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Category: bioengineering

Unlocking The Potential Of Salt and Drought Tolerant Crops And Seawater Agriculture — Professor Dr. Mark Tester — Center for Desert Agriculture, King Abdullah University of Science and Technology; Co-founder & CSO, Red Sea Farms.

Professor Dr. Mark Tester is Professor, Plant Science, and Associate Director, Center for Desert Agriculture, Biological and Environmental Science and Engineering Division, of King Abdullah University of Science and Technology (KAUST) in Saudi Arabia.

Prior to joining King Abdullah University of Science and Technology in February 2013, Professor Tester was a professor of plant physiology at the University of Adelaide and the Australian Centre for Plant Functional Genomics from 2009 to 2013. He has a PhD from the University of Cambridge in plant sciences.

The aim of Professor Tester’s research program is to elucidate the molecular genetic mechanisms that enable certain plants to thrive in sub-optimal conditions, such as those of high salinity or high temperature, and then deliver the outputs in economically viable systems, such as barley, rice, tomatoes and quinoa.

An immediate applied aim of the program is to modify crop plants in order to increase productivity in conditions of challenging abiotic stress, with consequent improvement of yield in Saudi Arabia, the region and globally.

A larger aspiration is to unlock seawater, by developing a new economically viable agricultural system where salt-tolerant crops are irrigated with partially desalinized seawater or brackish groundwater.

A company, Red Sea Farms, has been established to facilitate this scientific translation, of which Dr. Tester is Co-founder and CSO.

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Getting closer.

Drugs and vaccines circulate through the vascular system reacting according to their chemical and structural nature. In some cases, they are intended to diffuse. In other cases, like cancer treatments, the intended target is highly localized. The effectiveness of a medicine —and how much is needed and the side effects it causes —are a function of how well it can reach its target.

“A lot of medicines involve intravenous injections of drug carriers,” said Ying Li, an assistant professor of mechanical engineering at the University of Connecticut. “We want them to be able to circulate and find the right place at the right time and to release the right amount of drugs to safely protect us. If you make mistakes, there can be terrible side effects.”

Li studies nanomedicines and how they can be designed to work more efficiently. Nanomedicine involves the use of nanoscale materials, such as biocompatible nanoparticles and nanorobots, for diagnosis, delivery, sensing or actuation purposes in a living organism. His work harnesses the power of supercomputers to simulate the dynamics of nanodrugs in the , design new forms of nanoparticles, and find ways to control them.

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Harvard’s Wyss Institute has created a new gene-editing tool that enable scientist to perform millions of genetic experiments simultaneously.

Researchers from the Harvard’s Wyss Institute for Biologically Inspired Engineering have created a new gene-editing tool that can enable scientists to perform millions of genetic experiments simultaneously. They’re calling it the Retron Library Recombineering (RLR) technique, and it uses segments of bacterial DNA called retrons that can produce fragments of single-stranded DNA.

When it comes to gene editing, CRISPR-Cas9 is probably the most well-known technique these days. It’s been making waves in the science world in the past few years, giving researchers the tool they need to be able to easily alter DNA sequences. It’s more accurate than previously used techniques, and it has a wide variety of potential applications, including life-saving treatments for various illnesses.

However, the tool has some major limitations. It could be difficult to deliver CRISPR-Cas9 materials in large numbers, which remains a problem for studies and experiments, for one. Also, the way the technique works can be toxic to cells, because the Cas9 enzyme — the molecular “scissors” in charge of cutting strands of DNA — often cuts non-target sites as well.

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While the CRISPR-Cas9 gene editing system has become the poster child for innovation in synthetic biology, it has some major limitations. CRISPR-Cas9 can be programmed to find and cut specific pieces of DNA, but editing the DNA to create desired mutations requires tricking the cell into using a new piece of DNA to repair the break. This bait-and-switch can be complicated to orchestrate, and can even be toxic to cells because Cas9 often cuts unintended, off-target sites as well.

Alternative gene editing techniques called recombineering instead perform this bait-and-switch by introducing an alternate piece of DNA while a cell is replicating its genome, efficiently creating without breaking DNA. These methods are simple enough that they can be used in many cells at once to create complex pools of mutations for researchers to study. Figuring out what the effects of those mutations are, however, requires that each mutant be isolated, sequenced, and characterized: a time-consuming and impractical task.

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School (HMS) have created a new gene editing tool called Retron Library Recombineering (RLR) that makes this task easier. RLR generates up to millions of mutations simultaneously, and “barcodes” mutant cells so that the entire pool can be screened at once, enabling massive amounts of data to be easily generated and analyzed. The achievement, which has been accomplished in , is described in a recent paper in PNAS.

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In this nearly 4-hour SPECIAL EPISODE, Rob Reid delivers a 100-minute monologue (broken up into 4 segments, and interleaved with discussions with Sam) about the looming danger of a man-made pandemic, caused by an artificially-modified pathogen. The risk of this occurring is far higher and nearer-term than almost anyone realizes.

Rob explains the science and motivations that could produce such a catastrophe and explores the steps that society must start taking today to prevent it. These measures are concrete, affordable, and scientifically fascinating—and almost all of them are applicable to future, natural pandemics as well. So if we take most of them, the odds of a future Covid-like outbreak would plummet—a priceless collateral benefit.

