Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical

It’s that time of the year again … the Science news writers and editors are homing in on the “Breakthrough of the Year,” their choice of the most significant scientific discovery, development, or trend in 2017. That selection, along with nine runners-up, will be announced when the last issue of the year goes online on 21 December.

Now, you can get in on the action! Pick your favorite breakthrough from the list of candidates below by 3 December. Then check back the next day, when we will start a second round of voting with your four top picks. We will announce your winner—the People’s Choice—along with Science’s choice on 21 December.

From cancer advances to the cosmos, what’s your top choice?

Read more

In this new Business Insider article, my ideas on peak labor and Universal Basic Income are pitted against MIT scientist Andrew McAfee. I’m excited to see my government shrinking Federal Land Dividend proposal getting out there. Story by journalist Dylan Love: http://www.businessinsider.com/will-universal-basic-income-save-us-from-job-stealing-robots-2017-11?r=UK&IR=T #transhumanism #libertarian

Does free money change nothing or everything?

Universal basic income (UBI) is the hottest idea in social security since Franklin Roosevelt signed the New Deal in 1935, and it is fairly understood as free money given to citizens by their government. Though the idea traces its roots back to the 16th century as a “cure for theft,” UBI has gained new consideration and momentum these days, as high-profile techno-doomsayers like SpaceX founder Elon Musk point to it as an economic solution for big problems predicted to arrive soon.

The future is coming, Musk and his ilk warn, and it’s bringing increased automation and intelligent technologies with it that will eventually overtake the human capacity for work. All-capable robots will cause widespread human unemployment, goes the thinking, plaguing our income and livelihood for generations.

If the “robots are stealing jobs” on the level that the party line portends, then UBI presents itself as a compelling solution to this unusual, hypothetical problem. There’s already some real-world precedent for it: a UBI pilot program in Finland sees the government send a small amount of money to 2,000 unemployed Finns each month, and the initial results are quite positive.

Read more

Innovation Group looked at three fundamental pillars of humanity and how they will evolve over the coming 10–15 years: our bodies, our thought, and our behavior. After identifying the driving forces that will transform these fundamental pillars, we extracted key themes emerging from their convergence. Ultimately our goal was to determine the ways in which the changing nature of humanity and transhumanism would affect individuals, society, businesses, and government.

A few of the trends that emerged from this study include the following seven trends. We hope they will spark discussion and innovation at your organizations.

Companies today are strategizing about future investments and technologies such as artificial intelligence, the internet of things, or growth around new business models. While many of these trends will make for solid investments for the next 5–10 years, fewer companies are considering the revolutionary convergence of disparate trends pulled from technology, behavioral and societal changes, and medical advances to understand how they will converge to transform society. This transformation will be messy, complex, and sometimes scary, but signals already point to a future of humanity that will blur our identities into “transhumanism.”

Read more

Another case of idiot MD’s who think they know everything not wanting to test for CJD, and getting mad when something they dont know existed contaminating instruments and spreading diseases.

AI doctors soon please.

Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, can be transmitted via neurosurgical instruments or corneal or dura mater transplants contaminated by infectious prions. Some epidemiological studies have associated sCJD risk with surgeries that involve the skin, but whether the skin of sCJD patients contains prion infectivity is not known. Orrú et al. now report detectable prion seeding activity and infectivity in skin from sCJD patients, although at much lower levels compared to brain tissues from sCJD patients. These data suggest that there may be a potential for iatrogenic sCJD transmission through skin.

Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of the prion protein (PrPSc)] in the central nervous system (CNS). Some epidemiological studies have associated sCJD risk with non-CNS surgeries. We explored the potential prion seeding activity and infectivity of skin from sCJD patients. Autopsy or biopsy skin samples from 38 patients [21 sCJD, 2 variant CJD (vCJD), and 15 non-CJD] were analyzed by Western blotting and real-time quaking-induced conversion (RT-QuIC) for PrPSc. Skin samples from two patients were further examined for prion infectivity by bioassay using two lines of humanized transgenic mice. Western blotting revealed dermal PrPSc in one of five deceased sCJD patients and one of two vCJD patients.

Read more

Yet CRISPR has a dirty secret: there’s really no perfect way to deliver the “molecular scissors” safely into cells. Most methods currently rely on viruses: the DNA that encodes the CRISPR machinery is spliced into a “viral vector” then injected into the troubled tissue.

That’s all well and good for diseases that affect blood and muscle. But for destinations buried deep within the body, delivery becomes a serious issue.

Yin’s workaround wasn’t ideal: he shot two milliliters of solution containing the CRISPR machinery into the mice’s veins using incredibly high pressure. The human equivalent? Your entire blood volume, injected in just five minutes.

Read more

You probably know the quote by Steve Jobs saying that death is life’s single best invention because it gets rid of the old and makes room for the new. This view is the core of another fairly common objection to rejuvenation, codename “cultural stagnation”.

Wouldn’t all those rejuvenated people, however physically young, be always old people “inside”, and drag everyone down with them into their anachronistic, surpassed ways of thinking, making it harder for fresh ideas to take hold, ultimately hindering social progress and our growth as a species? Maybe it’d be best not to take the risk, forget rejuvenation, and be content with old age as it is.

Well, try explaining to your grandfather that the reason he has to put up with heart disease is that we’re afraid people his age may all become troublemakers when you let them live too long.

Read more

Dr. Calos’s work has inspired us for over a decade: she has pioneered a radically novel approach to gene therapy that has the potential to overcome all the key obstacles that have held that field back for so long. We are delighted to welcome her to Berlin to discuss the latest advances in this technology.

https://www.undoing-aging.org/news/dr-michele-calos-to-speak-at-undoing-aging-2018

Read more

“How healthy are clones? What about clones of clones?”

This seems like a pretty silly way to go about testing this. I’d clone like 1,000 to 10,000 mice and track them down generations to see if there was anything abnormal. Then, 1,000 cloned rats. And, finally clone 100 monkeys.

In the 1996 film Multiplicity, Michael Keaton plays an overworked construction worker who gets cloned so that he can spend more time with his family. Eventually his clone gets cloned, but this clone is defective, with a low IQ and weird personality. As might be expected, the movie was a total flop at the box office*.

Silly as it was, the movie does raise an interesting question: How healthy are clones? What about clones of clones?

Dolly the sheep, the world’s first cloned animal, died young at the age of six. This, along with other data, suggested that cloned animals may not be entirely healthy, specifically that they may have shorter lifespans. However, a follow-up study that examined 13 cloned sheep concluded that cloning had “no obvious detrimental long-term health effects.”

Read more