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Category: neuroscience

A woman in her forties has become the latest known case of SARS-CoV-2 infection associated with a “sudden and complete” loss of smell. Known as anosmia, loss of smell is regarded as one of the tell-tale signs of COVID-19.

When an odor enters the nose, neurons in the nasal cavity send messages to the olfactory bulb, a structure in the front part of the brain. These signals are then shipped off to different parts of the brain, leading some medical experts to wonder whether the novel coronavirus could cause adverse neurological reactions.

But how could a virus associated with respiratory infections impact the brain? Researchers are trying to find out. Dr Serena Spudich, a neurologist at the Yale School of Medicine specializing in infectious diseases, says that it is too early to say definitively whether SARS-CoV-2 directly infects the brain but limited data suggests it is a possibility.

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I rarely use the words transformative or breakthrough for neuroscience findings. The brain is complex, noisy, chaotic, and often unpredictable. One intriguing result under one condition may soon fail for a majority of others. What’s more, paradigm-shifting research trends often require revolutionary tools. When we’re lucky, those come once a decade.

But I can unabashedly say that the 2010s saw a boom in neuroscience breakthroughs that transformed the field and will resonate long into the upcoming decade.

In 2010, the idea that we’d be able to read minds, help paralyzed people walk again, incept memories, or have multi-layered brain atlases was near incomprehensible. Few predicted that deep learning, an AI model loosely inspired by neural processing in the brain, would gain prominence and feed back into decoding the brain. Around 2011, I asked a now-prominent AI researcher if we could automatically detect dying neurons in a microscope image using deep neural nets; we couldn’t get it to work. Today, AI is readily helping read, write, and map the brain.

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New hope for stroke patients as scientists find way to restore mobility and touch using human stem cells to recreate nerve connections in damaged rat brain…

Scientists have found a way to restore mobility and touch in rats after a stroke using human stem cells to recreate nerve connections in damaged brains — offering patients a new hope.

The study — conducted on rats — showed that the new cells could repair the damage caused by a stroke within six months of being transplanted into the brain.

However, the researchers caution that there is much work to be done before the procedure can be considered suitable and safe to try in human patients.

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Resveratrol may reduce aging within the brain.

Deficits in the cerebral microcirculation contribute to age-related cognitive decline. In a pilot study of postmenopausal women, we found that supplementation with a low dose of resveratrol, a phytoestrogen, for 14 weeks improved cerebrovascular and cognitive functions. We have since undertaken a larger, longer term study to confirm these benefits. Postmenopausal women aged 45–85 years (n = 129) were randomized to take placebo or 75 mg trans-resveratrol twice daily for 12 months. Effects on cognition, cerebral blood flow, cerebrovascular responsiveness (CVR) and cardiometabolic markers (blood pressure, diabetes markers and fasting lipids) were assessed. Compared to placebo, resveratrol improved overall cognitive performance (P < 0.001) and attenuated the decline in CVR to cognitive stimuli (P = The latter effect was associated with reduction of fasting blood glucose (r = P = This long-term study confirms that regular consumption of resveratrol can enhance cognitive and cerebrovascular functions in postmenopausal women, with the potential to slow cognitive decline due to ageing and menopause. View Full-Text.

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Presence and location of gray matter in the brain may indicate whether acupuncture is an effective method of treating migraine without aura, according to a study published in Frontiers in Neurology.

Presence and location of gray matter (GM) in the brain may indicate whether acupuncture is an effective method of treating migraine without aura (MwoA), according to a study published in Frontiers in Neurology.

In many countries acupuncture is used as a treatment for migraine, but there is insufficient evidence to claim it is effective for all migraineurs. According to researchers, “about 50% of patients do not achieve substantial improvement after acupuncture.” However, determining which patients may benefit from acupuncture will prevent nonresponders from undergoing time-consuming and unsuccessful treatment.

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Massaging key parts of the brain with a pulsating magnetic field can do wonders for some living with chronic depression. For others, it falls well short of promising a life without a debilitating mood disorder.

The overwhelmingly positive results of an unblinded experiment on a small group of volunteers suggests some tweaks to the protocol might improve the odds of it working for people who have failed to find a solution elsewhere.

Researchers from Stanford and Palo Alto University in the US have shown in an open study on 21 people that administering five times the overall dosage of pulses across a higher number of daily sessions not only seems safe, but could achieve much better results.

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An ongoing long-term trial suggests high levels of amyloid proteins in the brain do serve as an early sign of Alzheimer’s disease before cognitive decline becomes apparent.

A new study presenting the first data from a long-running US government trial is suggesting high levels of amyloid proteins in the brains of cognitively normal older adults can be an effective presymptomatic sign of early stage Alzheimer’s disease.

Over the last few decades, the amyloid hypothesis has guided the majority of research into an Alzheimer’s disease treatment. The idea is that a build up of toxic amyloid proteins in the brain, called plaques, is the primary degenerative driver behind the disease.

Unfortunately a near-constant parade of failed clinical trials testing anti-amyloid drugs has caused many researchers to begin doubting the amyloid hypothesis. From neuroinflammation to bacterial infection, a broad number of alternative hypotheses are currently being investigated, however, some scientists suspect anti-amyloid treatments could still work, as long as they commence before major degenerative symptoms appear.

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Researchers at Lund University in Sweden have succeeded in restoring mobility and sensation of touch in stroke-afflicted rats by reprogramming human skin cells to become nerve cells, which were then transplanted into the rats’ brains. The study has now been published in the research journal PNAS.

“Six months after the transplantation, we could see how the new cells had repaired the damage that a stroke had caused in the rats’ brains,” says Professor Zaal Kokaia, who together with senior professor Olle Lindvall and researcher Sara Palma-Tortosa at the Division of Neurology is behind the study.

Several previous studies from the Lund team and others have shown that it is possible to transplant cells derived from human stem cells or from reprogrammed cells into brains of rats afflicted by stroke. However, it was not known whether the transplanted cells can form connections correctly in the rat in a way that restores normal movement and feeling.

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