Toggle light / dark theme

LongeCity has been doing advocacy and research for indefinite life extension since 2002. With the Methuselah Foundation and the M-Prize’s rise in prominence and public popularity over the past few years, it is sometimes easy to forget the smaller-scale research initiatives implemented by other organizations.

LongeCity seeks to conquer the involuntary blight of death through advocacy and research. They award small grants to promising small-scale research initiatives focused on longevity. The time to be doing this is now, with the increasing popularity and public awareness of Citizen Science growing. The 2020 H+ Conference’s theme was The Rise of the Citizen Scientist. Open –Source and Bottom-Up organization have been hallmarks of the H+ and TechProg communities for a while now, and the rise of citizen science parallels this trend.

Anyone can have a great idea, and there are many low-hanging fruits that can provide immense value and reward to the field of life extension without necessitating large-scale research initiatives, expensive and highly-trained staff or costly laboratory equipment. These low-hanging fruit can provide just as much benefit as large scale ones – and, indeed, even have the potential to provide more benefit per unit of funding than large-scale ones. They don’t call them low-hanging fruit for nothing – they are, after all, potentially quite fruitful.

In the past LongeCity has raised funding by matching donations made by the community to fund a research project that used lasers to ablate (i.e. remove) cellular lipofuscin. LongeCity raised $8,000 dollars by the community which was then matched by up to $16,000 by SENS Founation. A video describing the process can be found here. In the end they raised over $18,000 towards this research! Recall that one of Aubrey’s strategies of SENS is to remove cellular lipofuscin via genetically engineered bacteria. Another small-scale research project funded by LongeCity involved mitochondrial uncoupling in nematodes. To see more about this research success, see here.

LongeCity’s second successfully funded research initiative was Mitochondrial uncoupling . More information can be found here. This project studied the benefits of transplanting microglia in the aging nervous system.

LongeCity’s 3rd success was their project on Microglia Stem Cells in 2010. The full proposal can be found here, and more information on this second successful LongeCity research initiative can be found here.

LongeCity’s fourth research-funding success was on Cryonics in 2012, specifically uncovering the mechanisms of cryoprotectant toxicity.

These are real projects with real benefits that LongeCity is funding. Even if you’re not a research scientist, you can have an impact on the righteous plight to end the involuntary blight of death, by applying for a small-scale research grant from LongeCity. What have you got to lose? Really? Because it seems to me that you have just about everything to gain.

LongeCity has also contributed toward larger scale research and development initiatives in the past as well. They have sponsored projects by Alcor, SENS Foundation and Methuselah Foundation. They crowdsourced a longevity-targeted multivitamin supplement called VIMMORTAL based on bottom-up-style community suggestion and deliberation (one of the main benefits of crowdsourcing).

So? Are you interested in impacting the movement toward indefinite life extension? Then please take a look at the various types of projects listed below that LongeCity might be interested in funding.

— — — — — — — — —

The following types of projects can be supported:

• Science support: contribution to a scientific experiment that can be carried out in a short period of time with limited resources. The experiment should be distinguishable from the research that is already funded by other sources. This could be a side-experiment in an existing programme, a pilot experiment to establish feasibility, or resources for an undergrad or high-school student.

• Chapters support: organizing a local meeting with other LongeCity members or potential members. LongeCity could contribute to the room hire, the expenses of inviting a guest speaker or even the bar tab.

• Travel support: attendance at conferences, science fairs etc. where you are presenting on a topic relevant to LongeCity. Generally this will involve some promotion of the mission and/or a report on the then conference to be shared with our Members

• Grant writing:

Bring together a team of scientists and help them write a successful grant application to a public or private funding body. Depending on the project, the award will be a success premium or sometimes can cover the costs of grant preparation itself.

• Micro matching fundraiser:

If you manage to raise funds on a mission-relevant topic, LongeCity will match the funds raised. (In order to initiate one of these initiatives LongeCity usually also requires that the fundraiser spends at least 500 ‘ThankYou points’ but this requirement can be waived in specific circumstances.)

• Outreach:

Support for a specific initiative raising public awareness of the mission or of a topic relevant to our mission. This could be a local event, a specific, organized direct marketing initiative or a media feature.

• Articles:

Write a featured article for the LongeCity website on a topic of interest to our members or visitors. LongeCity is mainly looking for articles on scientific topics, but well-researched contributions on a relevant topic in policy, law, or philosophy are also welcome.

Grant Size:

‘micro grants’ — up to $180

‘small grants’ — up to $500

Grant applications exceeding $500 can be received, but will not be evaluated conclusively under the small grants scheme. Instead, LongeCity will review the application as draft and may invite a full application afterward.

Decisions as part of the small grants programme are usually pretty quick and straightforward. However please contact LongeCity with a proposal ahead of time, as they will not normally consider applications where the money has already been spent!

Proposals can be as short or elaborate as necessary, but normally should be about half a page long.

Only LongeCity Members can apply, but any Member is free to apply on behalf of someone else — thus, non-Members are welcome to find a Member to ‘sponsor’ their application.

Please email [email protected] with your proposal.

You can also use the ideas forum to prepare the proposal. For general questions, or to discuss the proposal informally, feel free to contact LongeCity at the above email.

— — — — — — — — —

In this essay I argue that technologies and techniques used and developed in the fields of Synthetic Ion Channels and Ion Channel Reconstitution, which have emerged from the fields of supramolecular chemistry and bio-organic chemistry throughout the past 4 decades, can be applied towards the purpose of gradual cellular (and particularly neuronal) replacement to create a new interdisciplinary field that applies such techniques and technologies towards the goal of the indefinite functional restoration of cellular mechanisms and systems, as opposed to their current proposed use of aiding in the elucidation of cellular mechanisms and their underlying principles, and as biosensors.

In earlier essays (see here and here) I identified approaches to the synthesis of non-biological functional equivalents of neuronal components (i.e. ion-channels ion-pumps and membrane sections) and their sectional integration with the existing biological neuron — a sort of “physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid membranes (i.e. lipid bilayer). The potential uses for such channels commonly listed in the literature have nothing to do with life-extension however, and the field is to my knowledge yet to envision the use of replacing our existing neuronal components as they degrade (or before they are able to), rather seeing such uses as aiding in the elucidation of cellular operations and mechanisms and as biosensors. I argue here that the very technologies and techniques that constitute the field (Synthetic Ion-Channels & Ion-Channel/Membrane Reconstitution) can be used towards the purpose of the indefinite-longevity and life-extension through the iterative replacement of cellular constituents (particularly the components comprising our neurons – ion-channels, ion-pumps, sections of bi-lipid membrane, etc.) so as to negate the molecular degradation they would have otherwise eventually undergone.

While I envisioned an electro-mechanical-systems approach in my earlier essays, the field of Synthetic Ion-Channels from the start in the early 70’s applied a molecular approach to the problem of designing molecular systems that produce certain functions according to their chemical composition or structure. Note that this approach corresponds to (or can be categorized under) the passive-physicalist sub-approach of the physicalist-functionalist approach (the broad approach overlying all varieties of physically-embodied, “prosthetic” neuronal functional replication) identified in an earlier essay.

The field of synthetic ion channels is also referred to as ion-channel reconstitution, which designates “the solubilization of the membrane, the isolation of the channel protein from the other membrane constituents and the reintroduction of that protein into some form of artificial membrane system that facilitates the measurement of channel function,” and more broadly denotes “the [general] study of ion channel function and can be used to describe the incorporation of intact membrane vesicles, including the protein of interest, into artificial membrane systems that allow the properties of the channel to be investigated” [1]. The field has been active since the 1970s, with experimental successes in the incorporation of functioning synthetic ion channels into biological bilipid membranes and artificial membranes dissimilar in molecular composition and structure to biological analogues underlying supramolecular interactions, ion selectivity and permeability throughout the 1980’s, 1990’s and 2000’s. The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of “in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others” through the “… transduction of bioelectrical and biochemical events into measurable electrical signals” [2].

Thus my proposal of gradually integrating artificial ion-channels and/or artificial membrane sections for the purpse of indefinite longevity (that is, their use in replacing existing biological neurons towards the aim of gradual substrate replacement, or indeed even in the alternative use of constructing artificial neurons to, rather than replace existing biological neurons, become integrated with existing biological neural networks towards the aim of intelligence amplification and augmentation while assuming functional and experiential continuity with our existing biological nervous system) appears to be novel, while the notion of artificial ion-channels and neuronal membrane systems ion general had already been conceived (and successfully created/experimentally-verified, though presumably not integrated in-vivo).

