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Category: biotech/medical

Difficulty swallowing after a Stroke occurs when the esophagus becomes damaged or the muscles and nerves that control swallowing are functioning poorly. There can also be a blockage in the esophagus, which is making it difficult to swallow. It will hurt when you try to swallow. Since it’s painful, it may cause you to not want to eat. This can cause other issues to occur in your body, such as weight loss. At Rehab, a nurse explained to me that my swallowing problem was caused by weak muscles in the esophageal sphincter. That information stimulated me to create my own therapy for the esophageal sphincter. I wrote out the transcript for the therapy, and a lady named Collette read it into a recorder. I listen to the recording several times a day. My swallowing problems resulted in a feeding being inserted up my nose. The therapy makes it possible for me to eat oatmeal, grits, eggs, pasta & beef, and corn flakes. After passing the swallowing test last Friday, the Speech Pathologist sent me to the Emergency Room, where they pulled the feeding tube from my nose.

Difficulty swallowing occurs when the esophagus becomes damaged or the muscles and nerves that control swallowing are functioning poorly. There can also be a blockage in the esophagus, which is making it difficult to swallow. It will hurt when you try to swallow. Since it’s painful, it may cause you to not want to eat. This can cause other issues to occur in your body, such as weight loss. When it comes to finding out what is causing the difficulty in swallowing, there are a number of reasons why it’s happening. Some reasons you can’t help, while others are simple.

Certain things that we do to our bodies could trigger our inability to swallow. Once you know what is causing the issue, it’ll be easier for you to swallow. Sometimes it is things you can do at home, while others need to be treated by a medical professional.

Here are eight frequent causes of difficulty swallowing.

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A new study published by researchers from MIT and also from Immersion Health, Portland raises the alarm about possible unintended consequences of the mRNA vaccines currently being deployed against the COVID-19 disease.

The study findings were published in the peer reviewed journal: International Journal Of Vaccine Theory, Practice And Research. https://ijvtpr.com/index.php/IJVTPR/article/view/23/29.

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They suggest that over the past millennium, the human gut has experienced an “extinction event,” losing dozens of species and becoming significantly less diverse, says lead author and Harvard Medical School microbiologist Aleksandar Kostic. “These are things we don’t get back.”

First DNA from paleofeces show people 1000 years ago in U.S., Mexico had much more diverse gut microbes.

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Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.

Keywords: hyaluronic acid, hyaluronic acid synthases, hyaluronidases, CD44, RHAMM, skin aging.

Human skin aging is a complex biological process, not yet fully understood. It is the result of two biologically independent processes. The first is intrinsic or innate aging, an unpreventable process, which affects the skin in the same pattern as it affects all internal organs. The second is extrinsic aging, which is the result of exposure to external factors, mainly ultraviolet (UV) irradiation, that is also referred to as photoaging.1 Intrinsic skin aging is influenced by hormonal changes that occur with age,2 such as the gradual decreased production of sex hormones from the mid-twenties and the diminution of estrogens and progesterone associated with menopause. It is well established that the deficiency in estrogens and androgens results in collagen degradation, dryness, loss of elasticity, epidermal atrophy and wrinkling of the skin.3

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CES 2021 is blowing up with a lot of announcements despite being a virtual event. Among the lot, a Japanese Startup now says that its wearable can help you monitor Blood Glucose without piercing your skin.

Quantum Operation Inc., has showcased a prototype of a Wearable that typically is like a Smartwatch. It says that the wearable can measure and monitor the Glucose levels in Blood precisely in addition to heart rate and ECG. Apparently, this is possible due to the presence of a Spectrometer inside.

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A COVID-19 vaccine that could provide protection against existing and future strains of the COVID-19 coronavirus, and other coronaviruses, and costs about $1 a dose has shown promising results in early animal testing.

