Lifeboat Foundation: Safeguarding Humanity
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Category: genetics

When a malignant tumor invades the body, immune cells rush to the site to begin to fight it. When that same tumor spreads throughout the body, however, the cancer cells become invisible to our immune systems and can metastasize unencumbered by our natural defenses. Researchers out of the University of British Columbia (UBC) are on to cancer’s tricky cloaking mechanism though, and their discovery could lead to new approaches to attacking the disease.

“We discovered a new mechanism that explains how metastatic tumours can outsmart the immune system and we have begun to reverse this process so tumours are revealed to the immune system once again,” said Wilfred Jefferies, senior author of a new study in Scientific Reports and a professor of medical genetics and microbiology and immunology at UBC.

The discovery hinges on a protein called interleukein-33, or IL-33 that’s present in primary tumors. When the tumors emit this protein, it causes another protein complex known as the major histocompatibility complex (MHC) to activate, which tags the cancer cells as a bad presence in the body and guides the immune system to get to work destroying them.

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Yesterday, in the New York Review of Books, Freeman Dyson analyzed a trio of recent books on humanity’s future in the larger cosmos. They were How to Make a Spaceship: A Band of Renegades, an Epic Space Race, and the Birth of Private Spaceflight; Beyond Earth: Our Path to a New Home in the Planets; and All These Worlds Are Yours: The Scientific Search for Alien Life.

Dyson is “a brilliant physicist and contrarian,” as the theoretical astrophysicist Lawrence Krauss recently told Nautilus. So I was waiting, as I read his review, to come across his profound and provocative pronouncement about these books, and it came soon enough: “None of them looks at space as a transforming force in the destiny of our species,” he writes. The books are limited in scope by looking at the future of space as a problem of engineering. Dyson has a grander vision. Future humans can seed remote environments with genetic instructions for countless new species. “The purpose is no longer to explore space with unmanned or manned missions, but to expand the domain of life from one small planet to the universe.”

Dyson can be just as final in his opinions on the destiny of scientific investigation. According to Krauss, Dyson once told him, “There’s no way we’re ever going to measure gravitons”—the supposed quantum particles underlying gravitational forces—“because there’s no terrestrial experiment that could ever measure a single graviton.” Dyson told Krauss that, in order to measure one, “you’d have to make the experiment so massive that it would actually collapse to form a black hole before you could make the measurement.” So, Dyson concluded, “There’s no way that we’ll know whether gravity is a quantum theory.”

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ETH researchers are developing tiny, sophisticated technological and biological machines enabling non-invasive, selective therapies. Their creations include genetically modified cells that can be activated via brain waves, and swarms of microrobots that facilitate highly precise application of drugs.

Richard Fleischner, who directed the 1966 cult film Fantastic Voyage, would have been delighted with Bradley Nelson’s research: similar to the story in Fleischner’s film, Nelson wants to load tiny robots with drugs and manoeuvre them to the precise location in the human body where treatment is needed, for instance to the site of a cancer tumour. Alternatively, the tiny creatures could also be fitted with instruments, allowing operations to be performed without surgical intervention. The advantages compared with conventional treatments with drugs are clear: far more targeted therapy, and as a result, fewer side effects.

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Microsoft has announced to solve’ cancer within the next decade by ‘reprogramming’ diseased cells like computer virus.

Researchers were able to prevent the death of neurons that causes ALS by introducing a genetic mutation to prevent the SOD1 protein from clumping.

The growing resistance of Gonorrhea, alarmed the researchers.

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In a recent experiment, a Swedish scientist, Fredrik Lanner, a developmental biologist at the Karolinska Institute in Stockholm, attempted to modify the genes of a human embryos injecting a gene-editing tool known as CRISPR-Cas9 into carefully thawed five human embryos donated by couples who had gone through in vitro fertilization (IVF). One did not survive the cooling and thawing process, while another one was severely damaged while being injected. The remaining three embryos, which were two-days old when they were injected, survived in good shape, with one of them dividing immediately after being injected.

Scientists have viewed modifying a human embryo as over the line for safety and ethical concerns. The fear is that Lanner’s work could open the door to others attempting to use genetically modified embryos to make babies. One mistake could introduce a new disease in the human gene pool that can be inherited by future generations. Scientists are also concerned on the possibility of “designer babies,” where parents could choose traits they want for their babies.