The field of Functionally-Restorative Medicine (and the orphan sub-field of whole-brain-gradual-substrate-replacement, or “physically-embodied” brain-emulation if you like) can take advantage of the decades of experimental progress in this field, incorporating both the technological and methodological infrastructures used in and underlying the field of Ion-Channel Reconstitution and Synthetic/Artificial Ion Channels & Membrane-Systems (and the technologies and methodologies underlying their corresponding experimental-verification and incorporation techniques) for the purpose of indefinite functional restoration via the gradual and iterative replacement of neuronal components (including sections of bilipid membrane, ion channels and ion pumps) by MEMS (micro-electrocal-mechanical-systems) or more likely NEMS (nano-electro-mechanical systems).

The technological and methodological infrastructure underlying this field can be utilized for both the creation of artificial neurons and for the artificial synthesis of normative biological neurons. Much work in the field required artificially synthesizing cellular components (e.g. bilipid membranes) with structural and functional properties as similar to normative biological cells as possible, so that the alternative designs (i.e. dissimilar to the normal structural and functional modalities of biological cells or cellular components) and how they affect and elucidate cellular properties, could be effectively tested. The iterative replacement of either single neurons, or the sectional replacement of neurons with synthesized cellular components (including sections of the bi-lipid membrane, voltage-dependent ion-channels, ligand-dependent ion channels, ion pumps, etc.) is made possible by the large body of work already done in the field. Consequently the technological, methodological and experimental infrastructures developed for the fields of Synthetic

Ion-Channels and Ion-Channel/Artificial-Membrane-Reconstitution can be utilized for the purpose of a.) iterative replacement and cellular upkeep via biological analogues (or not differing significantly in structure or functional & operational modality to their normal biological counterparts) and/or b.) iterative replacement with non-biological analogues of alternate structural and/or functional modalities.

Rather than sensing when a given component degrades and then replacing it with an artificially-synthesized biological or non-biological analogue, it appears to be much more efficient to determine the projected time it takes for a given component to degrade or otherwise lose functionality, and simply automate the iterative replacement in this fashion, without providing in-vivo systems for detecting molecular or structural degradation. This would allow us to achieve both experimental and pragmatic success in such cellular-prosthesis sooner, because it doesn’t rely on the complex technological and methodological infrastructure underlying in-vivo sensing, especially on the scale of single neuron components like ion-channels, and without causing operational or functional distortion to the components being sensed.

A survey of progress in the field [3] lists several broad design motifs. I will first list the deign motifs falling within the scope of the survey, and the examples it provides. Selections from both papers are meant to show the depth and breadth of the field, rather than to elucidate the specific chemical or kinetic operations under the purview of each design-variety.

For a much more comprehensive, interactive bibliography of papers falling within the field of Synthetic Ion-Channels or constituting the historical foundations of the field, see Jon Chui’s online biography here, which charts the developments in this field up until 2011.

First Survey

Unimolecular ion channels:

Examples include a.) synthetic ion channels with oligocrown ionophores, [5] b.) using a-helical peptide scaffolds and rigid push–pull p-octiphenyl scaffolds for the recognition of polarized membranes, [6] and c.) modified varieties of the b-helical scaffold of gramicidin A [7]

Barrel-stave supramolecules:

Examples of this general class falling include avoltage-gated synthetic ion channels formed by macrocyclic bolaamphiphiles and rigidrod p-octiphenyl polyols [8].

Macrocyclic, branched and linear non-peptide bolaamphiphiles as staves:

Examples of this sub-class include synthetic ion channels formed by a.) macrocyclic, branched and linear bolaamphiphiles and dimeric steroids, [9] and by b.) non-peptide macrocycles, acyclic analogs and peptide macrocycles [respectively] containing abiotic amino acids [10].

Dimeric steroid staves:

Examples of this sub-class include channels using polydroxylated norcholentriol dimer [11].

pOligophenyls as staves in rigid rod b barrels:

Examples of this sub-class include “cylindrical self-assembly of rigid-rod b-barrel pores preorganized by the nonplanarity of p-octiphenyl staves in octapeptide-p-octiphenyl monomers” [12].

Synthetic Polymers:

Examples of this sub-class include synthetic ion channels and pores comprised of a.) polyalanine, b.) polyisocyanates, c.) polyacrylates, [13] formed by i.) ionophoric, ii.) ‘smart’ and iii.) cationic polymers [14]; d.) surface-attached poly(vinyl-n-alkylpyridinium) [15]; e.) cationic oligo-polymers [16] and f.) poly(m-phenylene ethylenes) [17].

Helical b-peptides (used as staves in barrel-stave method):

Examples of this class include: a.) cationic b-peptides with antibiotic activity, presumably acting as amphiphilic helices that form micellar pores in anionic bilayer membranes [18].

Monomeric steroids:

Examples of this sub-class falling include synthetic carriers, channels and pores formed by monomeric steroids [19], synthetic cationic steroid antibiotics [that] may act by forming micellar pores in anionic membranes [20], neutral steroids as anion carriers [21] and supramolecular ion channels [22].

Complex minimalist systems:

Examples of this sub-class falling within the scope of this survey include ‘minimalist’ amphiphiles as synthetic ion channels and pores [23], membrane-active ‘smart’ double-chain amphiphiles, expected to form ‘micellar pores’ or self-assemble into ion channels in response to acid or light [24], and double-chain amphiphiles that may form ‘micellar pores’ at the boundary between photopolymerized and host bilayer domains and representative peptide conjugates that may self assemble into supramolecular pores or exhibit antibiotic activity [25].

Non-peptide macrocycles as hoops:

Examples of this sub-class falling within the scope of this survey include synthetic ion channels formed by non-peptide macrocycles acyclic analogs [26] and peptide macrocycles containing abiotic amino acids [27].

Peptide macrocycles as hoops and staves:

Examples of this sub-class include a.) synthetic ion channels formed by self-assembly of macrocyclic peptides into genuine barrel-hoop motifs that mimic the b-helix of gramicidin A with cyclic b-sheets. The macrocycles are designed to bind on top of channels and cationic antibiotics (and several analogs) are proposed to form micellar pores in anionic membranes [28]; b.) synthetic carriers, antibiotics (and analogs) and pores (and analogs) formed by macrocyclic peptides with non-natural subunits. [Certain] macrocycles may act as b-sheets, possibly as staves of b-barrel-like pores [29]; c.) bioengineered pores as sensors. Covalent capturing and fragmentations [have been] observed on the single-molecule level within engineered a-hemolysin pore containing an internal reactive thiol [30].

Summary

Thus even without knowledge of supramolecular or organic chemistry, one can see that a variety of alternate approaches to the creation of synthetic ion channels, and several sub-approaches within each larger ‘design motif’ or broad-approach, not only exist but have been experimentally verified, varietized and refined.

Second Survey

The following selections [31] illustrate the chemical, structural and functional varieties of synthetic ions categorized according to whether they are cation-conducting or anion-conducting, respectively. These examples are used to further emphasize the extent of the field, and the number of alternative approaches to synthetic ion-channel design, implementation, integration and experimental-verification already existent. Permission to use all the following selections and figures were obtained from the author of the source.

There are 6 classical design-motifs for synthetic ion-channels, categorized by structure, that are identified within the paper:

A: unimolecular macromolecules,
B: complex barrel-stave,
C: barrel-rosette,
D: barrel hoop, and
E: micellar supramolecules.

Cation Conducting Channels:

UNIMOLECULAR

“The first non-peptidic artificial ion channel was reported by Kobuke et al. in 1992” [33].

“The channel contained “an amphiphilic ion pair consisting of oligoether-carboxylates and mono- (or di-) octadecylammoniumcations. The carboxylates formed the channel core and the cations formed the hydrophobic outer wall, which was embedded in the bilipid membrane with a channel length of about 24 to 30 Å. The resultant ion channel, formed from molecular self-assembly, is cation selective and voltage-dependent” [34].

“Later, Kokube et al. synthesized another channel comprising of resorcinol based cyclic tetramer as the building block. The resorcin-[4]-arenemonomer consisted of four long alkyl chains which aggregated to forma dimeric supramolecular structure resembling that of Gramicidin A” [35]. “Gokel et al. had studied [a set of] simple yet fully functional ion channels known as “hydraphiles” [39].

“An example (channel 3) is shown in Figure 1.6, consisting of diaza-18-crown-6 crown ether groups and alkyl chain as side arms and spacers. Channel 3 is capable of transporting protons across the bilayer membrane” [40].

“A covalently bonded macrotetracycle4 (Figure 1.8) had shown to be about three times more active than Gokel’s ‘hydraphile’ channel, and its amide-containing analogue also showed enhanced activity” [44].

“Inorganic derivative using crown ethers have also been synthesized. Hall et. al synthesized an ion channel consisting of a ferrocene and 4 diaza-18-crown-6 linked by 2 dodecyl chains (Figure 1.9). The ion channel was redox-active as oxidation of the ferrocene caused the compound to switch to an inactive form” [45]

B STAVES:

“These are more difficult to synthesize [in comparison to unimolecular varieties] because the channel formation usually involves self-assembly via non-covalent interactions” [47].“A cyclic peptide composed of even number of alternating D- and L-amino acids (Figure 1.10) was suggested to form barrel-hoop structure through backbone-backbone hydrogen bonds by De Santis” [49].

