnologies from impoverished countries, if we know such direct action will increase their economic independence or improve their health. Put simply, our inaction in a situation can become an immoral deed if we have the necessary tools to stop suffering.

Beyond the way they alter our moral structures and expectations, Wurgaft notes that much fear over emerging technologies stems from the belief “technology might introduce a new plasticity into our concept of what it is to be human.” This is already expected to be the case with potential transhuman technologies, which critics of transhumanism find greatly troubling. Fully respecting the sanctity of animal life may ultimately coincide with respecting the same for all sentient beings, such as artificial and posthuman beings. Alternatively, the plasticity being described may ultimately undermine all our rights, leaving sentient life open to a whole new range of abuses, which certainly is the outcome critics of transhumanism fear. The fear of human rights being only more easily degraded and devalued by technology, or the notion technology will broaden the scope of all things morally wrong, is frequently expressed in the British dystopian Netflix series Black Mirror.

The moral appetite of the advocates of cultured meat is clear. They seek increased animal protection primarily, followed by environmental protection, but much rarer are their appeals to food security and human health. Wurgaft points out there is no apparent compelling philosophical defence or apologetic for the eating of animals. Perhaps the aforementioned plasticity of our morals to align with our species’ technological abilities, however, means most of us will remain unable to develop an acceptance of the sanctity of animal life until it becomes more broadly convenient to do so.

A chapter of Meat Planet addresses promises, noting how hopeful expectations often reinforce each other. The author also discusses “hype”, noting it is both necessary to the success of, and yet also a component leading to eventual (in Wurgaft’s view inevitable) disillusionment with any emerging technology. Such lessons may seem dissatisfying to those of us who are more enthusiastic about the future, but they seem necessary. Those of us who write science fiction know it is still fiction, and at best can only inspire some small part of the real future.

Wurgaft acknowledges “physical technologies (in energy, in transport, in medicine, in manufacturing) have lagged behind our digital ones”. This is regrettably true. Far too much effort in the tech sectors goes into software and smarter approaches to old problems rather than achieving real breakthroughs or actually inventing something. This only adds to the disappointment many feel. Rather than entering a sci-fi world filled with new domains of advanced technology, we are striding into a world only filled with new gimmicky apps and ever more efficient ways of doing whatever we already did.

Staying on the issue of technological disappointment, many problems are especially frustrating because they are the result of our culture rather than hurdles in engineering itself. Wurgaft makes a good point that privately funded labs don’t share their research and are “at risk of reinventing the wheel”. If we are to imagine a solution, it may be that governments should purchase the research of failed biotech start-ups, then hand it out freely with a goal to reduce any duplicated work and accelerate research.

It is my own observation that states are often capable of a significant amount of heavy lifting on the way to new technologies where private companies were not willing to take risks. Companies focused on new experimental technologies often leave it to engineers to solve the problem of scaling – work that too often simply doesn’t get done, as was the case with a lab-tested fuel production method using bacteria. It is possible that a state could learn best when to step in and could compensate both for the poor communication between innovators and the lack of engineering expertise and funding necessary for scaling.

On the topic of cultured meat specifically, maybe the focus should not currently be on replacing the most desired forms of meat (e.g., burgers and steaks) with cultured meat but in replacing at least a substantial percentage of lower-quality meat products with cultured meat. This, of course, depends on government adopting an agenda of phasing out industrial animal slaughter in much the same way carbon reduction targets were adopted.

A final consideration, for me, is that there may be alternative ways of achieving the same goals as cultured meat proponents. If genetic engineering could produce animals that efficiently yield greater quantities of meat, and of better quality, this may result in fewer individual animals suffering. Better yet, if synthetic biology is what it claims to be, it may eventually be possible to remake our favourite meats using the body of some wholly engineered or cognitively suppressed animal that does not experience suffering and exists its whole life as a steak.

To conclude, Wurgaft’s Meat Planet is quite nutritious food for thought. Beyond directly addressing and critically examining the hopes behind cultured meat, it raises a number of questions that should be asked of the advocates of other emerging technologies. The most important lesson is that we should not view new technology as morally neutral. It is almost certain to reconfigure our morality, whether it is for better or worse. I like to think technology only better supports us to make good moral choices in the long-term, even if there are short-term instances of abuse, as can be seen by looking at the overall course of human history.

More from me: Catalyst: A Techno-Liberation Thesis

Quantum twist on optical coherence tomography offers million-fold improvement in imaging.


