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Category: biotech/medical

In this video Dr. Lustgarten introduces his N of 1 experiment and gives an overview of the processes that he follows. He also discusses why he thinks it is important to track your own markers and not just rely on published trials.

Dr. Michael Lustgarten is a scientist at the Tufts University Human Nutrition Research Center on Aging in Boston, Massachusetts. His research currently focuses on the role of the gut microbiome and serum metabolome on muscle mass and function in older adults.
In this series of interviews Dr Lustgarten shares his experience with his rigorous n of 1 experiment over the last 7 years and shows how we or anyone can conduct a similar trial by tracking food, exercise and sleep, measure results and derive relationships between them, with a goal of extending our healthspan.

Dr Lustgarten’s channel on YouTube: https://www.youtube.com/channel/UCT1UMLpZ_CrQ_8I431K0b-g.

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Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation.

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Abstract. The cnidarian model organism Hydra has long been studied for its remarkable ability to regenerate its head, which is controlled by a head organizer located near the hypostome. The canonical Wnt pathway plays a central role in head organizer function during regeneration and during bud formation, which is the asexual mode of reproduction in Hydra. However, it is unclear how shared the developmental programs of head organizer genesis are in budding and regeneration. Time-series analysis of gene expression changes during head regeneration and budding revealed a set of 298 differentially expressed genes during the 48-h head regeneration and 72-h budding time courses. In order to understand the regulatory elements controlling Hydra head regeneration, we first identified 27,137 open-chromatin elements that are open in one or more sections of the organism body or regenerating tissue. We used histone modification ChIP-seq to identify 9,998 candidate proximal promoter and 3,018 candidate enhancer-like regions respectively. We show that a subset of these regulatory elements is dynamically remodeled during head regeneration and identify a set of transcription factor motifs that are enriched in the enhancer regions activated during head regeneration. Our results show that Hydra displays complex gene regulatory structures of developmentally dynamic enhancers, which suggests that the evolution of complex developmental enhancers predates the split of cnidarians and bilaterians.

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Moderator: Michael Wall.
Panelists: Kennda Lynch, Abigail Fraeman, Morgan Cable.

Part of the Earth at the Crossroads conference held on Nov. 18, 2021.

Tantalizing new discoveries suggest that we are probably not alone in the universe. And yet, as Enrico Fermi first put in 1950: where is everybody? Are habitable worlds rare, unlikely, and therefore cosmically precious? Or is life easily overwhelmed by changing planetary conditions? Do technological societies in particular face an inevitable “Great Filter” that causes their extinction? These questions link the search for extraterrestrial life to the urgent environmental challenges facing our own civilization, from deadly pandemics to human-caused climate change. On November 18th, Georgetown University and the SETI Institute will unite scholars, journalists, artists and activists in conversations that explore what the search for alien life may reveal about the future of life on Earth. These conversations will be open to Georgetown students and will be broadcast to the public. They will culminate in a roundtable debate intended to draft a proclamation on the state of Earth’s environment and its future potential in a cosmic context.

If you like science, support the SETI Institute! We’re a non-profit research institution whose focus is understanding the nature and origins of life in the universe. Donate here: https://seti.org/donate.

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Lex Fridman Podcast full episode: https://www.youtube.com/watch?v=K78jqx9fx2I
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GUEST BIO:
Jamie Metzl is an author specializing in topics of genetic engineering, biotechnology, and geopolitics.

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Blocking matrix metalloproteinases MMP2 and MMP9 can have the opposite effect on neuroplasticity depending on whether the brain is healthy or injured.

Summary: Blocking the matrix metalloproteinases MMP2 and MMP9 can have the opposite effect on neuroplasticity depending on whether the brain is healthy or injured.

Source: University of Gottingen

The brain is a remarkably complex and adaptable organ. However, adaptability decreases with age. As new connections between nerve cells in the brain form less easily, the brain’s plasticity decreases.

If there is an injury to the central nervous system, such as after a stroke, the brain needs to compensate by reorganizing itself. To do this, a dense network of molecules between the nerve cells—known as the extracellular matrix—must loosen.

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NASA has again delayed the multi-billion dollar James Webb Space Telescope (JWST), this time citing communications issues.

The space telescope was due to launch on December 22, 2021, from the European Spaceport in Korou, French Guiana.

The space agency is now saying “no earlier than” December 24, 2021.

The launch window closes on January 7, 2022, though opens again on January 12, 2022.

“Webb” was originally conceived in the 1990s and was first expected to launch in 2007. It had been expected to launch in March 2021, which COVID-19 delays put back to October 31 this year, then December 18 after an incident.

Designed and funded by NASA, the European Space Agency (ESA), and the Canadian Space Agency (CSA), Webb is around the size of a tennis court and set to be the largest, most powerful, and most complex space science telescope ever constructed.

Its ability to detect faint infrared light will be its biggest advantage over the Hubble Space Telescope because seeing in the infrared will enable it to look much farther back in time. It’s hoped that Webb will help solve mysteries in our Solar System, closely study exoplanets and probe the structures and origins of the Universe.

Full Story:

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What if your brain at 77 were as plastic as it was at 7? What if you could learn Mandarin with the ease of a toddler or play Rachmaninoff without breaking a sweat? A growing understanding of neuroplasticity suggests these fantasies could one day become reality. Neuroplasticity may also be the key to solving diseases like Alzheimer’s, depression, and autism. In this program, leading neuroscientists discuss their most recent findings and both the tantalizing possibilities and pitfalls for our future cognitive selves.

PARTICIPANTS: alvaro pascual-leone, nim tottenham, carla shatz.

MODERATOR: Guy McKhann.

MORE INFO ABOUT THE PROGRAM AND PARTICIPANTS: https://www.worldsciencefestival.com/programs/nuts-bolts-better-brains-harnessing-power-neuroplasticity/

This program is part of the BIG IDEAS SERIES, made possible with support from the JOHN TEMPLETON FOUNDATION.

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In the future Biotechnology may allows us repair, modify, or augment humans, but how will this be done? What will these technologies look like and should we embrace them?

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Listen or Download the audio of this episode from Soundcloud: Episode’s Audio-only version: https://soundcloud.com/isaac-arthur-148927746/biotech-human-modification-and-augmentation.
Episode’s Narration-only version: https://soundcloud.com/isaac-arthur-148927746/biotech-human-modification-and-augmentation-narration-only.

Credits:
Biotech: Human Modification and Augmentation.
Science & Futurism with Isaac Arthur.
Episode 289, May 6, 2021

Produced & narrated by isaac arthur.

Writers:
Isaac Arthur.
Jason Burbank.

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Genetic Engineering and DNA alteration is an emerging technology with huge ramifications in the future, including potentially altering the DNA of adult humans, not just embryos or plants & animals.

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Listen or Download the audio of this episode from Soundcloud: Episode’s Audio-only version:
https://soundcloud.com/isaac-arthur-148927746/dna-manipulation-in-living-subjects.
Episode’s Narration-only version: https://soundcloud.com/isaac-arthur-148927746/dna-manipulation-in-living-subjects-narration-only.

Credits:
DNA Manipulation in Living Subjects.
Episode 227; Feb 27, 2020

Writers:
Isaac Arthur.

Editors:
David Jackson.
Jerry Guern.
Keith Blockus.

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