Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension

Time to reimagine aging.

2016-09-02-1472779608-3740299-girlapple.png

Caption: Woman taking apple of youth (Image credit)

This article first appeared on the blog of Intentional Insights, a nonprofit organization that empowers people to refine and reach their goals by providing research-based content to help improve thinking, feeling, and behavior patterns.

Can you imagine what it would be like to be young and healthy forever? What a wonderful dream! Envision a body that stays strong and fit and beautiful, a mind dynamic, flexible, and sharp — for decades, centuries, even millennia.

Read more

Classifying aging as a disease, the debate is hotting up as ICD11 at WHO draws near.

What is considered to be normal and what is considered to be diseased is strongly influenced by historical context (Moody, ). Matters once considered to be diseases are no longer classified as such. For example, when black slaves ran away from plantations they were labeled to suffer from drapetomania and medical treatment was used to try to “cure” them (Reznek, ). Similarly, masturbation was seen as a disease and treated with treatments such as cutting away the clitoris or cauterizing it (Reznek, ). Finally, homosexuality was considered a disease as recently as 1974 (Reznek, ). In addition to the social and cultural influence on disease definition, new scientific and medical discoveries lead to the revision of what is a disease and what is not (Butler, ). For example, fever was once seen as a disease in its own right but the realization that different underlying causes would lead to the appearance of fever changed its status from disease to symptom (Reznek, ). Conversely, several currently recognized diseases, such as osteoporosis, isolated systolic hypertension, and senile Alzheimer’s disease, were in the past ascribed to normal aging (Izaks and Westendorp, ; Gems, ). Osteoporosis was only officially recognized as a disease in 1994 by the World Health Organization (WHO, ).

Disease is a complex phenomenon and a current definition must consider both a biological and social explanation. The medical definition of disease is any abnormality of bodily structure or function, other than those arising directly from physical injury; the latter, however, may open the way for disease (Marcovitch, ). The disorder has a specific cause and recognizable signs and symptoms, and can affect humans, other animals, and plants (Martin, ). The social aspect of disease is significant when trying to divide a line between a healthy and a pathological state. This is a highly context and value driven process and, considering the WHO definition of health as a “state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity,” it is not as simple as classifying disease as the opposite of health (WHO, ). “Someone starving to death is not taken to have a disease, but is still not considered healthy” (Reznek, ).

Read more

How society can profit from treating age-related diseases.

We’re now living longer than ever – only to suffer from diseases of old age. New therapies promise a new lease of life for the elderly – and big profits for investors, says Matthew Partridge.

Over the past century, average life expectancy in most countries has grown substantially. Vastly lower infant mortality, improved living standards, better public sanitation, and the discovery of cures or vaccines for many once-deadly diseases, have seen average life expectancy in most developed nations rise to around 80, compared with 50 in 1900. Developing nations have benefited too. Life expectancy in China, for example, was just 43 in 1960 – it’s 75 today. Indeed, according to the World Health Organisation, no individual nation outside Africa now has a life expectancy of below 60, and even Africa has seen huge gains since 2000, helped by improved anti-malarial measures and wider availability of HIV/Aids treatments.

However, the pace of progress is slowing. From 1900, it took less than 30 years for life expectancy in the US to rise from 50 to 60 years. It took another 40 years to rise to 70, and now, nearly 50 years later, it is still hovering at just below 80. The problem is that while we’ve largely beaten the diseases that used to kill people in childhood, early adulthood and even middle age, we’re having much less success in prolonging the life of the elderly. Here’s a stark illustration: in Britain in 1840, if you made it to 65, you could expect, on average, to die at age 76. In 2011, a 65-year-old could expect to die aged 83. In other words, today you have a far better chance of living to 65 than you did 170-odd years ago. But if you do, your remaining life expectancy won’t be much greater than that of your 19th-century peers.

Read more

My new story for TechCrunch on why a new generation of kids might “really” love robots. What would Freud say?

Robots intrigue us. We all like them. But most of us don’t love them. That may dramatically change over the next 10 years as the “robot nanny” makes its way into our households.

