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Category: nanotechnology

This #COVID19 is quite weird it just keeps evolving. In a weird way it is pushing evolution through our immune system. The only thing I know that is similar is like the flu or a bigger organism like cancer. Based on this information the virus just keeps evolving not dying off. Among the weird stuff it doesn’t effect cats or most animals or plants. Basically we either need a universal vaccine which is still being developed or we may need quantum radar to kill off the virus in our bodies when it comes out either that or foglet armor to not breathe it in like Ironman. I find it is just an odd virus as essentially it evolves so fast past even human beings abilities to fend it off even with suits it seems to spread so fast that it cannot be completely contained. From dogs that sniff it out it seems sorta everywhere. I know minor things like high dosages of vitamin c work with zinc and probiotics which was the first way to battle it when it didn’t become this whole pandemic because oddly enough it wasn’t a big deal in previous years because the 19th version of the virus. I know some things that kill it off are ultra violet and lysol as well as bleach. So it makes me think it is more a bioweapon where the universal vaccine would work. But oddly enough I am uncertain if it really dies off especially if it is airborne. If we can destroy the virus by reprogramming it to be sterile or innert or even for it to just kill itself off with crispr like we have done with mosquitoes to stop malaria. We can easily make new vaccines which is good but nearly every year or so there is an entirely new version. This isn’t new but it sorta is like the flu. But there are some theories that I sorta have where it seems to be near heat sources where it grows. Like my uncle who had the virus which we had him turn off electricity and also do vitamin c probiotics and zinc which did work. He ended up getting an antibody naturally this way. I personally got the vaccine and found that it does work but when the new delta version came out it did the same as the last one it sorta just randomly evolves for some reason even smells similar but oddly enough it still remains even after all the lysol. So to me it seems like a bioweapon that is self evolving which is we could use the mechanism to essentially evolve ourselves taking the components of it. If this was a nanobot swarm I would say it spreads from radio waves or something but this virus keeps spreading in odd ways like even from the sky. Which sorta makes me believe that it is sorta being manipulated maybe by a signal perhaps or it has its own program inside it. It reminds me of a Grey goo nanobot swarm that keeps evolving but the biological virus version. I mean it could actually be an exterrestial virus there was a meteorite that came around then and odd things that followed from the meteorite like dogs attacking people and cats attacking people even huge mountain lions. Which makes me think of a sorta an invasion of something. We need to maybe get the viruses input and output to find what it is going to do next. All and all seems odd because even other viruses don’t evolve or like fly or spread that fast. Ideally we should have cyborg nanobots running through Ironman in avengers endgame but so far our best better is treating it like the flu pumping out a new vaccine each year till we know a universal vaccine like using henreitta lacks immortal unlimited cell division cells like they did with polio. But till then we need to keep watching the virus as seems sorta more than it appears based on its original version.

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I am pleased to announce that my lead-author review paper has been published in ACS Nano! If you are interested in learning about the convergence of synthetic biology and adenoviral gene therapy, I encourage you to check out my paper.

If you cannot access the full text, I have also posted a local copy at the following link: https://logancollinsblog.files.wordpress.com/2021/08/synthetic-biology-approaches-for-engineering-next-generation-adenoviral-gene-therapies-2021.pdf.

#ACS #ACSNano #SyntheticBiology #GeneTherapy #Biology #Biotech #Science #Biotechnology #Nanotechnology #Adenovirus #Engineering #Virology

Synthetic biology centers on the design and modular assembly of biological parts so as to construct artificial biological systems. Over the past decade, synthetic biology has blossomed into a highly productive field, yielding advances in diverse areas such as neuroscience, cell-based therapies, and chemical manufacturing. Similarly, the field of gene therapy has made enormous strides both in proof-of-concept studies and in the clinical setting. One viral vector of increasing interest for gene therapy is the adenovirus (Ad). A major part of the Ad’s increasing momentum comes from synthetic biology approaches to Ad engineering. Convergence of gene therapy and synthetic biology has enhanced Ad vectors by mitigating Ad toxicity in vivo, providing precise Ad tropisms, and incorporating genetic circuits to make smart therapies which adapt to environmental stimuli. Synthetic biology engineering of Ad vectors may lead to superior gene delivery and editing platforms which could find applications in a wide range of therapeutic contexts.

