AgeX Therapeutics Inc (NYSEAMERICAN: AGE) CEO Michael West sat down with Proactive’s Christine Corrado at the Biotech Showcase 2020 in San Francisco. The Alameda, California biotechnology company is developing a cell therapy treatment for metabolic disorders such as Type 2 diabetes.
Jane McLelland beat cervical, lung, and blood cancers using the missing link to defeat cancer: starving it. She is partnering with Life Extension® to help other patients achieve the same results.
By Laurie Mathena.
After getting a considerable success in convincing scientists and investors, in the last decades, that undoing aging through a damage repair approach is possible and desirable, Aubrey de Grey is turning his advocacy efforts to politicians. In this video, he explains why.
Aubrey de Grey delivers a keynote on the next steps for longevity for policy makers.
Dr Aubrey de Grey is a biomedical gerontologist based in Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501©(3) biomedical research charity that performs and funds laboratory research dedicated to combating the ageing process. He is also VP of New Technology Discovery at AgeX Therapeutics, a biotechnology start up developing new therapies in the field of biomedical gerontology. In addition, he is Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in ageing. He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterisation of all the types of self-inflicted cellular and molecular damage that constitute mammalian ageing and the design of interventions to repair and/or obviate that damage. Dr de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organisations. He is a highly sought-after speaker who gives 40–50 invited talks per year at scientific conferences, universities, companies in areas ranging from pharma to life insurance, and to the public.
There are a few dozen antiaging rejuvenation treatments that are progressing through pre-clinical and clinical trials.
Lifespan.io is tracking the antiaging rejuvenation treatments on a rejuvenation roadmap.
Two treatments are in phase 3 clinical trial.
Researchers at the Buck Institute have extensively profiled the various inflammatory signals given off by senescent human cells and have generated a curated database available for use in the field.
Senescent cells, which stop dividing under stress, are long- recognized drivers of multiple diseases of aging. Mouse studies have shown that targeted removal of these cells and the inflammatory factors they secrete, known as the senescence-associated secretory phenotype (SASP), has beneficial results on multiple organ systems and functions. Success in the laboratory has given rise to companies and research projects aimed at developing either senolytics, drugs that clear senescent cells, or senomorphics, drugs that suppress the SASP. But drug development and clinical utilization require simple, reliable biomarkers to assess the abundance of senescent cells in human tissues. Publishing in PLOS Biology, researchers at the Buck Institute have extensively profiled the SASP of human cells and have generated a curated database available for use in the field.
“The stage is now set for the development of clinically-relevant biomarkers of aging,” said Judith Campisi, Ph.D., Buck professor and one of the senior authors on the paper. “This will speed efforts to get safe and effective drugs into the clinic and, in the long term, could enable physicians to give patients a clear read-out of how well, or poorly, their various tissues and organs are aging.”
The study, led by postdoc Nathan Basisty, Ph.D., expanded the number of proteins known to be secreted by human senescent cells by about 10-fold, to over 1000. Researchers show that a ‘core’ set of senescence factors, which were secreted by all types of senescent cells studied, are significantly increased in human plasma as we age, and may be the basis for developing “whole body” biomarkers of aging, and biomarkers to assess the efficacy of senolytics and senomorphics in human trials. Using advanced proteomic analysis, researchers also propose signatures that identify specific subsets of senescent cells.
The freezing procedure, called cryonics, costs $36,000 for a whole body and $15,000 for the brain alone.
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How long should an EV battery last? Elon Musk seems to think that a million miles is just about right — last April he announced that Tesla had a “1 million-mile battery pack” in the pipeline. That’s an ambitious goal, to say the least — do we really need a battery that lasts three to four times as long as a typical car? We will.
Source: Charged
As a recent article posted on Forbes points out, while today’s typical Li-ion battery packs are more than adequate for individual EV owners, applications such as taxi services and long-distance trucking will require batteries optimized for longevity (according to writer Ariel Cohen, the average trucker logs some 100,000 to 150,000 miles per year). Thus, long-life batteries are likely to be critical to the success of the Tesla Network (a proposed fleet of robo-taxis) and the Tesla Semi.
Ira Pastor, ideaXme exponential health ambassador, interviews Dr. Magomed Khaidakov, Assistant Research Professor, Department of Internal Medicine, University of Arkansas for the Medical Sciences. https://www.amazon.com/Pessimistic-Guide-Anti-aging-Research/dp/1527534359
Ira Pastor Comments
Today we are going to be talking about mitochondria, among many other longevity and anti-aging themed topics.
We’re also going to talk a little bit about the role of pessimism and realism when it comes to the human translation of certain technologies, and why it is important to limit “messianic thinking” as much as possible.
Mitochondria
The mitochondria are double-membrane-bound organelles found in most eukaryotic organisms and are responsible for generating most of the cell’s supply of adenosine triphosphate (ATP), used as a source of chemical energy. Thus mitochondria is termed the “powerhouse of the cell.”
“For me, the key to longevity – and immortality, in a sense – has to do with transformation.”–Marilyn Manson.
