Lifeboat Foundation: Safeguarding Humanity
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Category: biological

In this nearly 4-hour SPECIAL EPISODE, Rob Reid delivers a 100-minute monologue (broken up into 4 segments, and interleaved with discussions with Sam) about the looming danger of a man-made pandemic, caused by an artificially-modified pathogen. The risk of this occurring is far higher and nearer-term than almost anyone realizes.

Rob explains the science and motivations that could produce such a catastrophe and explores the steps that society must start taking today to prevent it. These measures are concrete, affordable, and scientifically fascinating—and almost all of them are applicable to future, natural pandemics as well. So if we take most of them, the odds of a future Covid-like outbreak would plummet—a priceless collateral benefit.

Rob Reid is a podcaster, author, and tech investor, and was a long-time tech entrepreneur. His After On podcast features conversations with world-class thinkers, founders, and scientists on topics including synthetic biology, super-AI risk, Fermi’s paradox, robotics, archaeology, and lone-wolf terrorism. Science fiction novels that Rob has written for Random House include The New York Times bestseller Year Zero, and the AI thriller After On. As an investor, Rob is Managing Director at Resilience Reserve, a multi-phase venture capital fund. He co-founded Resilience with Chris Anderson, who runs the TED Conference and has a long track record as both an entrepreneur and an investor. In his own entrepreneurial career, Rob founded and ran Listen.com, the company that created the Rhapsody music service. Earlier, Rob studied Arabic and geopolitics at both undergraduate and graduate levels at Stanford, and was a Fulbright Fellow in Cairo. You can find him at www.after-on.

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Phosphorus, the element critical for life´s origin and life on Earth, may be even Venus.

Scientists studying the origin of life in the universe often focus on a few critical elements, particularly carbon, hydrogen, and oxygen. But two new papers highlight the importance of phosphorus for biology: an assessment of where things stand with a recent claim about possible life in the clouds of Venus, and a look at how reduced phosphorus compounds produced by lightning might have been critical for life early in our own planet’s history.

First a little biochemistry: Phosphine is a reduced phosphorus compound with one phosphorus atom and three hydrogen atoms. Phosphorus is also found in its reduced form in the phosphide mineral schreibersite, in which the phosphorus atom binds to three metal atoms (either iron or nickel). In its reduced form, phosphorus is much more reactive and useful for life than is phosphate, where the phosphorus atom binds to four oxygen atoms. Phosphorus is also the element that is most enriched in biological molecules as compared to non-biological molecules, so it’s not a bad place to start when you’re hunting for life.

In the second of the new papers, Benjamin Hess from Yale University and colleagues highlight the contribution of lightning as a source of reduced phosphorus compounds such as schreibersite. It has long been recognized that meteorites supplied much of the reduced phosphorus needed for the origin of life on Earth. But Hess thinks the contribution of lightning has been underestimated. For one thing, lightning was much more common early in our planet’s history. The authors calculate that it could have produced up to 10000 kilograms of reduced phosphorus compounds per year—which may have been enough to jump-start life, especially because we don’t know how much of the reduced phosphorus from meteorites actually survives (in that form) the impact on Earth.

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There are several key technologies converging on an inevitable effect, namely a dramatic, explosive increase in human population. Currently around 40% of Earth’s total land area is dedicated to agricultural production to feed seven billion people, but, interestingly, while the human population will increase, the land area required to sustain this population will decrease, approaching zero land area to sustain a trillion human lives. In this era, bulk elements such as gold will have no value, since they will be so easy to produce by fusion separation of elements from bulk rock. Instead, value will be attached to biological material and, most importantly, new technologies themselves.

The several key emerging technologies that make this state of affairs unstoppable are listed along with aspects of their impact:

1) Most important is fusion energy, an unlimited, scalable energy, with no special fuel required to sustain it. This will allow nearly all agriculture to be contained in underground “vertical farm” buildings, extending thousands of feet downwards. Cheap artificially-lighted, climate-controlled environments will allow the maximum efficiency for all food crops. Thus, agriculture will take up close to zero surface area, largely produced underground on Earth or the Moon.

2) Crispr-gene edited foods, allowing the transformation of thousands of currently inedible plants into new types of fruits, vegetables and cereals, while also allowing diversity of currently-existing ones. Everything people eat has been genetically modified by thousands of years of human cultivation; that modification will take place over several years instead of thousands.

3) Acellular agriculture, where yeasts are bioengineered to produce milk and other proteins without any live mammals. Products using this method began to enter the market in 2020.

4) Cell-base meat, the production of animal meat in bioreactors, without the need for killing of animals. This will also broaden the choices of widely-available meats from a few bulk types, such as beef, pork and chicken, to thousands of choices.

5) Micro-organism farming, as with the “Solar Foods” company’s use of micro-organisms to produce limitless quantities of protein, fats and carbohydrates in bioreactors.

6) Increasing life-span, which continues to steadily grow for all of human history. New developments in the science of aging will likely boost the average human lifespan significantly. At some point, this will dramatically increase.

Under these circumstances, it will be economically necessary to preserve global biodiversity, since such diversity will become the bedrock of all biological development–one source of value in this era. Thus, it will become necessary to maintain a large proportion of Earth’s surface in an untamed state, while supplementing that with countless contained ecosystems throughout the solar system. The inhabited, urban areas will intermesh with vast interconnected zones where “the deer and antelope roam free.” Humanity will need those deer and antelope in their original state, as they will be the basis for bioengineering new forms of cell-based deer and antelope meat. Similarly, all forms of wild plants will be required as the control stock, for a parallel bioengineered agricultural system.

