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“Researchers report today that they’ve created a nontoxic and nonhallucinogenic chemical cousin of ibogaine that combats depression and addictive behaviors in rodents. The work provides new hope that chemists may one day be able to create medicines for people that offer the purported therapeutic benefits of ibogaine and other psychoactive compounds without their side effects.”


Analog of ibogaine could hold hope for humans.

Advanced, others might like.


The exact gene that caused stem cell aging has been identified.

Above – When mesenchymal stem/stromal cells (MSCs) age, the transcription factor GATA6 is increasingly produced in the cell to induce aging response. By transcription factor-based cellular reprogramming, aged MSCs are rejuvenated with a reduction in GATA6 effects on cellular aging. CREDIT AlphaMed Press

University of Wisconsin-Madison researchers found that the expression of GATA6, a protein that plays an important role in gut, lung and heart development, was repressed in the reprogrammed cells compared to the control cells. This repression led to an increase in the activity of a protein essential to embryonic development called sonic hedgehog (SHH) as well as the expression level of yet another protein, FOXP1, necessary for proper development of the brain, heart and lung. “Thus, we identified the GATA6/SHH/FOXP1 pathway as a key mechanism that regulates MSC aging and rejuvenation,” Dr. Li said.

The French armed forces now have permission to develop “augmented soldiers” following a report from a military ethics committee.

The report, released to the public on Tuesday, considers medical treatments, prosthetics and implants that improve “physical, cognitive, perceptive and psychological capacities,” and could allow for location tracking or connectivity with weapons systems and other soldiers.

Exciting momentum!! — Home Depot Founder, Bernie Marcus (age 91), and the Adolph Coors Foundation (beer family), putting millions of $$$ into comprehensive integrative health and wellness — Good to see the trend!!


The Marcus Institute of Integrative Health was established in Philadelphia in 2017 by Thomas Jefferson University and Jefferson Health, and a multi-million $$$ grant from the Marcus Foundation (headed by it’s Chairman, Bernie Marcus, Co-Founder of The Home Depot) to expand the research, education and clinical care profile of Jefferson’s integrative medicine program, and to set the international standard of excellence in evidence-based, patient-centered integrative care.

The institute features a novel curriculum focusing on the clinical applications of integrative medicine with an emphasis on functional biochemistry, nutrient-based therapies, mind-body neuroscience, novel mechanisms of healing and emerging therapies.

Dr. Daniel Monti, MD, MBA is the Founding Director and Chief Executive Officer of the Marcus Institute of Integrative Health — Jefferson Health. He is also Professor and Founding Chair of the historic, first-ever Department of Integrative Medicine and Nutritional Sciences, Sidney Kimmel Medical College, Thomas Jefferson University.

Dr. Monti received his MD from The State University of New York at Buffalo School of Medicine. His Postdoctoral work was in the Research Scholars Program, Department of Psychiatry and Human Behavior, at Jefferson Medical College.

Dr. Monti works closely with his colleagues in the institute and department to continuously expand, refine, and define Integrative Medicine at Jefferson, including innovative clinical programs of excellence, cutting edge medical education, and world-class research. Dr. Monti has dozens of journal publications, international presentations, and media appearances.

He’s also an accomplished author with books including: “Integrative Psychiatry and Brain Health” (Weil Integrative Medicine Library) and “The Great Life Makeover: Weight, Mood, and Sex”.

His newest book, “Tapestry of Health: Weaving Wellness into Your Life Through the New Science of Integrative Medicine”, which was co-written with Dr. Anthony J. Bazzan, was just released in August 2020.

NEW YORK (AP) — Brain scans offer a tantalizing glimpse into the mind’s mysteries, promising an almost X-ray-like vision into how we feel pain, interpret faces and wiggle fingers.

Studies of brain images have suggested that Republicans and Democrats have visibly different thinking, that overweight adults have stronger responses to pictures of food and that it’s possible to predict a sober person’s likelihood of relapse.

But such buzzy findings are coming under growing scrutiny as scientists grapple with the fact that some brain scan research doesn’t seem to hold up.

This is very helpful in reducing signs in aging.


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Brain Muraresku, author of “The Immortality Key — The Secret History Of The Religion With No Name”, discussing his fascinating journey to discover psychedelic potions from antiquity, reconstruct their history in the development of religion and civilization, and their development into a modern neuro-pharmacopoeia.


On today’s show we are going to be weaving together a really interesting range of themes including psychedelics, pharmacognosy and medicinal botany, history, religion & spirituality, end of life care, dreaming, mental health and a whole lot more.

Brian Muraresku is the author of “The Immortality Key: The Secret History of the Religion with No Name”.

Brian graduated Phi Beta Kappa from Brown University with a degree in Latin, Greek and Sanskrit. As an alumnus of Georgetown Law and a member of the New York Bar, he has been practicing law internationally for fifteen years.

He is also founding executive director of Doctors for Cannabis Regulation. Their work has been featured on CNN and ESPN, as well as The Washington Post and San Francisco Chronicle. In arbitration with the NFL in 2018, Mr. Muraresku represented the first professional athlete in the United States to seek a therapeutic use exemption for cannabis.

The Immortality Key is his debut book.