“A tubular nanotube synthesized by Ghadiri et al. consisting of cyclic D and L peptide subunits form a flat, ring-shaped conformation that stack through an extensive anti-parallel β-sheet-like hydrogen bonding interaction (Figure 1.11)” [51].

“Experimental results have shown that the channel can transport sodium and potassium ions. The channel can also be constructed by the use of direct covalent bonding between the sheets so as to increase the thermodynamic and kinetic stability” [52].

“By attaching peptides to the octiphenyl scaffold, a β-barrel can be formed via self-assembly through the formation of β-sheet structures between the peptide chains (Figure 1.13)” [53].

“The same scaffold was used by Matile etal. to mimic the structure of macrolide antibiotic amphotericin B. The channel synthesized was shown to transport cations across the membrane” [54].

“Attaching the electron-poor naphthalenediimide (NDIs) to the same octiphenyl scaffold led to the hoop-stave mismatch during self-assembly that results in a twisted and closed channel conformation (Figure 1.14). Adding the compleentary dialkoxynaphthalene (DAN) donor led to the cooperative interactions between NDI and DAN that favors the formation of barrel-stave ion channel.” [57].

MICELLAR

“These aggregate channels are formed by amphotericin involving both sterols and antibiotics arranged in two half-channel sections within the membrane” [58].

“An active form of the compound is the bolaamphiphiles (two-headed amphiphiles). (Figure 1.15) shows an example that forms an active channel structure through dimerization or trimerization within the bilayer membrane. Electrochemical studies had shown that the monomer is inactive and the active form involves dimer or larger aggregates” [60].

ANION CONDUCTING CHANNELS:

“A highly active, anion selective, monomeric cyclodextrin-based ion channel was designed by Madhavan et al (Figure 1.16). Oligoether chains were attached to the primary face of the β-cyclodextrin head group via amide bonds. The hydrophobic oligoether chains were chosen because they are long enough to span the entire lipid bilayer. The channel was able to select “anions over cations” and “discriminate among halide anions in the order I-> Br-> Cl- (following Hofmeister series)” [61].

“The anion selectivity occurred via the ring of ammonium cations being positioned just beside the cyclodextrin head group, which helped to facilitate anion selectivity. Iodide ions were transported the fastest because the activation barrier to enter the hydrophobic channel core is lower for I- compared to either Br- or Cl-“ [62]. “A more specific artificial anion selective ion channel was the chloride selective ion channel synthesized by Gokel. The building block involved a heptapeptide with Proline incorporated (Figure 1.17)” [63].

Cellular Prosthesis: Inklings of a New Interdisciplinary Approach

The paper cites “nanoreactors for catalysis and chemical or biological sensors” and “interdisciplinary uses as nano –filtration membrane, drug or gene delivery vehicles/transporters as well as channel-based antibiotics that may kill bacterial cells preferentially over mammalian cells” as some of the main applications of synthetic ion-channels [65], other than their normative use in elucidating cellular function and operation.

However, I argue that a whole interdisciplinary field and heretofore-unrecognized new approach or sub-field of Functionally-Restorative Medicine is possible through taking the technologies and techniques involved in in constructing, integrating, and experimentally-verifying either a.) non-biological analogues of ion-channels & ion-pumps (thus trans-membrane membrane proteins in general, also sometimes referred to as transport proteins or integral membrane proteins) and membranes (which include normative bilipid membranes, non-lipid membranes and chemically-augmented bilipid membranes), and b.) the artificial synthesis of biological analogues of ion-channels, ion-pumps and membranes, which are structurally and chemically equivalent to naturally-occurring biological components but which are synthesized artificially – and applying such technologies and techniques toward the purpose the gradual replacement of our existing biological neurons constituting our nervous systems – or at least those neuron-populations that comprise the neo- and prefrontal-cortex, and through iterative procedures of gradual replacement thereby achieving indefinite-longevity. There is still work to be done in determining the comparative advantages and disadvantages of various structural and functional (i.e. design) motifs, and in the logistics of implanting the iterative replacement or reconstitution of ion-channels, ion-pumps and sections of neuronal membrane in-vivo.

The conceptual schemes outlined in Concepts for Functional Replication of Biological Neurons [66], Gradual Neuron Replacement for the Preservation of Subjective-Continuity [67] and Wireless Synapses, Artificial Plasticity, and Neuromodulation [68] would constitute variations on the basic approach underlying this proposed, embryonic interdisciplinary field. Certain approaches within the fields of nanomedicine itself, particularly those approaches that constitute the functional emulation of existing cell-types, such as but not limited to Robert Freitas’s conceptual designs for the functional emulation of the red blood cell (a.k.a. erythrocytes, haematids) [69], i.e. the Resperocyte, itself should be seen as falling under the purview of this new approach, although not all approaches to Nanomedicine (diagnostics, drug-delivery and neuroelectronic interfacing) constitute the physical (i.e. electromechanical, kinetic and/or molecular physically-embodied) and functional emulation of biological cells.

The field of functionally-restorative medicine in general (and of nanomedicine in particular) and the field of supramolecular and organic chemistry converge here, where these technological, methodological, and experimental infrastructures developed in field of Synthetic Ion-Channels and Ion Channel Reconstitution can be employed to develop a new interdisciplinary approach that applies the logic of prosthesis to the cellular and cellular-component (i.e. sub-cellular) scale; same tools, new use. These techniques could be used to iteratively replace the components of our neurons as they degrade, or to replace them with more robust systems that are less susceptible to molecular degradation. Instead of repairing the cellular DNA, RNA and protein transcription and synthesis machinery, we bypass it completely by configuring and integrating the neuronal components (ion-channels, ion-pumps and sections of bilipid membrane) directly.

Thus I suggest that theoreticians of nanomedicine look to the large quantity of literature already developed in the emerging fields of synthetic ion-channels and membrane-reconstitution, towards the objective of adapting and applying existing technologies and methodologies to the new purpose of iterative maintenance, upkeep and/or replacement of cellular (and particularly neuronal) constituents with either non-biological analogues or artificially-synthesized-but-chemically/structurally-equivalent biological analogues.

This new sub-field of Synthetic Biology needs a name to differentiate it from the other approaches to Functionally-Restorative Medicine. I suggest the designation ‘cellular prosthesis’.

References:

[1] Williams (1994)., An introduction to the methods available for ion channel reconstitution. in D.C Ogden Microelectrode techniques, The Plymouth workshop edition, CambridgeCompany of Biologists.

[2] Tomich, J., Montal, M. (1996). U.S Patent No. 5,16,890. Washington, DC: U.S. Patent and Trademark Office.

[3] Matile, S., Som, A., & Sorde, N. (2004). Recent synthetic ion channels and pores. Tetrahedron, 60(31), 6405-6435. ISSN 0040-4020, 10.1016/j.tet.2004.05.052. Access: http://www.sciencedirect.com/science/article/pii/S0040402004007690:

[4] XIAO, F., (2009). Synthesis and structural investigations of pyridine-based aromatic foldamers.

[5] Ibid., p. 6411.

[6] Ibid., p. 6416.

[7] Ibid., p. 6413.

[8] Ibid., p. 6412.

[9] Ibid., p. 6414.

[10] Ibid., p. 6425.

[11] Ibid., p. 6427.

[12] Ibid., p. 6416.

[13] Ibid., p. 6419.

[14] Ibid., p. 6419.

[15] Ibid., p. 6419.

[16] Ibid., p. 6419.

[17] Ibid., p. 6419.

[18] Ibid., p. 6421.

[19] Ibid., p. 6422.

[20] Ibid., p. 6422.

[21] Ibid., p. 6422.

[22] Ibid., p. 6422.

[23] Ibid., p. 6423.

[24] Ibid., p. 6423.

[25] Ibid., p. 6423.

[26] Ibid., p. 6426.

[27] Ibid., p. 6426.

[28] Ibid., p. 6427.

[29] Ibid., p. 6327.

[30] Ibid., p. 6427.

[31] XIAO, F. (2009). Synthesis and structural investigations of pyridine-based aromatic foldamers.

[32] Ibid., p. 4.

[33] Ibid., p. 4.

[34] Ibid., p. 4.

[35] Ibid., p. 4.

[36] Ibid., p. 7.

[37] Ibid., p. 8.

[38] Ibid., p. 7.

[39] Ibid., p. 7.

[40] Ibid., p. 7.

[41] Ibid., p. 7.

[42] Ibid., p. 7.

[43] Ibid., p. 8.

[44] Ibid., p. 8.

[45] Ibid., p. 9.

[46] Ibid., p. 9.

