By half, it would soon ask health officials around the world to authorise its use ⤵️.
If authorised for use, it would be the first pill shown to treat COVID and a major step in controlling the pandemic.
By half, it would soon ask health officials around the world to authorise its use ⤵️.
If authorised for use, it would be the first pill shown to treat COVID and a major step in controlling the pandemic.
A ransomware gang called Vice Society claims it grabbed confidential data such as patient benefits, financial documents and lab results.
Another health care provider has apparently been the victim of a ransomware attack that exposed private patient information and other sensitive data. A ransomware group known as Vice Society has claimed responsibility for an August attack against United Health Centers that allegedly impacted all of its locations. The incident reportedly led to the theft of patient data and forced the organization to shut down its entire network, BleepingComputer reported on Friday.
Scientists at the Washington University School of Medicine have made an intriguing discovery that could see radiation therapy become a less invasive treatment for heart arrhythmia. The technique seems to activate the heart cells to revert to a younger state and repair the tissue.
Arrhythmia is a condition where the heart beats in an irregular fashion, which can lead to potentially dangerous health problems. It’s a result of issues with the way electrical signals are sent through the tissue, and one of the main treatments is called catheter ablation. This invasive procedure involves threading thin tubes through arteries into the heart, making a small burn to create scar tissue that interrupts the signals.
A few years ago, the Washington University team discovered a far less invasive alternative – radiation therapy, of the kind often used to treat cancer patients. When directed at the heart, the treatment was found to improve arrhythmia symptoms, just as well as, or perhaps even better than, catheter ablation.
The killer product of robotics is hidden in plain sight and may be just a few years away. Summary The robotic space is still waiting for a truly widespread general purpose product which deeply changes our everyday life. I argue that such a product could be a low cost collaborative manipulator powered by an ecosystem of AI-based applications. It will create value in novel ways and automate tasks at an unthinkable price point, impacting both our homes and businesses. As in the case of smartphones, the real value is in the apps sitting in the app store, which will be built by a new generation of startups and creators. I analyse where we stand and I predict that we are just a few years away from seeing such a product go live. Manipulators State of the Art in Brief When thinking about manipulators or robotic arms, the first thing that pops to your mind is probably an industrial robot, as the one in the picture: These robots are precise, fast, durable and capable of lifting heavy weights. They are also very dangerous, therefore they need to be fenced and kept separate from human workers. A more recent development is the introduction of collaborative robots or cobots. These robots are generally slower than industrial robots, but they are safe to work in direct contact with humans thanks to sensors and algorithms to detect collisions and stop the robot motion just in time, enabling many new use-cases. The market leader is Universal Robotics, a Danish company which recently sold its robot number 50.000. In 2021 the cheapest UR cobot can be purchased for about 20.000 dollars, but there are more affordable competitors which are sold for less than 10.000 dollars. The future looks bright for collaborative robots and for us consumers, since the price is expected to keep going down quickly following Wright’s Law, that is the price should be reduced by a fixed percentage every times the number of units sold is doubled. Keep in mind that UR sold its robot number 25.000 in 2,018 so it doubled the number of all-time robots sold in just two years! Still, if you go through the tech specs of these arms you will start noticing something, see here and here. Current robotic arms are overqualified for many of the mundane tasks we would like them to do, for instance in our kitchens and homes. Seriously, look at the UR5, when was the last time you loaded a dishwasher with 0.1 millimeter precision? Or which kitchen appliance did you use for 35.000 hours at full capacity? Or what clothes weigh 5+ kilograms? On the other side of the tech specs there is a market for toy robots and desktop robots, which are inexpensive, but unfortunately suffer from limited arm reach, payload and overall reliability. Can a hybrid be built? I think so, and it may very well be the killer product of robotics. What does the iPhone of Robotics look like? The killer product of robotics may be a collaborative robot which is intuitive to use and low cost, by making trade offs with speed and accuracy. Drawing from my research, this is how I believe it will look like: Must Have: Low cost: Less than 1,000 USD for the robot hardware. Compatible with a wide set of end effectors, to cover multiple use cases. Lightweight and Compliant: Able to interact safely in environments with untrained staff and children, easy to physically carry around. Self-contained and Portable: it includes a computing platform, with a form factor similar to a Raspberry pi or Jetson Nano and a standard networking stack (Wifi, Bluetooth). It should be easy to deploy third party apps on it. Nice to Have: 6 Degrees of Freedom (while 7 DOF gives more flexibility, 6 DOF can already reach any position in the workspace, but are easier to control and more affordable) Reach 700mm Payload 2Kg Repeatability 1mm Max Speed 0.5 m/s Operating Lifetime 10,000 hours at full capacity. Open Source and ROS compatible Payload and Reach are very use cases dependent. If I had to pick a sweet spot for a general purpose robot, I would say 3kg and 750mm. One of the crucial