Lifeboat Foundation: Safeguarding Humanity
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Category: health

Dr. Aubrey de Grey from the SENS Research Foundation was kind enough to talk in support of CellAge and their campaign on Lifespan.io

We are developing tools to help researchers accurately target and remove dysfunctional cells in the body that have entered a state called “senescence”, and thereby assist in restoring it to youthful functionality. Please subscribe, share, and fund our campaign today! ►Campaign Link: https://www.lifespan.io/campaigns/cellage-targeting-senescent-cells-with-synthetic-biology/ ►Subscribe: https://www.youtube.com/user/LifespanIO?sub_confirmation=1

Our society has never aged more rapidly – one of the most visible symptoms of the changing demographics is the exponential increase in the incidence of age-related diseases, including cancer, cardiovascular diseases and osteoarthritis. Not only does aging have a negative effect on the quality of life among the elderly but it also causes a significant financial strain on both private and public sectors. As the proportion of older people is increasing so is health care spending. According to a WHO analysis, the annual number of new cancer cases is projected to rise to 17 million by 2020, and reach 27 million by 2030. Similar trends are clearly visible in other age-related diseases such as cardiovascular disease. Few effective treatments addressing these challenges are currently available and most of them focus on a single disease rather than adopting a more holistic approach to aging.

Recently a new approach which has the potential of significantly alleviating these problems has been validated by a number of in vivo and in vitro studies. It has been demonstrated that senescent cells (cells which have ceased to replicate due to stress or replicative capacity exhaustion) are linked to many age-related diseases. Furthermore, removing senescent cells from mice has been recently shown to drastically increase mouse healthspan (a period of life free of serious diseases).

Here at CellAge we are working hard to help translate these findings into humans!

CellAge, together with a leading synthetic biology partner, Synpromics, is going to develop synthetic promoters which are specific to senescent cells (SeneSENSE), as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies. The most prominently used p16 gene promoter has a number of limitations, for example. As our primary mission is to expand the interface between synthetic biology and aging research as well as drive translational research forward, we will offer senescence reporter assay to academics for free. We predict that in the very near future this assay will be also used as a quality control step in the cell therapy manufacturing process to make cell therapies safer!

As our secondary goal, we will focus on validating gene therapies for senescent cell eradication (SeneHEALTH) – initially for patients with progeroid syndromes, then for patients who underwent radiotherapy (during which the number of senescent cells are increased) or developed age-related disease and eventually for healthy individuals.

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Lilly announced today that CYRAMZA® (ramucirumab) has been approved by the Singapore Health Sciences Authority to treat people with advanced gastric cancer, whose cancer has progressed after prior chemotherapy. First country in ASEAN to approve the new biologic therapy that extends survival in patients with advanced stomach cancer after prior chemotherapy

CYRAMZA® (ramucirumab) is now available to Singaporeans living with advanced gastric cancer. The drug gained approval by Singapore’s Health Science’s Authority (HSA) earlier this year, marking the first regulatory approval in ASEAN. CYRAMZA is already available to patients in Japan, Korea, Taiwan and Hong Kong.

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More proof that Precision Medicine can predict and solve complex health issues.

Brain scans could help predict response to psychotherapy for anxiety and depression.

brain-scan-treatment-research

Nov. 10, 2016 – Brain imaging scans may one day provide useful information on the response to psychotherapy in patients with depression or anxiety, according to a review of current research in the November/December issue of the Harvard Review of Psychiatry, published by Wolters Kluwer.

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Removing Glucosepane crosslinks from tissue is one of the most important things groups like SENS Research Foundation are doing and their progress relies on our support.

In this interesting open access paper, the authors propose that too little attention has been given to immune cell behavior in tissues rather than in blood, and that means that researchers have overlooked the possibility that age-related changes in the extracellular matrix structures that support tissues might be a significant cause of the growing immune dysfunction that takes place in later life. One of the more important of these changes in the extracellular matrix is the growing presence of cross-links, persistent sugary compounds produced as a byproduct of normal metabolic operations that chain together the large molecules of the extracellular matrix. In doing so these cross-links change the chemical and structural properties of the matrix and the tissue as a whole, producing results such as loss of elasticity in skin and blood vessels, which in turn contribute to a variety of age-related diseases. If cross-linking does indeed contribute to immunosenescence, the decline of the immune system with age, then that only increases the importance of ongoing research funded by the SENS Research Foundation aimed at safely breaking down this unwanted form of metabolic waste. In humans near all persistent cross-links appear to involve a single class of compound, glucosepane. So in theory there is only a single target here, needing just one drug development program to make a large difference to long-term health and longevity.

