Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

(Phys.org) —Tufts University biologists using new, automated training and testing techniques have found that planarian flatworms store memory outside their brains and, if their heads are removed, can apparently imprint these memories on their new brains during regeneration.

The work, published online in the Journal of Experimental Biology, can help unlock the secrets of how memories can be encoded in living tissues, noted Michael Levin, Ph.D., Vannevar Bush professor of biology at Tufts and senior author on the paper.

“As and biomedicine advance, there’s a great need to better understand the dynamics of memory and the brain-body interface. For example, what will happen to stored memory if we replace big portions of aging brains with the progeny of fresh ?” said Levin, who directs the Center for Regenerative and Developmental Biology in Tufts’ School of Arts and Sciences.

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Very cool.

Scientists have developed a new 5D technique for analysing images, an advance that may make it easier to quickly find tell-tale signs of diseases from pictures taken using cell phones. Called “Hyper-Spectral Phasor” analysis, or HySP, it is much faster and far less expensive than current techniques, and may be useful for diagnosing and monitoring diseases by using cell phone images, researchers said.

Through the new imaging technology, researchers at the University of Southern California (USC) in the US have used fluorescent imaging to locate proteins and other molecules in cells and tissues. It works by tagging the molecules with dyes that glow under certain kinds of light – the same principle behind so-called “black light” images.

Fluorescent imaging can help scientists understand which molecules are produced in large amounts in cancer or other diseases, information that may be useful in diagnosis or in identifying possible targets for therapeutic drugs.

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The quest for the fountain of youth is as ancient as humanity itself. Now, it appears scientists may have found the source.

Using a process designed to “reprogram” normal adult cells into pluripotent stem cells—cells that can transform into many different kinds of cells—researchers have managed to boost the life spans of mice by up to 30% and rejuvenate some of their tissues.

The treatment did not change the cell’s genetic code, but rather chemical attachments on their DNA called epigenetic marks, responsible for regulating the genome and determining how active certain genes are.

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In Brief A multicomponent virus is divided into a number of different pieces. In this respect, each one is packaged separately into a viral particle. One particle of each type is needed for cell infection. And there’s a new one impacting animals.

A new type of virus has been identified, and it’s so weird, it’s challenging long-held notions of what it takes for a virus to infect and proliferate in an animal host.

Conventional wisdom states that if a single virus manages to insert its genes into a cell, the host becomes infected. But what if you chopped up that virus, and tried stuffing the pieces into an animal cell separately? It wouldn’t work, right?

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https://www.youtube.com/watch?v=a6s2qk_ILnU

I missed this one. A Liz lecture with what they do and about regulation questions from the audience.

The fourth speaker at the “Designing New Advances” conference hosted by the Institute of Exponential Sciences in Utrecht. Liz Parrish, CEO BioViva Sciences, talks about her work. Learn more about gene therapies and ageing diseases.

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Liviu Babitz is not content waiting around for evolution to improve upon his human form. Like other transhumanists, Babitz believes that science and technology can take a person’s intelligence, physical performance and psychological state to the next level, all in less than the span of a single lifetime.

To that end, he helped develop North Sense, a small silicone gadget that detects magnetic north. This is not a GPS device, nor a tracker. It’s not even connected to the Internet nor any other network. This is a new sensory organ designed to be pierced to a person’s body and vibrate each time the wearer faces magnetic north.

The idea is that over time, the brain will assimilate the vibration into the everyday human experience, enhancing it. That will open a person up to a world that exists beyond his or her own current capabilities.

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I got my autosomal DNA analysed for $50 by FTDNA recently. Not a full gene sequence though. You get NGS tests for about $400 now.

The first sequencing of the whole human genome in 2003 cost roughly $2.7 billion, but DNA sequencing giant Illumina has now unveiled a new machine that the company says is “expected one day” to order up your whole genome for less than $100.

Illumina’s CEO Francis deSouza showed off the machine, called the NovaSeq, onstage at the JP Morgan Healthcare Conference in downtown San Francisco today, telling the crowd the machine’s scanning speed could decipher an entire human genome in less than an hour.

Let that sink in. In less than 15 years we went from what once took billions of dollars and over a decade of research to an hour’s worth of time with the promise of a blip of the cost.

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A new way to treat brain cancer with our own immune cells.

Injecting genetically modified immune cells directly into the brain and spinal fluid has had remarkable effects on a deadly brain cancer

Glioblastoma is a particularly virulent form of brain cancer. Around 20,000 people in the United States are diagnosed each year and the disease typically has poor survival rates. In a new case reported in the New England Journal of Medicine, a man has undergone experimental CAR-T therapy to treat the condition. CAR-T therapy is a branch of immunotherapy, the field taking cancer treatment by storm, and involves infusing genetically modified T cells back into a patient to target cancer cells.

A new hope

50-year-old Richard Grady received the treatment in California, and it involved dripping these specialised cells through a narrow tube into the brain. CAR-T therapy (also called chimeric antigen receptor) involves adding novel receptors on the surface of T cells; allowing them to better recognise and destroy any cancer cells they come across. Grady’s therapy began with surgery to remove 3 larger tumours, and then followed with 6 weekly infusions into the brain.

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