It’s called cognitive reserve, and it’s the phenomenon of the mind’s resistance to damage of the brain. It’s also the subject of not only an upcoming new data and biomedical sample resource, but also a related request for information (RFI) from the NIA and a first-of-its-kind workshop in September.
The push to study cognitive reserve in more depth across the scientific disciplines was born out of recommendations from the Cognitive Aging Summit III. Some 300 researchers attended the summit in Bethesda, Maryland in 2017. Coordinated by the NIA of the National Institutes of Health (NIH) and supported by the McKnight Brain Research Foundation, the summit centered on age-related brain and cognitive changes, with a particular focus on issues related to cognitive resilience and reserve. According to the NIA, investigators from around the world delivered presentations and engaged in discussion “about some of the most important scientific questions relating to the biological, physiological, social and behavioral aspects of reserve and resilience in aging individuals. Attendees also discussed strategies to preserve and bolster cognitive function during aging.”
We’re now rapidly approaching a pivotal moment in the history of this planet, when through scientific discovery an intelligent species could become a race of demigods, THE RACE OF THE IMMORTALS.
It’s quite achievable now. In fact, that will probably happen in two stages: First stage — we have to extend our lifespan with ever-improving Biotechnology. Aging is declared a desease, and around 2029, with the advances in Nanotechnology and Artificial Intelligence, we will be able start to reverse aging and add more than one year every year to an average life expectancy.
So if you’re alive in 2030, chances are you’ll live to 100 and beyond. What life would be like on the other side, when you know you can live indefinitely long? Well, we’ll get used to it and adjust accordingly. We’ll merge into the Global Brain, and emerge as the Global Mind.
To the scientists here, could humans live for 300 years?
Those portions of the modern longevity community interested in bringing an end to aging and extending healthy human life span indefinitely tend to be the older portions, people who have been a part of the broader movement for quite some time. Newcomers tend to be more moderate, aiming at lesser goals. Perhaps this is a result of the successful projects, such as the SENS Research Foundation and Methuselah Foundation, tending to moderate their rhetoric as they attract a broader and larger base of support. I think that this road to moderation might be a problem, and that there is thus a continued role for those who loudly declaim that the goal is to control aging absolutely, via new medical technology, and that the natural consequence of that control is healthy, active, youthful life that extends for centuries or more.
If the goals that our movement works towards are broadly watered down from radical life extension of centuries to just adding a few more years, then marginal projects that can do no more than add a few more years will come to dominate the field to the exclusion of everything else. We are already more or less in this situation, in that the vast majority of funding goes towards discovery and development of small molecules that tinker with the operation of an aged metabolism to make it a little more resilient to the underlying causes of aging. If that is all that is done, then we’ll all age and die on basically the same schedule as our parents and grandparents. It will be a grand waste of opportunity, given that we have the knowledge and the means to do far better, such as by following the SENS agenda for rejuvenation biotechnologies based on repairing the root causes of aging.
This popular media article looks at a few of the people who do make no bones about aiming at radical life extension. It isn’t terrible, thankfully, though it doesn’t quite manage to escape the straitjacket of conformity, the author suggesting that it is somehow strange to want to live for a long time in good health, or strange to want to avoid a slow, crumbling, painful death. There is no present status quo so terrible that it will not have its defenders, and for whatever reason the status quo of aging and suffering and omnipresent death and loss are aggressively defended. But setting that aside, the article manages to capture the present state of development and the viewpoints of its subjects quite well, which is a change over past years of media attention.
A new mouse study highlights the proteins responsible for LC3-associated endocytosis (LANDO), an autophagy process that is involved in degrading β-amyloid, the principal substance associated with Alzheimer’s disease.
Proteostasis
Proteins in the human brain can form misfolded, non-functional, and toxic clumps known as aggregates. Preventing these aggregates from forming, and removing them when they do, is a natural function of the human body, and it is known as proteostasis. However, as we age, this function degrades, and loss of proteostasis is one of the hallmarks of aging. The resulting accumulation of aggregates leads to several deadly diseases, one of which is Alzheimer’s.