[47] Ibid., p. 9.

[48] Ibid., p. 10.

[49] Ibid., p. 10.

[50] Ibid., p. 10.

[51] Ibid., p. 10.

[52] Ibid., p. 11.

[53] Ibid., p. 12.

[54] Ibid., p. 12.

[55] Ibid., p. 12.

[56] Ibid., p. 12.

[57] Ibid., p. 12.

[58] Ibid., p. 13.

[59] Ibid., p. 13.

[60] Ibid., p. 14.

[61] Ibid., p. 14.

[62] Ibid., p. 14.

[63] Ibid., p. 15.

[64] Ibid., p. 15.

[65] Ibid., p. 15.

[66] Cortese, F., (2013). Concepts for Functional Replication of Biological Neurons. The Rational Argumentator. Access: http://www.rationalargumentator.com/index/blog/2013/05/concepts-functional-replication/

[67] Cortese, F., (2013). Gradual Neuron Replacement for the Preservation of Subjective-Continuity. The Rational Argumentator. Access: http://www.rationalargumentator.com/index/blog/2013/05/gradual-neuron-replacement/

[68] Cortese, F., (2013). Wireless Synapses, Artificial Plasticity, and Neuromodulation. The Rational Argumentator. Access: http://www.rationalargumentator.com/index/blog/2013/05/wireless-synapses/

[69] Freitas Jr., R., (1998). “Exploratory Design in Medical Nanotechnology: A Mechanical Artificial Red Cell”. Artificial Cells, Blood Substitutes, and Immobil. Biotech. (26): 411–430. Access: http://www.ncbi.nlm.nih.gov/pubmed/9663339

UPDATE: A generous contribution of $5,000 from the Methuselah Foundation has been received! This will put the fundraiser over the top of the cost and pay for the advanced Champions Oncology treatment described below.

However, Dr. Coles still has other medical expenses outstanding, and more will be coming in.

To cover these as well as Dr. Coles’s many other personal expenses, the fundraiser will now have an extended timeframe and the limit has been raised to $20,000.

We are currently at $13,385 of our 20,000 goal! Help us make it all the way!

Your contribution would help Dr. Coles continue his contributions and be greatly appreciated.

*** PLEASE alert your friends. L Stephen Coles spend his entire professional career trying to save your life; take a second to help save his.***

CLICK HERE TO DONATE, OR TO HELP BY LIKING AND SHARING THE PAGE VIA FACEBOOK, TWITTER, GOOGLE+ OR PINTEREST.

Supporters

Methuselah Foundation

Offline Donation

donated $5,000.00

Friday, June 07, 2013

Anonymous

Offline Donation

donated $400.00

Friday, June 07, 2013

Chuck Wade

donated $20.00

Thursday, June 06, 2013

Anonymous

donated Hidden Amount

Wednesday, June 05, 2013

Tom Funk

donated $100.00

Wednesday, June 05, 2013

Gennady Stolyarov II

donated $50.00

Wednesday, June 05, 2013

Stephen Coles is one of the heroes of our time, who has contributed immensely to the prospects for longevity for all of us. I am honored to be able to assist him in his own struggle against a life-threatening illness, so that he could have decades and centuries more to fight the most dangerous, the most destructive enemies of senescence and death.Anonymous

Anonymous

donated $50.00

Tuesday, June 04, 2013

marshall zablen

donated $300.00

Tuesday, June 04, 2013

Anonymous

donated $200.00

Tuesday, June 04, 2013

Anonymous

donated $200.00

Tuesday, June 04, 2013

Björn Kleinert

donated $50.00

Tuesday, June 04, 2013

Get well !

Joao Pedro Magalhaes

donated $50.00

Tuesday, June 04, 2013

Anonymous

donated Hidden Amount

Monday, June 03, 2013

Otto

donated $20.00

Monday, June 03, 2013

Anonymous

donated $20.00

Monday, June 03, 2013

Franco Cortese

donated $100.00

Monday, June 03, 2013

PLEASE donate ANYTHING you can to help save the life of L. Stephen Coles, who has spent his entire professional career trying to save yours!

Aubrey de Grey

donated $300.00

Monday, June 03, 2013

Anonymous

Offline Donation

donated$5,000.00

Monday, June 03, 2013

RetirementSingularity.com

donated Hidden Amount

Monday, June 03, 2013

Anonymous

donated Hidden Amount

Monday, June 03, 2013

Sven Bulterijs

donated $15.00

Monday, June 03, 2013

Anonymous

donated Hidden Amount

Sunday, June 02, 2013

kg goldberger

donated $20.00

Sunday, June 02, 2013

prayers are on the way for more than 65% of deaths. Aging is a cause of adult cancer, stroke and many others age related diseases. Researchers fighting aging are the best people, they are fighting for all of us. Let’s pay them back!

Bijan Pourat MD

donated$250.00

Saturday, June 01, 2013

Maxim Kholin

donated Hidden Amount

Saturday, June 01, 2013

Aging is a disease. Aging is responsible

Anonymous

donated $60.00

Saturday, June 01, 2013

Nils Alexander Hizukuri

donated $30.00

Saturday, June 01, 2013

All the best!

Anonymous

donated $40.00

Saturday, June 01, 2013

Danny Bobrow

donated Hidden Amount

Saturday, June 01, 2013

Steve, win this fight for us all. I send you healing thoughts.

Danny

Steve, friends and family, but it is an outstanding, real-world example of the advancing frontier of science and medicine. The entire life-extension community should rally in support of this effort for Steve and for the acquisition of important scientific knowledge.

Cliff Hague

donated $100.00

Saturday, June 01, 2013

Best wishes for a speedy recovery.

Tom Coote

donated $100.00

Friday, May 31, 2013

With Best Wishes!

Anonymous

donated $100.00

Friday, May 31, 2013

Allen Taylor

donated$25.00

Friday, May 31, 2013

Gunther Kletetschka

donated Hidden Amount

Friday, May 31, 2013

john mccormack, Australia

donated $50.00

Friday, May 31, 2013

phil kernan

donated $100.00

Friday, May 31, 2013

Gary and Marie Livick

donated $100.00

Friday, May 31, 2013

ingeseim

donated Hidden Amount

Friday, May 31, 2013

TeloMe Inc.

donated $100.00

Friday, May 31, 2013

Not only is this an important cause for

-Preston Estep, Ph.D.

CEO and Chief Scientific Officer, TeloMe, Inc.

Not only is this an important cause for Steve, friends and family, but it is an outstanding, real-world example of the advancing frontier of science and medicine. The entire life-extension community should rally in support of this effort for Steve and for the acquisition of important scientific knowledge. –Preston Estep, Ph.D. CEO and Chief Scientific Officer, TeloMe, Inc.

Anonymous

donated $5.00

Thursday, May 30, 2013

Anonymous

donated $60.00

Thursday, May 30, 2013

Larry Abrams

donated $100.00

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Wednesday, May 29, 2013

*** PLEASE alert your friends—Our own continued health and longevity may depend on Steve continuing his work.***

This call for support was also posted by Ilia Stambler on the Longevity Alliance Website, and organized on YouCaring.com by John M. Adams. Eric Schulke has also helped tremendously in spreading the word about the Fundraiser.

Since founding the Los Angeles Gerontology Research Group in 1990, Dr. L. Stephen Coles M.D., Ph.D., has worked tirelessly to develop new ways to slow and ultimately reverse human aging.

Everyone active in the LA-GRG or the Worldwide GRG Discussion Group have benefited from his expertise. His continual reporting of news about the latest developments to the List and his work in areas such as gathering blood samples for a complete genome analysis of the oldest people in the world (supercentenarians, aged 110+) is ground breaking and far ahead of anything that has ever been accomplished before. Publication of this work is expected in collaboration with Stanford University before the end of the year. Other accomplishments are equally notable

CLICK HERE TO HELP!

BRIEF summary of his work: L. Stephen Coles, M.D. Ph.D — Cited in more than 250 scientific articles — Profiled as notable person in Wikipedia — Many other contributions to aging research and advancing long, healthy life

Steve Coles was diagnosed with Adenocarcinoma (Pancreatic Cancer) at the head of the pancreas on Christmas Eve of last year. Pancreatic cancer is particularly insidious. He underwent a Whipple (Surgical) Procedure on January 3rd that produced a beneficial result. The tumor’s complete obstruction to the common bile duct that had caused jaundice and severe pruritus (skin itching leading to scratching to the point of bleeding) was almost immediately reversed in two days. His subsequent chemotherapy with Gemzar over the past three months will hopefully prevent metastases from spreading to other organs. But we won’t know his prognosis until June 7th when a CT Scan will be compared with a baseline scan performed before the start of chemo interpreted by a cancer radiologist.

