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2019 is quite a milestone for LEAF; this will be our fourth year of bringing you the latest industry news, organizing online events, hosting our annual conference in New York, and crowdsourcing important research projects over at Lifespan.io. We have been incredibly busy and, as has been customary in previous years, we will be taking a look back at the year.

January

YouGov conducted a survey determining that younger Americans are more interested in longer lives, and indefinite lifespans, than their older counterparts.

Epigenetic reprogramming. “We are very radical life extensionists, neither healthspan increase no morbidity compression are enough, we would like to add decades if not centuries to the human lifespan.”


Yuri Deigin Founder of Youthereum, speaking at Master Investor’s Investing in the Age of Longevity 2019 event.

Master Investor is an investment media and events company that delivers independent, financial commentary and analysis to UK private investors and traders through events, magazines, news, blogs, podcasts and daily/weekly newsletters.

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Once you hit a certain age you start to see subtle changes and many begin to search for options to hold onto the appearance of youthfulness for as long as they can in the form of lotions, potions, creams, supplements, serums, diets, and concoctions among others.

Soon there may be a new addition to the anti-aging lineup, that being rapamycin which is an FDA approved drug that is normally used to prevent organ rejection after transplant, the drug may also be helpful in slowing in aging skin according to a recent study published in Geroscience.

Studies have used rapamycin to effectively slow aging in worms, flies, and mice but this study from Drexel University College of Medicine is the first to show an effect on aging in human tissues, specifically the skin; findings showed signs of aging to be reduced including decreases in wrinkles, reduced sagging, and more even skin tone when delivered to humans topically.

The researchers wanted to know how tardigrades protected themselves against such harsh conditions. So Kunieda and his colleagues began by sequencing the genome of Ramazzottius varieornatus, a species that is particularly stress tolerant. It’s easier to study processes within the tardigrade’s cells when the animal’s genome is inserted into mammalian cells, says Kunieda. So researchers manipulated cultures of human cells to produce pieces of the water bear’s inner machinery to determine which parts were actually giving the animals their resistance.

Eventually, Kunieda and his colleagues discovered that a protein known as Dsup prevented the animal’s DNA from breaking under the stress of radiation and desiccation. And they also found that the tardigrade-tinged human cells were able to suppress X-ray induced damage by about 40%.

“Protection and repair of DNA is a fundamental component of all cells and a central aspect in many human diseases, including cancer and ageing,” says Ingemar Jönsson, an evolutionary ecologist who studies tardigrades at Kristianstad University in Sweden.

The Race To Find A Cure For Aging Learn about three pioneers working to turn back the clock ~ via Medium #perpetuallife

https://medium.com/discourse/the-race-to-find-a-cure-for-aging-98676b0318dc
We want to look & feel young again, and every year we spend hundreds of billions of dollars on beauty serums, cosmetic surgery, and exotic supplements in the hopes of appearing more vibrant, healthy, and desirable.