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Tokyo (AFP)

Paralysed from the neck down, the man stares intently at a screen. As he imagines handwriting letters, they appear before him as typed text thanks to a new brain implant.

The 65-year-old is “typing” at a speed similar to his peers tapping on a smartphone, using a device that could one day help paralysed people communicate quickly and easily.

As researchers learn more about the brain, it has become clear that responsive neurostimulation is becoming increasingly effective at probing neural circuit function and treating neuropsychiatric disorders, such as epilepsy and Parkinson’s disease. But current approaches to designing a fully implantable and biocompatible device able to make such interventions have major limitations: their resolution isn’t high enough and most require large, bulky components that make implantation difficult with risk of complications.

A Columbia Engineering team led by Dion Khodagholy, assistant professor of electrical engineering, has come up with a new approach that shows great promise to improve such devices. Building on their earlier work to develop smaller, more efficient conformable bioelectronic transistors and materials, the researchers orchestrated their devices to create implantable circuits that enable allow reading and manipulation of brain circuits. Their multiplex-then-amplify (MTA) system requires only one amplifier per multiplexer, in contrast to that need an equal number of amplifiers as number of channels.

“It is critical to be able to detect and intervene to treat brain-disorder-related symptoms, such as epileptic seizures, in real time,” said Khodagholy, a leader in bio-and neuroelectronics design. “Not only is our system much smaller and more flexible than current devices, but it also enables simultaneous stimulation of arbitrary waveforms on multiple independent channels, so it is much more versatile.

As the digital revolution has now become mainstream, quantum computing and quantum communication are rising in the consciousness of the field. The enhanced measurement technologies enabled by quantum phenomena, and the possibility of scientific progress using new methods, are of particular interest to researchers around the world.

Recently two researchers at Tampere University, Assistant Professor Robert Fickler and Doctoral Researcher Markus Hiekkamäki, demonstrated that two– interference can be controlled in a near-perfect way using the spatial shape of the photon. Their findings were recently published in the prestigious journal Physical Review Letters.

“Our report shows how a complex light-shaping method can be used to make two quanta of light interfere with each other in a novel and easily tuneable way,” explains Markus Hiekkamäki.

Stress management.


Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others. In a few cases, the cause is genetic. In humans, mutations in the OPHN1 gene cause a rare X-linked disease that includes poor stress tolerance. Cold Spring Harbor Laboratory (CSHL) Professor Linda Van Aelst seeks to understand factors that cause specific individuals to respond poorly to stress. She and her lab studied the mouse gene Ophn1, an analog of the human gene, which plays a critical role in developing brain cell connections, memories, and stress tolerance. When Ophn1 was removed in a specific part of the brain, mice expressed depression-like helpless behaviors. The researchers found three ways to reverse this effect.

To test for stress, the researchers put mice into a two-room cage with a door in between. Normal mice escape from the room that gives them a light shock on their feet. But animals lacking Ophn1 sit helplessly in that room without trying to leave. Van Aelst wanted to figure out why.

Her lab developed a way to delete the Ophn1 gene in different brain regions. They found that removing Ophn1 from the prelimbic region of the medial prefrontal cortex (mPFC), an area known to influence behavioral responses and emotion, induced the helpless phenotype. Then the team figured out which brain circuit was disrupted by deleting Ophn1, creating overactivity in the brain region and ultimately the helpless phenotype.

Autistic people tend to switch between images more slowly than non-autistic people do, a previous study shows. And they spend more time seeing a combination of the two images.


Children with genetic conditions linked to autism perform atypically on a test of binocular rivalry, according to a new unpublished study.

Researchers presented the work virtually today at the 2021 International Society for Autism Research annual meetin g. (Links to abstracts may work only for registered conference attendees.)

Binocular rivalry is what happens when a person’s eyes each receive a different input. Most people gradually shift between perceiving one image and then the other as their eyes compete for dominance over the neural circuits involved.

After doubling its sample size, the largest study of genetic data from autistic people has identified 255 genes associated with the condition, an increase of more than 40 genes since the researchers’ 2019 update; 71 of the genes rise above a stringent statistical bar the team had not previously used. The new analysis also adds data from people with developmental delay or schizophrenia and considers multiple types of mutations.

“It’s a really significant step forward in what we do,” said Kyle Satterstrom, a computational biologist in Mark Daly’s lab at the Broad Institute in Cambridge, Massachusetts. Satterstrom presented the findings virtually on Tuesday at the 2021 International Society for Autism Research annual meeting. (Links to abstracts may work only for registered conference attendees.)

The team’s previous analyses used data from the Autism Sequencing Consortium, which enrolls families through their doctors. The researchers mainly scoured the genetic data to find rare, non-inherited mutations linked to autism.

Our physical space-time reality isn’t really “physical” at all, its apparent solidity of objects, as well as any other associated property such as time, is an illusion. As a renowned physicist Niels Bohr once said: “Everything we call real is made of things that cannot be regarded as real.” But what’s not an illusion is your subjective experience, i.e., your consciousness; that’s the only “real” thing, according to proponents of Experiential Realism. It refers to interacting entangled conscious agents at various ontological levels, giving rise to conscious experience all the way down, and I’d argue all the way up, seemingly ad infinitum. It’s a “matryoshka” of embedded realities: conscious minds within larger minds.

#ExperientialRealism


So, why Experiential Realism? From the bigger picture perspective, we are here for experience necessary for evolution of our conscious minds. Our limitations, such as our ego, belief traps, political correctness, our very human condition define who we are, but the realization that we largely impose those limitations on ourselves gives us more evolvability and impetus to overcome these self-imposed limits to move towards higher goals and state of being.

We are what we’ve experienced — the sum of our experiences define who we are. In this sense, as free will agents, we are co-creators within this experiential matrix. Non-duality is the essence of Experiential Realism — experience and experiencer are one. How can you possibly separate your own existence from the world, the observer from the observed? Today, philosophers and scientists argue that information is fundamental but consciousness is required to assign meaning to it. That makes consciousness (our experience in a broader sense) the most fundamental, irreducible ground of existence itself, while some philosophers suggest consciousness is all that is.

Experiential realism refers to interacting entangled conscious agents at various ontological levels, giving rise to conscious experience all the way down, and I’d argue all the way up, seemingly ad infinitum. It is a “matryoshka” of embedded realities: conscious minds within larger minds. Experiential Realism is a non-physicalist, monistic idealism. It is not to be confused with Naïve Realism, the idea that we see the world around us objectively, as it is. We don’t. Just the opposite is true. Experiential Realism is predicated on the centrality of observers and all-encompassing quantum computational principles. The objective world, i.e., the world whose existence does not depend on the perceptions of a particular observer, consists entirely of conscious agents, more precisely their experiences. What exists in the objective world, independent of your perceptions, is a world of conscious agents, not a world of unconscious particles and fields.

I believe that schizophrenia although an illness could be a quantum sense in the quantum realm essentially feeling different dimensions which still remain unknown. The minds developed by the military in different projects like the stranger things series is an example of such a wild reality we live in and how interesting dimensions beyond ours touch our reality.


To the average person, most quantum theories sound strange, while others seem downright bizarre. There are many diverse theories that try to explain the intricacies of quantum systems and how our interactions affect them. And, not surprisingly, each approach is supported by its group of well-qualified and well-respected scientists. Here, we’ll take a look at the two most popular quantum interpretations.

Does it seem reasonable that you can alter a quantum system just by looking at it? What about creating multiple universes by merely making a decision? Or what if your mind split because you measured a quantum system?

You might be surprised that all or some of these things might routinely happen millions of times every day without you even realizing it.