“Deep in the forests of Germany, nestled neatly into the hollowed-out shells of acorns, live a smattering of ants who have stumbled upon a fountain of youth. They are born workers, but do not do much work. Their days are spent lollygagging about the nest, where their siblings shower them with gifts of food. They seem to elude the ravages of old age, retaining a durably adolescent physique, their outer shells soft and their hue distinctively tawny. Their scent, too, seems to shift, wafting out an alluring perfume that endears them to others. While their sisters, who have nearly identical genomes, perish within months of being born, these death-defying insects live on for years and years and years,” Katherine J. Wu writes.
A parasite gives its hosts the appearance of youth, and an unmatched social power in the colony.
A 2010 study had found that people who were given zoledronate after experiencing hip fractures showed slightly reduced all-cause mortality compared to a control group. Patients who took the drug were at significantly lower risk for heart arrhythmias and pneumonia.
As this is a drug that is already being given to people, the choice to go back to genetically modified fruit flies, a much simpler model of aging, may seem counterintuitive. The team chose to test these insects for two principal reasons. The first is that Drosophila flies are a common subject of studies on basic aging pathways, which the researchers wished to explore. The second is simpler: Drosophila flies lack bones, making the bone-affecting properties of zoledronate irrelevant to the study.
The Retrobiome, Cancer, And Aging — Roswell Park Comprehensive Cancer CtrThe Retrobiome, Cancer, And Aging — Dr. Andrei Gudkov, PhD, DSci, Roswell Park Comprehensive Cancer Center, joins me on Progress, Potential, And Possibilities Cornell University College of Veterinary Medicine #Cancer #Vaika #Genome #DnaDamage #ImmunoSenescence #Pets #Dogs #Health #Lifespan #LifeExtension #Inflammaging #Longevity #Aging #Oncology
Dr Andrei Gudkov, PhD, DSci, is a preeminent cancer researcher who serves as Senior Vice President, Research Technology and Innovation, Chair of the Department of Cell Stress Biology, and a member of the senior leadership team for National Cancer Institute (NCI) Cancer Center Support Grant at Roswell Park Comprehensive Cancer Center (https://www.roswellpark.org/andrei-gudkov).
Dr. Gudkov is responsible for building on the basic and translational research strengths of the Cell Stress Biology program in DNA damage and repair, photodynamic therapy, thermal and hypoxic stress and immune modulation.
Dr. Gudkov assists the President & CEO in developing and implementing strategic plans for new scientific programs and enhancing collaborations in research programs with regional and national academic centers as well as with industry.
Before joining Roswell Park, Dr. Gudkov served as chair of the Department of Molecular Genetics at Lerner Research Institute, Cleveland Clinic Foundation, and Professor of Biochemistry at Case Western University. He earned his doctoral degree in Experimental Oncology at the Cancer Research Center, USSR and a Doctorate of Science (D.Sci) in Molecular Biology at the Moscow State University, USSR. He has authored or co-authored over 135 scientific articles and holds 27 patents.
Dr. Gudkov is also an accomplished entrepreneur who founded Cleveland BioLabs, Inc., OncoTartis LLC and Everon Biosciences, Inc.
He holds the position of Director & Chief Scientific Advisor at Panacela Labs, Inc., Chief Scientific Officer of OncoTartis LLC, Chief Scientific Officer for Everon Biosciences, Inc., Chief Science Officer at Genome Protection, Inc. and Chief Scientific Officer of Cleveland BioLabs, Inc. Andrei V. Gudkov is also on the board of Incuron LLC.
Dr. Gudkov also serves on the Scientific Advisory Board and is author of the founding concept for the Vaika (https://www.vaika.org/) program, a not-for-profit charitable medical research organization with a mission to extend the health-span and life-span of domestic animals, with a focus on aged sled dogs.
Summary: Ketamine and exposure to 60-hertz flickering light show promise as a potentially new, non-invasive therapy to help rejuvenate the aging brain.
Source: IST Austria
Can you remember the smell of flowers in your grandmother’s garden or the tune your grandpa always used to whistle? Some childhood memories are seemingly ingrained into your brain. In fact, there are critical periods in which the brain learns and saves profound cognitive routines and memories. The structure responsible for saving them is called the perineuronal net.