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COVID-19 mRNA vaccines and existing gene therapies, including those built with the CRISPR-Cas9 gene-editing tool, are delivered into cells with viral vectors or lipid nanoparticles. A research team led by CRISPR pioneer Feng Zhang, Ph.D., of the Broad Institute has developed a new mRNA delivery system that harnesses a human protein.

The system, dubbed SEND, leverages the ability of a human protein called PEG10 to bind to its own mRNA and form a protective capsule around it. In a new study published in Science, Zhang and colleagues engineered PEG10 to take on RNA cargoes of their choice and successfully delivered the system to mouse and human cells.

The findings support SEND as an efficient delivery platform for RNA-based gene therapies that can be repeatedly dosed, the researchers suggested. Because SEND uses a protein that’s produced naturally in the body, it may not trigger immune responses that can render gene therapies ineffective, the team said.

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Artificial camouflage is the functional mimicry of the natural camouflage that can be observed in a wide range of species1,2,3. Especially, since the 1800s, there were a lot of interesting studies on camouflage technology for military purposes which increases survivability and identification of an anonymous object as belonging to a specific military force4,5. Along with previous studies on camouflage technology and natural camouflage, artificial camouflage is becoming an important subject for recently evolving technologies such as advanced soft robotics1,6,7,8 electronic skin in particular9,10,11,12. Background matching and disruptive coloration are generally claimed to be the underlying principles of camouflage covering many detailed subprinciples13, and these necessitate not only simple coloration but also a selective expression of various disruptive patterns according to the background. While the active camouflage found in nature mostly relies on the mechanical action of the muscle cells14,15,16, artificial camouflage is free from matching the actual anatomies of the color-changing animals and therefore incorporates much more diverse strategies17,18,19,20,21,22, but the dominant technology for the practical artificial camouflage at visible regime (400–700 nm wavelength), especially RGB domain, is not fully established so far. Since the most familiar and direct camouflage strategy is to exhibit a similar color to the background23,24,25, a prerequisite of an artificial camouflage at a unit device level is to convey a wide range of the visible spectrum that can be controlled and changed as occasion demands26,27,28. At the same time, the corresponding unit should be flexible and mechanically robust, especially for wearable purposes, to easily cover the target body as attachable patches without interrupting the internal structures, while being compatible with the ambient conditions and the associated movements of the wearer29,30.

System integration of the unit device into a complete artificial camouflage device, on the other hand, brings several additional issues to consider apart from the preceding requirements. Firstly, the complexity of the unit device is anticipated to be increased as the sensor and the control circuit, which are required for the autonomous retrieval and implementation of the adjacent color, are integrated into a multiplexed configuration. Simultaneously, for nontrivial body size, the concealment will be no longer effective with a single unit unless the background consists of a monotone. As a simple solution to this problem, unit devices are often laterally pixelated12,18 to achieve spatial variation in the coloration. Since its resolution is determined by the numbers of the pixelated units and their sizes, the conception of a high-resolution artificial camouflage device that incorporates densely packed arrays of individually addressable multiplexed units leads to an explosive increase in the system complexity. While on the other hand, solely from the perspective of camouflage performance, the delivery of high spatial frequency information is important for more natural concealment by articulating the texture and the patterns of the surface to mimic the microhabitats of the living environments31,32. As a result, the development of autonomous and adaptive artificial camouflage at a complete device level with natural camouflage characteristics becomes an exceptionally challenging task.

Our strategy is to combine thermochromic liquid crystal (TLC) ink with the vertically stacked multilayer silver (Ag) nanowire (NW) heaters to tackle the obstacles raised from the earlier concept and develop more practical, scalable, and high-performance artificial camouflage at a complete device level. The tunable coloration of TLC, whose reflective spectrum can be controlled over a wide range of the visible spectrum within the narrow range of temperature33,34, has been acknowledged as a potential candidate for artificial camouflage applications before21,34, but its usage has been more focused on temperature measurement35,36,37,38 owing to its high sensitivity to the temperature change. The susceptible response towards temperature is indeed an unfavorable feature for the thermal stability against changes in the external environment, but also enables compact input range and low power consumption during the operation once the temperature is accurately controlled.

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Majoranas particles found.

Majorana particles have been getting bad publicity: a claimed discovery in ultracold nanowires had to be retracted. Now Leiden physicists open up a new door to detecting Majoranas in a different experimental system, the Fu-Kane heterostructure, they announce in Physical Review Letters.