We now have the opportunity to carry out a personalized chemo treatment regimen created by a start-up company called Champions Oncology in Baltimore, MD; USA affiliated with the Johns Hopkins School of Medicine. Champions is a world class organization that will analyze the tissue sample that has already been sent to them. Then, a custom treatment program will be prescribed for Steve based on a mouse model, since each tumor is unique and pure test tube trials have not been shown to be effective.

Champions Oncology’s service is to test in mice what can work for Dr. Coles. This is done through two steps:

(1) To implant Dr. Coles’s cancer on mice. (This part has been successfully carried out, and it will allow us to test nine different treatment protocols on Dr. Coles’s specific tumor tissue in mice).

(2) Test the treatments on the mice (The treatments have been defined with Dr. James P. Watson, Dr. Coles, and his oncologists.)

Dr. Joao Pedro de Magalhes of Liverpool, UK was the first to propose employing the services of Champions Oncology. They have a good track record. The biggest risk is that the process normally takes so long that the patient dies before the results can be obtained (especially with such an aggressive, malignant cancer, as Dr. Coles’s). Luckily, this part went right. Also, there is a risk is that Step-1 won’t work. Luckily for us, this part went right, too. Therefore, so far, it seems that choosing Champions Oncology’s approach was the right choice. We can’t be sure that Step-2 will be as successful, but we need to try.

In addition to his medical team here in the U.S., our international friends have been active on his behalf. They successfully negotiated a 60 percent reduction in cost.

NOW, YOU CAN HELP IN TWO WAYS:

(1) CONTRIBUTE TO THIS FUND

Time is of the essence. The good people at Champions Oncology have agreed to begin the analysis immediately.

Steve Coles needs your support.

It may make THE difference. Please dig deep and support him by contributing to the fund.

*** Our own continued health and longevity may depend on Steve continuing his work.***

(2) SEND REFERRALS TO CHAMPIONS ONCOLOGY

Champions Oncology is an early-stage for-profit company. Champions is not a philanthropy. Like many companies offering breakthrough technologies, it has light bills to pay, payroll to make on time, and many other typical expenses.

Please think of any oncologists how may refer patients to Champions, then contact any of the individuals listed below so we may get life-saving information about Champions into their hands. Champions is particularly well set up to accommodate physicians and patients in the Eastern U.S., Germany, France, Brazil, and Japan.

We wish to acknowledge the GRG (the Gerontology Research Group—A discussion group of ~400 members worldwide.

We owe a special thank you to The International Longevity Alliance Movement for their support.

Contacts:

1. Edouard Debonneuil [email protected] France Skype ID: edebonneuil

2. Daniel Wuttke [email protected] Germany Skype: admiral_atlan

3. Ilia Stambler [email protected] Israel Skype: iliastam

4. John M. (Johnny) Adams [email protected]

U.S. (949) 922‑9786 Skype: agingintervention

Updates 06/03/2013

by John M. (Johnny) Adams

IMPORTANT MESSAGE: Dr. Coles has received a contribution and is forwarding it directly to Champions Oncology.

So as of now, 10:20 am PDT, we have $6175 of the needed $10,000!

I have contacted YouCaring and asked how to change the “$1475 raised of $10000 goal”.

Supporters

Franco Cortese

donated$100.00

Monday, June 03, 2013

PLEASE donate ANYTHING you can to help save the life of L. Stephen Coles, who has spent his entire professional career trying to save yours!

Aubrey de Grey

donated$300.00

Monday, June 03, 2013

Anonymous

Offline Donation

donated$5,000.00

Monday, June 03, 2013

RetirementSingularity.com

donated Hidden Amount

Monday, June 03, 2013

Anonymous

donated Hidden Amount

Monday, June 03, 2013

Sven Bulterijs

donated$15.00

Monday, June 03, 2013

Anonymous

donated Hidden Amount

Sunday, June 02, 2013

kg goldberger

donated$20.00

Sunday, June 02, 2013

prayers are on the way for more than 65% of deaths. Aging is a cause of adult cancer, stroke and many others age related diseases. Researchers fighting aging are the best people, they are fighting for all of us. Let’s pay them back!

Bijan Pourat MD

donated$250.00

Saturday, June 01, 2013

Maxim Kholin

donated Hidden Amount

Saturday, June 01, 2013

Aging is a disease. Aging is responsible

Anonymous

donated$60.00

Saturday, June 01, 2013

Nils Alexander Hizukuri

donated$30.00

Saturday, June 01, 2013

All the best!

Anonymous

donated$40.00

Saturday, June 01, 2013

Danny Bobrow

donated Hidden Amount

Saturday, June 01, 2013

Steve, win this fight for us all. I send you healing thoughts.

Danny Steve, friends and family, but it is an outstanding, real-world example of the advancing frontier of science and medicine. The entire life-extension community should rally in support of this effort for Steve and for the acquisition of important scientific knowledge.

Cliff Hague

donated $100.00

Saturday, June 01, 2013

Best wishes for a speedy recovery.

Tom Coote

donated $100.00

Friday, May 31, 2013

With Best Wishes!

Anonymous

donated$100.00

Friday, May 31, 2013

Allen Taylor

donated$25.00

Friday, May 31, 2013

Gunther Kletetschka

donated Hidden Amount

Friday, May 31, 2013

john mccormack, Australia

donated$50.00

Friday, May 31, 2013

phil kernan

donated$100.00

Friday, May 31, 2013

Gary and Marie Livick

donated$100.00

Friday, May 31, 2013

ingeseim

donated Hidden Amount

Friday, May 31, 2013

TeloMe Inc.

donated$100.00

Friday, May 31, 2013

Not only is this an important cause for

-Preston Estep, Ph.D.

CEO and Chief Scientific Officer, TeloMe, Inc.

Anonymous

donated$5.00

Thursday, May 30, 2013

Anonymous

donated$60.00

Thursday, May 30, 2013

Larry Abrams

donated$100.00

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Wednesday, May 29, 2013

By Avi Roy, University of Buckingham

In rich countries, more than 80% of the population today will survive past the age of 70. About 150 years ago, only 20% did. In all this while, though, only one person lived beyond the age of 120. This has led experts to believe that there may be a limit to how long humans can live.

Animals display an astounding variety of maximum lifespan ranging from mayflies and gastrotrichs, which live for 2 to 3 days, to giant tortoises and bowhead whales, which can live to 200 years. The record for the longest living animal belongs to the quahog clam, which can live for more than 400 years.

If we look beyond the animal kingdom, among plants the giant sequoia lives past 3000 years, and bristlecone pines reach 5000 years. The record for the longest living plant belongs to the Mediterranean tapeweed, which has been found in a flourishing colony estimated at 100,000 years old.

This jellyfish never dies. Michael W. May

Some animals like the hydra and a species of jellyfish may have found ways to cheat death, but further research is needed to validate this.

The natural laws of physics may dictate that most things must die. But that does not mean we cannot use nature’s templates to extend healthy human lifespan beyond 120 years.

Putting a lid on the can

Gerontologist Leonard Hayflick at the University of California thinks that humans have a definite expiry date. In 1961, he showed that human skin cells grown under laboratory conditions tend to divide approximately 50 times before becoming senescent, which means no longer able to divide. This phenomenon that any cell can multiply only a limited number of times is called the Hayflick limit.

Since then, Hayflick and others have successfully documented the Hayflick limits of cells from animals with varied life spans, including the long-lived Galapagos turtle (200 years) and the relatively short-lived laboratory mouse (3 years). The cells of a Galapagos turtle divide approximately 110 times before senescing, whereas mice cells become senescent within 15 divisions.

The Hayflick limit gained more support when Elizabeth Blackburn and colleagues discovered the ticking clock of the cell in the form of telomeres. Telomeres are repetitive DNA sequence at the end of chromosomes which protects the chromosomes from degrading. With every cell division, it seemed these telomeres get shorter. The result of each shortening was that these cells were more likely to become senescent.

Other scientists used census data and complex modelling methods to come to the same conclusion: that maximum human lifespan may be around 120 years. But no one has yet determined whether we can change the human Hayflick limit to become more like long-lived organisms such as the bowhead whales or the giant tortoise.

What gives more hope is that no one has actually proved that the Hayflick limit actually limits the lifespan of an organism. Correlation is not causation. For instance, despite having a very small Hayflick limit, mouse cells typically divide indefinitely when grown in standard laboratory conditions. They behave as if they have no Hayflick limit at all when grown in the concentration of oxygen that they experience in the living animal (3–5% versus 20%). They make enough telomerase, an enzyme that replaces degraded telomeres with new ones. So it might be that currently the Hayflick “limit” is more a the Hayflick “clock”, giving readout of the age of the cell rather than driving the cell to death.

The trouble with limits

Happy last few days? It doesn’t have to end this way. ptimat

The Hayflick limit may represent an organism’s maximal lifespan, but what is it that actually kills us in the end? To test the Hayflick limit’s ability to predict our mortality we can take cell samples from young and old people and grow them in the lab. If the Hayflick limit is the culprit, a 60-year-old person’s cells should divide far fewer times than a 20-year-old’s cells.

