Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience

Why Synbio computing is where we ultimately want to more and more progress towards especially once the basic infrastructure is updated with technology like QC.

Cells are often likened to computers, running an operating system that receives signals, processes their input, and responds, according to programming, with cellular output. Yet untangling computer-like pathways in cells is anything but simple, say Denise Montell, professor at the University of California, Santa Barbara, and Aviv Regev, a Howard Hughes Medical Institute investigator at the Massachusetts Institute of Technology and the Broad Institute. However, both are eager to try and will outline their latest efforts at the “Logic of Signaling” symposium at the 2016 ASCB Annual Meeting.

“My lab is understanding how cells maintain and build normal tissues. We’re studying cellular behaviors that underlie normal behavior and tumor metastasis, a great unsolved question in cancer,” Montell said. Her lab recently discovered that cells can bounce back from the brink of apoptotic cell death. “This wasn’t known before so now we’re looking at how cells do it, when do they do it, under what circumstances, and what does it mean,” Montell said.

To track these near-death experiences in cells the Montell lab generated a genetically coded sensor in Drosophila. The researchers expected the mechanism to be a stress response, but they found that it was normal during development. “It makes sense retrospectively,” Montell explained, pointing to neuronal development as an example. “You produce way more neurons that you need, and the neurons compete for trophic factors. If a group of cells are competing for trophic factors, then one cell starts to die, but if it gets more trophic factor, it could bounce back.”

Read more

Northwestern Medicine scientists have discovered for the first time that the rhythm of breathing creates electrical activity in the human brain that enhances emotional judgments and memory recall.

These effects on behavior depend critically on whether you inhale or exhale and whether you breathe through the nose or mouth.

In the study, individuals were able to identify a fearful face more quickly if they encountered the face when breathing in compared to breathing out. Individuals also were more likely to remember an object if they encountered it on the inhaled breath than the exhaled one. The effect disappeared if breathing was through the mouth.

Read more

Scientists hoping to get a glimpse of molecules that control brain activity have devised a new probe that allows them to image these molecules without using any chemical or radioactive labels.

Currently the gold standard approach to imaging molecules in the brain is to tag them with radioactive probes. However, these probes offer low resolution and they can’t easily be used to watch dynamic events, says Alan Jasanoff, an MIT professor of biological engineering.

Jasanoff and his colleagues have developed new sensors consisting of proteins designed to detect a particular target, which causes them to dilate blood vessels in the immediate area. This produces a change in blood flow that can be imaged with magnetic resonance imaging (MRI) or other imaging techniques.

Read more

Great.

Research published in Acta Neuropathologica, identified alterations in a protein known as ATRX in human brain tumours; researchers might also be able to target microRNAs directly, altering their levels to make cancer cells less likely to form tumours.

A recent study suggests that two recently discovered genetic differences between brain cancer cells and normal tissue cells could offer clues to tumour behaviour and potential new targets for therapy.

Published in Acta Neuropathologica, the study identified alterations in a protein known as ATRX in human brain tumours that arise as part of a genetically inherited condition known as neurofibromatosis type 1 (NF1). The disorder, marked initially by benign tumours on nerves, often leads to brain cancer, and although most NF1-related malignancies are nonaggressive, a fraction are “high-grade” and difficult to treat, experts say.

Read more

Hmmmm.

Sam Gussman arrived four years ago at Stanford University hoping to eventually parlay an engineering degree into a product manager job at Google or Facebook.

Working for the National Security Agency or other intelligence bureaus never crossed his mind. For Gussman, the government didn’t seem like the place for the most exciting, cutting-edge research in human computer interaction — his area of interest. Plus, it did no on-campus recruiting, unlike the many tech startups that e-mailed him daily about job opportunities and happy hours.

That career plan changed dramatically after Gussman took a new graduate class at Stanford’s engineering school called Hacking for Defense, or H4D, where he got to tackle real-life national security challenges. There he met with U.S. military officers and studied the mental duress soldiers face during combat and then worked on software that distinguishes insurgents from civilians in video feeds from drones. Suddenly government work was “super cool.”

Read more

A huge discovery has just been made about Parkinson’s disease that scientists may have been looking for answers in the wrong place all along. Scientists have found that there is a strong correlation between symptoms of Parkinson’s and bacteria in the gut, not the brain, based on examinations of mice.

Parkinson’s disease is the second most common debilitating brain disorder in the world after Alzheimer’s. It is a neurodegenerative disease that involves a type of protein that builds up around brain cells and then causes the patient to lose motor function. Naturally, scientists had been looking at the brain for answers in dealing with it, but a new study finds that perhaps the answer was in the gut bacteria all along, according to an Axial Biotherapeutics statement.

The finding could lead to a new generation of probiotics that are far more sophisticated than typical brands currently available to the public.

Read more

Correction:
Fluid intelligence is just the ability to think and reason abstractly. The higher your fluid intelligence, in theory, the faster and more efficient you become at thinking abstractly.

One study shows that people with very high fluid intelligence have closer connections between neurons which allows them to reach conclusions faster. Another shows that the brain organizes itself in a more efficient manner allowing them to use less brain power to reach the same conclusions someone of lower intelligence would take longer to come to.

Read more

In Brief

  • Scientists are developing new ways to bridge the gap between our bodies and electronics by mimicking the connections between neurons.
  • Countless individuals stand to gain increased functionality and quality of life by these new developments in bio-hybrid devices like prosthetics and brain implants.

Read more