Most people don’t realize that all human beings have two sets of DNA in their bodies, the DNA inside our chromosomes, and a foreign DNA inside our mitochondria, that our ancestors stole from bacteria over a billion years ago.
Look into any of your cells, and you’ll see mysterious foreign DNA lurking inside your mitochondria, the tiny organelles that litter your cells. Recently, mitochondria have come under a growing scientific spotlight; scientists increasingly believe they play a central role in many, if not most, human illnesses. Mitochondria are the powerhouses of the cell, and when they falter, our cells lose power, just as a flashlight dims when its batteries weaken. Recently, researchers have linked mitochondria to an array of metabolic and age-related maladies, including autism, type 2 diabetes, cancer, Alzheimer’s, Parkinson’s, and cardiovascular disease.
While our mitochondria did not come from another planet, they might as well have. Peer through a microscope, and you’ll swear that tiny aliens have invaded your cells. You are partially correct. Mitochondria appear out of place compared to the other structures within the cell. Something ‘alien’ has invaded our cells, eons ago, but it came from primordial bacteria, a distinctly terrestrial source.
Michael B. Fossel, M.D., Ph.D. (born 1950, Greenwich, Connecticut) was a professor of clinical medicine at Michigan State University and is the author of several books on aging, who is best known for his views on telomerase therapy as a possible treatment for cellular senescence. Fossel has appeared on many major news programs to discuss aging and has appeared regularly on National Public Radio (NPR). He is also a respected lecturer, author, and the founder and former editor-in-chief of the Journal of Anti-Aging Medicine (now known as Rejuvenation Research).
Prior to earning his M.D. at Stanford Medical School, Fossel earned a joint B.A. (cum laude) and M.A. in psychology at Wesleyan University and a Ph.D. in neurobiology at Stanford University. He is also a graduate of Phillips Exeter Academy. Prior to graduating from medical school in 1981, he was awarded a National Science Foundation fellowship and taught at Stanford University.
In addition to his position at Michigan State University, Fossel has lectured at the National Institute for Health, the Smithsonian Institution, and at various other universities and institutes in various parts of the world. Fossel served on the board of directors for the American Aging Association and was their executive director.
Fossel has written numerous articles on aging and ethics for the Journal of the American Medical Association and In Vivo, and his first book, entitled Reversing Human Aging was published in 1996. The book garnered favorable reviews from mainstream newspapers as well as Scientific American and was published in six languages. A magisterial academic textbook on by Fossel entitled Cells, Aging, and Human Disease was published in 2004 by Oxford University Press.
Since his days as a teacher at Stanford University, Fossel has studied aging from a medical and scientific perspective with a particular emphasis on premature aging syndromes such as progeria, and since at least 1996 he has been a strong and vocal advocate of [telomerase therapy]] as a potential treatment of age-related diseases, disorders, and syndromes such as progeria, Alzheimer’s disease, atherosclerosis, osteoporosis, cancer, and other conditions. However, he is careful to qualify his advocacy of telomerase therapy as being a potential treatment for these conditions rather than a “cure for old age” and a panacea for age-related medical conditions, albeit a potential treatment that could radically extend the maximum human life span and reverse the aging process in most people. Specifically, Fossel sees the potential of telomerase therapy as being the single most effective point of intervention in a wide variety of age-related medical conditions. His new book, The Telomerase Revolution, (BenBella, 2015) gives a careful explanation of aging, age-related diseases, and the prospects for intervention, including upcoming human trials. —— Facebook: https://www.facebook.com/agingreversed Tumblr: http://agingreversed.tumblr.com Twitter: https://twitter.com/Aging_Reversed
Researchers at the Institute of Molecular Biology (IMB) in Mainz, Germany, have made a breakthrough in understanding the origin of the ageing process. They have identified that genes belonging to a process called autophagy — one of the cells most critical survival processes — promote health and fitness in young worms but drive the process of ageing later in life. This research published in the journal Genes & Development gives some of the first clear evidence for how the ageing process arises as a quirk of evolution. These findings may also have broader implications for the treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s disease where autophagy is implicated. The researchers show that by promoting longevity through shutting down autophagy in old worms there is a strong improvement in neuronal and subsequent whole body health.
Getting old, it’s something that happens to everyone and nearly every species on this planet, but the question is, should it? In a recent publication in the journal Genes & Development titled “Neuronal inhibition of the autophagy nucleation complex extends lifespan in post-reproductive C. elegans,” the laboratory of Dr Holger Richly at IMB, has found some of the first genetic evidence that may put this question to rest.