But this experiment fails time after time. The 60-year-old’s skin cells still divide approximately 50 times – just as many as the young person’s cells. But what about the telomeres: aren’t they the inbuilt biological clock? Well, it’s complicated.

When cells are grown in a lab their telomeres do indeed shorten with every cell division and can be used to find the cell’s “expiry date”. Unfortunately, this does not seem to relate to actual health of the cells.

It is true that as we get older our telomeres shorten, but only for certain cells and only during certain time. Most importantly, trusty lab mice have telomeres that are five times longer than ours but their lives are 40 times shorter. That is why the relationship between telomere length and lifespan is unclear.

Apparently using the Hayflick limit and telomere length to judge maximum human lifespan is akin to understanding the demise of the Roman empire by studying the material properties of the Colosseum. Rome did not fall because the Colosseum degraded; quite the opposite in fact, the Colosseum degraded because the Roman Empire fell.

Within the human body, most cells do not simply senesce. They are repaired, cleaned or replaced by stem cells. Your skin degrades as you age because your body cannot carry out its normal functions of repair and regeneration.

To infinity and beyond

If we could maintain our body’s ability to repair and regenerate itself, could we substantially increase our lifespans? This question is, unfortunately, vastly under-researched for us to be able to answer confidently. Most institutes on ageing promote research that delays onset of the diseases of ageing and not research that targets human life extension.

Those that look at extension study how diets like calorie restriction affect human health or the health impacts of molecules like resveratrol derived from red wine. Other research tries to understand the mechanisms underlying the beneficial effects of certain diets and foods with hopes of synthesising drugs that do the same. The tacit understanding in the field of gerontology seems to be that, if we can keep a person healthy longer, we may be able to modestly improve lifespan.

Living long and having good health are not mutually exclusive. On the contrary, you cannot have a long life without good health. Currently most ageing research is concentrated on improving “health”, not lifespan. If we are going to live substantially longer, we need to engineer our way out of the current 120-year-barrier.

Avi Roy does not work for, consult to, own shares in or receive funding from any company or organisation that would benefit from this article, and has no relevant affiliations.

Read the original article.

The following article was originally published by Immortal Life

When asked what the biggest bottleneck for Radical or Indefinite Longevity is, most thinkers say funding. Some say the biggest bottleneck is breakthroughs and others say it’s our way of approaching the problem (i.e. that we’re seeking healthy life extension whereas we should be seeking more comprehensive methods of indefinite life-extension), but the majority seem to feel that what is really needed is adequate funding to plug away at developing and experimentally-verifying the various, sometimes mutually-exclusive technologies and methodologies that have already been proposed. I claim that Radical Longevity’s biggest bottleneck is not funding, but advocacy.

This is because the final objective of increased funding for Radical Longevity and Life Extension research can be more effectively and efficiently achieved through public advocacy for Radical Life Extension than it can by direct funding or direct research, per unit of time or effort. Research and development obviously still need to be done, but an increase in researchers needs an increase in funding, and an increase in funding needs an increase in the public perception of RLE’s feasibility and desirability.

There is no definitive timespan that it will take to achieve indefinitely-extended life. How long it takes to achieve Radical Longevity is determined by how hard we work at it and how much effort we put into it. More effort means that it will be achieved sooner. And by and large, an increase in effort can be best achieved by an increase in funding, and an increase in funding can be best achieved by an increase in public advocacy. You will likely accelerate the development of Indefinitely-Extended Life, per unit of time or effort, by advocating the desirability, ethicacy and technical feasibility of longer life than you will by doing direct research, or by working towards the objective of directly contributing funds to RLE projects and research initiatives. Continue reading “Longevity’s Bottleneck May Be Funding, But Funding’s Bottleneck is Advocacy & Activism” | >

Dirrogate_fundawear_memories_with_maya

Emotions and Longevity:

If the picture header above influenced you to click to read more of this article, then it establishes at least part of my hypothesis: Visual stimuli that trigger our primal urges, supersede all our senses, even over-riding intellect. By that I mean, irrespective of IQ level, the visual alone and not the title of the essay will have prompted a click through –Classic advertising tactic: Sex sells.

Yet, could there be a clue in this behavior to study further, in our quest for Longevity? Before Transhumanism life extension technology such as nano-tech and bio-tech go mainstream… we need to keep our un-amped bodies in a state of constant excitement, using visual triggers that generate positive emotions, thereby hopefully, keeping us around long enough to take advantage of these bio-hacks when they become available.

dirrogate_emotion_transhumanism

Emotions on Demand — The “TiVo-ing” of feelings:

From the graphic above, it is easy to extrapolate that ‘positive’ emotions can contribute significantly to Longevity. When we go on a vacation, we’re experiencing the world in a relaxed frame of mind and encoding these experiences, even if sub-consciously, in our brains (minds?). Days, or even years later we can call on these experiences, on-demand, to bring us comfort.

Granted, much like analog recordings… over time, these stored copies of positive emotions will deteriorate, and just as we can today digitize images and sounds, making for pristine everlasting copies… can we digitize Emotions for recall and to experience them on-demand?

How would we go about doing it and what purpose does it serve?

durex_fundawear_dirrogate_sex

Digitizing Touch: Your Dirrogate’s unique Emotional Signature:

Can we digitize Touch; a crucial building block that contributes to the creation of Emotions? For an answer, we need to look to the (and to some, the questionable) technology behind Teledildonics.

While the tech to experience haptic feed-back has been around for a while, it’s been mostly confined to Virtual Reality simulations and for training purposes. Crude haptic-force feedback gaming controllers are available on the market, but advances in actuators, and nano-scale miniaturization are soon to change that, even going as far as to give us tactile imaging capability — “Smart Skin

Recently, Durex announced “Fundawear”. It’s purpose? To experience the “touch” of your partner in a fun light-hearted way. Yet, what if a Fundawear session could be recorded and played back later? The unique way your partner touches, forever digitized for playback when desired… allowing you to experience the emotion of joy and happiness at will?

Fundawear can be thought of as a beta v1.0 of something akin to smart-skin in reverse, which could eventually allow a complete “feel-stream” to be digitized and played back on-demand.

Currently we are already able to digitize some faculties that stimulate two of our primary senses:

  • Sight — via a video camera.
  • Sound — via microphones.

So how do we go about digitizing and re-creating the sense of Touch?

Solutions such as the one from NuiCapture shown in the video above, in combination with off the shelf game hardware such as the Kinect, can Digitize a whole body “performance” — Also known as performance capture.

Dirrogates and 3D Printing a Person:

In the near future if we get blue-prints to 3D print a person, ready for re-animation and complete with “smart-skin”… such a 3D printed surrogate could reciprocate our touch.

It would be an exercise in imagination, to envision 3D printing your partner, if they couldn’t be with you when you wanted them, or indeed it could raise moral and ethical issues such as ‘adultery’ if an un-authorized 3D printed copy was produced of a person, and their “signature” performance files was pirated.

But with every evil, there is also the good. 3D printers can print guns, or as seen in the video above: a prosthetic hand, allowing a child to experience life the way other children do — That is the ethos of Transhumanism.

3d-tv-family-conference

Loneliness can kill you:

Well maybe not exactly kill you, but it can negatively impact your health, says The World of Psychology. That would be counterproductive in our quest for Longevity.

A few years ago, companies such as Accenture introduced family collaboration projects. I recommend clicking on the link to read the article, as copyright restrictions prevent including it in this essay. In essence, it allows older relatives to derive emotional comfort from seeing and interacting with their families living miles away.

At a very basic level, we are already Transhuman. No stigma involved… no religious boundaries crossed. This ethical use of technology, can bring comfort to an aging section of society, bettering their condition.

In a relationship, the loss of a loved one can be devastating to the surviving partner, even more so, if the couple had grown old together and shared their good and bad times. Experiencing and re-living memories that transcend photographs and videos, could contribute towards generating positive emotions and thus longevity in the person coping with his/her loss.

While 3D printing and re-animating a person is still a few years away, there is another stop-gap technology: Augmented Reality. With AR visors, we can see and interact with a “Dirrogate” (Digital Surrogate) of another person as though they were in the same room with us. The person’s Dirrogate can be operated in real-time by another person living thousands of miles away… or a digitized touch stream can be called on… long after the human operator is no more.

In the story: “Memories with Maya”, the context and it’s repercussion on our evolution into a Transhuman species, is explored in more detail.

The purpose of this essay is to seed ideas only, and is not to be taken as expert advice.

1inftri

Immortal Life is presenting a public event in Washington D.C., titled “Radical Life Extension: are you ready to live 1,000 years?”