points above is the possibility to install third party apps. Today, robotic companies are forced to curate the whole software-hardware stack to deliver a product, so the company building the robot behaviours (say the algorithms to control the stirring movements of an omelette-making robot) are also the companies selling the robotic hardware to the end customer. Sometimes they are also the companies building the hardware, even if it’s more common to see companies buying hardware off the shelf, say a UR cobot, and customising it. On top of this, today the same companies also build the user interface, say a mobile app, to actually control the robot. When a popular general purpose cobot will be available on the market, there will start to be a clear division between the company selling the general purpose hardware (and the onboard app-store) and the companies building apps for it, that is the skills of the cobot. Translated into the smartphone dictionary, the robot and app store store manufacturer is Apple, while the app developers are Facebook, Netflix, etc. To further stress the analogy, you may think of your smartphone as a very limited robot, with capabilities such as making sounds and coloring the screen, but with no movement capabilities (apart from vibrations!). A cobot will have multiple apps installed, exactly as our smartphones, and will be able to perform different tasks as programmed by domain experts in each use case. These domain experts will be 100% software-based robotic companies. It is in this period that we will see an exponential growth in cobot capabilities, as companies can iterate quickly in software. To sustain this demand of new use cases, companies will mainly take approaches based on computer vision, supervised learning and reinforcement learning. In the very long term, I see a further division between robotic companies building the low-level APIs to control the robot and companies specialising in building the user interface to interact with the robot, which will include mobile apps, vocal and gesture commands. In the figure: Evolution of the robotic ecosystem over time (from 2026+ on, with robot manufacturers I’m only referring to the manufacturers of cobots allowing third party apps). The years indicate approximately the predicted first time we will see these models hitting the market. What will we use these collaborative robots for? Pretty much everything. Let’s do a quick calculation to see why I say this. Let’s assume that the apps will have a subscription fee comparable to today’s smartphone apps, say the approximately 20 USD of Nextlix monthly subscription. By the way, given the success of the freemium model for mobile apps, I would not be surprised to see free to use robot skills. Also let’s say that each cobot will last about 3 years. This is much less than what a cobot could last, but it’s in line with the replacement cycle of our high end gadgets such as smartphones (we should strive to do better, the environment would be thankful). As a final assumption, let’s add another 30 USD monthly for a subscription package that includes robot maintenance and support plus the cost of electricity. Over 3 years, that’s about 50 x 36 + 1,000 = 3,000 USD to buy the robot and use it with only 1 app, or 3 USD every day. Let’s take as a reference the lowest possible minimum wage in London, the one for apprentices, which is about 5 USD per hour. This means that for the robot investment to breakeven, it’s enough to have the robot automate just 36 minutes worth of tasks a day! With the 2022 15 USD minimum wage in California, this goes down to 12 minutes! Personally I’m very excited by the role that they will play in removing repetitive tasks in our kitchens, lowering the cost of preparing food and increasing consistency without compromising on food quality. The first deployments will be in commercial kitchens, including dark kitchens, cafeterias and restaurants, and then they will start entering the home kitchen market. For commercial kitchens this will be the second wave of robotics, as more expensive collaborative robots are starting to enter kitchens as we speak, given that their economics are viable today. I may cover this topic in a future blog post. Inside our homes they will take on tasks like washing machine load/unloading, clothes folding, laundries and overall home clean-up. There are multiple ways for manipulators to be able to move to different places, including being mounted on mobile bases and rails, but I believe we will see very low tech solutions get traction first: small fixed bases where the robot can clamp and get power, after being physically moved there by the owner (a “robot charger”?). Other areas that will be impacted by low cost robots include areas with repetitive manual actions like laboratories, hospitals, agriculture, packaging, light manufacturing and remote areas which require infrequent manual intervention. We will also see completely novel applications in the area of communication (“physical” zoom calls!?), remote work and entertainment. I want to stress that all these use cases are very price sensitive, so it’s really the ability of robot manufacturers to offer very low cost that will enable this ecosystem to start blossoming. I see the low cost coming from four main sources: Lowering of all the specs that makes current collaborative robots overqualified. The decoupling of selling hardware vs selling the final use case. New revenue streams: app-store fees, data-mining, new advertisement channels. Robotic-as-a-Service business models, that is other revenue streams in the form of support, maintenance, upselling. Where we stand and what to expect next Let’s start from the hardware, how far are we all from good-enough specs at a good price point? There is work to do, but we are getting there. This is an early stage prototype that we built last year at Nyrvan (in 2 weeks, we didn’t tune the PID parameters much, which resulted in quite some shaking!) The 6 DOF cobot in the video could perform basic kitchen tasks, with