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Category: life extension

In this video Dr. Lustgarten introduces his N of 1 experiment and gives an overview of the processes that he follows. He also discusses why he thinks it is important to track your own markers and not just rely on published trials.

Dr. Michael Lustgarten is a scientist at the Tufts University Human Nutrition Research Center on Aging in Boston, Massachusetts. His research currently focuses on the role of the gut microbiome and serum metabolome on muscle mass and function in older adults.
In this series of interviews Dr Lustgarten shares his experience with his rigorous n of 1 experiment over the last 7 years and shows how we or anyone can conduct a similar trial by tracking food, exercise and sleep, measure results and derive relationships between them, with a goal of extending our healthspan.

Dr Lustgarten’s channel on YouTube: https://www.youtube.com/channel/UCT1UMLpZ_CrQ_8I431K0b-g.

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Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation.

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A stem cell researcher who founded his startup with the psychedelic-loving German billionaire Christian Angermayer, Peyer believes that aging is a disease that humans can fight with pharmaceuticals. He plans to prove it first by identifying disorders and diseases that mimic aging, such as those that cause loss of muscle mass, and then partner with researchers studying medicines for said diseases.

A bold proposal: that by 2050, a 70-year-old will look and feel like they’re 50.

That’s the gamble that 35-year-old James Peyer is taking with this Cambrian Biopharma “longevity startup,” the Times of London reports.

“Of our 100,000-year-plus history as a species, it’s been for only about 75 years that these diseases of ageing have been the primary predators of humankind,” he told the newspaper. “We are rapidly zeroing in on our biggest predators — diseases of [aging] — and figuring out how to beat them back.”

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Sorry if re-post…

A team of researchers affiliated with a large number of institutions in Japan has developed a vaccine that tricks the immune system into removing senescent cells. In their paper published in the journal Nature Aging, the group describes their vaccine, how it works and how effective it was when given to test mice.

Prior research has shown that part of the aging process is the development of —cells that outlive their usefulness but fail to die naturally. Instead, they produce chemicals that can lead to inflammation, aging and a host of other ailments. Prior research has shown that senescence occurs when cells stop dividing. Prior research has also shown that senescent cells can lead to in some instances and tumor suppression in others. Senescence also plays a role in tissue repair, and its impacts on the body vary depending on factors such as overall health and age. It is suspected that senescence is related to telomere erosion, and in some cases, environmental factors that lead to cell damage. In this new effort, the researchers have developed a vaccine that creates antibodies that attach to senescent cells, marking them for removal by .

The team was able to create the vaccine after identifying a protein made in senescent cells but not in healthy active cells. That allowed them to develop a type of vaccine based on the amino acids in the protein. When injected, the vaccine incites the body to produce antibodies that bind only to senescent cells, and that sets off an immune response that involves sending white blood cells to destroy the senescent cells.

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Yesterday’s longevity AMA: michael lustgarten, phd.

Questionsabout yesterday’s video, and more…AMA!

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Timestamps:
0:51 Evaluating what’s optimal for biomarkers that are genetically low or high.
3:59 Details on replicating the approach.
6:59 EVOO
9:41 Carotid artery thickness scan.
10:55 Exercise routine.
18:26 Sirtuins, resveratrol and longevity.
19:31 Using blood testing to identify which supplements are detrimental, neutral, or beneficial at n=1
23:00 Devices that I use.
24:54 TG/HDL ratio.
26:47 Use of herbs, adaptogens.
30:00 Rapamycin.
33:23 Fish oil.
35:30 Other fish besides sardines?
37:12 Balance between taste and health.
38:00 Tracking starch intake?
40:50 Current macros.
42:32 Importance of thymus and immunosenescence.
45:04 Evaluating what’s optimal for dietary vitamin/mineral intake.
47:46 Taking time off from supplements before blood testing (or not)
49:52 Thoughts on genetic biomarkers.
51:32 Adding weights to the biomarkers/Are they all equal for their effects during aging.
57:20 Cinnamon vs biomarkers.
58:50 Managing the diet/approach in social settings.
1:00:30 Oils and cooking.
1:01:45 Biomarker weights.
1:03:05 Investigating factors surrounding thymus hypertrophy.
1:04:08 Liposomal delivery and aging.
1:06:52 Finding trusted sources for supplements.
1:08:00 Attia, Rhonda.
1:10:18 Not just focusing on cardio for health.
1:11:05 ION test.
1:15:00 What if I don’t beat the longevity record.
1:16:30 Where would I bet on anti-aging tech.
1:18:45 Liver detox.
1:19:36 How often I eat junk food.
1:21:10 Metformin.
1:22:50 Sauna.
1:24:41 Blood donation: impact on biological age?
1:25:25 Is there an upper limit for venous recovery after blood testing?
1:26:15 No cheat days for Christmas?
1:27:29 Next-generation biological age clocks?
1:31:09 Parabiosis.
1:33:19 CR and lymphocytes.
1:36:27 Protein intake.
1:40:08 Cortisol and hormones.
1:42:00 Blood pressure.
1:43:44 TruAge clock.
1:47:35 Noise in epigenetic testing.

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Contrary to what you may think, getting old is not inevitable. And by getting old, I mean the bad parts: weakened muscles, fading memory, aching joints … or perhaps a disease such as cancer or diabetes makes an unwelcome appearance.

James Peyer, 35, is out to prove that age is, instead, like polio or tuberculosis. Those and other infectious diseases once were the biggest killers, until we developed effective vaccines or treatments.

Why, asked Peyer, co-founder of the New York longevity start-up Cambrian Biopharma, should age be any different? “Of our 100,000-year-plus history as a species, it’s been for only about 75 years that these diseases of ageing have been the primary predators of humankind.” He added: “We are rapidly zeroing in on our biggest.

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Senescent cells refer to those that have stopped dividing but do not die. They damage nearby healthy cells by releasing chemicals that cause inflammation.

The team identified a protein found in senescent cells in humans and mice and created a peptide vaccine based on an amino acid that constitutes the protein.

The vaccine enables the body to create antibodies that attach themselves to senescent cells, which are removed by white blood cells that adhere to the antibodies.

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Clip during an interview made by Nicholas Singh, Senior Product Manager at Novos Labs to Kris Verburgh, CSO and Co-Founder of Novos Lab.

The clip shows the answer made by Kris Verburgh to a question made by José Cordeiro, PhD, MBA, Vice-Chairman of Humanity Plus, about the prediction made by Ray Kurzweil on the availability of full body human biological rejuvenation by 2045.

The episode took place during the webinar “Why Do We Age (And What Can We Do About It)?” organized by Novos Labs that took place on December 9, 2021.

To watch the entire webinar clic here: https://zoom.us/rec/play/lF-M5nVdYmXSiHQUAwC2YfrtaiUBfXUQP0NGtiPi9_1j73vYzNdAy82NiacAoXkdRUJYCP3O9Dgsji80.GH_Ca4pN068ViIHM

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