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Invariant natural killer T cells might lead to cheaper and more effective immunotherapy.


Researchers at the Imperial College London have discovered that specifically employing invariant natural killer T cells, rather than generic T cells, in cancer immunotherapies based on chimeric antigen receptors might lead to significantly more effective, cheaper, and more easily mass-produced treatments [1].

Abstract

Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical remissions in CD19+ B cell lymphomas are often short lived. We tested whether CAR19-engineering of the CD1d-restricted invariant natural killer T (iNKT) cells would result in enhanced anti-lymphoma activity. CAR19-iNKT cells co-operatively activated by CD1d- and CAR19-CD19-dependent interactions are more effective than CAR19-T cells against CD1d-expressing lymphomas in vitro and in vivo. The swifter in vivo anti-lymphoma activity of CAR19-iNKT cells and their enhanced ability to eradicate brain lymphomas underpinned an improved tumor-free and overall survival. CD1D transcriptional de-repression by all-trans retinoic acid results in further enhanced cytotoxicity of CAR19-iNKT cells against CD19+ chronic lymphocytic leukemia cells. Thus, iNKT cells are a highly efficient platform for CAR-based immunotherapy of lymphomas and possibly other CD1d-expressing cancers.

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Current brain-computer interface (BCI) research helps people who have lost the ability to affect their environment in ways many of us take for granted. Future BCIs may go beyond motor function, perhaps aiding with memory recall, decision-making, and other cognitive functions.


Have you ever studied a foreign language and wished you could upload the vocabulary lists directly into your brain so that you could retain them? Would you like to do mental math with the speed and accuracy of a calculator? Do you want a literal photographic memory? Well, these dreams are still the stuff of science fiction, but the brave new world of brain-computer interfaces, or BCI, is well on its way to making technological miracles of this sort a reality.

The story of BCI begins with the discovery of electrical signals emitted by the brain. In 1924, German scientist Hans Berger recorded the first electroencephalogram, or EEG, by placing electrodes under a person’s scalp. Although his research was at first met with derision, a whole new way to study the brain was born from his work. It is now well accepted that the human brain emits electric signals at a variety of frequencies currently known as brainwaves.

BCI researchers attempt to harness these signals to create some desired effect in the world outside the brain. In other words, BCI seeks to make things happen based on a thought in a person’s head. Actually, humans do this all the time when they decide to do anything. A person thinks, “I’m thirsty; I need a drink,” and then the brain sends a litany of instructions to the extremities that allows the person to pour a glass of water, lift it to their mouth, swallow the water, and so on. Most of us go through our days executing these kinds of actions, which require complex interaction between the body and brain, without giving them a second thought.

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Today, we are going to be taking a look at GAIM and what it might mean for treating amyloid-based diseases, such as Alzheimer’s, Parkinson’s, and amyloidosis. This approach has the potential to treat multiple age-related diseases at once by targeting a common characteristic that they all share.

Misfolded proteins cause multiple age-related diseases

Proteins are large, complex molecules that regulate almost everything in our bodies, either directly or indirectly. They do the majority of the work in cells and are critical for the function, regulation, and structure of tissues and organs.

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Best Brain Game To Stave Off Alzheimer’s Could Be Your Job : Shots — Health News Alzheimer’s prevention specialist Jessica Langbaum says that like most working people she gets plenty of mental exercise without playing crossword puzzles or brain games. She says work is the key.

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The Singularity is Near.


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For fifteen years, I’ve assumed that the Matrix Sequels were irredeemable failures. But looking back on them with fresh eyes reveals a pair of films that are exhilarating, interesting, and sometimes hilarious. In this video I try to make sense of these two movies, and what they have to say about free will and the systems that control society.

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Works Cited:

DRAGUNOIU, DANA. “Neo’s Kantian Choice: ‘The Matrix Reloaded’ and the Limits of the Posthuman.” Mosaic: An Interdisciplinary Critical Journal, vol. 40, no. 4, 2007, pp. 51–67. JSTOR, JSTOR, www.jstor.org/stable/44030393. https://www.jstor.org/stable/44030393?read-now=1&loggedin=true&seq=1#metadata_info_tab_contents

For more on Immanuel Kant’s Categorical Imperative read: Groundwork of the Metaphysics of Morals.

More Matrix analysis:

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Scarlet protein has a protective effect against Parkinson’s disease in fruit flies.


Researchers at the Department of Biological Sciences at Lehigh University in Bethlehem, Pennsylvania, discovered that a protein known as Scarlet has protective effects against the fruit fly version of Parkinson’s disease [1].

Abstract

Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons, resulting in progressive locomotor dysfunction. Identification of genes required for the maintenance of these neurons should help to identify potential therapeutic targets. However, little is known regarding the factors that render dopaminergic neurons selectively vulnerable to PD. Here we show that Drosophila melanogaster scarlet mutants exhibit an age-dependent progressive loss of dopaminergic neurons, along with subsequent locomotor defects and a shortened lifespan. Knockdown of Scarlet specifically within dopaminergic neurons is sufficient to produce this neurodegeneration, demonstrating a unique role for Scarlet beyond its well-characterized role in eye pigmentation.

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https://www.youtube.com/watch?v=EX1PiRyIOis