It will take place in the historic Friends Meeting House on September 22 (Sunday). The event will be from 5:30–7:30.

We will have 10–12 speakers discussing Immortality / Life Extension from a wide variety of perspectives: scientific, political, social, poetic, religious, atheistic, economic, demographic, moral, etc.

Our lineup of speakers even features numerous Lifeboat Foundation Advisors , including myself, Gabriel Rothblatt, Hank Pellissier, Antonei B. Csoka, and Didier Coeurnelle. Other speakers include Mark Waser, Gray Scott, Jennifer ‘Dotora’ Huse, Apneet Jolly, Tom Mooney, Hank Fox, Maitreya One Paul Spiegel and Rich Lee.

There are still a few available slots for speakers but they’re filling fast, so if you’re interested in reserving a seat, being a speaking or contributing in any other way, please have them send an email to [email protected]

We have already attained the support of numerous life extension groups in the Washington DC area, but are always grateful for funding contributions from sponsors to help us with travel and advertising costs, and speaker stipends, for this event and future events. Promoters are always welcome as well.

Medical science has changed humanity. It changed what it means to be human, what it means to live a human life. So many of us reading this (and at least one person writing it) owe their lives to medical advances, without which we would have died.

Live expectancy is now well over double what it was for the Medieval Briton, and knocking hard on triple’s door.

What for the future? Extreme life extension is no more inherently ridiculous than human flight or the ability to speak to a person on the other side of the world. Science isn’t magic – and ageing has proven to be a very knotty problem – but science has overcome knotty problems before.

A genuine way to eliminate or severely curtail the influence of ageing on the human body is not in any sense inherently ridiculous. It is, in practice, extremely difficult, but difficult has a tendency to fall before the march of progress. So let us consider what implications a true and seismic advance in this area would have on the nature of human life.

keep-calm-and-be-forever-young-138

One absolutely critical issue that would surround a breakthrough in this area is the cost. Not so much the cost of research, but the cost of application. Once discovered, is it expensive to do this, or is it cheap? Do you just have to do it once? Is it a cure, or a treatment?

If it can be produced cheaply, and if you only need to do it once, then you could foresee a future where humanity itself moves beyond the ageing process.

The first and most obvious problem that would arise from this is overpopulation. A woman has about 30–35 years of life where she is fertile, and can have children. What if that were extended to 70–100 years? 200 years?

Birth control would take on a vastly more important role than it does today. But then, we’re not just dropping this new discovery into a utopian, liberal future. We’re dropping it into the real world, and in the real world there are numerous places where birth control is culturally condemned. I was born in Ireland, a Catholic nation, where families of 10 siblings or more are not in any sense uncommon.

What of Catholic nations – including some staunchly conservative, and extremely large Catholic societies in Latin America – where birth control is seen as a sin?

Of course, the conservatism of these nations might (might) solve this problem before it arises – the idea of a semi-permanent extension of life might be credibly seen as a deeper and more blasphemous defiance of God than wearing a condom.

But here in the West, the idea that we are allowed to choose how many children we have is a liberty so fundamental that many would baulk to question it.

We may have to.

quizzical baby

There is another issue. What about the environmental impact? We’re already having a massive impact on the environment, and it’s not looking pretty. What if there were 10 times more of us? 100 times more? What about the energy consumption needs, in a world running out of petrol? The food needs? The living space? The household waste?

There are already vast flotillas of plastic waste the size of small nations that float across the surface of the Pacific. Carbon dioxide levels in the atmosphere have just topped 400 parts per million. We are pushing hard at the envelope of what the world of capable of sustaining, and a massive boost in population would only add to that ever-increasing pressure.

Of course, science might well sort out the answer to those things – but will it sort it out in time? The urgency of environmental science, and cultural change, suddenly takes on a whole new level of importance in the light of a seismic advance in addressing the problem of human ageing.

These are problems that would arise if the advance produced a cheap treatment that could (and would) be consumed by very large numbers of people.

But what if it wasn’t a cure? What if it wasn’t cheap? What if it was a treatment, and a very expensive one?

All of a sudden, we’re looking at a very different set of problems, and the biggest of all centres around something Charlie Chaplin said in the speech he gave at the end of his film, The Great Dictator. It is a speech from the heart, and a speech for the ages, given on the eve of mankind’s greatest cataclysm to date, World War 2.

In fact, you’d be doing yourself a favour if you watched the whole thing, it is an astounding speech.

chaplin great dictator

The quote is this:

“To those who can hear me, I say — do not despair.

The misery that is now upon us is but the passing of greed, the bitterness of men who fear the way of human progress. The hate of men will pass, and dictators die, and the power they took from the people will return to the people. And so long as men die, liberty will never perish.”

And so long as men die, liberty will never perish.

What if Stalin were immortal? And not just immortal, but immortally young?

Immortally vigourous, able to amplify the power of his cult of personality with his literal immortality.

This to me seems a threat of a very different kind, but of no less importance, than the dangers of overpopulation. That so long as men die, liberty will never perish. But what if men no longer die?

And of course, you could very easily say that those of us lucky enough to live in reasonably well-functioning democracies wouldn’t have to worry too much about this. It doesn’t matter if you live to be 1000, you’re still not getting more than 8 years of them in the White House.

But there is something in the West that would be radically changed in nature. Commercial empires.

What if Rupert Murdoch were immortal?

It doesn’t matter how expensive that treatment for ageing is. If it exists, he’d be able to afford it, and if he were able to buy it, he’d almost certainly do so.

If Fox News was run by an immortal business magnate, with several lifetimes worth of business experience and skill to know how to hold it all together, keep it going, keep it growing? What then?

Charles-Montgomery-Burns--007

Not perhaps the sunny utopia of a playground of immortals that we might hope for.

This is a different kind of issue. It’s not an external issue – the external impact of population on the environment, or the external need of a growing population to be fed. These problems might well sink us, but science has shown itself extremely adept at finding solutions to external problems.

What this is, is an internal problem. A problem of humanity. More specifically, the fact that extreme longevity would allow tyranny to achieve a level of entrenchment that it has so far never been capable of.

But then a law might be passed. Something similar to the USA’s 8 year term limit on Presidents. You can’t be a CEO for longer than 30 years, or 40 years, or 50. Something like that might help, might even become urgently necessary over time. Forced retirement for the eternally young.

Not an unproblematic idea, I’m sure you’ll agree. Quite the culture shock for Western societies loathe to accept government intervention in private affairs.

But it is a new category of problem. A classic problem of humanity, amplified by immortality. The centralisation of control, power and influence in a world where the people it centres upon cannot naturally die.

This, I would say, is the most obvious knotty problem that would arise, for humanity, in the event of an expensive, but effective, treatment for ageing.

But then, let’s just take a quick look back at the other side of the coin. Is there a problem inherent in humanity that would be amplified were ageing to be overcome, cheaply, worldwide?

Let me ask you a question.

Do people, generally speaking, become more open to new things, or less open to new things, as they age?

Do older people – just in general terms – embrace change or embrace stasis?

Well, it’s very obvious that some older people do remain young at heart. They remain passionate, humble in their beliefs, they are open to new things, and even embrace them. Some throw the influence and resources they have accrued throughout their lifetimes into this, and are instrumental to the march of progress.

More than this, they add a lifetime of skill, experience and finesse to their passion, a melding of realism and hope that is one of the most precious and potent cocktails that humanity is capable of mixing.

But we’re not talking about the few. We’re talking about the many.

Is it fair to say that most older people take this attitude to change? Or is it fairer to say that older people who retain that passion and spark, who not only have retained it, but have spent a lifetime fuelling it into a great blaze of ability and success – is it fair to say that these people are a minority?

I would say yes. They are incredibly precious, but part of that preciousness is the fact that they are not common.

Perhaps one day we will make our bodies forever young. But what of our spirit? What of our creativity?

I’m not talking about age-related illnesses like Parkinson’s, or Alzheimer’s disease. I’m talking about the creativity, passion and fire of youth.

The temptation of the ‘comfort zone’ for all human beings is a palpable one, and one that every person who lives well, who breaks the mold, who changes the future, must personally overcome.

Do the majority of people overcome it? I would argue no. And more than this, I would argue that living inside a static understanding of the world – even working to protect that understanding in the face of naked and extreme challenges from reality itself – is now, and has historically been, through all human history, the norm.

Those who break the mold, brave the approbation of the crowd, and look to the future with wonder and hope, have always been a minority.

mind closed till further notice

Now add in the factor of time. The retreat into the comforting, the static and the known has a very powerful pull on human beings. It is also not a binary process, but an analogue process – it’s not just a case of you do or you don’t. There are degrees of retreat, extremes of intellectual conservatism, just as there are extremes of intellectual curiosity, and progress.

But which extremes are the more common? This matters, because if all people could live to 200 years old or more, what would that mean for a demographic shift in cultural desire away from change and toward stasis?

