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https://www.youtube.com/watch?v=yiRf5NClQ8A

Website: http://sensproject21.org/

Building the bridge to human clinical trials for rejuvenation biotechnologies.

INTERNET ENTREPRENEUR MICHAEL GREVE COMMITS $10 MILLION TO SENS RELATED RESEARCH AND STARTUPS INCLUDING A $5 MILLION DONATION OVER 5 YEARS TO SENS RESEARCH FOUNDATION.

The social and economic burdens of age-related disease are rising steeply. For an increasing number of older individuals, healthcare is too often reduced to crisis management in the emergency room, painfully harsh treatments for diseases such as cancer, or best efforts at palliative care.

It doesn’t have to be this way.

Project|21 is a new initiative created by SENS Research Foundation to end age-related disease through human clinical trials, starting in 2021, through investment in rejuvenation biotechnology. We have all the pieces in place–core research groups, key players, shared knowledge, and underlying tools—for the creation of this industry. Through three new programs, the Bridge fund, The Center of Excellence, and The Alliance Program, Project|21 will deliver the perfect environment for this fusion of opportunity and investment. With proper stewardship of this emerging industry, we can create an environment where the first damage repair interventions to address specific age-related disease will be brought to human clinical trials within five years.

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Awesome! Just imagine all the benefits that we will see through this research. Not only will we figure out more on the root cause of gene mutations, and cures including CRISPR; but also we will be more effective in mimicking the human system in synthetic systems, synthetic cell or gene circuitry, humanoids, synthetic immune systems, combat aging more effectively, etc.


With more data, a pioneer of gene sequencing hopes to unlock the connections between DNA and illness.

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MOUNTAIN VIEW, Calif. — July 11, 2016 — SENS Research Foundation today announced its Project|21 campaign to secure $50 million in private support from individual donors, foundations, and corporations. The goal of Project|21 is for SRF to partner with a new generation of visionary philanthropists, build the Rejuvenation Biotechnology industry, and bridge the most challenging gulf between research and treatment by enabling human clinical trials by 2021.

Aubrey de Grey, founder and chief science officer of SENS Research Foundation said, “Ending aging will require large-scale investment to flow into a globally-recognized industry for rejuvenation biotechnology. Since we began in 2009, SENS Research Foundation has been putting all the pieces in place — core research groups, key players, shared knowledge, underlying tools — for the creation of this industry. The key programs funded by Project|21 can create an environment where the first damage repair interventions addressing specific age-related diseases will be brought to human clinical trials within five years.”

The programs funded under Project|21 focus on three major barriers to the development of truly effective rejuvenation therapies. First, funding to convert promising basic research programs into solid investment candidates remains far too scarce. Second, there are too few opportunities for dynamic collaborations with mainstream regenerative medicine. Finally, there is little understanding of the regulatory pathways and clinical infrastructure these technologies will require. Project|21 addresses these three areas by creating a $15 million bridge fund to support promising early stage technologies; a center of excellence to deliver better opportunities for collaborative development of early stage programs; and a Rejuvenation Biotechnology Alliance Program to address challenges in regulation, manufacturing, and investment.

The first donation received for Project|21 is a commitment from German internet entrepreneur Michael Greve’s Forever Healthy Foundation for $5 million in philanthropic support over the next five years. In addition Michael Greve’s company KIZOO Technology Ventures will be committing seed investments of $5 million in startups focused on bringing rejuvenation biotechnology treatments to market.

For more information on the SENS Research Foundation visit www.sens.org. For information on Project|21 visit www.SENSProject21.org. For information on Michael Greve visit www.kizoo.com and www.forever-healthy.org.

Companion Press Release: “Internet Entrepreneur Michael Greve Commits $10 Million to SENS Related Research and Startups including a $5 Million Donation Over 5 Years to SENS Research Foundation.”

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Will we live longer lives in the future? According to Ray Kurzweil, it’s only a matter of time until technology begins successfully tackling age-related disease—and life expectancy grows longer and longer. At some point, technology will annually add more than a year to our life expectancy—allowing us to indefinitely increase lifespans, and perhaps eventually live as long as we want.

“We will get to a point where our longevity, our remaining life expectancy is moving on away from us. The sands of time will run in rather than run out,” Kurzweil says.

How will this happen? We’re now learning to reprogram biology to cure disease and repair the body. This will accelerate in coming decades and be followed by the nanotechnology revolution.

