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A keen sense of smell is a powerful ability shared by many organisms. However, it has proven difficult to replicate by artificial means. Researchers combined biological and engineered elements to create what is known as a biohybrid component. Their volatile organic compound sensor can effectively detect odors in gaseous form. They hope to refine the concept for use in medical diagnosis and the detection of hazardous materials.

Electronic devices such as cameras, microphones and pressure sensors enable machines to sense and quantify their environments optically, acoustically and physically. Our sense of smell however, despite being one of nature’s most primal senses, has proven very difficult to replicate artificially. Evolution has refined this sense over millions of years and researchers are working hard to catch up.

“Odors, airborne chemical signatures, can carry useful information about environments or samples under investigation. However, this information is not harnessed well due to a lack of sensors with sufficient sensitivity and selectivity,” said Professor Shoji Takeuchi from the Biohybrid Systems Laboratory at the University of Tokyo. “On the other hand, biological organisms use information extremely efficiently. So we decided to combine existing biological sensors directly with artificial systems to create highly sensitive volatile organic compound (VOC) sensors. We call these biohybrid sensors.”

Dr. Halima Benbouza is an Algerian scientist in the field of agronomic sciences and biological engineering.

She received her doctorate in 2004 from the University Agro BioTech Gembloux, Belgium studying Plant Breeding and Genetics and was offered a postdoctoral position to work on a collaborative project with the Agricultural Research Service, United States Department of Agriculture in Stoneville, Mississippi.

Subsequently, Dr. Benbouza was funded by Dow Agro Science to study Fusarium wilt resistance in cotton. In 2009 she was awarded the Special Prize Eric Daugimont et Dominique Van der Rest by the University Agro BioTech Gembloux, Belgium.

Dr. Benbouza is Professor at Batna 1 University where she teaches graduate and postgraduate students in the Institute of Veterinary Medicine and Agronomy. She also supervises Master’s and PhD students.

From 2010–2016, Dr. Benbouza served as inaugural Director of the Biotechnology Research Center (CRBt) in Constantine, appointed by the Ministry of Higher Education and Scientific Research. In 2011, she was appointed by the Algerian government as President of the Intersectoral Commission of Health and Life Sciences. Dr. Benbouza is a member of the Algerian National Council for Research Evaluation and a past member of the Sectorial Permanent Board of the Ministry of Higher Education and Scientific Research.

In 2013, Dr. Benbouza was appointed by the Prime Minister as President of the steering committee of Algeria’s Biotech Pharma project. In 2014 she was honored by the US Embassy in Algiers as one of the “Women in Science Hall of Fame” for her research achievements and her outstanding contribution to promote research activities and advance science in her country.

Annotated!


Aubrey David Nicholas Jasper de Grey is an English author and biomedical gerontologist. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics.
Feel free to ask any related questions that you want Aubrey to try and answer!

Futurist Foundation is a non-profit organization with the goal to connect futurists and promote crowd-sourced projects in science, technology, engineering, mathematics & design.

Donate to Futurist Foundation — https://opencollective.com/future.
Donate to SENS — https://www.sens.org/get-involved/donate/
Discord: https://discord.gg/u3JM2cu.
Website: http://thefuturistfoundation.com.
Our Other Links: https://linktr.ee/futuristfoundation.

0:00 Introduction.
2:30 Aubreys last 25 years & Starting at SENS
14:35 SENS in 2020
21:27 Will there be a cut off age when its too late to repair aging?
24:36 Elasticity & Glycation.
30:13 As a medical student how can I get involved in longevity research?
33:07 SENS projects Underdog & Oisin.
38:51 mRNA Gene Therapy.
42:10 Effect of Aging on the Neural System.
49:41 Aubreys thoughts on Hyberbaric Oxygen Therapy.
51:21 SENS experience with regulators.
53:42 How do we make life extension treatments affordable?
58:28 Longevity Escape Velocity & Aubreys Timeline.
1:02:57 Is cryonics the backup plan?
1:08:28 Donate to SENS & Futurist Foundation.

In Michelle O’Malley’s lab, a simple approach suggests a big leap forward in addressing the challenge of antibiotic-resistant bacteria.

Scientists have long been aware of the dangerous overuse of antibiotics and the increasing number of antibiotic-resistant microbes that have resulted. While over-prescription of antibiotics for medicinal use has unsettling implications for human health, so too does the increasing presence of antibiotics in the natural environment. The latter may stem from the improper disposal of medicines, but also from the biotechnology field, which has depended on antibiotics as a selection device in the lab.

“In biotech, we have for a long time relied on antibiotic and chemical selections to kill cells that we don’t want to grow,” said UC Santa Barbara chemical engineer Michelle O’Malley. “If we have a genetically engineered cell and want to get only that cell to grow among a population of cells, we give it an antibiotic resistance gene. The introduction of an antibiotic will kill all the cells that are not genetically engineered and allow only the ones we want — the genetically modified organisms [GMOs] — to survive. However, many organisms have evolved the means to get around our antibiotics, and they are a growing problem in both the biotech world and in the natural environment. The issue of antibiotic resistance is a grand challenge of our time, one that is only growing in its importance.”

The idea of slowing down the ageing process and living healthier, more productive lives is hugely appealing. It’s led to a growing trend for people looking to take control of their own biology, optimising their bodies and minds through ‘biohacking’. But how safe and ethical is this pursuit of longevity? And are there more natural ways of expanding your healthy lifespan? Video by Dan John Animation by Adam Proctor.

Biochemists use protein engineering to transfer photocaging groups to DNA.

DNA (deoxyribonucleic acid) is the basis of life on earth. The function of DNA is to store all the genetic information, which an organism needs to develop, function and reproduce. It is essentially a biological instruction manual found in every cell.

Biochemists at the University of Münster have now developed a strategy for controlling the biological functions of DNA with the aid of light. This enables researchers to better understand and control the different processes which take place in the cell – for example epigenetics, the key chemical change and regulatory lever in DNA.

#JustAReminder why knowing the origin of this disease is so important. Shi Zhengli who ran the lab in Wuhan worked with Ralph Baric on this gain of function research.

Declan Butler.

12 November 2015

An experiment that created a hybrid version of a bat coronavirus — one related to the virus that causes SARS (severe acute respiratory syndrome) — has triggered renewed debate over whether engineering lab variants of viruses with possible pandemic potential is worth the risks.

In an article published in Nature Medicine 1 on 9 November, scientists investigated a virus called SHC014, which is found in horseshoe bats in China. The researchers created a chimaeric virus, made up of a surface protein of SHC014 and the backbone of a SARS virus that had been adapted to grow in mice and to mimic human disease. The chimaera infected human airway cells — proving that the surface protein of SHC014 has the necessary structure to bind to a key receptor on the cells and to infect them. It also caused disease in mice, but did not kill them.

The findings reinforce suspicions that bat coronaviruses capable of directly infecting humans (rather than first needing to evolve in an intermediate animal host) may be more common than previously thought, the researchers say.

But other virologists question whether the information gleaned from the experiment justifies the potential risk. Although the extent of any risk is difficult to assess, Simon Wain-Hobson, a virologist at the Pasteur Institute in Paris, points out that the researchers have created a novel virus that “grows remarkably well” in human cells. “If the virus escaped, nobody could predict the trajectory,” he says.


Lab-made coronavirus related to SARS can infect human cells.