a 1kg payload. We used carbon fiber tubes for the links, we 3D printed the joints structure in PLA (probably something with higher heat resistance would have been better), used an Arduino as computing unit and a 48V power supply. All these components can be bought cheaply on Amazon. The lion share of the bill of materials is taken by the actuators. We have chosen the servo brushless motors from Gyems model RMD-X7, RMD-X8 and RMD-X8 PRO, for about 2000 USD in total. Another option that we considered was T-Robot. In total we spent less than 2,500 USD to assemble a cobot, buying all the components at retail price. Actually bulk discounts are consistent for these robotic components, going up to 40%. As building hardware is not our focus, this was simply an excellent exercise in probing the future of robotics. During my research, I have discovered interesting projects and startups which look well equipped to offer or inspire these robotic platforms in the future. I’m going to cover a few of those here, but I’m surely missing many good ones. Please let me know about other promising projects in the comments! Project Blue from Berkeley’s Robot Learning Lab developed a Quasi-Direct Drive for Low-Cost Compliant Robotic Manipulation, which can be used for daily tasks such as folding clothes. They also included a manufacturing BoM estimate in the paper, in which they show they can bring the cost of the robot arm down to 1,250 USD, assuming 10.000 units sold. Elephant Robotics is selling myCobot which introduces the very interesting concept of selling small cobots with an integrated computing unit (a Raspberry Pi). The cobots can integrate with ROS and overall they tick many of the boxes of an iPhone of robotics. Innfos is another Chinese company, with a very interesting modular robotic arm, with amazing specs for less than 1,000 USD. Unfortunately, after a successful kickstarter campaign, they had internal issues and had to close the company. A shout out also to Skyentific 0 which runs a super thoughtful youtube channel on robotics. I spoke with him some time ago, he is really a cool guy and he is spreading a lot of knowledge on low cost robotic arms. Overall the area is still very niche and projects often have troubles going from early stage to growth stage: it’s hard to get funded, since there is a strong bias against hardware-heavy projects by angel investors and venture capitalists. Part of the problem is also due to the lack of demand, since in the past it was very hard to program collaborative robots and therefore hard and expensive to build actual products out of collaborative robots. Now, I would not say that today it’s easy to build robotic software (very often the best backend/frontend/devops practices are ignored in robotics, in which a good share of developers comes from an academic or mechanical/electronics background), but things are getting way more standardised and scalable thanks to standards like the Robotic Operating System and large pretrained computer vision models. Advancement in AI models applied to control and manipulation are also opening up dynamic use-cases like pick-and-place of arbitrary objects. Regarding a proper app store, it’s a chicken-egg issue, we will not see it until an affordable general-purpose cobot platform pops up. Also today there is a very small number of developers able to program these robots and they are employed by the companies selling vertically the use-case. So, what to expect next? We can expect the cost of the hardware to keep going down in the next few years, thanks to the increasing sales and the improving state of the software development cost. Tech directions to lower the cost of the cobots hardware also include: Using modular designs, therefore cutting down the cost of each degree of freedom thanks to economies of scale. Using gearless motors and other last gen motors to get rid of expensive force-torque sensors, brakes and harmonic gears. Using vision based control, to ease inverse kinematics and reduce the cost of position encoders and sensors. In terms of geography, all indications point to Chinese companies taking the lead in terms of development, at least regarding the hardware platform. The software situation is much more distributed. I think it would be nice to conclude this blogpost with an actual prediction, so here we go: If I had to guess the exact timeline, I would say that we will see a collaborative robot with the specs and price-point written above announced by the end of 2,026 so 5 years. I believe shortly after, say 1–2 years, we will see the first ecosystem approaches and the first cobots shipping with an app-store. What do you think? Let me know in the comments!
Similarly, the CNSA told the Chinese state-run news outlet Global Times that its Tianwen-1 space probe and Zhurong rover will pause their work and enter safe mode during the transit.
But just because the rovers aren’t getting any new instructions doesn’t mean they’re stopping altogether.
“Though our Mars missions won’t be as active these next few weeks, they’ll still let us know their state of health,” the NASA Jet Propulsion Laboratory’s Mars Relay Network manager, Roy Gladden, said in the NASA announcement. “Each mission has been given some homework to do until they hear from us again.”
Re-Imagining Health and Wellbeing — Lisa Esch & Dr. Michael Petersen, M.D., NTT.
The Nippon Telegraph and Telephone Corporation (https://hello.global.ntt/en-us/), commonly known as NTT, is a Japanese telecommunications company headquartered in Tokyo, Japan.
NTT DATA Services (https://www.nttdata.com/global/en), is a global digital business and IT services leader focused on a range of business services, including cloud, data and applications, and which has recently embarked on an ambitious new initiative, as part of their goal “To Change The Future For Good”, towards Re-Imagining Health and Well-Being, towards what NTT defines as a more human-empowered, knowledge-driven and technology-enabled approach (https://www.global.ntt/healthandwellbeing/).
