http://www.ivoox.com/programa-4x8-inmortalidad-gran-desafio-de-audios-mp3_rf_23260454_1.html
Category: life extension
Summary: Google’s ultra-secretive Calico Labs announces a significant discovery – the naked mole rat is the first and only non-aging mammal and shows little signs of aging as it gets older. [This article first appeared on the website LongevityFacts.com. Author: Brady Hartman. ]
With wrinkly skin and completely bald, the naked mole rat is one of the ugliest creatures around but lives an exceptionally long life for a small mammal. It rarely develops the chronic diseases of aging such as cancer and lives 10 times longer than regular rats.
The First Non-Aging Mammal
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https://www.intouchrugby.com/magazine/feature-diet-nutrition-changing-look-bio-chemical-standing-energy-rich-state-improving-immunity-age-resistence-using-natural-plants-herbs-poultries-feature-part-1/
In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.
In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.
Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), a novel co-inhibitory receptor, was upregulated in CD8 + T cells of elderly adults. Aged TIGIT + CD8 + T cells expressed high levels of other inhibitory receptors including PD-1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor CD28, representative intrinsic transcriptional regulation, low production of cytokines, and high susceptibility to apoptosis. Importantly, their functional defects associated with aging were reversed by TIGIT knockdown.
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That wisdom from Ecclesiastes is the theme of five new novels, which, if they did not give me a taste of immortality, at least made me feel like the week would never end. The coincidence of their arrival is a little creepy, but it suggests the growing relevance of this subject for a generation reviewing itineraries to the undiscovered country with deep ambivalence. In shades of comedy and tragedy, realism and fantasy, these contemporary authors dig up a lot of old conceits and, like Dr. Frankenstein, zap them to life with mixed results.
The dark side of immortality: “How to Stop Time,” “Eternal,” “The Immortalists,” “Immortal Life” and “The Afterlives.”
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