Summary: Study identifies a significant way in which a disrupted circadian clock drives inflammation in the body’s immune cells.
Source: RCSI
New research from RCSI has demonstrated the significant role that an irregular body clock plays in driving inflammation in the body’s immune cells, with implications for the most serious and prevalent diseases in humans.
In this DNA factory, organism engineers are using robots and automation to build completely new forms of life.
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Ginkgo Bioworks, a Boston company specializing in “engineering custom organisms,” aims to reinvent manufacturing, agriculture, biodesign, and more.
Biologists, software engineers, and automated robots are working side by side to accelerate the speed of nature by taking synthetic DNA, remixing it, and programming microbes, turning custom organisms into mini-factories that could one day pump out new foods, fuels, and medicines.
While there are possibly numerous positive and exciting outcomes from this research, like engineering gut bacteria to produce drugs inside the human body on demand or building self-fertilizing plants, the threat of potential DNA sequences harnessing a pathological function still exists.
That’s why Ginkgo Bioworks is developing a malware software to effectively stomp out the global threat of biological weapons, ensuring that synthetic biology can’t be used for evil.
Learn more about synthetic DNA and this biological assembly line on this episode of Focal Point.
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I have a small YouTube channel which I create videos on clean energy and the environment. I have under 600 subs and many videos have not even hit 100 views but I am being increasingly targeted by fossil fuel activists and supporters, with personal attacks and misinformation.
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We can show them that they are the minority, not us, and the wider the information spreads the quicker the change will be and the better life will be for everyone.
Thanks in advance and have an awesome day.
It is very likely that treatments to address the issues that cause aging & its related conditions & diseases will be within our reach in 15 to 20 years.
It is highly likely that a general realisation that these treatments are not only scientifically possible but within our reach will start to become increasingly apparent to the wider population in as little as maybe 5 years.
On this channel I will seek to hasten this realisation, & provide answers to the most common questions & concerns. I will also seek to distil the current scientific knowledge base into an easy to use action plan for those wishing to take measures to make sure they see this in good health.
To raise awareness of how close longevity treatments are.
To debate and dispute arguments against it happening.
To show the pathway (diet/exercise/mental health/current medications and supplements) to make sure you live long enough to see it.
To present technologies & ideas to show what it may look like in the future.
Posted in bioengineering, biotech/medical, food, information science, robotics/AI | Leave a Comment on Enhancing the workhorse: Artificial intelligence, hardware innovations boost confocal microscope’s performance
Since artificial intelligence pioneer Marvin Minsky patented the principle of confocal microscopy in 1957, it has become the workhorse standard in life science laboratories worldwide, due to its superior contrast over traditional wide-field microscopy. Yet confocal microscopes aren’t perfect. They boost resolution by imaging just one, single, in-focus point at a time, so it can take quite a while to scan an entire, delicate biological sample, exposing it light dosages that can be toxic.
To push confocal imaging to an unprecedented level of performance, a collaboration at the Marine Biological Laboratory (MBL) has invented a “kitchen sink” confocal platform that borrows solutions from other high-powered imaging systems, adds a unifying thread of “Deep Learning” artificial intelligence algorithms, and successfully improves the confocal’s volumetric resolution by more than 10-fold while simultaneously reducing phototoxicity. Their report on the technology, called “Multiview Confocal Super-Resolution Microscopy,” is published online this week in Nature.
“Many labs have confocals, and if they can eke more performance out of them using these artificial intelligence algorithms, then they don’t have to invest in a whole new microscope. To me, that’s one of the best and most exciting reasons to adopt these AI methods,” said senior author and MBL Fellow Hari Shroff of the National Institute of Biomedical Imaging and Bioengineering.
P.E.I. will be making a vaccine that prevents shingles free for seniors next year.
The two dose Shingrix vaccine will be available for Islanders who are 65 and older beginning in January.
Erin MacKenzie, executive director of the P.E.I. Pharmacists Association, said one dose of the vaccine usually costs around $180.
Most human diseases can be traced to malfunctioning parts of a cell—a tumor is able to grow because a gene wasn’t accurately translated into a particular protein or a metabolic disease arises because mitochondria aren’t firing properly, for example. But to understand what parts of a cell can go wrong in a disease, scientists first need to have a complete list of parts.
By combining microscopy, biochemistry techniques and artificial intelligence, researchers at University of California San Diego School of Medicine and collaborators have taken what they think may turn out to be a significant leap forward in the understanding of human cells.
The technique, known as Multi-Scale Integrated Cell (MuSIC), is described November 24, 2021 in Nature.
Research led by UT Southwestern and the University of Washington could lead to a wealth of drug targets.
UT Southwestern and University of Washington researchers led an international team that used artificial intelligence (AI) and evolutionary analysis to produce 3D models of eukaryotic protein interactions. The study, published in Science, identified more than 100 probable protein complexes for the first time and provided structural models for more than 700 previously uncharacterized ones. Insights into the ways pairs or groups of proteins fit together to carry out cellular processes could lead to a wealth of new drug targets.
“Our results represent a significant advance in the new era in structural biology in which computation plays a fundamental role,” said Qian Cong, Ph.D., Assistant Professor in the Eugene McDermott Center for Human Growth and Development with a secondary appointment in Biophysics.
Natural selection, the evolutionary process that guides which traits become more common in a population, has been acting on us for the past 3,000 years, right up to the modern day, new research suggests.
And it seems to be acting in surprising ways on complex traits encoded by multiple genes, such as those tied to intelligence, mental illness and even cancer.
The SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. Comparing 44 Sarbecovirus genomes provides a high-confidence protein-coding gene set. The study characterizes protein-level and nucleotide-level evolutionary constraints, and prioritizes functional mutations from the ongoing COVID-19 pandemic.
𝐌𝐀𝐆𝐈𝐂 𝐌𝐔𝐒𝐇𝐑𝐎𝐎𝐌 𝐒𝐓𝐔𝐃𝐘 𝐒𝐔𝐆𝐆𝐄𝐒𝐓𝐒 𝐏𝐒𝐈𝐋𝐎𝐂𝐘𝐁𝐈𝐍 𝐌𝐀𝐘 𝐑𝐄𝐕𝐄𝐑𝐒𝐄 𝐀𝐋𝐂𝐎𝐇𝐎𝐋-𝐈𝐍𝐃𝐔𝐂𝐄𝐃 𝐁𝐑𝐀𝐈𝐍 𝐃𝐀𝐌𝐀𝐆𝐄
𝘼𝙁𝙏𝙀𝙍 𝙃𝘼𝙇𝙁 𝘼 𝘾𝙀𝙉𝙏𝙐𝙍𝙔 𝙤𝙛 𝙗𝙡𝙤𝙘𝙠𝙨 𝙩𝙤 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝 𝙤𝙣 𝙥𝙨𝙮𝙘𝙝𝙚𝙙𝙚𝙡𝙞𝙘𝙨’ 𝙥𝙤𝙩𝙚𝙣𝙩𝙞𝙖𝙡 𝙛𝙤𝙧 𝙩𝙧𝙚𝙖… See more.
The psychedelic drug psilocybin can restore alcohol-induced damage to the brain’s glutamate receptors — that’s the finding of a new study published in ‘Science Advances.’
