Lifeboat Foundation: Safeguarding Humanity
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Category: neuroscience

(credit: OpenAI)

Elon Musk and associates announced OpenAI, a non-profit AI research company, on Friday (Dec. 11), committing $1 billion toward their goal to “advance digital intelligence in the way that is most likely to benefit humanity as a whole, unconstrained by a need to generate financial return.”

The funding comes from a group of tech leaders including Musk, Reid Hoffman, Peter Thiel, and Amazon Web Services, but the venture expects to only spend “a tiny fraction of this in the next few years.”

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Glucosepane is one of the most significant mechanisms of aging and yet very few people are working on it!

As we age skin and blood vessels lose their elasticity. People care too much about the skin and too little about the blood vessels, but that is always the way of it. Appearance first and substance later, if at all. Yet you can live inside an aged skin; beyond the raised risk of skin cancer its damaged state arguably only makes life less pleasant, and the present state of medical science can ensure that the numerous age-related dermatological dysfunctions can be kept to a state of minor inconvenience. Loss of blood vessel elasticity, on the other hand, will steadily destroy your health and then kill you. Arterial stiffening causes remodeling of the cardiovascular system and hypertension. The biological systems that regulate blood pressure become dysfunctional as blood vessels depart from ideal youthful behavior, creating a downward spiral of increasing blood pressure and reactions to that increase. Small blood vessels fail under the strain in ever larger numbers, damaging surrounding tissue. In the brain this damage contributes to age-related cognitive decline by creating countless tiny, unnoticed strokes. Ultimately this process leads to dementia. More important parts of the cardiovascular system are likely to fail first, however, perhaps causing a stroke, or a heart attack, or the slower decline of congestive heart failure.

From what is known today, it is reasonable to propose that the two main culprits driving loss of tissue elasticity are sugary cross-links generated as a byproduct of the normal operation of cellular metabolism and growing numbers of senescent cells. Elasticity is a property of the extracellular matrix, an intricate structure of collagens and other proteins created by cells. Different arrangements of these molecules produce very different structures, ranging from load-bearing tissues such as bone and cartilage to elastic tissues such as skin and blood vessel walls. Disrupting the arrangement and interaction of molecules in the extracellular matrix also disrupts its properties. Persistent cross-links achieve this by linking proteins together and restricting their normal range of motion. Senescent cells, on the other hand, secrete a range of proteins capable of breaking down or remodeling portions of the surrounding extracellular matrix, and altering the behavior of nearby cells for the worse.

The most important cross-linking compound in humans is glucosepane. Our biochemistry cannot break down glucosepane cross-links, and as a result it accounts for more than 99% of cross-links in our tissues. This isn’t a big secret. Given this you might expect to find researchers working flat out in scores of laboratories to find a viable way to break it down. After all here we have one single target molecule, and any drug candidate capable of clearing even half of existing cross-links would provide a treatment that can both reverse skin aging and vascular aging to a much greater degree than any presently available therapy. The size of the resulting market is every human being, the potential for profit staggering. Yet search on PubMed, and this is all of relevance that you will see published on the topic in the past few years:

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If human-less self-driving cars of the future creep you out, then this latest experimental automotive technology from China might offer you some respite. Or freak creep you out even more. Researchers from the port city of Tianjin have revealed what they claim is the country’s first ever car to be driven without the use of human hands or feet but with a driver still in control. All it takes is some brain power. And some highly specialized equipment, of course.

Mind-reading devices aren’t actually new. In fact, many companies and technologies make that claim year after year, but few have actually been able to deliver an actual consumer product, with most successful prototypes designed for therapeutic or medical uses. The theory, however, is the same throughout. Sensors read electroencephalogram or EEG from the wearer’s brain. These are then interpolated and interpreted as commands for a computer. In this case, the commands are mapped to car controls.

The application of direct brain control to driving is a two-edged sword. On the one hand, removing the delay between brain to muscle movement, which sometimes can be erroneous, could actually lead to better driver safety. On the other hand, given how easily drivers can be distracted even while their hands are on the wheel, the idea is understandably frightening to some.