Entangled pairs of photons have been used by physicists in Germany and Austria to image structures beneath the surfaces of materials that scatter light. The research was led by Aron Vanselow and Sven Ramelow at Humboldt University of Berlin and achieved high-resolution images of the samples using “ultra-broadband” photon pairs with very different wavelengths. One photon probed the sample, while the other read out image information. Their compact, low-cost and non-destructive system could be put to work inspecting advanced ceramics and mixing in fluids.

Optical coherence tomography (OCT) is a powerful tool for imaging structures beneath the surfaces of translucent materials and has a number of applications including the 3D scanning of biological tissues. The technique uses interferometry to reject the majority of light that has scattered many times in an object, focussing instead on the rare instances when light only scatters once from a feature of interest. This usually involves probing the material with visible or near-infrared light, which can be easily produced and detected. Yet in some materials such as ceramics, paints, and micro-porous samples, visible and near-infrared light is strongly scattered – which limits the use of OCT. Mid-infrared light, however, can penetrate deeper into these samples without scattering – but this light is far more difficult to produce and detect.

Vanselow, Ramelow and colleagues circumvented this problem by using pairs of quantum-mechanically entangled photons in which one photon is mid-infrared and the other is either visible or near-infrared. The entangled pairs are generated by firing a “pump” laser beam at a specialized nonlinear crystal developed by the team. This creates entangled pairs of photons – one mid-infrared “idler” photon and one visible/near-infrared “signal” photon.

The idea of slowing down the ageing process and living healthier, more productive lives is hugely appealing. It’s led to a growing trend for people looking to take control of their own biology, optimising their bodies and minds through ‘biohacking’. But how safe and ethical is this pursuit of longevity? And are there more natural ways of expanding your healthy lifespan? Video by Dan John Animation by Adam Proctor.

Scientists have figured out a cheaper, more efficient way to conduct a chemical reaction at the heart of many biological processes, which may lead to better ways to create biofuels from plants.

Scientists around the world have been trying for years to create biofuels and other bioproducts more cheaply; this study, published today in the journal Scientific Reports, suggests that it is possible to do so.

“The process of converting sugar to alcohol has to be very efficient if you want to have the end product be competitive with ,” said Venkat Gopalan, a senior author on the paper and professor of chemistry and biochemistry at The Ohio State University. “The process of how to do that is well-established, but the cost makes it not competitive, even with significant government subsidies. This new development is likely to help lower the cost.”

Discovery of liquid glass sheds light on the old scientific problem of the glass transition: An interdisciplinary team of researchers from the University of Konstanz has uncovered a new state of matter, liquid glass, with previously unknown structural elements—new insights into the nature of glass and its transitions.

While glass is a truly ubiquitous material that we use on a daily basis, it also represents a major scientific conundrum. Contrary to what one might expect, the true nature of glass remains something of a mystery, with scientific inquiry into its chemical and physical properties still underway. In chemistry and physics, the term glass itself is a mutable concept: It includes the substance we know as window glass, but it may also refer to a range of other materials with properties that can be explained by reference to glass-like behavior, including, for instance, metals, plastics, proteins, and even biological cells.

While it may give the impression, glass is anything but conventionally solid. Typically, when a material transitions from a liquid to a the molecules line up to form a crystal pattern. In glass, this does not happen. Instead, the molecules are effectively frozen in place before crystallization happens. This strange and disordered state is characteristic of glasses across different systems and scientists are still trying to understand how exactly this metastable state forms.

“For example, a number of animals benefit from solar-powered molecules. The pea aphid produces pigments that, with the aid of light, generate adenosine triphosphate, or ATP, the compound that powers reactions with cells. In addition, a stripe of yellow pigment on the exoskeleton of the Oriental hornet (Vespa orientalis) converts light to electricity, which could help to explain why these insects become more active during the middle of the day. Other animals make use of actual photosynthesis, using sunlight, water and carbon dioxide to produce sugars and other vital compounds. Plants and algae rely on chloroplasts, structures within their cells, to carry out photosynthesis, but Elysia sea slugs can steal chloroplasts from algae they graze on, to help them live solely on photosynthesis for months… Many other animals reap benefits from photosynthesis by forming partnerships instead. For instance, most corals partner with photosynthetic symbiotic microbes known as zooxanthellae, while the eggs of spotted salamanders receive valuable oxygen from algae.”


If humans had green skin, for instance, what if it granted us the ability to perform photosynthesis, which plants use to live off of sunlight?