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A new finding in experiments studying the dry preservation of living cells — a potentially revolutionary alternative to cryopreservation — has defined a clear limit where continuing dehydration kills cells. The data, combined with molecular dynamics simulations, provides insight into an important processing factor that has limited recent attempts at dry preservation.

“What we have done is identified what appears to be a materials constraint in our method of dry preservation. I think this new understanding suggests some interesting avenues to pursue in developing a successful process,” said Gloria Elliott, Professor of Mechanical Engineering at the University of North Carolina at Charlotte, one of the study’s authors.

The findings, reported in the July 8 issue of Scientific Reports, analyzes changes in the molecular arrangements of trehalose (a sugar) and water molecules during a typical dehydration process that they use to immobilize cells in a stable trehalose glass for long-term storage.

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SENS has a fund match for its current campaign on lifespan.io, if you are concerned about cancer like me and you want to help directly fund a lab working on solutions please think about donating. smile


There is a month left to go in the SENS crowdfunding campaign that aims to accelerate development of an important component of a universal cancer therapy, a way to block the mechanisms of telomere lengthening that every type of cancer depends upon. The SENS Research Foundation and Lifespan.io volunteers are looking for donors to put up matching funds of a few thousand dollars or more, in order to take that news and that inducement to a number of conferences and other events over the next few weeks. More than 150 people have donated to the campaign to date, and we’d like to triple that number in the next 30 days.

To start things off, I’ll offer up $2,000 of my own funds: the next $2,000 in donations to this SENS cancer research initiative will be matched dollar for dollar. That is a start, and if you can join in to help out, please contact me to let me know. Can you help to make a difference here?

With last week’s $10 million pledge in support of other portions of the SENS rejuvenation research portfolio, we can clearly see that grassroots fundraising works. It lights the way, and as we grow the community and show our determination, that success draws in larger donors. When this is amply demonstrated by the arrival of large amounts of new funding … well, that is precisely the time to pile on and keep up the good work. All major medical research non-profits have several tiers of fundraising, from grassroots to high net work philanthropy, and all of these tiers are essential: they can’t exist without one another. The SENS Research Foundation is transitioning to become a solid organization with a high end tier of fundraising to complement our efforts, and that couldn’t exist without the support of the grassroots. It is a sign that we are winning.

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Researchers at the Stanford University School of Medicine found a way to trick human embryonic stem cells to become pure populations of any of 12 cell types, including bone, heart muscle and cartilage within days.

Scientists at the Stanford University School of Medicine have identified the sets of biological and chemical signals necessary to quickly and efficiently direct human embryonic stem cells. If successful, researchers could grow pure populations of any of 12 cell types, including bone, heart muscle and cartilage within days rather than the weeks or months previously required.

This is key toward clinically useful regenerative medicine – potentially allowing researchers to generate new beating heart cells to repair damage after a heart attack or to create cartilage or bone to reinvigorate creaky joints or heal from trauma.

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https://youtube.com/watch?v=VlGADx1s1zQ

It’s not just religious terrorism that is killing people. A religious anti-science culture—which most of us live amongst—also cuts short everyone’s lives. People simply don’t care much about longevity if they believe in an afterlife.


All around the world, religious terror is striking and threatening us. Whether in France, Istanbul, London, or the USA, the threat is now constant. We can fight it all we want. We can send out our troops; we can chip refugees; we can try to monitor terrorist’s every move. We can even improve trauma medicine to deal with extreme violence they bring us. But none of this solves the underlying issue: Abrahamic religions like Christianity and Islam are fundamentally violent philosophies with violent Gods. Sam Harris, Richard Dawkins, Christopher Hitchens and others have all reiterated essentially the same thing.

Consider these verses from the Koran:

Koran (3:56): As to those who reject faith, I will punish them with terrible agony in this world and in the Hereafter, nor will they have anyone to help.

Koran (8:12): I will cast terror into the hearts of those who disbelieve. Therefore strike off their heads and strike off every fingertip of them.

