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Category: neuroscience

The Singularity is Near.

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For fifteen years, I’ve assumed that the Matrix Sequels were irredeemable failures. But looking back on them with fresh eyes reveals a pair of films that are exhilarating, interesting, and sometimes hilarious. In this video I try to make sense of these two movies, and what they have to say about free will and the systems that control society.

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Works Cited:

DRAGUNOIU, DANA. “Neo’s Kantian Choice: ‘The Matrix Reloaded’ and the Limits of the Posthuman.” Mosaic: An Interdisciplinary Critical Journal, vol. 40, no. 4, 2007, pp. 51–67. JSTOR, JSTOR, www.jstor.org/stable/44030393. https://www.jstor.org/stable/44030393?read-now=1&loggedin=true&seq=1#metadata_info_tab_contents

For more on Immanuel Kant’s Categorical Imperative read: Groundwork of the Metaphysics of Morals.

More Matrix analysis:

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BY HANK PELLISSIER

Hank Pellissier

Editor’s Note: The U.S. Transhumanist Party / Transhuman Party features this proposal by our member Hank Pellissier for a new website called Paradise2040, which will focus on the abolition of involuntary suffering and incremental ways of getting there within the next 21 years. This is an endeavor supported by Article IV of the Transhumanist Bill of Rights, Version 3.0. It is also a current within transhumanist thinking that, as Mr. Pellissier points out, could bring additional support to the movement. Different transhumanists will have different views as to what the most important aims of transhumanism should be. As an organization that embraces pluralism and diversity of thought, the U.S. Transhumanist Party / Transhuman Party would encourage any of our members who agree with the direction Mr. Pellissier proposes to collaborate with him on the creation of the Paradise2040 website.

~ Gennady Stolyarov II, Chairman, United States Transhumanist Party / Transhuman Party, March 25, 2019

A survey I conducted in 2010 of 818 transhumanists identified “brain enhancement” as the #1 priority, with “maximizing” health and life extension as #2 and #3. The top three “values” of the U.S. Transhumanist Party (the Core Ideals) are #1) Life Extension, #2) “a cultural, societal, and political atmosphere informed and animated by reason, science, and secular values”, and #3) “to reduce and eliminate existential risks.”

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A new graphene-based brain implant could help provide information about the onset and progression of epileptic seizures and pave the way for next generation brain-computer interfaces.

The new implant, which records electrical activity in the brain over large areas and at frequencies below 0.1Hz, is said to overcome the limitations of electrode arrays that have only been able to detect activity over a certain frequency threshold.

The technology was developed by Graphene Flagship partners at the Barcelona Microelectronics Institute (IMB-CNM, CSIC), the Catalan Institute of Nanoscience and Nanotechnology (ICN2), and ICFO.

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https://paper.li/e-1437691924#/ https://www.nature.com/articles/s41591-019-0375-9

The hippocampus is one of the most affected areas in Alzheimer’s disease (AD). Moreover, this structure hosts one of the most unique phenomena of the adult mammalian brain, namely, the addition of new neurons throughout life. This process, called adult hippocampal neurogenesis (AHN), confers an unparalleled degree of plasticity to the entire hippocampal circuitry3,4. Nonetheless, direct evidence of AHN in humans has remained elusive. Thus, determining whether new neurons are continuously incorporated into the human dentate gyrus (DG) during physiological and pathological aging is a crucial question with outstanding therapeutic potential. By combining human brain samples obtained under tightly controlled conditions and state-of-the-art tissue processing methods, we identified thousands of immature neurons in the DG of neurologically healthy human subjects up to the ninth decade of life. These neurons exhibited variable degrees of maturation along differentiation stages of AHN. In sharp contrast, the number and maturation of these neurons progressively declined as AD advanced. These results demonstrate the persistence of AHN during both physiological and pathological aging in humans and provide evidence for impaired neurogenesis as a potentially relevant mechanism underlying memory deficits in AD that might be amenable to novel therapeutic strategies.