This extracellular structure envelops certain neurons, thereby stabilizes existing connections – the synapses – between them and prevents new ones from forming. But what if we could remove the perineuronal net and restore the adaptability of a young brain? The neuroscientist Sandra Siegert and her research group at IST Austria now published two promising techniques to do so.
It’s an astonishing achievement — and in an eyebrow-raising twist, Simons says he plans to live forever, by turning himself into a cyborg.
It sounds like Simons has thought out his plan.
“This is the first puzzle piece in my goal of replacing body parts with mechanical parts,” Simons told De Telegraaf, adding that his goal is “immortality.”
Long vid. Slight annotation in the comments. A few takaways I liked: We need to move to human data instead of mice. People’s attitude towards life extension should change drastically soon. There is human data among this group and have released it, will keep following it, and some to be released soon. Sinclair thinks he can start primate trials this year. And overall everyone is optimistic.
A couple of weeks ago Avi Roy, alongside Nathan Cheng & Laura Minquini, hosted the Longevity Panel discussion, which assembled some of the biggest scientists in the field currently working on reversing aging.
This discussion was intended to illuminate how they are approaching longevity and to know if we are any closer in achieving it.
The talk was split into two sections: the first being open discussion guided by questions from the hosts. The talk was then opened up to the floor, allowing audience questions. Part 1 will provide the transcript from the first section of the Longevity Panel. Enjoy!
You can check out the full transcript, with addition links on the Gowing Life website: https://www.gowinglife.com/longevity-panel-the-scientists-working-on-reversing-aging-part-1/ ——————
The questions: 05:35 — How do you plan on reversing aging?
14:52 — If we want to reverse aging or slow it, what are the most promising approaches to measuring biological aging and the effectiveness of the therapeutic interventions that we’re developing?
28:28 — In 1969, gerontologist Alex Comfort suggested that life expectancy, not simply maximum lifespan, could be extended to 120 years within the next 20 years. That didn’t happen because he obviously is not with us anymore. What will be different this time as we try to get people interested in longevity or promise them that this is imminent in some way or form?
Researchers and entrepreneurs are starting to ponder how AI could create versions of people after their deaths—not only as static replicas but as evolving digital entities that may steer companies or influence world events.
Experts are exploring ways artificial intelligence might confer a kind of digital immortality, preserving the personalities of the departed in virtual form and then allowing them to evolve.
The Gist: They think they can start wider human trials soon which would last 2 years then have a product in 3 to 4 years.
In this video, Drs Irina and Mike Conboy talk how TPE, therapeutic plasma exchange is already available as an FDA approved procedure and the plans to extend the usage to include more age related diseases. We also discuss the company that they have formed IMU
Our guests today are Drs. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. their discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.
Papers mentioned in this video. Plasma dilution improves cognition and attenuates neuroinflammation in old mice. https://pubmed.ncbi.nlm.nih.gov/33191466/ Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin. https://pubmed.ncbi.nlm.nih.gov/32474458/ Rejuvenation of aged progenitor cells by exposure to a young systemic environment. https://pubmed.ncbi.nlm.nih.gov/15716955/
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Did you know that life extension is impossible? I didn’t until the keen minds over at the Guardian informed me as such. Fortunately before I decided to give up my career in regenerative medicine I decided to look into exactly how the Guardian came to such a revelation. What I discovered was so earth shattering that it rocked my very understanding of the world, and made me question everything I thought I knew. That realisation was that, despite their consistent insistence to the contrary, the media lies, a lot.
Ok maybe this was not as shocking as I made it out to be, in fact it’s pretty widely known by now that the media is generally no stranger to the odd lie here and there. If you are not familiar with the story allow me to give you a recap. A recent study was conducted in order to find out if human lifespans have actually increased due to advanced in medicine. To do this, scientists used statistical models to remove non-age related causes of death from historical records (such as murder, death in child birth, plague etc) in order to determine what the uninterrupted human lifespan is, and if it has increased over time. What was found is that our medical science is yet to fundamentally extend human lifespan. This comes as no surprise to anyone in the field of longevity research as we know full well that none of our current medical treatments address causes of ageing. What this study does not conclude however is that life extension is impossible.