Vaccines created by UVA Health’s Steven L. Zeichner, MD, PhD, and Virginia Tech’s Xiang-Jin Meng, MD, PhD, prevented pigs from being becoming ill with a pig model coronavirus, porcine epidemic diarrhea virus (PEDV). The vaccine was developed using an innovative approach that Zeichner says might one day open the door to a universal vaccine for coronaviruses, including coronaviruses that previously threatened pandemics or perhaps even coronaviruses that cause some cases of the common cold.

Their coronavirus vaccine offers several advantages that could overcome major obstacles to global vaccination efforts. It would be easy to store and transport, even in remote areas of the world, and could be produced in mass quantities using existing vaccine-manufacturing factories.

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A clinical-stage leader in immune-stimulatory vaccines for cancer announced the publication of its favorable long-term Overall Survival (OS) data from a Phase I trial evaluating a universal cancer vaccine candidate, UV1, in combination with checkpoint inhibitor ipilimumab, in patients with metastatic malignant melanoma.

UV1 is a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase.

Published in the Frontiers in Immunology journal on May 11, 2021, Norway-based Ultimovacs ASA’s UV1 vaccine candidate achieved the primary endpoints of safety and tolerability.

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Influenza, commonly known as the flu virus, places a substantial burden on public health in the United States. The U.S. Centers for Disease Control and Prevention (CDC) estimates that influenza has resulted in about 9 million to 45 million diseases, 140000 to 810000 hospitalizations, and 12000 to 61000 deaths each year over the past decade.

Though flu vaccines are readily available to the public, they need to be remodeled and administered every year to combat new viral variants, which can undermine vaccine efficacy. Because of this, scientists have aimed to develop a universal vaccine that can protect against all influenza strains, and that can last for many years.

Now, researchers at the National Institute of Allergy and Infectious Diseases (NIAID)’s Vaccine Research Center (VRC) and the University of Washington School of Medicine’s Institute for Protein Design (IPD) developed a universal flu vaccine candidate using small particles (nanoparticles), which can induce a long-lasting immune response.

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These studies provide a clear proof of principle for a new type of gene therapy in which one copy of a mutated gene could be repaired from a partially intact second copy of the gene,” said Bier, senior author of the Nature Communications study and science director for the Tata Institute for Genetics and Society-UC San Diego. “The need for such a design occurs in genetic situations with patients with inherited genetic disorders, if their parents were carriers for two different mutations in the same gene.

Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques.

Working in fruit flies and , research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of Biological Sciences Professor Ethan Bier’s laboratory demonstrates that new DNA repair mechanisms could be designed to address the effects of debilitating diseases and damaged cell conditions.

The scientists developed a novel genetic sensor called a ‘CopyCatcher,’ which capitalizes on CRISPR-based gene drive technology, to detect instances in which a genetic element is copied precisely from one chromosome to another throughout in the body of a fruit fly.

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As researchers learn more about the brain, it has become clear that responsive neurostimulation is becoming increasingly effective at probing neural circuit function and treating neuropsychiatric disorders, such as epilepsy and Parkinson’s disease. But current approaches to designing a fully implantable and biocompatible device able to make such interventions have major limitations: their resolution isn’t high enough and most require large, bulky components that make implantation difficult with risk of complications.

A Columbia Engineering team led by Dion Khodagholy, assistant professor of electrical engineering, has come up with a new approach that shows great promise to improve such devices. Building on their earlier work to develop smaller, more efficient conformable bioelectronic transistors and materials, the researchers orchestrated their devices to create implantable circuits that enable allow reading and manipulation of brain circuits. Their multiplex-then-amplify (MTA) system requires only one amplifier per multiplexer, in contrast to that need an equal number of amplifiers as number of channels.

“It is critical to be able to detect and intervene to treat brain-disorder-related symptoms, such as epileptic seizures, in real time,” said Khodagholy, a leader in bio-and neuroelectronics design. “Not only is our system much smaller and more flexible than current devices, but it also enables simultaneous stimulation of arbitrary waveforms on multiple independent channels, so it is much more versatile.

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