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Over the past twenty years, neuroscientists have been quietly building a revolutionary technology called BrainGate that wirelessly connects the human mind to computers and it just hit the world stage. Entrepreneurs such as Elon Musk and Mark Zuckerberg have entered the race with goals of figuring out how to get computer chips into everyone’s brains. The attention of Musk and Zuckerberg means the potential for giant leaps forward. But the question no one seems to be asking is whether our dependence on machines and technology has finally gone too far. Countries annually celebrate their independence from other countries, but it now seems we should start asking deeper questions about our personal independence.

60 Minutes recently ran a piece showing how engineers are using what scientists have learned about the brain to manipulate us into staying perpetually addicted to our smartphones. The anxiety most of us feel when we are away from our phone is real: During the 60 Minutes piece, researchers at California State University Dominguez Hills connected electrodes to reporter Anderson Cooper’s fingers to measure changes in heart rate and perspiration. Then they sent text messages to his phone, which was out of his reach, and watched his anxiety spike with each notification.

The segment revealed that virtually every app on your phone is calibrated to keep you using it as often and as long as possible. The show made an important point: a relatively small number of Silicon Valley engineers are experimenting with, and changing in a significant way, human behavior and brain function. And they’re doing it with little insight into the long-term consequences. It seems the fight for independence has gone digital.

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NEW ORLEANS—Exposure to the widely used chemical bisphenol A (BPA) during pregnancy, even at levels lower than the regulated “safe” human exposure level, can lead to changes in circadian rhythms, according to a mice study to be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. The researchers report these changes may be a contributing factor in hyperactivity seen in BPA-exposed mice.

“The hypothalamus, which we have identified as a brain region that is particularly susceptible to developmental disruption by BPA, contains the site of the clock cells that govern daily rhythms throughout the body,” said researcher Deborah Kurrasch, Ph.D., Associate Professor at the University of Calgary in Calgary, Canada. “We have shown in previous research that BPA exposure in utero can cause defects to the development of hypothalamic nuclei and hyperactivity, and here we explored whether a shift in circadian biology might explain why the animals moved more.”

BPA is a chemical that is added to many commercial products, including water bottles, paper receipts, can liners and food storage containers. It is known as an endocrine-disrupting chemical—a chemical that interferes with the body’s hormones.

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What happens in our brain when we listen to the rhythmic pace of a song or when, at the traffic light, the light is red and we are trembling awaiting the green? How do we perceive such an abstract feature of the world? For the first time in humans, an imaging study shows that in a specific area of the brain, the so-called “supplementary motor area (SMA)”, a time map exists. The study, conducted by the team led by SISSA Professor Domenica Bueti and published in PLOS Biology, shows that distinct portions of the SMA, a region of the cerebral cortex important for both motor preparation and time perception—respond preferentially to different durations. The portions of the SMA responding to similar durations are in close spatial proximity on the cortical surface according to an anterior-to-posterior spatial gradient. The most anterior portions of SMA are greatly active for the shortest duration (200 ms), while the most posterior bits are active for the longest duration (3 sec), the intermediate durations led to the activation of the cortex between those extremes. These novel findings, which are the result of a collaborative effort between SISSA and research institutions in Japan, Switzerland and the Netherlands, are important to gain insights on the computational architecture underlying time perception and they also open up new perspectives to the study of temporal cognition.

The representation of time

“Topography i.e., the fact that neurons processing similar stimulus properties occupy neighbouring positions on the nervous system, is an encoding mechanism widely used in the brain to represent sensory and motor information. For example, there is a body map in our primary somatosensory cortex. In this map, the portions of the cortex receiving tactile information from the hand and the wrist are neighbours compared to those receiving information from the toe” says Domenica Bueti, coordinator of the research whose leading author is the Greek researcher Foteini Protopapa: “our findings show that a topographic representation exists also for something immaterial like time”. Previous studies conducted in humans and other animals have shown the involvement of SMA in time perception. However none of those previous works clarified how temporal information is represented in this area.

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