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In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite called NAD+ that is critical for cellular energy production and protection against stress and DNA damage.

Levels of NAD+ (first discovered by biochemists in 1906) diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline.

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For the past two years, Zoltan Istvan has been campaigning for the US presidency on the Transhumanist Party, a largely one-man show which nevertheless remains faithful to the basic tenets of transhumanism. Now suppose he won. Top of his policy agenda had been to ensure the immortality of all Americans. But even Zoltan realized that this would entail quite big changes in how the state and society function. So, shortly after being elected president, he decides to hold a national referendum on the matter.

The question on the ballot is one that makes the stakes crystal clear: ‘The government shall endeavour to release all Americans from the constraints of mortality’. Zoltan liked this way of putting things because were he to lose to the referendum, which he half-presumed, the opportunity to air publicly the relevant issues would continue to shift naysayers in Congress to increase funding for broadly anti-death research and treatments — a step in the right direction, as far as he’s concerned.

Zoltan also liked the idea that the referendum effectively ‘rotated the political axis’, from left-right to up-down, a turn of phrase he picked up from some philosopher whose name he couldn’t remember. But this also meant that the ensuing campaign, which was fierce, attracted a motley crew of supporters on both sides.

The ‘Remainers’ (as the anti-immortalists call themselves) were composed of a mix of traditional religious believers, environmental activists and hard-headed sceptics who distrust all transcendental hype, whether it comes from religion or science. In other words, those who wanted us to remain in our normal bodies held that our fate either is confined to our current circumstances or requires that we remain in those circumstances in order for something better to happen post mortem. The stakes were so high that even the Pope was called out to argue the case, which of course he was more than happy to do, Obama-style.

On the other hand, the ‘Leavers’ who espouse immortality were an even more mixed bag. Some on the ‘soft’ side of the argument wanted us to remain in our biological bodies, but in a fortified form that makes us forever resistant to foreign agents. Thus, the prospect of reversing the ageing process got sold as an indefinite productivity booster, allowing us to do what we already do but without the constraints imposed by age and death. In contrast, the ‘hard’ side wanted us to leave our biological bodies altogether and enter into the relatively unregulated realm of ‘digital immortality’, which was sold as enabling us to interact with a broader range of agents than we could otherwise do, both on Earth and maybe even in the cosmos. Indeed, various interfaces were being developed that would enable us to exchange data easily with all sorts of non-human beings to mutual benefit. And matters could go much further – even towards a ‘Singularity’, a universal free trade data zone! However, none of this could be brought to fruition unless we first release ourselves from various codes and norms that inhibit their development and use.

It turns out that the Leavers managed to suppress their differences during the campaign and surprisingly eked out a narrow win. But what was President Zoltan to do? Understandably he wanted to keep his options open with regard to how immortality is implemented. So the first thing he did was to appoint a cabinet with a broad church of Leavers on board, and so both Aubrey de Grey and Ray Kurzweil figured prominently. But these guys pulled the implementation of Leave in opposing directions. De Grey wanted to focus on a radical extension of conventional medical research. Indeed, when de Grey first heard that President Zoltan was holding a referendum, he was concerned that ‘immortality’ might mean only the digital immortality favoured by Kurzweil, which de Grey regards as a complete fantasy.

By the time the referendum campaign began, Zoltan had managed to get Congressional approval to increase funding and loosen regulation in ways that enabled various pro-immortality research projects to move forward at an unprecedented pace. However, as the campaign progressed, it became clear that the soft immortalist side was lagging: There appeared to be much greater cellular complexity to the reversal of ageing than de Grey and his colleagues had imagined.

Meanwhile a clever tech entrepreneur, inspired by the economist Robin Hanson, had figured out a way to scan living brains for purposes of uploading them into machines capable of enhancing their computational power indefinitely. These brain emulations (or ‘ems’) are indeed at least in principle immortal, but at the cost of leaving the original human in a state of disorganized mush, which is to say, biologically ‘dead’. Because Zoltan had already de-regulated all transhumanist-related industries, the ‘ems’ end up dominating the market, with large public relations firms emerging to persuade people that they will live better lives by abandoning their biological bodies and uploading into what some liken to Star Trek’s Borg.

After a few generations, Earth had earned a reputation as the most rational death cult in the cosmos.

And they all ‘lived’ happily ever after…

People have been hunting down the legendary fountain of youth since antiquity. Does it exist? Could it ever, even theoretically, exist? A Russian scientist named Dr. Anatoli Brouchkov believes it’s out there, and he thinks he found it in 3.5-million-year-old bacteria. So what does Dr. Brouchkov do next? Inject himself with it, of course.

The bacteria, Bacillus F, was discovered in Siberia in 2009. The bacteria was at once impressive because, despite being roughly 3.5 million years old, it was alive in Siberian permafrost. Brouchkov believes there is a mechanism in this bacteria that allowed it to stay alive in the frost for millions of years. Hey, if bacteria can do it, so can we, right? Who knows, but Dr. Brouchkov was eager enough to experiment with that thought to inject himself with the stuff. Though it’s hard to say if the bacteria “worked” to make the scientist immortal, Dr. Brouchkov claimed in 2015 that he’s feeling better than ever. Only time will tell the rest of his story… Hear more about the unbelievable tale in the video below.