Aging is just natural, while rejuvenation therapies aren’t, but does this mean we should accept aging as it is and forget about rejuvenation? Not at all, and as Nicola explains in this video, just because something is natural, it’s not also automatically good for you.
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At 100 years old, the world’s oldest billionaire would be forgiven for taking it easy and enjoying the riches of his eight-decade career.
But for Chang Yun Chung, founder of Pacific International Lines (PIL), staying at home isn’t an option. Despite handing over the role of executive chairman to his son, Teo Siong Seng, earlier this year, the centenarian Singaporean insists on going into the office every day.
“It’s my habit,” Chang told CNBC in a recent episode of “Managing Asia.”
Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.
More than 80 million men, women and children in the United States experience hair loss. Genetics, aging, childbirth, cancer treatment, burn injuries and medical disorders such as alopecia can cause the condition. Hair loss is often associated with emotional distress that can reduce quality of life and lead to anxiety and depression.
“Our new protocol described today overcomes key technological challenges that kept our discovery from real-world use,” says Alexey Terskikh, Ph.D., an associate professor in Sanford Burnham Prebys’ Development, Aging and Regeneration Program and the co-founder and chief scientific officer of Stemson Therapeutics. “Now we have a robust, highly controlled method for generating natural-looking hair that grows through the skin using an unlimited source of human iPSC-derived dermal papilla cells. This is a critical breakthrough in the development of cell-based hair-loss therapies and the regenerative medicine field.”
An all-star panel of experts in nutritional studies with an emphasis on longevity. At some point in your life, you have heard the following. “Eat the right food. It will help you live longer.” What if I told you the right food could help you heal as well. This panel of longevity driven nutritionist will give you a broad range of fact-based regiments and compelling individual opinions on Nutrition and longevity. This segment will cover many diverse understandable methods that can make a change in longevity for you or your loved ones. Fill yourself with the knowledge of proper nutrition for longevity.
Speakers Will Include: Brian Clement – Plant-Based & founder of “Hippocrates Health Institute” A typical American growing up in the New Jersey/New York area, Brian likes to joke that he was a pioneer in the field of obesity—he was fat even before many Americans were fat! Raised in an Irish household on the standard American diet of meat, processed foods, and sugary sodas, he was unfit and gasping for air every few steps. When he was 20 years old, he was dating a girl whose best friend’s boyfriend was 30—and a vegetarian. Despite the fact he had been more or less educated by his family that the body would die without animal-based foods, the lure of an influential peer inspired him to give up meat in one fell swoop. For the first year and a half, he kept his vegetarian diet a secret from his family. Yet after losing 120 pounds and experiencing the difference in his health, he came out of the proverbial closet (much to his family’s dismay!) and became a complete vegan three years later.
Wendi Blum – Founder of “Founder of Create Your Best Life” Wendi Blum worked in the pharmaceutical industry for over 20 years until (at age 45) felt a calling to completely change every aspect of her life. After two decades in a successful sales career (having worked for Zenecca Pharmaceuticals, PDI and Bristol Myers Squibb, wearing many different hats including advocacy, sales, and training) Wendi decided to re-write the story of her life literally and become an international inspirational speaker, author, workshop leader, success coach, and life-shift retreat guru. She is the author of 5 books – known for her focus on reinvention, goal mastery, and business savvy – she is known as “the queen of reinvention” Her titles include: “Your Life, Your Destiny, Uncover Yours, LifeShift” and “Goals Setting Workbook: Success Strategies for The New Economy” – and many more. Blum is known for her blend of Spiritual flare with business savvy” because of how she merges these two powerful components together.
Bill Faloon — Director and Co-founder of the “Life Extension Foundation”.
Bill Faloon compiled the 1,500-page medical reference book Disease Prevention and Treatment, and his latest book is Pharmocracy: How Corrupt Deals and Misguided Medical Regulations Are Bankrupting America—and What to Do About It. He is also director and co-founder of the Life Extension Foundation, a consumer advocacy organization that funds research and disseminates information to consumers about optimal health. Mr. Faloon has made hundreds of media appearances, including guest spots on The Phil Donohue Show, Tony Brown’s Journal, and ABC News Day One, and has been interviewed Newsweek and other magazines.