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Transhumanists will know that the science fiction author Zoltan Istvan has unilaterally leveraged the movement into a political party contesting the 2016 US presidential election. To be sure, many transhumanists have contested Istvan’s own legitimacy, but there is no denying that he has generated enormous publicity for many key transhumanist ideas. Interestingly, his lead idea is that the state should do everything possible to uphold people’s right to live forever. Of course, he means to live forever in a healthy state, fit of mind and body. Istvan cleverly couches this policy as simply an extension of what voters already expect from medical research and welfare provision. And while he may be correct, the policy is fraught with hazards – especially if, as many transhumanists believe, we are on the verge of revealing the secrets to biological immortality.

In June, Istvan and I debated this matter at Brain Bar Budapest. Let me say, for the record, that I think that we are sufficiently close to this prospect that it is not too early to discuss its political and economic implications.

Two months before my encounter with Istvan, I was on a panel at the Edinburgh Science Festival with the great theorist of radical life extension Aubrey de Grey, where he declared that people who live indefinitely will seem like renovated vintage cars. Whatever else, he is suggesting that they would be frozen in time. He may actually be right about this. But is such a state desirable, given that throughout history radical change has been facilitated generational change? Specifically, two simple facts make the young open to doing things differently: The young have no memory of past practices working to anyone else’s benefit, and they have not had the time to invest in those practices to reap their benefits. Whatever good is to be found in the past is hearsay, as far as the young are concerned, which they are being asked to trust as they enter a world that they know is bound to change.

Questions have been already raised about whether tomorrow’s Methuselahs will wish to procreate at all, given the time available to them to realize dreams that in the past would have been transferred to their offspring. After all, as human life expectancy has increased 50% over the past century, the birth rate has correspondingly dropped. One can only imagine what will happen once ageing can be arrested, if not outright reversed!

So, where will the new ideas of the future come from? The worry here is that society may end up being ruled by people with overlong memories who value stability over change: Think China and Japan. But perhaps the old Soviet Union is the most telling example, as its self-consciously revolutionary image gradually morphed into a ritualistic veneration of the original 1917 revolutionary moment. To these gerontocratic indicators, the recent UK vote to leave the European Union (‘Brexit’) adds a new twist. There were some clear age-related patterns in the outcome: The older the voter, the more likely to vote to leave – and the more likely to vote at all. To be sure, given the closeness of the vote (52% to leave vs. 48% to remain), had the young voted in comparable numbers to their elders, Brexit would have lost.

One might think that the simple solution is to encourage, if not force, the young to vote in larger numbers. However, this does not take into account the liabilities of their elders when it comes to dictating the terms for living in the future. Whatever benefits might accrue to people living longer, the clarity of the memories of such people may not be an unmitigated good, as it might incline them to perpetuate what they regard as the best of their own pasts. One way around this situation is to weight votes inversely to age. In other words, the youngest voters would effectively get the most votes and the oldest voters the least. This would continually force the elders to make their case in terms that their juniors can appreciate. The exercise would serve to destabilize any sense of nostalgia that members of the same generation might experience simply by virtue of having experienced the same events at the same age.

However, two technologically based solutions also come to mind. One is for the elderly to be subject to the strategic memory loss procedure described in the film, The Eternal Sunshine of the Spotless Mind, which might be understood as a the cognitive correlate of an inheritance tax – or even a high-class lobotomy! In other words, the elders would lose their personal attachment to events which would nevertheless remain available in the historical record for more detached scrutiny vis-à-vis their lessons for the future. The other, more drastic solution involves incentivizing the elders to exchange biological for digital immortality. This would enable them to enjoy a virtual existence in perpetuity. They might be resurrected (‘downloaded’) on a regular or simply a need-to-remember basis, depending on prior contractual arrangements. The former might be seen as more ‘religious’, as in a Roman Catholic feast day, and the latter more ‘secular’, as in an ‘on tap’ consultant. But in either virtual form, the elders could retain their attachment to certain past events with impunity while at the same time not inflicting their memories needlessly on present generations.

David Wood, the head of the main UK transhumanist organization, London Futurists, has recently published a summa of anti-ageing arguments, which makes a cumulatively persuasive case for indefinite life extension being within our grasp. But most assuredly, this would create as many social problems as it solves biological ones. Under most direct threat would be the sorts of values historically associated with generational change, namely, those related to new thinking and fresh starts. Of course, as I have suggested, there are ways around this, but they will invariably revive in a new high-tech key classic debates concerning the desirability of brainwashing and suicide.

Transhuman Terminology.