In as little time as a decade, affordable robots that can bottle-feed babies, change diapers and put a child to sleep might be here. The human-machine bond that a new generation of kids grows up with may be unbreakable. We may end up literally loving our machines almost like we do our mothers and fathers.

I’ve already seen some of this bonding in action. I have a four-foot interactive Meccanoid robot aboard my Immortality Bus, which I’ve occasionally used for my presidential campaign. The robot can do about 1,000 functions, including basic interaction with people, like talking, answering questions and making wisecracks. When my five-year-old rides with me on the bus, she adores it. After being introduced to it, she obsessively wanted to watch Inspector Gadget videos and read books on robots.

My two daughters (the other one is two years old) have always been near technology, and both were able to successfully navigate YouTube watching videos on iPhones by the time they were 12 months old. Yet, while my kids love the iPhone, and they want to use it regularly, it doesn’t bond them to technology in a maternal sense like the Meccanoid robot does. More importantly, the smartphone doesn’t bond them to technology in an anthropomorphic sense — where one gives technology human attributes, like personalities.

Read more

More progress in repairing damage to the cornea which could have implications for aging research as well as for injury.

Media Contacts: Suzanne Day Media Relations, Mass. Eye and Ear 617−573−3897 [email protected]

New findings may pave the way for the development of pharmaceutical therapies to reverse corneal scarring

Boston, Mass. — In cases of severe ocular trauma involving the cornea, wound healing occurs following intervention, but at the cost of opaque scar tissue formation and damaged vision. Recent research has shown that mesenchymal stem cells (MSCs) — which can differentiate into a variety of cells, including bone, cartilage, muscle and fat cells — are capable of returning clarity to scarred corneas; however, the mechanisms by which this happens remained a mystery — until now. In a study published online today in Stem Cell Reports, researchers from Schepens Eye Research Institute of Massachusetts Eye and Ear have identified hepatocyte growth factor (HGF), secreted by MSCs, as the key factor responsible for promoting wound healing and reducing inflammation in preclinical models of corneal injury. Their findings suggest that HGF-based treatments may be effective in restoring vision in patients with severely scarred corneas.

Read more

Interesting article that suggests Acne sufferers may live longer.

Spotty teenagers may have the last laugh over their peers with perfect skin after research found that those who suffer from acne are likely to live longer.

Their cells have a built-in protection against ageing which is likely to make them look better in later life, a study has found.

By the time she reaches middle age, the spotty girl who could never find a boyfriend could be attracting envious glances from her grey and wrinkly peers.

Read more

How we can use CRISPR/Cas9 to treat the processes of aging.

Oliver Medvedik, Cofounder of the Life Extension Advocacy Foundation and the Lifespan.io Crowdfunding platform, discusses the CRISPR/Cas9 gene editing system in depth and highlights how it may be used to help overcome the diseases and disabilities of aging. He also gives an overview of other promising areas in aging research, such as senescent cell-clearing drugs, or “senolytics”, and “augmentive” compounds that may help restore the body to youthful functionality.

Support our campaigns: https://www.lifespan.io/

Read more

Please sign this petition to the NIH to help get more funding for aging research.

Every year about two million Americans die of illnesses doctors cannot cure. Cancer afflicts 50% of men and 30% of women. Five hundred and ninety five thousand Americans will die of cancer this year. Millions get heart diseases, strokes, etc. Every year 1,612,552 Americans die of the top 8 illnesses that doctors are unable to cure. Over a 30-year period, 48,376,560 United States citizens will die of the top 8 illnesses. Let us not forget other disabling and potentially curable illnesses. How much is it worth to save them? We have the resources and opportunity to cure age-related disease.

History has shown that medical research actually saves money. We now spend three trillion two hundred billion dollars yearly for health care. The health care expenditures will increase as our population grows with more senior citizens.

Every year we also spend hundreds of billions of dollars for services such as Social Security Disability, welfare, food stamps, special transportation, etc. Medical research will help cut down on the need for these services. It will also extend our lives.

Read more