Muscle constitutes the largest organ in humans, accounting for 40% of body mass, and it plays an essential role in maintaining life. Muscle tissue is notable for its unique ability for spontaneous regeneration. However, in serious injuries such as those sustained in car accidents or tumor resection which results in a volumetric muscle loss (VML), the muscle’s ability to recover is greatly diminished. Currently, VML treatments comprise surgical interventions with autologous muscle flaps or grafts accompanied by physical therapy. However, surgical procedures often lead to reduced muscular function, and in some cases result in a complete graft failure. Thus, there is a demand for additional therapeutic options to improve muscle loss recovery.
A promising strategy to improve the functional capacity of the damaged muscle is to induce de novo regeneration of skeletal muscle via the integration of transplanted cells. Diverse types of cells, including satellite cells (muscle stem cells), myoblasts, and mesenchymal stem cells, have been used to treat muscle loss. However, invasive muscle biopsies, poor cell availability, and limited long-term maintenance impede clinical translation, where millions to billions of mature cells may be needed to provide therapeutic benefits.
Bonny Lemma. Originally published in the HIR Winter 2019 Issue.
Jennifer Lopez has one more industry to add to her illustrious résumé: molecular biology. In 2016, she was asked to be the executive producer of a new futuristic bio-crime drama for NBC called C.R.I.S.P.R. While that project is a work of science fiction, the CRISPR technology that it is based on is very real.
CRISPR, or Clustered Regularly Interspaced Short Palindromic Repeats, is not just a gene editing technique, but also a phenomenon that carries significant implications for the future of biotechnology. Therefore, the interactions between the countless players in this field and the objectives driving them are crucial to understanding of CRISPR and the promise it holds.
Chair emeritus, SETI institute — the search for extraterrestrial intelligence.
Dr. Jill Tarter is Chair Emeritus for SETI (Search for Extraterrestrial Intelligence) Research at the SETI Institute, a not-for-profit research organization whose mission is to explore, understand, and explain the origin and nature of life in the universe, and to apply the knowledge gained to inspire and guide present and future generations.
Dr. Tarter received her Bachelor of Engineering Physics Degree with Distinction from Cornell University and her Master’s Degree and a Ph.D. in Astronomy from the University of California, Berkeley. She served as Project Scientist for NASA’s SETI program, the High Resolution Microwave Survey, and has conducted numerous observational programs at radio observatories worldwide. Since the termination of funding for NASA’s SETI program in 1993, she has served in a leadership role to secure private funding to continue the exploratory science. Currently, she serves on the management board for the Allen Telescope Array, an innovative array of 350 (when fully realized) 6-m antennas at the Hat Creek Radio Observatory, it will simultaneously survey the radio universe for known and unexpected sources of astrophysical emissions, and speed up the search for radio emissions from other distant technologies by orders of magnitude.
Dr. Tarter’s work has brought her wide recognition in the scientific community, including the Lifetime Achievement Award from Women in Aerospace, two Public Service Medals from NASA, Chabot Observatory’s Person of the Year award (1997), Women of Achievement Award in the Science and Technology category by the Women’s Fund and the San Jose Mercury News (1998), and the Tesla Award of Technology at the Telluride Tech Festival (2001). She was elected an AAAS Fellow in 2002 and a California Academy of Sciences Fellow in 2003. In 2004 Time Magazine named her one of the Time 100 most influential people in the world, and in 2005 Dr. Tarter was awarded the Carl Sagan Prize for Science Popularization at Wonderfest, the biannual San Francisco Bay Area Festival of Science.
Dr. Tarter is deeply involved in the education of future citizens and scientists. In addition to her scientific leadership at NASA and SETI Institute, Dr. Tarter was the Principal Investigator for two curriculum development projects funded by NSF, NASA, and others. The first, the Life in the Universe series, created 6 science teaching guides for grades 3–9 (published 1994–96). Her second project, Voyages Through Time, is an integrated high school science curriculum on the fundamental theme of evolution in six modules: Cosmic Evolution, Planetary Evolution, Origin of Life, Evolution of Life, Hominid Evolution and Evolution of Technology (published 2003).
Dr. Tarter is a frequent speaker for science teacher meetings and at museums and science centers, bringing her commitment to science and education to both teachers and the public.
Many people are now familiar with her work as portrayed by Jodie Foster in the movie Contact. She is also the subject of the book, Making Contact: Jill Tarter and the Search for Extraterrestrial Intelligence.
Is a postdoctoral scholar at Tufts University, where she conducts research in their Human Robot Interaction Lab (https://hrilab.tufts.edu/).
With a background in psychology and the social sciences, Dr. Chita-Tegmark is interested in topics at the intersection of technology and psychology, such as using artificial social agents in healthcare and the impact of such emerging technologies on human social interactions and well-being.
