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Category: bioprinting

Researchers from China continue in the quest to improve methods for bone regeneration, publishing their findings in “Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization.”

A wide range of projects have emerged regarding new techniques for bone regeneration—especially in the last five years as 3D printing has become more entrenched in the mainstream and bioprinting has continued to evolve. Bone regeneration is consistently challenging, and while bioprinting is still relatively new as a field, much impressive progress has been made due to experimentation with new materials, nanotubes, and innovative structures.

Cell viability is usually the biggest problem. Tissue engineering, while becoming much more successful these days, is still an extremely delicate process as cells must not only be grown but sustained in the lab too. For this reason, scientists are always working to improve structures like scaffolds, as they are responsible in most cases for supporting the cells being printed. In this study, the authors emphasize the need for both “excellent osteogenesis and vascularization” in bone regeneration.

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In just two years a robotic device that prints a patient’s own skin cells directly onto a burn or wound could have its first-in-human clinical trials. The 3D bioprinting system for intraoperative skin regeneration developed by Australian biotech start-up Inventia Life Science has gained new momentum thanks to major investments from the Australian government and two powerful new partners, world-renowned burns expert Fiona Wood and leading bioprinting researcher Gordon Wallace.

Codenamed Ligō from the Latin “to bind”, the system is expected to revolutionize wound repairs by delivering multiple cell types and biomaterials rapidly and precisely, creating a new layer of skin where it has been damaged. The novel system is slated to replace current wound healing methods that simply attempt to repair the skin, and is being developed by Inventia Skin, a subsidiary of Inventia Life Science.

“When we started Inventia Life Science, our vision was to create a technology platform with the potential to bring enormous benefit to human health. We are pleased to see how fast that vision is progressing alongside our fantastic collaborators. This Federal Government support will definitely help us accelerate even faster,” said Dr. Julio Ribeiro, CEO, and co-founder of Inventia.

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Bioprinting could be used for testing potential treatments for Covid-19, cancer and other diseases.

Bioprinting’s importance for pharmaceutical analysis is paramount now, not only for potential Covid-19 treatments, but also for testing treatments for cancer and other diseases. Dr. Atala says that the organoids allow researchers to analyze a drug’s impact on an organ “without the noise” of an individual’s metabolism.

He cited Rezulin, a popular diabetes drug recalled in 2000 after there was evidence of liver failure. His lab tested an archived version of the drug, and Dr. Atala said that within two weeks, the liver toxicity became apparent. What accounts for the difference? An organoid replicates an organ in its purest form and offers data points that might not occur in clinical trials, he said, adding that the testing is additive to, rather than in lieu of, clinical trials.

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It’s happening…

MOSCOW — KFC has partnered with a Russian bioprinting company to bring 3D printed chicken nuggets to the table.

Coined as the “meat of the future,” the lab-created chicken meat is KFC’s response to the growing interest of healthy lifestyles, the rise in demand for meat alternatives and the increasing need to develop more environmentally friendly methods of food production.

It is also KFC’s next step in creating a “restaurant of the future.”

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“The partners are working together to develop the world’s first laboratory-produced chicken nuggets. The 3D printed nuggets are expected to be similar in taste and appearance to KFC’s original product, but will have the benefit of being more environmentally friendly to produce.”

When I think of KFC and its largely unchanging menu of fried chicken, I do not immediately think of innovation. However a new collaboration forged between the fast-food company and Russia-based bioprinting firm 3D Bioprinting Solutions might just change my mind. The partners are working together to develop the world’s first laboratory-produced chicken nuggets. The 3D printed nuggets are expected to be similar in taste and appearance to KFC’s original product, but will have the benefit of being more environmentally friendly to produce.

The bioprinted chicken nugget project is already underway, and the unlikely partners plan to have a final product ready for testing by this fall. The effort is part of KFC’s mission to create a “restaurant of the future” which leverages state-of-the-art technologies like 3D bioprinting to overcome solutions in the food industry today: such as finding more eco-friendly alternatives to traditional meat.

“At KFC, we are closely monitoring all of the latest trends and innovations and doing our best to keep up with the times by introducing advanced technologies to our restaurant networks,” said Raisa Polyakova, General Manager of KFC Russia & CIS. “Crafted meat products are the next step in the development of our “restaurant of the future” concept. Our experiment in testing 3D bioprinting technology to create chicken products can also help address several looming global problems. We are glad to contribute to its development and are working to make it available to thousands of people in Russia and, if possible, around the world.”

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Their new approach to 3D bioprinting and allows for non-invasive tissue growth and wound healing. It works through injecting bioink cells, the additive material traditionally used in 3D bioprinting, under the skin and using near-infrared light to penetrate the tissue and transfer customizable building designs — like an ear or an abstract shape — to newly injected cells.

The ear began to form in just 20 seconds.

Using a new approach to 3D bioprinting researchers have designed a way to non-invasively grow a wide range of customizable tissue under living skin.

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https://www.youtube.com/watch?v=uV4GjW6O6_0&t=1s

A burn that is over 25% of the human body area can be life threatening. However a burn that is only 1 percent but on a visible area of the body can be life-worsening. That is why advancements in the area of wound care and burns treatment are so important from patient perspective. Being a doctor of the future will include having a point-of-care device such as a 3D-Bioprinter that will scan the lesions in dept and width and print a gel imbued with cells and prolo-factors.

Forgive me my conservatism… we already have such clinics that are on the clinical trials for such treatments.

Read more in the article. Stay tuned for more topics through the Academy blog. Gain more knowledge in Regenerative Medicine and practical experience with biologics through the Annual Congress — Global Regenerative Congress 18–20 September 2020 in Dubai. Registrations are open: www.grc2020dubai.com

Researchers from the University of Toronto (ON, Canada) have reported success in trials of a handheld bioprinter for treating serious burns and wounds.

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3D bio-printed Lung tissue.

Rice University researcher’s bioprinting method could be scaled up to one day construct an entire organ and allow organs to be made using some of a patient’s own cells to prevent organ rejection. Researcher’s long term goals are to bioprint fully functioning organs. Synthetic organs can extend the waiting period of an average 3.6 years for a real organ.

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