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Excercise is the best low cost activity you can do as part of your personal longevity strategy. Here we see data showing it can improve resistance to oxidative stress.

Researchers digging deeper into the mechanisms by which exercise produces benefits have found that it improves the resistance of blood vessels to oxidative stress. With age the presence of oxidizing molecules and oxidative modification of proteins, preventing correct function, increases for reasons that include damage to mitochondria, the power plants of the cell. Oxidative damage to molecular machinery is somewhere in the middle of the chain of cause and effect that starts with fundamental forms of damage to cells and tissues and spirals down into age-related diseases. Near all of this oxidation is repaired very quickly, the damaged molecules dismantled and recycled, but in most contexts more of it over the long term is worse than less of it.

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Yes, renewable energy technologies exist. But solar power, the one with arguably the most promise for significant, scalable deployment, is intermittent. Although the sun provides more energy in one hour than humans consume in a year, we can only tap into this power when the sun is shining. At least, that’s been the predominant school of thought.

But since the 1960s, a group of researchers from NASA and the Pentagon have been thinking outside the box — or in this case, outside the atmosphere. Solar power captured in outer space would not be limited by nighttime hours or cloud cover. And — unlike 23 percent of current incoming solar energy — it wouldn’t be absorbed by water vapor, dust and ozone before reaching us. Finally, because space solar is constant, it wouldn’t need to be stored, which can lead to energy losses of up to 50 percent. In other words, taking our solar panels from the ground to the cosmos could be a great deal more efficient. It may also be key to humanity’s survival.

“In countries right now where they’re trying to deal with poverty, water scarcity, poor health, lack of education and political instability — these are all things you need energy in order to fight,” Paul Jaffe, PhD, spacecraft engineer at the U.S. Naval Research Laboratory, said in a recent TakeApart story. Or, as John C. Mankins, founder of Mankins Space Technology and author of “The Case for Space Based Solar,” told Salon, “In the long run, renewable large-scale energy sources such as space solar power are essential to sustaining industrial civilization, and the long and increasingly high quality of lives that we enjoy.”

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In Brief

  • By observing the transparent cells of roundworms, researchers have uncovered a link between lifespan and the natural cellular process of RNA splicing.
  • This research could lead to new breakthroughs in anti-aging treatments that would allow humans to indefinitely keep ourselves healthy, stalling death for as long as possible.

Though aging seems like one of the most natural things, an affair common to all living creatures, the process is actually poorly understood by scientists. A new study detailed in Nature aims to shed light on the phenomenon as a research team led by the Harvard T.H. Chan School of Public Health has uncovered a relationship between lifespan and RNA splicing, a core function of cells that allows a single gene to produce a variety of proteins.

The researchers already knew that mutations in RNA splicing could lead to disease, but they wanted to find out if the act of splicing itself had an impact on the aging process. To find out, they designed experimental setups using the roundworm Caenorhabditis elegans, which show visible signs of aging during their short three-week lifespan.

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That’s the bad news.

The good news is that mental health professionals have smarter tools than ever before, with artificial intelligence-related technology coming to the forefront to help diagnose patients, often with much greater accuracy than humans.

A new study published in the journal Suicide and Life-Threatening Behavior, for example, showed that machine learning is up to 93 percent accurate in identifying a suicidal person. The research, led by John Pestian, a professor at Cincinnati Children’s Hospital Medical Center, involved 379 teenage patients from three area hospitals.

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AI (someday once things are more secured) is going to drastically reduce our cost of government. At least the VA believes AI is going to make them better at treating folks; my guess it’s a mix of cost saving potential via automation and improving diagnosis.

Flow Health and the VA are building a medical knowledge graph with deep learning to inform medical decision-making and train AI to personalize care plans.

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