ADHOCRACY
AEONOMICS
A-LIFE
AGORIC SYSTEM

AI-COMPLETE ALEPH ALGERNON AMORTALIST ARACHNIOGRAPHY ARCH-ANARCHY ARCOLOGY ARROW IMPOSSIBILITY THEOREM ARTILECT ASEX ASIMORT ASIMOV ASSEMBLER ATHANASIA ATHANOPHY ATHEOSIS AUGMENT AUTOEVOLUTIONIST AUTOMATED ENGINEERING AUTOMORPHISM AUTOPOTENT AUTOSCIENT BABY UNIVERSE BASEMENT UNIVERSE BEAN DIP CATASTROPHE BEANSTALK BEKENSTEIN BOUND BERSERKER BETELGEUSE-BRAIN BIG CRUNCH BINERATOR BIOCHAUVINISM BIOLOGICAL FUNDAMENTALISM BIONICS BIONOMICS BIOPHILIAC BIOSTASIS B-LIFE BLIGHT BLIND UPLOADING BLUE GOO BOGOSITY FILTER BORGANISM BREAKEVEN POINT BROADCATCHING BRUTE FORCE UPLOADING BUSH ROBOT CALCUTTA SYNDROME CALM TECHNOLOGY CALORIE RESTRICTION CASIMIR EFFECT CEREBROSTHESIS CHINESE ROOM CHRONONAUTS CHURCH-TURING THESIS COBOTS COMPUFORM COMPUTRONIUM CONCENTRATED INTELLIGENCE CONSILIENCE CONNECTIONISM CONTELLIGENCE CONTINUITY IDENTITY THEORY COSMYTHOLOGY CRYOBIOLOGY CRYOCRASTINATE CRYOGENICS CRYONICS CRYONIC SUSPENSION CRYPTO ANARCHY CRYPTOCOSMOLOGY CYBERCIDE CYBERFICTION CYBERGNOSTICISM CYBERIAN CYBERNATE/CYBERNIZE CYBERSPACE/CYBERMATRIX CYBRARIAN CYPHERPUNK DEANIMALIZE DEATH FORWARD DEATHISM DEEP ANARCHY DEFLESH DIGITAL PSEUDONYM DIAMONDOID DISASSEMBLER DISASTERBATION DISTRIBUTED INTELLIGENCE DIVERGENT TRACK HYPOTHESIS DIVERSITY IQ DIVIDUALS DOOMSDAY ARGUMENT DOWNLOAD DRYWARE DUBIFIER DYSON SPHERE ECOCALYPSE ECTOGENESIS

EMBRYOMEME
EMULATION
ENHANCED REALITY
ENVIROCAPITALISM
EPHEMERALISTS
E-PRIME
ESCALATORLOGY
THE ETERNAL LIFE POSTULATE
EUPSYCHIA
EUTHENICS
EVOLUTIONARILY STABLE STRATEGY (ESS)
EVOLUTURE
EXCONOMICS
EXES
EXFORMATION
EXISTENTIAL TECHNOLOGY
EXOPHOBIA
EXOSELF
EXTROPIAN
EXTROPIATE
EXTROPIC
EXTROPOLIS
EXTROPY
FACULTATIVE ANAGOROBE
FAR EDGE PARTY
THE FERMI PARADOX
FEMTOTECHNOLOGY
FLATLANDER
FLUIDENTITY
FOGLET
FORK
FREDKIN’S PARADOX
FUNCTIONAL SOUP
FUTIQUE
FUTURE SHOCK
GALAXY BRAIN
GAUSSIAN
GENEGENEERING
GENETIC ALGORITHM
GENIE
GREEN GOO
GÖDEL’S THEOREM
GOLDEN GOO
GREAT FILTER, THE
GREY GOO
GUY FAWKES SCENARIO
HALLUCINOMEMIC
HIVE COMPUTING
HOMORPH
HPLD
HYPERTEXT
HYPONEIRIA
HYPOTECH