Majorana particles are quasiparticles: collective movements of particles (electrons in this case) which behave as single particles. If detected in real life, they could be used to build stable quantum computers.

“Majoranas are quantum mechanical superpositions,” explains Gal Lemut. This superposition, a special kind of combination, comprises an electron and a hole (a place in a crystal where an electron is missing.

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Deployment of functional circuits on a 3D freeform surface is of significant interest to wearable devices on curvilinear skin/tissue surfaces or smart Internet-of-Things with sensors on 3D objects. Here we present a new fabrication strategy that can directly print functional circuits either transient or long-lasting onto freeform surfaces by intense pulsed light-induced mass transfer of zinc nanoparticles (Zn NPs). The intense pulsed light can locally raise the temperature of Zn NPs to cause evaporation. Lamination of a kirigami-patterned soft semi-transparent polymer film with Zn NPs conforming to a 3D surface results in condensation of Zn NPs to form conductive yet degradable Zn patterns onto a 3D freeform surface for constructing transient electronics. Immersing the Zn patterns into a copper sulfate or silver nitrate solution can further convert the transient device to a long-lasting device with copper or silver. Functional circuits with integrated sensors and a wireless communication component on 3D glass beakers and seashells with complex surface geometries demonstrate the viability of this manufacturing strategy.

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At the University of Chicago, scientists have developed an absolutely innovative, promising treatment for COVID-19 in the form of nanoparticles with the ability to trap SARS-CoV-2 viruses inside the body and use the body’s own immune system to kill them.

The “nanotraps” lure the virus by imitating the target cells infected by the virus. When the virus gets trapped by the nanotraps, it is then sequestered from other cells and targeted for destruction by the immune system.

Theoretically, these nanotraps could be used on different variants of the virus, resulting in a promising new way to suppress the virus in the future. The therapy is still in the early stages of testing, but the researchers believe that it could be administered through a nasal spray as a treatment for COVID-19.

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Bio-Digital Twins, Quantum Computing, And Precision Medicine — Mr. Kazuhiro Gomi, President and CEO, and Dr. Joe Alexander, MD, Ph.D., Director, Medical and Health Informatics (MEI) Lab, NTT Research.

Mr. Kazuhiro Gomi, is President and CEO of NTT Research (https://ntt-research.com/), a division of The Nippon Telegraph and Telephone Corporation, commonly known as NTT (https://www.global.ntt/), a Japanese telecommunications company headquartered in Tokyo, Japan. Mr. Gomi has been at NTT for more than 30 years and was involved in product management/product development activities at the beginning of his tenure. In September of 2009, Mr. Gomi was first named to the Global Telecoms Business Power100 — a list of the 100 most powerful and influential people in the telecoms industry. He was the CEO of NTT America Inc. from 2010 to 2019 and also served on the Board of Directors at NTT Communications from 2012 to 2019. Mr. Gomi received a Masters of Science in Industrial Engineering from the University of Illinois at Urbana-Champaign, and a Master of Science in Electrical Engineering from Keio University, Tokyo. Mr. Gomi is a member of the board at US Japan Council, a non-profit organization aimed at fostering a better relationship between the US and Japan.

Dr. Joe Alexander, is Director of the Medical and Health Informatics (MEI) Lab at NTT Research, where he oversees the MEI Lab research in multi-scale Precision Cardiology platforms such as the cardiovascular bio-digital twin, as well as heart-on-a-chip technology, specifically aimed at developing the infrastructure for a digital replica of an individual’s heart. In addition, the MEI Lab is working on nano-and micro-scale sensors and electrodes, other organ-on-a-chip micro-fluidics technologies, as well as wearable and remote sensing to support future bio-digital twin applications.

Before coming to NTT Research, Dr. Alexander spent 18 years at Pfizer, Inc., where he had most recently served as Senior Medical Director, Global Medical Affairs, working in cardiovascular medicine, worldwide clinical imaging and measurement technologies, medical devices and pulmonary hypertension, and regularly conducting modeling and simulation research in many of these areas. He previously worked for two years at Merck, Inc. and spent eight years at Vanderbilt University, where he completed a two-year residency in internal medicine and served as a professor of medicine and biomedical engineering. Dr. Alexander obtained his M.D. and Ph.D. (in biomedical engineering) degrees at the Johns Hopkins University School of Medicine.

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