Dr. Chita-Tegmark has her Ph.D from Boston University in Psychology and Developmental Sciences, and she is an alumna of the Harvard Graduate School of Education, where she spent time studying role of social information in children’s lives, how social information influences the way children cooperate and engage in strategic decision-making, as well as on projects related to the development of social attention and language skills in children with Autism Spectrum Disorder (ASD).
Dr. Chita-Tegmark is also a Co-Founder of the Future of Life Institute (https://futureoflife.org/), a non-profit research institute and outreach organization that works to mitigate existential risks facing humanity, including those from advanced artificial intelligence (AI), to bio-engineering, to autonomous weapons, and to help promote positive uses of technology.
Richard Feynman, one of the most respected physicists of the twentieth century, said “What I cannot create, I do not understand.” Not surprisingly, many physicists and mathematicians have observed fundamental biological processes with the aim of precisely identifying the minimum ingredients that could generate them. One such example are the patterns of nature observed by Alan Turing. The brilliant English mathematician demonstrated in 1952 that it was possible to explain how a completely homogeneous tissue could be used to create a complex embryo, and he did so using one of the simplest, most elegant mathematical models ever written. One of the results of such models is that the symmetry shown by a cell or a tissue can break under a set of conditions.
An anthropologist dives into the world of genetic engineering to explore whether gene-editing tools such as CRISPR fulfill the hope of redesigning our species for the better.
The Mutant Project: Inside the Global Race to Genetically Modify Humans by Eben Kirksey. St. Martin’s Press, November 2020. Excerpt previously published by Black Inc.
Surreal artwork in the hotel lobby—a gorilla peeking out of a peeled orange, smoking a cigarette; an astronaut riding a cyborg giraffe—was the backdrop for bombshell news rocking the world. In November 2018, Hong Kong’s Le Méridien Cyberport hotel became the epicenter of controversy about Jiankui He, a Chinese researcher who was staying there when a journalist revealed he had created the world’s first “edited” babies. Select experts were gathering in the hotel for the Second International Summit on Human Genome Editing—a meeting that had been called to deliberate about the future of the human species.
Self-assembly is ubiquitous in the natural world, serving as a route to form organized structures in every living organism. This phenomenon can be seen, for instance, when two strands of DNA—without any external prodding or guidance—join to form a double helix, or when large numbers of molecules combine to create membranes or other vital cellular structures. Everything goes to its rightful place without an unseen builder having to put all the pieces together, one at a time.
For the past couple of decades, scientists and engineers have been following nature’s lead, designing molecules that assemble themselves in water, with the goal of making nanostructures, primarily for biomedical applications such as drug delivery or tissue engineering. “These small-molecule-based materials tend to degrade rather quickly,” explains Julia Ortony, assistant professor in MIT’s Department of Materials Science and Engineering (DMSE), “and they’re chemically unstable, too. The whole structure falls apart when you remove the water, particularly when any kind of external force is applied.”
She and her team, however, have designed a new class of small molecules that spontaneously assemble into nanoribbons with unprecedented strength, retaining their structure outside of water. The results of this multi-year effort, which could inspire a broad range of applications, were described on Jan. 21 in Nature Nanotechnology by Ortony and coauthors.
Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own.
There are two major hurdles to overcome on the road to laboratory-grown organs and tissues. The first is to use a biologically compatible 3D scaffold in which cells can grow. The second is to decorate that scaffold with biochemical messages in the correct configuration to trigger the formation of the desired organ or tissue.
In a major step toward transforming this hope into reality, researchers at the University of Washington have developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages that affect cell behavior. Their approach, published the week of Jan. 18 in the Proceedings of the National Academy of Sciences, uses a near-infrared laser to trigger chemical adhesion of protein messages to a scaffold made from biological polymers such as collagen, a connective tissue found throughout our bodies.
A team of researchers at Columbia University has developed a way to allow DNA strands to store more data. In their study, published in the journal Science, the group applied a small amount of electricity to DNA strands to allow for encoding more information than was possible with other methods.
For several years, researchers have been looking for ways to increase data storage capacity—storage requirements are expected to exceed capacity in the near future as demand skyrockets. One such approach has involved encoding data into strands of DNA—prior research has shown that it is possible. In the early stages of such research, scientists manually edited strands to add characteristics to represent zeroes or ones. More recently, researchers have used the CRISPR gene editing tool. Most such studies used DNA extracted from the tissue of deceased animals. More recently, researchers have begun efforts to move the research to living animals because it will last longer. And not just in the edited strands—the information they contain could conceivably be passed on to offspring, allowing data to be stored for very long periods of time.
Back in 2017, another team at Columbia University used CRISPR to detect a certain signal—in their case, it was the presence of sugar molecules. Adding such molecules resulted in gene expressions of plasmid DNA. Over time, the editing process was improved as genetic bits were added to represent ones and zeroes. Unfortunately, the system only allowed for storing a few bits of data.