IDEAL IDENTITY
IMMORTALIST
IMMORTECHNICS
IMP
INACTIVATE
INFOGLUT
INFOMORPH
INFORMATION-THEORETICAL DEATH
INLINE UNIVERSITIES
INTERFACER
INTERNALNET
JUPITER-BRAIN
KHAKI GOO
KARDASCHEV TYPES
KNOWBOTS
KOLMOGOROV COMPELXITY
LEONARDO DA VINCI SYNDROME
LINDE SCENARIO
LIQUIDENTITY
LOFSTROM LOOP
LONGEVIST
MASPAR
MATAGLAP
MEGATECHNOLOGY (or MEGASCALE ENGINEERING)
MEMETICS
MEMIE
MEMIUS
MEMOTYPE
MEMOID (or MEMEOID)
MEHUM
MERCHANCY
MESOSCALE
MINDKIND
MOLMAC
MORPHOLOGICAL FREEDOM
MUTUAL REALITY
NANARCHIST
NANARCHY
NANITE
NANOCHONDRIA
NANOFACTURE
NANOMEDICINE
NANOSOME
NANOTECH
(MOLECULAR) NANOTECHNOLOGY
NEG
NEOMORPH
NEOLOGOMANIA
NEOPHILE
NEOPHILIA
NEOPHOBE
NEUROCOMPUTATION
NEURONAUT
NEURON STAR
NEUROPROSTHESIS
NEUROSUSPENSION
NOOTROPIC
NOW SHOCK
NUTRACEUTICAL
OFFLOADING
OMEGA POINT
OMEGON
OMNESCIENCE
O’NEILL COLONY
O’NEILL CYLINDERS
ONTOLOGICAL CONSERVATIVES
OPTIMAL PERSONA
PANCRITICAL RATIONALISM
ORBITAL TOWER
PARTIALATE
PATTERN IDENTITY THEORY
PERICOMPUTER
PERIMELASMA
PERSOGATE
PERVERSION ATTACK
PHARMING
PHYLE
PHYSICAL ESCHATOLOGY
PICO TECHNOLOGY
PIDGIN BRAIN
PINK GOO
PLEXURE
POME
POSTHUMAN
POSTJUDICE
POWERSHIFT
PRISONERS’ DILEMMA
PRIVACY MANAGEMENT
PROLONGEVITY
QUANTUM COMPUTING
QUANTUM CRYPTOGRAPHY
QUASISPECIES
RAPTURE OF THE FUTURE
RED GOO
RED QUEEN PRINCIPLE
RED QUEENED
REMEMBRANCE AGENT
REVERSIBLE
RIF
SANS CEILING HYPOTHESIS
SANTA MACHINE
SAPPER MEME
SCHEME
SENTIENCE QUOTIENT
SHIH
SINGULARITY
SINGULARITARIAN
SKY HOOK
SMART-FACED
SOCIOTYPE
SOLID STATE CIVILIZATION
SPIKE, THE
SPOCK MEME
SPONTANEOUS VOLUNTARISM
SPACE FOUNTAIN
STAR LIFTING
STELLAR HUSBANDRY
STEWARD
STRONG AI POSTULATE
STRONG CONVERGENCE HYPOTHESIS
SUSPENDED ANIMATION
SYNTHESPIAN
TAZ/Temporary Autonomous Zone.
TECHNOCYTE
TECHNOSPHERE
TECHNOCALYPS
TELEOLOGICAL THREAD
THEORETICAL APPLIED SCIENCE
TITHONUS SYNDROME
TIPLER CYLINDER
TIPLERITE
TRANSBIOMORPHOSIS (TRANSBIOLOGICAL METAMORPHOSIS)
TRANSCEND
TRANSCENSION
TRANSCIENT
TRANSCLUSION
TRANSHUMANISM
TRANSHUMANITIES
TRAPDOOR FUNCTION
TURING MACHINE
TURING TEST
ÜBERGOO
UBIQUITOUS COMPUTING
UPLIFT
UPLOADER
UNIVERSAL CONSTRUCTOR
UNIVERSAL IMMORTALISM
UNIVERSAL TURING MACHINE
UTILITY FOG
VACCIME
VASTEN
VENTURISM
VIEWQUAKE
VIRIAN
VIRION
VIRTUAL COMMUNITY
VIRTUAL RIGHTS
VITOLOGY
VIVISYSTEM
VON NEUMANN MACHINE
VON NEUMANN PROBE
WEBORIZE
WETWARE
WORMHOLE
XENOBIOLOGY
XENOEVOLUTURE
XEROPHILIA
XOXER
ZERO KNOWLEDGE PROOF


This may not be the best possible neologism for this sort of entity, but I think it’s a good idea on principle to generate neologisms. They are good for us and solidify our thinking. Bruce Sterling, Speech at Lifelike Computer Characters ‘95.

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