Lifeboat Foundation: Safeguarding Humanity
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Category: genetics

In a new interview, Elon Musk identifies genetics, AI, and brain bandwidth as three areas in which today’s youth can have the biggest impact on the future. However, he doesn’t think an idea needs to be revolutionary to be worthwhile.

While many 2o-something-year-olds are just finding their way in the world, young Elon Musk was already looking for ways to change it way back in 1995 (when he was that age).

In a well-known 2015 discussion with Neil deGrasse Tyson for the physicist’s StarTalk Radio podcast, Musk lists the five things he thought would most affect the future of humanity (the internet, sustainable energy, space exploration, artificial intelligence, and rewriting human genetics).

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By now, you’ve no doubt heard of CRISPR, the latest gene-editing tool sweeping research labs across the globe. It was first discovered in certain strains of bacteria, who use it as an important weapon against dangerous viruses. In bacteria, CRISPR identifies a virus that poses a threat, records the virus’ genetic data and imprints it onto RNA molecules. An immune enzyme called Cas9 grabs one of the RNA molecules and goes exploring. When Cas9 encounters a virus that matches the data on the RNA molecule, it latches on and slices the virus in half to prevent it from replicating and posing any threat.

Researchers have co-opted the CRISPR/Cas9 mechanism to edit genes. Instead of copying dangerous viral DNA sequences onto the RNA molecules, they can copy over any sequence they want to edit. And instead of Cas9 destroying viruses, it makes precise cuts and removes specific bits of genetic data from the designated sequence. This allows researchers to target and edit specific gene sequences with genetic data of their choosing.

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Scientists have completed reprogramming DNA on the largest scale ever, making the concept of superhumans a reality while advancing Singularity.

Cloned embryo.

Most of us like the idea of superpowers. Though we may never have the strength of Superman, we could be made stronger, faster, and even better-looking, with total control over our genome, or genetic makeup. What about becoming disease-resistant, weight gain resistant, and even slowing down the aging process? This might be possible in decades to come, as geneticists are now getting ever closer to, not just removing and replacing genes, but rewriting entire genomes. It sounds like the realm of science fiction. Yet, consider that geneticists at Harvard recently recoded the genome of a synthetic E. coli bacteria. Prof. George Church and colleagues conducted the study.

Researchers replaced 62,214 base pairs of DNA. What they have done is recreate the DNA from scratch, though they haven’t actually brought the bacteria to life, yet. What was once thought impossible is no longer. This is the first synthetic genome ever assembled, and is being hailed as the most complex feat of genetic engineering, thus far.

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An international collaboration of scientists involving a team of researchers at Manchester led by Dr. David J. Lewis has developed a tiny electric sensor, which could potentially improve patient survival rates by telling doctors if a person has had a heart attack.

Cardiovascular diseases account for around 30 per cent of adult deaths in the 30–70 year age group, which is greater than the combined deaths from all types of cancer. The ability to diagnose cardiac disease is therefore of utmost concern to doctors. When someone has a heart attack, certain chemicals are released into their bloodstream in elevated amounts, and blood tests are therefore the key to diagnosis.

Lewis, from Manchester’s School of Materials, has worked with his colleagues and a team at India’s Institute of Nano Science and Technology (INST) since 2014 to develop a nanoscale sensor made from ‘few-layer black phosphorus’, a new 2D material, which was coated in Deoxyribonucleic Acid (DNA)/genetic material. The immobilised DNA binds to a chemical called myoglobin, which increases in blood plasma after a heart attack and can be detected and measured by a simple electrical test. This could have a major impact, as it is potentially the most rapid, sensitive, selective and accurate method currently available to detect if someone has elevated levels of myoglobin – the measurement of which is one of the methods used in hospitals to check if someone has suffered a heart attack. The researchers predict that its eventual introduction into the clinic could potentially improve patient survival rates after an attack.

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https://youtube.com/watch?v=kUZn1Rh0HO8

Hmmmmm.

The drugs that built a super soldier : past.

During the Vietnam War, the U.S. military plied its servicemen with speed, steroids, and painkillers to help them handle extended combat.