Lisa Esch is Senior Vice President-Healthcare Provider, Digital Health, Innovation, & Industry Offerings, at NTT DATA Services, where she oversees solutions and offering development, as well as their Go-To-Market strategy within the vertical and serves as the subject matter expert in the client engagements.
Lisa has an extensive background in disruptive technologies, healthcare innovation, strategic planning, and business process improvement.
Before joining NTT Data Services, Lisa was a Senior Healthcare Executive with DXC Technology, and Computer Science Corporation, where she served as the Chief Innovation Officer-Providr Healthcare.
Along with her executive career, Lisa has served on the boards for Empower Education International, Children’s Heart Alliance, Head Start Health, and Student for Student. She began her healthcare career as a Registered Dietitian.
Lisa graduated with a Bachelor of Science in Nutrition, from the University of Nebraska, Lincoln, and completed Graduate Studies in Public Administration from the University of Colorado at Colorado Springs. Lisa is Yellow Belt Certified in Spartans Sales Training and holds a Certificate in Medical Nutrition & Dietetic Internship from the University of Nebraska Medical Center.
Getting a quick and accurate reading of an X-ray or some other medical images can be vital to a patient’s health and might even save a life. Obtaining such an assessment depends on the availability of a skilled radiologist and, consequently, a rapid response is not always possible. For that reason, says Ruizhi “Ray” Liao, a postdoc and a recent Ph.D. graduate at MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL), “we want to train machines that are capable of reproducing what radiologists do every day.” Liao is the first author of a new paper, written with other researchers at MIT and Boston-area hospitals, that is being presented this fall at MICCAI 2,021 an international conference on medical image computing.
Today, the World Health Organization (WHO) and partners launched the first ever global strategy to defeat meningitis — a debilitating disease that kills hundreds of thousands of people each year. By 2,030 the goals are to eliminate epidemics of bacterial meningitis – the most deadly form of the disease – and to reduce deaths by 70% and halve the number of cases. The organizations estimate that in total, the strategy could save more.
Than 200,000 lives annually and significantly reduce disability caused by the disease. This strategy, the Global Roadmap to Defeat Meningitis by 2,030 was launched by a broad coalition of partners involved in meningitis prevention and control at a virtual event, hosted by WHO in Geneva. Its focus is on preventing infections and improving.
Care and diagnosis for those affected.“Wherever it occurs, meningitis can be deadly and debilitating; it strikes quickly, has serious health, economic and social consequences, and causes devastating outbreaks,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General.
Posted in bioengineering, biotech/medical, health | Leave a Comment on A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for which neutralizing single domain antibodies (nanobodies) have significant potential. Their small size and stability mean that nanobodies are compatible with respiratory administration. We report four nanobodies (C5, H3, C1, F2) engineered as homotrimers with pmolar affinity for the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Crystal structures show C5 and H3 overlap the ACE2 epitope, whilst C1 and F2 bind to a different epitope. Cryo Electron Microscopy shows C5 binding results in an all down arrangement of the Spike protein. C1, H3 and C5 all neutralize the Victoria strain, and the highly transmissible Alpha (B.1.1.7 first identified in Kent, UK) strain and C1 also neutralizes the Beta (B.1.35, first identified in South Africa). Administration of C5-trimer via the respiratory route showed potent therapeutic efficacy in the Syrian hamster model of COVID-19 and separately, effective prophylaxis. The molecule was similarly potent by intraperitoneal injection.
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nat. Struct. Mol. Biol. 27 846–854 (2020).
Innovator, philanthropist, humanitarian — khaliya — discussing radical solutions for the global mental health crisis.
Khaliya (https://www.khaliya.net/) is a Columbia University-trained public health specialist and Harvard University-trained specialist in Global Mental Health and Refugee Trauma. She is also a Venture Partner for Gender Equity Diversity Investments (www.gedi.vc), a new female-led VC firm targeting high growth investments that deliver top-quartile returns and measurable impact towards the UN Sustainable Development Goals with a preliminary focus on health.
Formerly an aid worker in over 32 countries and a former Peace Corps Volunteer for the US State Department, she has won numerous awards for her international service. Khaliya was the youngest member of the WEF’s Futures Council on the Future of Health and Healthcare and her opinion pieces have run in the New York Times (International and Domestic Editions) as well as WiredUK.
Currently at work on a book on the future of mental health, Khaliya continues to be a sought after public speaker, having spoken at the Obama White House organized United States of Women Summit, the World Economic Forum’s Family Business Summit, the Vatican, Clinton Global Initiative, WiredHealth, WebSummit and at the United Nations General Assembly, among others.
Khaliya is next scheduled to speak at the G20 Women’s Summit in Milan, Italy, and the Ethical Assembly Summit in Lisbon, Portugal, both taking place in October, 2021.