Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

https://www.youtube.com/watch?v=T4U6qvNt81E&feature=youtu.be

The MMTP has recorded this film in support of SENS Research and their quest to find solutions to ALT cancer.

To support OncoSENS project with a donation click the link:

https://www.lifespan.io/campaigns/sens-control-alt-delete-cancer/

Telomere shortening acts as a biological mechanism for limiting cellular life span. Most cancer cells bypass this failsafe by synthesizing new telomeres using the enzyme telomerase.

Several therapies targeting this well-described telomerase-based pathway are in the advanced stages of clinical development, but as with any cancer therapy there is the potential for development of resistance against telomerase-based strategies to defeat cancer. Studies using mice and human cancer cell lines have demonstrated that cancer can overcome the loss of telomerase by using a telomerase-independent mechanism called Alternative Lengthening of Telomeres (ALT).

Furthermore, tumor cells have also been observed to switch over to the ALT pathway as a result of telomerase-inhibiting treatment.

From 10 to 15% of all cancers are ALT-dependent — and incurable, because there are currently no ALT-targeted anti-cancer therapeutics.

OncoSENS is a high-throughput screening of a library of diverse drugs to find treatments for ‘ALT’ cancers, those which rely on Alternative Lengthening of Telomeres.

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Blended Reality is a versatile concept that can be extended from the physical and digital worlds to the chemical and biological world. In the convergence of healthcare diagnostics and digital health, it can play a fundamental role: the transformation of human biology, real-world parameters into digital data to obtain contextual health information and enable personalized drug treatments. The fusion of microfluidics, edge computing and commercial mobility with diagnostics, digital health, big data, precision medicine, and theranostics will disrupt existing, established structures in our healthcare system. This will allow new models of partnerships among technology and pharmaceutical industries (see fig. 1).

From the very beginning of mankind, healthcare was purely empirical and mostly a combination of empirical and spiritual skills. While access to cures was exclusive and very limited, the success rate was not very high in most cases. During the Renaissance a systematic exploration of natural phenomena and physiology laid the scientific foundation of modern medicine. A real breakthrough in quality and access to healthcare services has taken place in the past 150 years as an aftermath of the Industrial Revolution. It brought significant advances in science as well as societal changes: expanding government-granted access to the establishing working classes as the main human capital of the industrialization process in the Western Hemisphere. Keeping a business employees healthy became an indispensable prerequisite to increasing the national economic output and well-being on a societal level.

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https://www.youtube.com/watch?v=5chIH_ozLkI

Inconvenient truths about aging, senescent cells and more.

Filmed August 16th 2016.

http://www.sens.org/

Judith campisi professor buck institute for research on aging.

John Jackson Associate Professor Institute for Regenerative Medicine, Wake Forest School of Medicine.

Gordon lithgow professor buck institute for research on aging.

Panel discussion moderator: aubrey de grey chief science officer SENS research foundation.

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Our friends at the Methuselah Foundation are working on macular degeneration.

Typically, a fellowship and participation in a research study to cure a major disease would occur years after completing undergrad, possibly even after earning a PhD. But Jennifer DeRosa is not a typical student.

As early as high school, DeRosa was already in the lab, conducting research in plant biotechnology at the College of Environmental Science and Forestry (SUNY-ESF) before graduating valedictorian from Skaneateles High School. As a freshman student at Onondaga Community College, she continued to develop skills in molecular biology, analytical chemistry, and cell biology. She logged over 1,600 hours in academic and industry laboratories while maintaining a perfect 4.0 GPA, completing her associate’s degree in Math and Science in only one year.

Although she had planned to continue to a bachelor’s program, DeRosa elected to defer enrollment after being offered a Methuselah Foundation research fellowship. “The fellowship provides distinguished students a year-long stipend to work in any laboratory of their choosing that conducts work on age-associated diseases,” said Methuselah Foundation CEO David Gobel. “We are very pleased that she chose to complete her fellowship at Ichor Therapeutics, where she has been working as a paid intern. Methuselah Foundation has a high degree of confidence in the quality and scope of work being conducted there.”

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Using light, a team of MIT researchers were able to print 3D structures that “remember” their original shapes. Even after being stretched, twisted, and bent at extreme angles, the structures sprang back to their original forms within seconds of being heated to a certain temperature “sweet spot.”

Beyond 3D-printed dinners, additive manufacturing has helped create artificial jaws, better prosthetics, and even brain tumors. Researchers at MIT have found a way to print 3D structures that remember their original shapes within seconds of being heated at a specific temperature “sweet spot,” paving the way towards developing tiny drug capsules that open upon early signs of infection.

Researchers often turn to 3D printing to fabricate shape-memory structures since the technology lets them to custom-design structures with relatively fine detail. The only problem is that conventional 3D printers come with size restrictions—the structures’ details can’t go any smaller than a few millimeters, and the restriction limits how fast the material can recover its original shape.

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Scientists from Northwestern University have been able to create a heat-sensitive bandage that coaxes naturally-occurring stem cells to heal wounds faster.

Technology that allows wounds to heal faster is in great need, especially for those patients that are susceptible to complications from seemingly simple injuries. For diabetics, small bruises and cuts can be life-threatening. What if there was a way to speed up healing these wounds?

The answer may lie in this new bandage. Researchers from Northwestern University have developed a heat-responsive bandage that helps wounds heal faster.

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