As Charles Darwin explained, natural selection results in the fittest individuals for a given environment surviving to breed and pass on their genes to the next generation. The more fruitful a trait is at promoting reproductive success, the stronger the selection for that trait will be. In theory, this should give rise to individuals with traits which prevent ageing as their genes could be passed on nearly continuously. Thus, despite the obvious facts to the contrary, from the point of evolution ageing should never have happened. This evolutionary contradiction has been debated and theorised on since the 1800s. It was only in 1953 with his hypothesis of antagonistic pleiotropy (AP) that George C. Williams gave us a rational explanation for how ageing can arise in a population through evolution. Williams proposed that natural selection enriches genes promoting reproductive success but consequently ignores their negative effects on longevity.
Summary: Researchers are testing a new vaccine and oral medication that could delay or prevent Alzheimer’s disease from developing in those with a genetic predisposition.
Source: Keck Medicine USC.
The Keck School of Medicine of USC launches a study exploring whether two different therapies can prevent a leading cause of death.
Nerve cells in the gut play a crucial role in the body’s ability to marshal an immune response to infection, according to a new study from Weill Cornell Medicine scientists.
The study, published in Nature, shows that the immune system and nervous system have co-evolved to respond to infectious threats. This means that scientists looking for ways to treat diseases like inflammatory bowel disease or asthma that involve an excessive immune system response may also have to address the nervous system’s role.
“The immune system and neuronal system don’t act independently,” said senior author Dr. David Artis, director of the Jill Roberts Institute for Research in Inflammatory Bowel Disease and the Michael Kors Professor of Immunology at Weill Cornell Medicine. “They are working together.”
NEWPORT BEACH, Calif., July 12, 2017 /PRNewswire/ — Strathspey Crown LLC, a lifestyle healthcare company focused in ophthalmology, medical aesthetic and elective technologies and procedures, today announced that the United States Patent and Trademark Office has issued U.S. Patent No. 9,662,199 covering an implantable intraocular lens with an optic (including accommodating, multifocal and phakic configurations), a camera and an LED display, and a communications module that wirelessly transmit and receive information from an external device (e.g. PDA).
Robert Edward Grant, Founder and Chairman of Strathspey Crown LLC commented, “Video cameras are now a standard feature of smart phone technology and wearable cameras have become popularized by companies like Google and Snap in recent years. This patent represents a significant step forward in the rapidly growing sector of human cyborg technology. The eye, as a transparent medium for light, is ideal for advanced and rechargeable implantables that enable video capture of all of life’s experiences. Our broader vision is to develop ground-breaking medical-grade ocular smart implantables that integrate cellular, WIFI and 802.11 transmissions in an elegant cognitive interface that we believe will enhance human intelligence, augment perceived reality, and digitally capture experiences and individual memories. We look forward to several continuations and expansions on this important intellectual property portfolio.”
Grant further commented, “Although Samsung, Sony and Google have all recently filed patent applications related to the same field, Strathspey Crown is thus far the only company to hold an issued patent in this promising ocular smart implant category. Our first camera-integrated acrylic IOLs will be completed in 2018, upon which we plan to pursue an FDA Investigational Device Exemption (IDE) and subsequent Pre-Market Approval (PMA) and related clinical trial.”
Brain-controlled computers are currently helping paralyzed patients, but one day they might be used to control everything around you.
The ability to control the world around you with only your mind has been a feature of some of the best science fiction stories ever written, but even today the idea sounds pretty futuristic. Still, neuroscientists around the world are hard at work trying to figure out how to make a digital interface for the brain and in recent years have made remarkable strides toward this goal. Although this technology is still in its infancy, it’s not quite as hard to imagine abandoning touch screens for mind control anymore.
For the most part, brain-computer interfaces (BCIs) are currently being created only for people who have suffered debilitating injuries that left them partially or completely paralyzed.
Researchers announced yesterday that they discovered a #genetic #brain #aging #clock that controls how our brains age. The clock controls brain aging according to a precise timetable. This discovery holds promise that scientists can prevent brain aging by stopping the clock.
Summary: Researchers announced yesterday that they discovered a genetic brain aging clock that controls how our brains age. The clock controls aging in our brains according to a precise timetable. This discovery holds promise that scientists can prevent brain aging by stopping the clock.
Imagine keeping your mind sharp as a teenager’s while you grow older, even into your twilight years.
Yesterday’s announcement brings us one step closer to realizing that dream, as researchers have discovered a genetic clock that ages our brains due to a predetermined timetable.