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Can we end violence? Can we create greater emotional well being and intellectual equality for the greater well being of humanity? Will we be able to keep up with machines? How can we augment our intelligence? Could we cure mental illness? After advancements in aging the next major area of research from a standpoint of eliminating personal and global suffering would be upgrades in intelligence. Transhumanist values at their core want to eliminate suffering and existential risk to people’s lives. With well founded logic, these goals are not completely out of reach, it is possible but as usual, we will have to take the complex issue from many angles and from the standpoint of a systems engineer, but let’s look at some fun stuff before we get into the heavy stuff.

The Benefits of Intelligence Upgrades

So, what is the benefit for intelligence upgrades for every day people? We live in a time of exponential technology and vast amounts of face paced information, breakthroughs and invention. So, the most obvious answer to what is the benefit of intelligence upgrade is dealing with the massive amount of information one needs to keep up with daily to be on top of the game for work, for research or for business. Sometimes it can be our mere storage capacity that limits us in our abilities to interact with this information, at other times it is our processing speed, and most fundamentally the rate at which we can interact with new information. In 2012, a prosthetic chip was invented that uses electrodes to expand one’s memory storage. Now, with biotechnology predicted to move more quickly in 2016 and Google ready to back more companies in biotechnology, it may be possible to augment or program selective photographic memory. This is just an example of what one could imagine and begin working with, when combining electronics and gene editing. Many big breakthroughs in enhanced intelligence could be achieved in the future. The implications for business professionals, scientists, and the progress of technology would be astounding if upgrades like these were available. Personally, I can’t wait for the day when me and my personal A.I. through my Google Glass or some sort of eye wear or ear piece could read my brainwaves so I can type and do all my work through what would be a virtual form of telepathy. I could store everything I will need later instantly in the cloud and exactly where I want on my computer, there would be almost no delay because, well, how could there be? Time is everything.

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Researchers at Carnegie Mellon University are building an AI platform that will “whisper” instructions in your ear to provide cognitive assistance. Named after Gabriel, the biblical messenger of God, the whispering robo-assistant can already guide you through the process of building a basic Lego object. But, the ultimate goal is to provide wearable cognitive assistance to millions of people who live with Alzheimer’s, brain injuries or other neurodegenerative conditions. For instance, if a patient forgets the name of a relative, Gabriel could whisper the name in their ear. It could also be programmed to help patients through everyday tasks that will decrease their dependence on caregivers.

For the software to exist as a working wearable assistant, it will need a head-mounted device to latch onto. For now, the team is using Google Glass for demos like a ping pong assistant, where the programs tells the user to hit the ball to the right or left depending on the position of the ball in relation to the opponent. In the video below, when the user follows the guidance it makes it harder for the opponent to defend the ball in the game.

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Tufts biologists induced one species of flatworm —- G. dorotocephala, top left — to grow heads and brains characteristic of other species of flatworm, top row, without altering genomic sequence. Examples of the outcomes can be seen in the bottom row of the image. (credit: Center for Regenerative and Developmental Biology, School of Arts and Sciences, Tufts University.)

Tufts University biologists have electrically modified flatworms to grow heads and brains characteristic of another species of flatworm — without altering their genomic sequence. This suggests bioelectrical networks as a new kind of epigenetics (information existing outside of a genomic sequence) to determine large-scale anatomy.

Besides the overall shape of the head, the changes included the shape of the brain and the distribution of the worm’s adult stem cells.

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The world’s first anti-ageing drug will be tested on humans next year in trials which could see diseases like Alzheimer’s and Parkinson’s consigned to distant memory.

Scientists now believe that it is possible to actually stop people growing old as quickly and help them live in good health well into their 110s and 120s.

Although it might seem like science fiction, researchers have already proven that the diabetes drug metformin extends the life of animals, and the Food and Drug Administration in the US has now given the go ahead for a trial to see if the same effects can be replicated in humans.

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The results are mixed, of course, but it’s fascinating to watch the neural network make mistakes (and sometimes correct itself) in real time. The open source program being used is called NeuralTalk and was first unveiled last year, with the researchers providing updates on the network’s capabilities since. Other companies and institutions are working on similar technology. Last month, for example, Facebook unveiled a prototype neural network that’s intended to help blind people by describing pictures.

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