Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

The state of the immune system is an important determinant of aging. With age, immune function both declines in effectiveness and becomes inflammatory. Chronic inflammation accelerates the progression of all of the common age-related diseases. It disrupts tissue maintenance and regeneration, to pick one of many examples. It is likely that a sizable component of variation in aging arises from the differences between individuals in the degree to which the immune system has become damaged and dysfunctional.

Some of this immune aging is a matter of the burden of exposure to more rather than fewer pathogens over a lifetime: persistent infections in particular, such as cytomegalovirus and other herpesviruses, appear to drive immune aging. Some immune aging stems from the atrophy of the thymus, the organ responsible for maturation of T cells. A lesser volume of active thymic tissue means fewer new T cells to take up an effective defense of the body. Some immune aging is due to failure of barriers in the gut, allowing gut bacteria to trigger inflammatory activity. Some immune aging arises from cellular senescence among immune cells, turning them into harmful centers of inflammatory signaling. All of these issues have potential solutions, but, as in all matters related to aging, far too little funding and attention are given to the relevant development programs.

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Dr. Alan Green’s patients travel from around the country to his tiny practice in Queens, N.Y., lured by the prospect of longer lives.

Over the past two years, more than 200 patients have flocked to see Green after learning that two drugs he prescribes could possibly stave off aging. One 95-year-old was so intent on keeping her appointment that she asked her son to drive her from Maryland after a snowstorm had closed the schools.

Green is among a small but growing number of doctors who prescribe drugs “off-label” for their possible anti-aging effects. Metformin is typically prescribed for diabetes, and prevents organ rejection after a transplant, but doctors can prescribe drugs off-label for other purposes—in this case, for “aging.”

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A look at the upcoming Undoing Aging Conference on March 28-30th, Berlin, Germany and some musings on why you should consider going.

As Undoing Aging 2019 in Berlin approaches, I have been reflecting on the previous year and the things that I am most looking forward to this year. So, today, as a journalist and longevity advocate, I am going to be sharing some of my personal musings and thoughts about this important event with you.

First of all, for those of you unfamiliar with the event, a little explanation is in order. Undoing Aging is an industry conference on March 28–30, Berlin, Germany that is organized by the SENS Research Foundation and the Forever Healthy Foundation.

The event has a firm focus on the science and progress being made in aging research and will see many of the leading experts come together for three days of exciting scientific talks, panels, and discussions. Undoing Aging 2019 is the second conference in this series and is one of the must-go events of the year.

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Presents its list of the top 30 Longevity Influencers in Singapore, whose efforts in science, technology, industry and policy are driving the growth of the Singaporean Longevity Landscape.

Link to the Report: https://www.aginganalytics.com/longevity-in-singapore

Dr Finian Tan Brian Kennedy #DannySoon #GaryKhoo #BussarawanTeerawichitchainan #ChongHockSia #JaniceChia #JeffreyLu #CarlFirth #KanwaljitSoin #ChristianiJeyakumarHenry #ColinStewart #HweePinkTan Kenneth Noonan MD #LimChweeTeck #LokSheeMei #MelisTay #NeoKahYean #NgHuckHui #PaoloRampichini #PaulSi #PennyWan #JudithSwain #VishalDoshi #WallaceToores #WilfBlackburn #YuCai #LimXinhong WanJin Hong Birgit Lane.

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Scientists have shown that the removal of non-dividing senescent cells, which are normally associated with aging, also appears to prevent Type 1 diabetes in diabetic mouse strains.

Clearing senescent beta cells prevents T1 diabetes

Type 1 diabetes (T1D) is a chronic condition in which the pancreas produces little or no insulin. Insulin is a hormone that allows sugar (glucose) to enter cells in order to create energy, so it is critical to cellular function and life.

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This platform was applied for the first time in our newly released Longevity Industry in Singapore report, utilizing data on the companies, investors, research labs and non-profit organizations featured in the report.

Aging Analytics Agency is planning to implement a number of updates, additions and enhancement for this platform in the coming months, including interactive and filterable mindmaps, infographics and network diagrams illustrating connections and interactions within the global Longevity Industry, as well as additional features, to be introduced throughout 2019.

Link to Platform: http://mindmaps.aginganalytics.com/

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Samsara Therapeutics has completed a seed financing round in collaboration with Apollo Ventures, a venture capital company and biotech incubator that supports longevity research and treatments for age-related diseases.

Samsara Therapeutics, Inc. (“Samsara,”) a platform biotechnology startup engaged in the discovery and development of compounds that address the primary molecular causes of aging, announced today the closing of a seed financing round. The financing was led by Apollo Ventures, a life sciences venture capital firm and company builder working across Europe and North America.

Additionally, on February 19th, 2019 Nature Communications published a peer-reviewed paper, “The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species” authored by Samsara’s scientific team [1]. The paper demonstrates the capability of the Samsara platform to identify novel MoA geroprotective small molecules that extend healthy lifespan across species and which are protective in mammalian models of disease.

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