Some historians call Vietnam the “last modern war,” others the “first postmodern war.” Either way, it was irregular: Vietnam was not a conventional war with the frontlines, rears, enemy mobilizing its forces for an attack, or a territory to be conquered and occupied. Instead, it was a formless conflict in which former strategic and tactical principles did not apply. The Vietcong were fighting in an unexpected, surprising, and deceptive way to negate Americans’ strengths and exploit their weaknesses, making the Vietnam War perhaps the best example of asymmetrical warfare of the 20th century.

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Interesting article overall; however, I have noticed many Gastric Bypass patients from my area who drastically loss weight quickly within a year had stomach, throat, and esophageal cancer. As with obesity being a trigger, I believe drastically changes with the body such as massive weight loss quickly could also trigger a cancer gene mutation. I would love to connect with others working of this type of research.

A review of more than a thousand studies has found solid evidence that being overweight or obese increases the risk for at least 13 types of cancer.

The study was conducted by a working group of the International Agency for Research on Cancer, part of the World Health Organisation.

Strong evidence was already available to link five cancers to being overweight or obese: adenocarcinoma of the esophagus, colorectal cancer, breast cancer in postmenopausal women, and uterine and kidney cancers.

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This is actually pretty significant to see from DARPA; however, not a total shock given the importance of Synthetic Biology and various parties in the military understanding how CRISPR can be used as a weapon.

A new DARPA program could help unlock the potential of advanced gene editing technologies by developing a set of tools to address potential risks of this rapidly advancing field. The Safe Genes program envisions addressing key safety gaps by using those tools to restrict or reverse the propagation of engineered genetic constructs.

“Gene editing holds incredible promise to advance the biological sciences, but right now responsible actors are constrained by the number of unknowns and a lack of controls,” said Renee Wegrzyn, DARPA program manager. “DARPA wants to develop controls for gene editing and derivative technologies to support responsible research and defend against irresponsible actors who might intentionally or accidentally release modified organisms.”

Safe Genes was inspired in part by recent advances in the field of “gene drives,” which can alter the genetic character of a population of organisms by ensuring that certain edited genetic traits are passed down to almost every individual in subsequent generations. Scientists have studied self-perpetuating gene drives for decades, but the 2012 development of the genetic tool CRISPR-Cas9, which facilitates extremely precise genetic edits, radically increased the potential value of—and in some quarters the demand for—experimental gene drives.

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DARPA’s Safe Genes program aims to build a biosafety and biosecurity toolkit to reduce potential risks and encourage innovation in the field of genome editing

The Safe Genes program could help unlock the potential of advanced gene editing technologies by developing a set of tools to address potential risks of this rapidly advancing field. The Safe Genes program envisions addressing key safety gaps by using those tools to restrict or reverse the propagation of engineered genetic constructs.

“Gene editing holds incredible promise to advance the biological sciences, but right now responsible actors are constrained by the number of unknowns and a lack of controls,” said Renee Wegrzyn, DARPA program manager. “DARPA wants to develop controls for gene editing and derivative technologies to support responsible research and defend against irresponsible actors who might intentionally or accidentally release modified organisms.”

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IBM wants to give people night vision capabilities, and they are doing it using Google Glass. This patent “tricks” the eyes with red light in order to increase visibility when in a low light environment.

Upon entering a dark room, human eyes obviously take time to adjust in order to see clearly. That’s because there are two types of photoreceptors in our eyes — the rods and the cones. Rods are responsible for letting humans see in the dark; however, it takes around 30 minutes for our rods to fully adjust to the darkness.

Night vision is a very complicated biological process, but it seems that we may be able to tweak and enhance it, and we can do so without using genetic manipulation or any other equally invasive and transformative method. In fact, all we may need is glasses.

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Synthetic biology is essentially an application of engineering principles to the fundamental molecular components of biology. Key to the process is the ability to design genetic circuits that reprogram organisms to do things like produce biofuels or excrete the precursors for pharmaceuticals, though whether this is commercially viable is another question.

MIT’s Jim Collins, one of the founders of synthetic biology, recently explained it to me as putting the engineering into genetic engineering.

“Genetic engineering is introducing a gene from species A to species B,” he said. “That’s the equivalent of replacing a red light bulb with a green light bulb. Synthetic biology is focused on designing the underlying circuitry expressing that red or green light bulb.”

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