Rob Reid is a podcaster, author, and tech investor, and was a long-time tech entrepreneur. His After On podcast features conversations with world-class thinkers, founders, and scientists on topics including synthetic biology, super-AI risk, Fermi’s paradox, robotics, archaeology, and lone-wolf terrorism. Science fiction novels that Rob has written for Random House include The New York Times bestseller Year Zero, and the AI thriller After On. As an investor, Rob is Managing Director at Resilience Reserve, a multi-phase venture capital fund. He co-founded Resilience with Chris Anderson, who runs the TED Conference and has a long track record as both an entrepreneur and an investor. In his own entrepreneurial career, Rob founded and ran Listen.com, the company that created the Rhapsody music service. Earlier, Rob studied Arabic and geopolitics at both undergraduate and graduate levels at Stanford, and was a Fulbright Fellow in Cairo. You can find him at www.after-on.

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There are several key technologies converging on an inevitable effect, namely a dramatic, explosive increase in human population. Currently around 40% of Earth’s total land area is dedicated to agricultural production to feed seven billion people, but, interestingly, while the human population will increase, the land area required to sustain this population will decrease, approaching zero land area to sustain a trillion human lives. In this era, bulk elements such as gold will have no value, since they will be so easy to produce by fusion separation of elements from bulk rock. Instead, value will be attached to biological material and, most importantly, new technologies themselves.

The several key emerging technologies that make this state of affairs unstoppable are listed along with aspects of their impact:

1) Most important is fusion energy, an unlimited, scalable energy, with no special fuel required to sustain it. This will allow nearly all agriculture to be contained in underground “vertical farm” buildings, extending thousands of feet downwards. Cheap artificially-lighted, climate-controlled environments will allow the maximum efficiency for all food crops. Thus, agriculture will take up close to zero surface area, largely produced underground on Earth or the Moon.

2) Crispr-gene edited foods, allowing the transformation of thousands of currently inedible plants into new types of fruits, vegetables and cereals, while also allowing diversity of currently-existing ones. Everything people eat has been genetically modified by thousands of years of human cultivation; that modification will take place over several years instead of thousands.

3) Acellular agriculture, where yeasts are bioengineered to produce milk and other proteins without any live mammals. Products using this method began to enter the market in 2020.

4) Cell-base meat, the production of animal meat in bioreactors, without the need for killing of animals. This will also broaden the choices of widely-available meats from a few bulk types, such as beef, pork and chicken, to thousands of choices.

5) Micro-organism farming, as with the “Solar Foods” company’s use of micro-organisms to produce limitless quantities of protein, fats and carbohydrates in bioreactors.

6) Increasing life-span, which continues to steadily grow for all of human history. New developments in the science of aging will likely boost the average human lifespan significantly. At some point, this will dramatically increase.

Under these circumstances, it will be economically necessary to preserve global biodiversity, since such diversity will become the bedrock of all biological development–one source of value in this era. Thus, it will become necessary to maintain a large proportion of Earth’s surface in an untamed state, while supplementing that with countless contained ecosystems throughout the solar system. The inhabited, urban areas will intermesh with vast interconnected zones where “the deer and antelope roam free.” Humanity will need those deer and antelope in their original state, as they will be the basis for bioengineering new forms of cell-based deer and antelope meat. Similarly, all forms of wild plants will be required as the control stock, for a parallel bioengineered agricultural system.

IMAGE: Earth and Terraformed Mars:

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Circa 2020 o.o

The NASA Perseverance Rover has a device aboard called MOXIE that will convert the air available on Mars into oxygen. The device is a test, and if the technology was used on a larger scale could produce oxygen for humans to breathe on the Red Planet and could be used for rocket fuel. NASA knows that one of the most challenging parts of putting people on Mars will be getting them off the planet and back to Earth.

Two get a crew for off Mars would require 55000 pounds of oxygen to produce thrust from 15000 pounds rocket fuel. Rather than send all of the oxygen needed from Earth to Mars, scientists want to enable the astronauts to create the rocket fuel on Mars. MOXIE is a first-generation oxygen generator meant to test technology that could create the required oxygen.

MOXIE stands for Mars Oxygen In-Situ Resource Utilization Experiment and is an experiment that is entirely separate from the Perseverance’s primary science mission. One of the main missions of Perseverance is to recover rock samples that can be returned to earth that might have signs of ancient microbial life. MOXIE is focused on the engineering required for future human exploration efforts.

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Scientists injected dozens of human stem cells into developing monkey embryos, and the resulting hybrids survived for up to 20 days in lab dishes.

These human-monkey embryos could someday serve as helpful models for human disease, embryonic development and aging, the study authors noted in a new report, published April 15 in the journal Cell. By zooming in on the interaction of human and animal cells in the embryos, scientists could also learn how to help human cells survive amongst animal cells, potentially advancing the effort to grow human organs in living animal models.

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New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.

Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing scientists to make targeted changes to organisms’ DNA. While the system could potentially be useful in treating a variety of diseases, CRISPR-Cas9 editing involves cutting DNA strands, leading to permanent changes to the cell’s genetic material.

Now, in a paper published online in Cell on April 9, researchers describe a new gene editing technology called CRISPRoff that allows researchers to control gene expression with high specificity while leaving the sequence of the DNA unchanged. Designed by Whitehead Institute Member Jonathan Weissman, University of California San Francisco assistant professor Luke Gilbert, Weissman lab postdoc James Nuñez and collaborators, the method is stable enough to be inherited through hundreds of cell divisions, and is also fully reversible.

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