Has he found the fountain of youth?

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Further criticism of the Nature article from Wednesday that suggested there was a limit to lifespan.


We’ve known there is a ‘natural’ maximal human life span for a while, but it would be extraordinarily naive to believe it will always be so

In the latest study published in Nature, researchers claim that human life span has a fundamental limit of around 115. This has been widely publicised around various news platforms, and has proved highly controversial, with many taking sides or making rather grandiose claims about future trajectories. After observing trends in survival from 1900 onwards, the team discovered that maximal life span has plateaued; forming a ceiling at around 115–120 years. Jeanne Calment is so far the longest lived (verified) person in history, passing away at an extensive 122 years. Despite dying in 1997, no one has surpassed her title in over 10 years. The research repeats previous observations and analysis suggesting that without intervention there is indeed a limit to human life span, and that it is exceedingly rare to approach this limit at all; explaining why Calment remains unchallenged.

“It is disheartening how many times the same mistake can be made in science and published in respectable journals” — James W. Vaupel, the director of the Max-Planck Odense Center on the Biodemography of Aging

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A great new biomarker for senescent cells is available and will allow researchers to more measure levels of aged cells easier and faster. Great news for gerontologists wishing to demonstrate changes to aged cell populations after therapies.


Scientists have discovered a new way to look for ageing cells across a wide range of biological materials; the new method will boost understanding of cellular development and ageing as well as the causes of diverse diseases.

Frustrated by the limitations of commercially available biomarkers — researchers led by The University of Manchester’s Professor Paul Townsend and senior author of the resulting paper, and honorary professor at Manchester, Professor Vassilis Gorgoulis, have developed a universally applicable method to assess senescence across biomedicine, from cancer research to gerontology.

Cellular senescence is a fundamental biological process involved in every day embryonic and adult life, both good – for normal human development – and, more importantly to researchers, dangerous by triggering disease conditions. Up to now available senescence detecting biomarkers have very limited and burdensome application. Therefore, a more effective, precise and easy-to-use biomarker would have considerable benefits for research and clinical practice.

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Rapamycin could lead to the development of drugs to delay some aspects of aging in particular the immune systems decline with age.


Nearly a decade of research showing that Rapamycin makes mice live up to 60% longer, scientists are trying it out as an anti-aging drug in dogs and humans.

Researchers at the University of Washington’s Dog Aging Project gave rapamycin to 16 dogs and imaged their hearts.

“It started to function better. It started to look like a more youthful heart,” said Matt Kaeberlein, co-director of the Dog Aging Project, who has presented this research at conferences but hasn’t yet published it.

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Circa News, a millennial site, did a story on transhumanism and my campaign. There are 3 videos embedded into this article (a general one on transhumanism, one on using tech to help the environment, and one on a Universal Basic Income):


WATCH | Zoltan Istvan thinks all sentient beings — including, but not limited to humans, artificial intelligence and cyborgs — have the right to be immortal. And that right should be protected under law.

Which is why, naturally, he decided to run for president of the United States.

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In Brief.

  • New research concludes that human lifespan has already reached its peak of 125 years.
  • The research does not take into account synthetic biology and advancements in biotech that could extend lifespans further.

Scientists at the Albert Einstein College of Medicine assert that they have discovered the maximum lifespan of human beings, and it’s a range we may no longer be able to exceed. Dr. Jan Vijg, professor of ophthalmology and visual sciences at Einstein, lead the research, which was published online today in the journal Nature.

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Scientific progress is being held back by established experts who lack ambition and vision.


The mainstream of aging research, at least in public, is characterized by a profound lack of ambition when it comes to treating aging as a medical condition. Researchers talk about slightly altering the trajectory of aging as though that is the absolute most that is possible, the summit of the mountain, and are in many cases ambivalent when it comes to advocating for even that minimal goal. It is this state of affairs that drove Aubrey de Grey and others into taking up advocacy and research, given that there are clear paths ahead to rejuvenation, not just a slight slowing of aging, but halting and reversing the causes of aging. Arguably embracing rejuvenation research programs would in addition cost less and take a much shorter span of time to produce results, since these programs are far more comprehensively mapped out than are efforts to produce drugs to alter the complex operations of metabolism so as to slightly slow the pace at which aging progresses. It is most frustrating to live in a world in which this possibility exists, yet is still a minority concern in the research community. This article is an example of the problem, in which an eminent researcher in the field takes a look at a few recently published books on aging research, and along the way reveals much about his own views on aging as an aspect of the human condition that needs little in the way of a solution. It is a terrible thing that people of this ilk are running the institutes and the funding bodies: this is a field crying out for disruption and revolution in the name of faster progress towards an end to aging.

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