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Undoubtedly the fear of death, encoded in our DNA to improve our chances of survival, is one of the least pleasant characteristics we are forced to live with. The idea that our life must have an end and then there is nothingness is not at all attractive, so it is not surprising that in the course of his history man has imagined countless ways to circumvent death.
Immortality (or eternal life) is the concept of surviving forever or for an indefinite period of time, without facing death or overcoming death itself.

Immortality can be intended in two main meanings, physical and spiritual. Physical immortality is generally conceived as the endless existence of the mind from a physical source, such as a brain or a computer. Spiritual immortality is generally conceived as the endless existence of an individual after physical death.

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00:00 Intro.

They are at the forefront in the fight against viruses, bacteria, and malignant cells: the T cells of our immune system. But the older we get, the fewer of them our body produces. Thus, how long we remain healthy also depends on how long the T cells survive. Researchers at the University of Basel have now uncovered a previously unknown signaling pathway essential for T cell viability.

Like human beings, every cell in our body tries to ward off death as long as it can. This is particular true for a specific type of immune cells, called T-lymphocytes, or T cells for short. These cells keep viruses, bacteria, parasites and cancerous cells at bay. While T cell production is an active process in infants, children and young adults, it comes to a gradual stop upon aging, meaning that in order to maintain adequate immunity up to an old age, your T cells should better live as long as you.

How T cells manage to survive for such a long time, up to several decades in humans, has long remained unclear. In collaboration with scientists at the Department of Biomedicine and sciCORE, the Center for Scientific Computing of the University of Basel, Professor Jean Pieters’ research group at the Biozentrum has now revealed the existence of a hitherto unrecognized pathway promoting long-term survival of T cells. In Science Signaling they report that this signaling pathway, regulated by the protein coronin 1, is responsible for suppressing T cell death.

A good deal of evidence points to declining kidney function as a cause of declining cognitive function in aging. There are strong correlations between loss of kidney function and risk of dementia, for example. Correlation isn’t a smoking gun in matters of aging, however: it is possible for any one of the underlying forms of molecular damage that cause aging, or for intermediate consequences of that damage, to give rise to otherwise unrelated pathologies in different parts of the body. Those pathologies appear more often in people with greater amounts of that form of damage, and thus appear correlated.

Nonetheless, there are good reasons to think that kidney failure and its downstream consequences contribute meaningful to neurodegeneration, perhaps largely by degrading the function of the vascular system. Vascular aging can cause damage and dysfunction in brain tissue via numerous mechanisms, including the pressure damage of hypertension, similar damage resulting from an acceleration of atherosclerosis, failing to delivery sufficient nutrients and oxygen to the energy-hungry brain, and disruption of the blood-brain barrier, allowing inflammatory cells and molecules into the brain.

Interactions Between Kidney Function and Cerebrovascular Disease: Vessel Pathology That Fires Together Wires Together.

An experimental vaccine successfully eliminated aging cells from the bodies of mice, helping to prolong the rodents’ lives and reverse some signs of age-related disease. The researchers say the experiment is a step on the road to a similar vaccine for humans, but could it really work?

Researchers at Stevens Institute of Technology show that strain on ventricular walls explains where lesions develop in the aging brain.

As our brains age, small lesions begin to pop up in the bundles of white matter that carry messages between our neurons. The lesions can damage this white matter and lead to cognitive deficits. Now, researchers at Stevens Institute of Technology and colleagues not only provide an explanation for the location of these lesions but also how they develop in the first place.

The work, led by Johannes Weickenmeier, an assistant professor of mechanical engineering at Stevens, highlights the importance of viewing the brain as more than neural circuitry that underpins how thoughts are formed, and memories created. It’s also a physical object that’s prone to glitches and mechanical failures. “The brain is susceptible to wear and tear in vulnerable areas,” Weickenmeier said. “Especially in an aging brain, we need to look at its biomechanical properties to better understand how things can start to go wrong.”

It doesn’t have to be this way. Unhealthy ageing is a human tragedy, and if governments and health authorities shift their focus from lifespan to healthspan, longevity technology can remedy it. Looking and feeling younger for longer is not the preserve of beauty brands or Silicon Valley billionaires.

The average human lifespan has increased by several decades in the past century, but our healthspan – the years we are in good health – has stayed the same. The solution is to treat unhealthy ageing like any other illness, that is, as a technical problem that can be overcome.

The 2021 Lifeboat Foundation Guardian Award has been given to Martine Rothblatt who has devoted her life to moving humanity towards a positive future.

Martine was the 500th person to join our Advisory Board, has contributed to our blog, and has generously supported the Lifeboat Foundation’s goal of “Safeguarding Humanity”.

Martine is cofounder of the Terasem Movement Foundation. Their mission is to promote the geoethical (world ethical) use of nanotechnology for human life extension. They conduct educational programs and support scientific research and development in the areas of cryonics, biotechnology, and cyber consciousness. This foundation is related to the Lifeboat Foundation programs LifePreserver and PersonalityPreserver (which Martine contributed text to).

The Terasem Movement Foundation publishes “The Journal of Personal Cyberconsciousness” and “The Journal of Geoethical Nanotechnology”.

Martine Rothblatt is winner of the 2021 Guardian Award.

When we think about gene editing, the first thing we remember is the designer babies, and that it’s usually called unethical. But actually, gene editing (CRISPR) may be one of the most promising upcoming medical technologies. Learn why in this video.

Check out other videos from this series:

0:00 — Opening scene.
0:20 — Gene editing is promising. Here’s why.
2:35 — Also, it can transform the beauty industry.
3:49 — How does gene editing work?
4:16 — My thoughts on that.
5:16 — End credits.

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Directed by Valentin Shevtsov.
© Shevtsov Originals, 2021.

#dna #science #medicine.
#geneediting #genetherapy #crispr #alzheimers

More than a million Americans undergo knee and hip replacements each year. It’s a last resort treatment for pain and mobility issues associated with osteoarthritis, a progressive disease caused by degeneration of the protective layer of cartilage that stops our bones grinding together when we sit, stand, write, or move around.

But what if doctors could intervene and repair damaged cartilage before surgery is needed?

For the first time, researchers at the Keck School of Medicine of USC have used a stem cell-based bio-implant to repair cartilage and delay joint degeneration in a large animal model. The work will now advance into humans with support from a $6 million grant from the California Institute of Regenerative Medicine (CIRM).