Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

And Vetek Association present their list of the top 60 Longevity Influencers in Israel, whose efforts in science, technology, industry and policy are driving the growth of the Israeli Longevity Landscape.

Link to the Report: https://www.aginganalytics.com/longevity-in-israel

Aaron Ciechanover Anat Ben-Zvi, Ph.D., Clinical Psychologist Boaz Misholi Dov Chernichovsky — דב צ’רניחובסקי Ehud Cohen Eyal banin Idan Segev Ilia Stambler Israel Issi Doron Itamar Harel Itamar Raz Jonathan Mandelbaum Michael Neeman Mooly Eden Nir Barzilai MD Rafi Eitan Raphael Gorodetsky Ruth Arnon Uri Alon Valery Krizhanovsky Yael Sorek-benvenisti Yechezkel Barenholz Yosef Gruenbaum.

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Press Release for Aging Analytics Agency and Vetek Association’s new 500+ page open-access report on the Longevity Industry in Israel, featuring quotes from Nir Barzilai MD, the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York, Rafi Eitan, former chairman of the Israel Pensioners’ Party “GIL”, founding minister of the Israel Ministry for Senior Citizens, and the current chairman of Vetek Association, Ilia Stambler, the Chief Science Officer of Vetek Association and Eric Kihlstrom, Director of Aging Analytics Agency and former Interim Director of the £98-million Healthy Ageing Industrial Strategy Challenge Fund.

Link to the Press Release: http://analytics.dkv.global/data/pdf/Longevity-in-Israel/Longevity_in_Israel_-_Press_Release.pdf

Link to the Report: https://www.aginganalytics.com/longevity-in-israel

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Today we have some clips and commentary from the SENS Webinar we did back in January where we asked Dr. Aubrey de Grey about his prediction for robust mouse and human rejuvenation and got a positive answer!

On January 28, 2019, we held a webinar with the SENS Research Foundation as part of a new ongoing series of research webinars. During the webinar, we asked Dr. Aubrey de Grey how close we might be to achieving robust mouse rejuvenation (RMR) and robust human rejuvenation, and his answer was somewhat surprising.

RMR is defined as reproducibly trebling the remaining lifespan of naturally long-lived (~3 years average lifespan) mice with therapies begun when they are already two years old.

Dr. de Grey now suggests that there is a 50/50 chance of achieving robust mouse rejuvenation within 3 years from now; recent interviews and conversation reveal that he’d adjusted this figure down from 5–6 years. He has also moved his estimation of this to arrive from around 20 years to 18 years for humans.

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Intervene Immune is a company focused on the age-related decline of the immune system, which is known as immunosenescence. Here, Bobby Brooke, CEO of Intervene Immune, discusses the clinical potential of regenerating the thymus as a means of reversing age-related immune system decline.

Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. This was a conference designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights.

As the human body ages, the thymus begins to shrink, and fewer numbers of T cells are created and trained to fight. The thymus tissue also turns to fat rather than healthy immune cell-producing thymic tissue. Eventually, the thymus wastes away, becoming a useless fatty organ that no longer produces immune cells.

This structural decay of the thymus and the failure of the immune system when we are old opens us up to multiple age-related diseases, particularly cancer, along with infectious diseases, such as pneumonia and flu.

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There is a strong correlation between the decline of the immune system and a decrease in future lifespan. As the immune system performs a myriad of functions with a multitude of specialized cell types, its breakdown has serious ramifications for health and longevity. As we age, our immune systems steadily decline, becoming less efficient and more inclined to contribute to chronic inflammation due to inappropriate activation.

This smoldering chronic inflammation, also known as inflammaging, speeds up the development of various age-related diseases due to the crosstalk it has with the various damages of aging. In many ways, inflammaging is the glue that binds these damages together, as each of them has an inflammatory component and their progress is often accelerated in the presence of increased inflammation.

At a basic level, inflammation disrupts tissue maintenance and regeneration by blocking various repair pathways, so when that inflammation is chronic, as is commonly seen in aged individuals, the healing of organs and tissues is poor. Therefore, it is no surprise that chronic inflammation causes most older people to struggle to heal and recover from injury.

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Dr. Barzilai is a chaired Professor of Medicine and Genetics and Director of the biggest Center in the world to study the Biology of Aging.

“Nir is our keynote speaker this year because, quite honestly, if I’d only given him half an hour there is no way he could do justice to his role in our movement. His scientific contributions have been world-leading for decades, but in recent years he has done so much more: he has taken a prominent role in two important rejuvenation startups, and he has also employed his exceptional political skills in forging invaluable new understandings between the biomedical gerontology and regulatory communities. Plus, he’s almost as entertaining a speaker as me!”, says Aubrey de Grey.

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Yaron Fuchs is the 2018 grand prize winner of the Sartorius & Science Prize for Regenerative Medicine & Cell Therapy, for work that reveals a role for programmed stem cell death in wound healing and tissue regeneration. The findings, described in his prize-winning essay, “The therapeutic promise of apoptosis,” could potentially pave the way to novel regenerative medicine and tumor therapies that target stem cells undergoing apoptosis — a type of programmed cell death.

The 2018 grand prize winner revealed a role for programmed stem cell death in wound healing and tissue regeneration, and potentially in tumor therapies.

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You’re cordially invited to the 1st of a series of blog entries I’m writing on anti-aging research smile

A: “It’s a dynamic system that veers away from its homeostasis (normal equilibrium point): hence a form of slow-progressing illness. Labeling it as ‘natural’ is a surrender to our traditional state of ignorance and powerlessness, which fortunately are beginning to be changed!”

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In the spirit of the progenitor of Budda, Mohammed, and Christ, accept that the purse is a tool of suffering.

This new book by Jim Mellon and Al Chalabi is a layman’s guide to longevity. It investigates the new technologies and explains how to benefit from the life extending technologies both personally and professionally. It helps readers unravel the science, offers ideas on potential investment and reveals the views of the key opinion leaders.

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