Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

Today, dementia affects over 46 million people worldwide, by 2050 it will affect more than 131 million people.

Global costs of dementia are estimated at $818 billion. As a result, if dementia care were a country, it would be the world’s 18th largest economy.

Dementias are one of the most expensive diseases for the healthcare system as patients require long-term care with daily activities like washing, getting dressed and eating. It has been estimated that the US health care would save an astonishing 40 billion dollars annually if the age of onset for Alzheimer’s disease was delayed by just 5 years. The estimated annual cost of dementia worldwide is 818 billion dollars, more than the current US defence budget. By 2018 the cost may reach a trillion dollars. Remarkably, if dementia were a country, it would be the 18th largest economy on earth.

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An article written by Dr Michael Fossel talking about telomerase therapy for Alzheimer’s and the work Bioviva and Telocyte are doing to beat this horrific condition.

Reversing Alzheimer’s by Lengthening Telomeres.

There are telomere lengthening compounds available right now for use in research labs. They are not currently available for human use. A group of scientists wants to test these compounds on aging humans now to see if the telomere lengthening effects will induce meaningful age reversal effects.

Telomeres in our cells shorten as we grow older and create cellular havoc that predisposes us to multiple age-related pathologies. These experimental enzymes promote telomere lengthening and in the process offer an intriguing opportunity to circumvent biological aging processes.

Alzheimer’s disease has no cure and evidence points at microglial epigenetic changes being the cause of the inability to remove misfolded proteins in neurons. This proposed study will evaluate the effect the use of hTERT (human telomerase reverse transcriptase) to reverse biomarkers and symptomatology of aging with special target of the microglia cells in Alzheimer’s patients. Misfolded beta amyloids can be effectively cleared by healthy microglia. This could represent a clinical breakthrough in Alzheimer’s treatment that would be immediately available in the clinical setting.

How Alzheimer’s Can Be Prevented and Cured…

Michael Fossel, MD, PhD

As I said in my medical textbook on aging, “If age is a thief, then the greatest treasure we lose is ourselves.”

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[From CNN]

Human ‘mini brains’ grown in labs may help solve cancer, autism, Alzheimer’s

mini_brain

Story highlights

  • Ohio State biomedical research team grows nearly complete human ‘mini brain’
  • Brain organoids can be used to learn more about diseases like cancer, Alzheimer’s and Parkinson’s
  • Brain organoids could yield autism breakthrough within 10 years, researcher says

By Thom Patterson | Video Source: CNN
Read the full story CNN…

He is working with Dr Maria Blasco of the CNIO in Madrid to bring telomerase therapy to the USA. Their approach is similar to Bioviva where targeting the microglial cells with telomerase inducing gene therapy should in theory reverse the condition. Best of luck to Telocyte!

Telocyte | HomePage.

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My new and first article for The Daily Dot. It’s about transhumanism and the Immortality Bus tour:

BY ZOLTAN ISTVAN

Even though I was born after the 1960s, I’ve always been fascinated with that era. Some people credit Ken Kesey’s cross country bus trip aboard colorfully painted “Further” as helping to create a generation of hippies. Of course, my Immortality Bus (shaped to look like a coffin) wants to stir up the national consciousness as well, aiming to usher in its own cultural shift. Whereas the ‘60s were about peace, love, drugs, and sex, I believe the next decade will be about virtual reality, implants, transhumanism, and overcoming death with science. For futurists like myself, that’s quite an intoxicating mix.

The fact is that a lot of radical tech, science, and medicine are already here in America. Consider that today the paralyzed can walk via exoskeleton suits, the blind can see via bionic eyes, and the limbless can grab a bottle of water and drink with artificial limbs that connect to their nervous system. Additionally, lifespans are increasing for people all around the planet. Science is rapidly making the world a better place, and it’s starting to eliminate suffering and hardship for billions of people.

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“Dr Brouchkov, the head of the Geocryology Department at Moscow State University, first injected himself with the bacteria two years ago.

He claims he has not had flu since, and that he has also been able to work harder and longer without getting tired.”

A RUSSIAN scientist claims he has cracked the secret of ETERNAL LIFE after injecting himself with primordial GERMS.

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Could discovering how neural stem cells protect themselves from damage lead to treatment that helps combat aging?

We now know that stem cells in the brain do in fact divide, and that this regenerative capacity begins to falter with age. The majority of our cells don’t divide, and the bulk of division falls to stem cell niches dotted across our body. Stem cell populations do age, but they’re more resistant than ‘normal’ cells are, and they produce higher levels of telomerase — enabling them to divide for years.

How do brain stem cells remain free of damage?

Neural stem cells aren’t perfectly protected from aging, but they’re generally a hardier bunch. Scientists from the University of Zurich have now discovered that part of this aging resistance in neural stem cells is due to a ‘diffusion barrier’. When they divide, these cells produce a barrier which filters out damaged proteins to one side, allowing the new cell to be damage-free.

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Science usually approaches aging from a mechanical viewpoint, but could there be more to the story?

Why do so many scientists now believe that aging has been programmed by evolution?

Science usually approaches aging from a mechanical viewpoint, but the evolutionary theory of aging has gained more support as we observe the wide variation in aging between species.

The million dollar question: Why do we age?

Theories like the free radical theory of aging propose that aging is an inevitable process of being alive; that every day on this earth exposes the body to reactive chemicals, and aging is simply the gradual accumulation of damage. While we know the body does indeed accumulate forms of damage, the suggestion that this is inevitable is now being challenged.

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BioViva USA, Inc. has become the first company to treat a person with gene therapy to reverse biological aging, using a combination of two therapies developed and applied outside the United States of America. Testing and research on these therapies is continuing in BioViva’s affiliated labs worldwide.

BioViva CEO Elizabeth Parrish announced Biobthat the subject is doing well and has resumed regular activities. Preliminary results will be evaluated at 5 and 8 months with full outcome expected at 12 months. The patient will then be monitored every year for 8 years.

Gene therapy allows doctors to treat disease at the cellular level by inserting a gene into a patient’s cells instead of using the regular modalities of oral drugs or surgery. BioViva is testing several approaches to age reversal, including using gene therapy to introduce genes into the body.

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