A worrying thought. And it might seem that in the light of all this, we should not seek to open the Pandora’s box of eternal life, but should instead stand against such progress, because of the dangers it holds.

But, frankly, this is not an option.

The question is not whether or not human beings should seek to conquer death.

The question is whether or not conquering death is possible.

If it is possible, it will be done. If it is not, it will not be.

But the obvious problem of longevity – massive population expansion – is something that is, at least in principle, amenable to other solutions arising from science as it now practiced. Cultural change is often agonising, but it does happen, and scientific progress may indeed solve the issues of food supply and environmental impact. Perhaps not, but perhaps.

At the very least, these sciences take on a massively greater importance to the cohesion of the human future than they already have, and they are already very important indeed.

But there is another, deeper problem of a very different kind. The issue of the human spirit. If, over time, people (on average) become more calcified in their thinking, more conservative, less likely to take risks, or admit to new possibilities that endanger their understanding, then longevity, distributed across the world, can only lead to a culture where stasis is far more valued than change.

Pandora’s box is already open, and its name is science. Whether it is now, or a hundred years from now, if it is possible for human beings to be rendered immortal through science, someone is going to crack it.

We cannot flinch the future. It would be churlish and naive to assume that such a seemingly impossible vision will forever remain impossible. Not after the last century we just had, where technological change ushered in a new era, a new kind of era, where the impossibilities of the past fell like wheat beneath a scythe.

Scientific progress amplifies the horizon of possible scientific progress. And we stand now at a time when what it means to be a human – something which already undergone enormous change – may change further still, and in ways more profound than any of us can imagine.

If it can be done, it will be done. And so the only sane approach is to look with clarity at what we can see of what that might mean.

The external problems are known problems, and we may yet overcome them. Maybe. If there’s a lot of work, and a lot of people take a lot of issues a lot more seriously than they are already doing.

climate-change-silence-630

But there is a different kind of issue. An issue extending from human nature itself. Can we overcome, as a people, as a species, our fear, and the things that send us scurrying back from curiosity and hope into the comforting arms of wilful ignorance, and static belief?

This, in my opinion, is the deepest problem of longevity. Who wants to live forever in a world where young bodies are filled with withered souls, beaten and embittered with the frustrations of age, but empowered to set the world in stone to justify them?

But perhaps it was always going to come to this. That at some point technological advancement would bring us to a kind of reckoning. A reckoning between the forces of human fear, and the value of human courage.

To solve the external problems of an eternal humanity, science must do what science has done so well for so long – to delve into the external, to open up new possibilities to feed the world, and balance human presence with the needs of the Earth.

But to solve the internal problems of an eternal humanity, science needs to go somewhere else. The stunning advances in the understanding of the external world must begin to be matched with new ways of charting the deeps of human nature. The path of courage, of open-mindedness, of humility, and a willingness to embrace change and leave behind the comforting arms of old static belief systems – this is not a path that many choose.

But many more must choose it in a world of immortal people, to counterbalance the conservatism of those who fail the test, and retreat, and live forever.

Einstein lived to a ripe old age, and never lost his wonder. Never lost his humility, or his courage to brave the approbation and ridicule of his peers in that task he set himself. To chart the deep simplicities of the real, and know the mind of God. The failure of the human spirit is not written in the stars, and never will be.

einstein laughing

We are none of us doomed to fail in matters of courage, curiosity, wonder or hope. But we are none of us guaranteed to succeed.

And as long as courage, hope and the ability to break new ground remain vague, hidden properties that we squeamishly refuse to interrogate, each new generation will have to start from scratch, and make their own choices.

And in a world of eternal humans, if any individual generation fails, the world will be counting that price for a very long time.

It is a common fear that if we begin to make serious headway into issues normally the domain of the spiritual, we will destroy the mystique of them, and therefore their preciousness.

Similar criticisms were, and sometimes still are, laid at the feet of Darwin’s work, and Galileo’s. But the fact is that an astronomer does not look to the sky with less wonder because of their deeper understanding, but more wonder.

Reality is both stunningly elegant, and infinitely beautiful, and in these things it is massively more amazing than the little tales of mystery humans have used to make sense of it since we came down from the trees.

In the face of a new future, where the consequences of human courage and human failure are amplified, the scientific conquest of death must be fused with another line of inquiry. The scientific pioneering of the fundamental dynamics of courage in living, and humility to the truth, over what we want to believe.

It will never be a common path, and no matter how clear it is made, or how wide it is opened, there will always be many who will never walk it.

But the wider it can be made, the clearer it can be made, the more credible it can be made as an option.

And we will need that option. We need it now.

And our need will only grow greater with time.

By Avi Roy, University of Buckingham

I want to live longer and help others do the same. I assumed the most effective way to do that is by understanding the science of aging and then engineering solutions to extend human lifespan. That is why I became a biomedical researcher and over the past several years I have pursued this goal almost single-mindedly.

When a 2004 study showed that reducing the calorie intake in mice extended their life by 42%, I enthusiastically embraced the results and even put myself on a calorie restricted diet. But, subsequently, a 2012 study showed that long-term calorie restriction may not have the promised benefits. On the contrary, fewer calories without the required nutrients might actually cause harm.

Calorie restriction is not the first such “promising” route that eventually did not live up to the promise, and it will not be the last. Antioxidants showed promise in holding back diseases caused by aging, but now we know that antioxidant supplements are more likely to shorten your life.

Earlier in May, researchers showed that reducing a protein called NF-kB in mouse brains modestly improved their lifespan. I am not holding out for this result either. Before too long, I’m sure there will be reports of severe side effects of manipulating levels of NF-kB.

Take it easy

Looking at the data I have come to the conclusion that “doing nothing” may be the best option in most cases. This may not be as pessimistic as it sounds and it is definitely not to say that research in fighting aging must not be carried out.

When I say “do nothing”, I am assuming that you do not smoke or drink too much alcohol, and have access to medical care in case of injury. Such measures are bound to increase your lifespan.

But currently, not intervening in the aging process is more likely to help you live longer than trying any of the methods I’ve mentioned, not by a few months but by many years. Trying any of those interventions may actually cause harm, and will do so for the foreseeable future.

Lesson from the past

The chart below shows the survival rates – the percentage of the population that lives to a certain age – for men in England and Wales from 1860 to 2010.

In the 1860s, more than 20% of children died at birth or soon after. On average, men’s health started to decline around the age of 30, and only about 20% of the population survived for more than 70 years.

By 1910, child mortality decreased, thanks to improvements in hygiene and better medical care. This meant more men lived past the age of 50. Circle A shows this reduction in childhood mortality between 1860 and 2010. But, as can be seen from Circle D, the gain towards the end was not significant. This is because only 30% of males passed the age of 70.

Fifty years later, after the discovery of penicillin and invention of more vaccines, 90% of English and Welsh men lived until 50, and more than half survived to 70. Arrow B marks this trend.

Today almost 80% of men live to the age of 70. Four times as many men reach 70 now than in 1860.

What accounts for the change? Between 1860 and 1960, the significant increase in survival rate was due to medical intervention. Since 1960, the survival curve has improved mainly due to reduction in smoking.

This trend is similar in many rich countries, including the US. Druin Burch, a physician and writer, says in his book Taking the Medicine, that eliminating smoking would provide more benefits than being able to cure people of every possible type of cancer.

Age gracefully

Many experts believe that human lifespan might actually have an upper limit of 125 years. The average may not increase much beyond 90. If we are to agree with them, this leaves little room for improvement.

But we have never concentrated on maximising human lifespan before. Most people believe human lifespan is finite, so all drugs being manufactured today are targeted towards certain age-related diseases such as diabetes and hypertension. They are not designed to extend human lifespan.

If this bleak outlook is indeed true, we should not practise naive interventionism because it is unlikely to help. As Nassim Nicholas Taleb describes in his book Antifragile, naive interventionism occurs when we try to fix a single thing, but end up disturbing a complex system.

In case of extending human lifespan, those naive interventions would include calorie restriction, antioxidant supplements or manipulating the protein NF-kB, as mentioned earlier. They also include the current obsession with replacing fat in foods with sugar, the health benefits of drinking red wine, or the use ofsurgery or supplements to “fight” aging. This latter industry has grown in the past decade from being non-existent to an estimated worth of $88 billion today.

If intervening in the aging process with current biomedical science has any positive effect at all, it will be far too small to worry about. It’s far more likely to harm us.

That is why I have decided to do nothing and follow a simple rule: unless I meet with an accident, or suffer from a terminal disease, I will not add anything to my life with the explicit purpose of extending it. To do anything else would most likely do more harm than good.

Avi Roy does not work for, consult to, own shares in or receive funding from any company or organisation that would benefit from this article, and has no relevant affiliations.

The Conversation

This article was originally published at The Conversation.
Read the original article.