Fredrik Lanner (right) of the Karolinska Institute in Stockholm and his student Alvaro Plaza Reyes examine a magnified image of an human embryo that they used to attempt to create genetically modified healthy human embryos. (Credit: Rob Stein/NPR)

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Bioquark, Inc., (http://www.bioquark.com) a life sciences company focused on the development of novel, natural bio-products for health, wellness and rejuvenation, has entered a collaboration whereby Forest Organics LLC & I-Beauty Charm LLC, a unique, integrated facial and body cosmetology facility, and their state-licensed, highly skilled skin care specialists, will be utilizing novel, natural Bioquantine™ extract complexes as part of their spa procedures, as well as providing consumer access to a range of proprietary skin care products (http://www.forestorganics.life).

“We are very excited about this first company collaboration in the area of beauty care and cosmetology,” said Ira S. Pastor, CEO, Bioquark Inc. “It is another step forward towards the wide applicability of our natural combinatorial bio-products, across a broad range of health and wellness segments, as well as future franchise opportunities.”

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The integrated Forest Organics LLC & I-Beauty Charm LLC model was conceived by local Tampa business women, Nadia Goetzinger and Tatyana Reshetnikova, to offer a new generation of products and services related to skin beautification and rejuvenation.

“We look forward to working closely with Bioquark Inc. on this initiative and providing an exclusive range of services and products to customers throughout the greater Tampa metropolitan area,” said Ms. Goetzinger”

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About Bioquark, Inc.

Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biopharmaceutical candidates, as well as non-Rx products for the global consumer health and wellness market segments.

About Forest Organics LLC & I-Beauty Charm LLC

Forest Organics LLC & I-Beauty Charm LLC operate a unique, integrated facial and body cosmetology facility providing novel rejuvenative spa and cosmetology services and products.

Tardigrades, tiny aquatic creatures found in habitats from backyard ponds to Antarctic glaciers, are tough enough to survive the radiation-fraught perils of space. But for a long time, scientists couldn’t agree on why the animals—also known as water bears—are so hardy. Now, researchers have identified a gene that protects the tardigrades’ DNA from radiation, BBC reports. The gene, called Dsup, showed its importance when researchers inserted it into human DNA strands and blasted them with x-rays. The modified genetic material suffered significantly less damage, they report today in. Scientists hope this finding will help them one day protect another animal—us—against radiation.

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In a World View opinion column published in Nature, a Case Western Reserve University School of Medicine researcher calls for animal-human embryo research to proceed — but only with strong animal protections in place. So-called “chimera” research raises the hope of producing human organs in genetically modified large animals, such as pigs and sheep, offering a potential solution to the persistent shortage of human organs for transplantation.

Insoo Hyun, PhD, associate professor of bioethics, urges such research to proceed only after “knowing the right and wrong ways to treat sentient beings according to complexities of their attributes.”

Hyun’s recommendations appear in the journal’s September 15th issue and come a week after the National Institutes of Health closed a month-long public comment period on proposed new regulations, widely expected to be adopted, that would lift a moratorium that currently forbids federal funding for chimera embryo research.

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That brought a lot of media attention, and Giorgio got skittish. “They didn’t want to have the perception from customers that their company was developing genetically modified organisms,” says Yang. Yang is still working to perfect the anti-browning in his academic lab, but he has no immediate plans to commercialize it.

The anti-browning trait might also just be a tough sell to customers: When a Canadian apple wanted to sell a GM apple that doesn’t brown—genetically altered through conventional means—it had to battle assumptions that growers just wanted to hide bruised produce. Which is, well, true. Produce that doesn’t brown when handled does also mean less waste for stores and growers.

In Sweden, Jansson is no stranger to unease over genetic engineering. His colleagues recently returned from a conference where activists flung cow dung and eggs at scientists. The CRISPR-edited cabbage he grew he actually got from researchers outside Sweden, who did not want their names or even their country revealed, fearing backlash from environmental activists. Jansson did his cabbage stunt because he wanted people to start thinking about what CRISPR could mean for food.

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