IMAGE: Earth and Terraformed Mars:

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The Syntellect Emergence seems to be a cosmic necessity, and in the long run, any voices calling to resist the cybernetic fusion of the mind will be no more influential than the voices calling, right now, to eradicate civilization and return to the jungle. Nature’s tendency to build up hierarchies of emergent patterns, the heuristic law of evolution, supersedes the human race itself. We see it time and again, Nature is constantly trying to combine seemingly opposing forces, to assemble existing parts into the new wholes through the universal process of radical emergence. We are bound to transcend our biology, our human condition, our limited dimensionality, we are bound to transcend ourselves.

#TranscendentalCybernetics #CyberneticSingularity #SyntellectEmergence

Syntellect Emergence is hypothesized to be the next meta-system transition, becoming one Global Mind — that constitutes the Cybernetic Singularity.

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It is an old-standing theory in evolutionary ecology: animal species on islands have the tendency to become either giants or dwarfs in comparison to mainland relatives. Since its formulation in the 1960s, however, the ‘island rule’ has been severely debated by scientists. In a new publication in Nature Ecology and Evolution on April 15, 2021, researchers solved this debate by analyzing thousands of vertebrate species. They show that the island rule effects are widespread in mammals, birds, and reptiles, but less evident in amphibians.

Dwarf hippos and elephants in the Mediterranean islands are examples of large species that exhibited dwarfism. On the other hand, small mainland species may have evolved into giants after colonizing islands, giving rise to such oddities as the St Kilda field mouse (twice the size of its mainland ancestor), the infamous dodo of Mauritius (a giant pigeon), and the Komodo dragon.

In 1973, Leigh van Valen was the first that formulated the theory, based on the study by mammologist J. Bristol Foster in 1964, that animal species follow an evolutionary pattern when it comes to their body sizes. Species on islands have the tendency to become either giants or dwarfs in comparison to mainland relatives. “Species are limited to the environment on an island. The level of threat from predatory animals is much lower or non-existent,” says Ana Benítez-Lopez, who carried out the research at Radboud University, now researcher at Doñana Biological Station (EBD-CSIC, Spain). “But also limited resources are available.” However, until now, many studies showed conflicting results which led to severe debate about this theory: is it really a pattern, or just an evolutionary coincidence?

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Topological insulators have notable manifestations of electronic properties. The helicity-dependent photocurrents in such devices are underpinned by spin momentum-locking of surface Dirac electrons that are weak and easily overshadowed by bulk contributions. In a new report now published on Science Advances, X. Sun and a research team in photonic technologies, physics and photonic metamaterials in Singapore and the U.K. showed how the chiral response of materials could be enhanced via nanostructuring. The tight confinement of electromagnetic fields in the resonant nanostructures enhanced the photoexcitation of spin-polarized surface states of a topological insulator to allow an 11-fold increase of the circular photogalvanic effect and a previously unobserved photocurrent dichroism at room temperature. Using this method, Sun et al. controlled the spin transport in topological materials via structural design, a hitherto unrecognized ability of metamaterials. The work bridges the gap between nanophotonics and spin electronics to provide opportunities to develop polarization-sensitive photodetectors.

Chirality

Chirality is a ubiquitous and fascinating natural phenomenon in nature, describing the difference of an object from its mirror image. The process manifests in a variety of scales and forms from galaxies to nanotubes and from organic molecules to inorganic compounds. Chirality can be detected at the atomic and molecular level in fundamental sciences, including chemistry, biology and crystallography, as well as in practice, such as in the food and pharmaceutical industry. To detect chirality, scientists can use interactions with electromagnetic fields, although the process can be hindered by a large mismatch between the wavelength of light and the size of most molecules at nanoscale dimensions. Designer metamaterials with structural features comparable to the wavelength of light can provide an independent approach to devise optical properties on demand to enhance the light-matter interaction to create and enhance the optical chirality of metamaterials. In this work, Sun et al.

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As the Tufts scientists were creating the physical xenobot organisms, researchers working in parallel at the University of Vermont used a supercomputer to run simulations to try and find ways of assembling these living robots in order to perform useful tasks.

Scientists at Tufts University have created a strange new hybrid biological/mechanical organism that’s made of living cells, but operates like a robot.

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Wildlife Care And Combating Emerging Zoonotic Diseases — Dr. Suzan Murray, D.V.M., D.A.C.Z.M. Smithsonian’s National Zoo and Conservation Biology Institute, Program Director, Global Health Program.

Dr. Suzan Murray, D.V.M., D.A.C.Z.M. is a board-certified zoo veterinarian at the Smithsonian Conservation Biology Institute (SCBI) and serves as both the Program Director of the Global Health Program and as SCBI’s chief wildlife veterinary medical officer.

Dr. Murray leads an interdisciplinary team engaged in worldwide efforts to address health issues in endangered wildlife and combat emerging infectious diseases of global significance, including zoonotic diseases.

Dr. Murray also acts as the Smithsonian liaison to the Foreign Animal Disease Threat and Pandemic Preparedness subcommittees of the White House’s Office of Science and Technology.

Dr. Murray’s work focuses on providing clinical care to free-ranging wildlife, pathogen detection, advanced diagnostics, training of international veterinarians and other health professionals, capacity building, and collaboration in infectious disease research at the human-wildlife-domestic animal interface. She previously served as chief veterinarian for the Smithsonian’s National Zoo and has a wealth of clinical knowledge and experience with wildlife and zoo animals both free-ranging and in human care.

Dr. Murray earned a bachelor’s degree from Amherst College, completed her veterinary degree from Tufts University, and after a surgical internship, she completed a residency in zoological medicine at the Smithsonian’s National Zoo and became a Diplomate of the American College of Zoological Medicine (DACZM) in 2000.

Dr. Murray has been either the principle investigator or co-principle investigator on several research grants including Morris Animal Foundation, Smithsonian Endowment, Smithsonian Women’s Committee, and James Bond Funds.

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