Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

ATLANTA—A molecule produced during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to blood vessels, such as cardiovascular disease, according to a study led by Georgia State University.

“As people become older, they are more susceptible to disease, like cancer, cardiovascular disease and Alzheimer’s disease,” said Dr. Ming-Hui Zou, senior author of the study, director of the Center for Molecular and Translational Medicine at Georgia State and a Georgia Research Alliance Eminent Scholar in Molecular Medicine. “Age is the most important so-called risk factor for human disease. How to actually delay aging is a major pathway to reducing the incident and severity of human disease.

”The most important part of aging is vascular aging. When people become older, the vessels that supply different organs are the most sensitive and more subject to aging damage, so studying vascular aging is very important. This study is focused on vascular aging, and in old age, what kind of changes happen and how to prevent vascular aging.”

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From the perspective of critics, there are many reasons to be concerned about the rise of artificial intelligence.

Billionaire inventor Elon Musk — perhaps the world’s most vocal AI antagonist — has warned that the technology could become “an immortal dictator from which we would never escape.”

Several years before his death, Stephen Hawking, the renowned theoretical physicist, said artificial intelligence could bypass biological evolution, leaving humans unable to compete.

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Today, we are going to take a look at the topic of NAD+, its precursor, nicotinamide mononucleotide, and the debate surrounding the ability of these molecules to pass through the cell membrane.

NAD+ is critical for cellular function

Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor, but it is also a critical signaling molecule that regulates cell function and survival in response to environmental changes such as nutrient intake and cellular damage. Age-related changes to the level of NAD+ in the cell impacts mitochondrial function, nutrient sensing and metabolism, redox reactions, circadian rhythm, immune and inflammatory responses, DNA repair, cell division, protein-to-protein signaling, chromatin, and epigenetics.

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An interesting article in Forbes on GDF11, anti-aging drugs and companies:

For an example of how hard it is to develop an anti-aging medicine, check this out. It’s some of the coolest and creepiest science to have been published in major academic journals. But is it ready to form the basis of a pharmaceutical company?

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I know 100 leaders in longevity area. All of them will be invited to the Longevity Impact Forum, to create sort of Alibaba of longevity. We can beat government agencies and big companies because of our spirit!

“Underdog” entrepreneur Jack Ma is now famous for his record setting IPO when he took his e-commerce company, Alibaba, public. But not many people know he started Alibaba in his one-room apartment with 17 friends. Watch where all the magic of Alibaba started and be sure to check out Jack Ma’s amazing life.

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David Gobel was the first to put forward the concept of longevity escape velocity, or LEV. How far are we from LEV, assuming the current pace of research and no serious showstoppers?

Twelve years, or 2030, is David’s best guess based on what is known today.

David Gobel cofounded the Methuselah Foundation with Aubrey de Grey and continues to run the Methuselah Foundation today.

Methuselah Foundation has given millions of dollars to regenerative medicine research, backing ventures such as Organovo, Oisin Biotechnologies, and SENS Research Foundation.

Organovo invented and is now selling high-fidelity 3D human liver and kidney tissues to the research market, is providing contract services, and is on track to deliver a 3D liver patch to the clinic in two years.

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What does it feel like when you know your doctor can’t really help you?

Some time ago, I noticed a stock photo of an old lady seeing her geriatrician, who was a much younger woman. Nothing special was happening in the picture, which showed just two people talking; however, it made me wonder what it must feel like to be an elderly person consulting a geriatrician.

One initial assumption could be that it isn’t much different than seeing a GP, but that seems unlikely. If you are seeing a GP, the odds are your disease or ailment is not debilitating, let alone life-threatening. Whatever it might be, you went to see your doctor knowing that, most likely, he or she would be able to cure you; especially if you are young, it’s probable that just taking a medicine for some time, or doing physical therapy, will make you better. You know that you will recover, and the discomfort or the suffering you’re going through is destined to go away. You will get back to your life as it used to be, healthy as ever.

Things are rather different when you are seeing a geriatrician. A geriatrician is a specialist who takes care of the needs of elderly patients, an activity that can be summarized as ensuring the highest possible life quality of a patient in spite of his or her failing body, which becomes increasingly less resilient and less able to respond to treatment with the passing of time. Existing drugs and exercise programs, for example, can ameliorate the symptoms that an elderly person experiences and improve his or her life quality, but the vast majority of age-related diseases simply cannot be cured right now.

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Lowell interviews the always fascinating Professor George Church in this new podcast series about aging research. Lifespan.io will be appearing on the show soon too so watch this space bigsmile

Harvard & MIT Professor, author of Regenesis, methods for 1st genome sequence (1994) & 10M-fold improvements (NGS, nanopore), genome editing, writing and recording. In this episode, we get to talk about Genghis Khan, Woolly Mammoth, storing data in DNA, advice for people getting started, and more all in under one hour!

George is one of the most interesting and down to earth people you’ll read about (might be from the future or an alien, but cannot confirm). He is always working to make all of our lives better. Anytime you are looking for inspiration, do what I do, and learn about what he and his team are working on. I always feel like I can do anything after reading or listening to the current things he is working on. I hope to one day contribute like he does! As a side note: I am working on something that was inspired from our discussion, so we shall see how that goes. If anyone is inspired after listening to him talk, please email me and let me know. We can start a fan group around George and scientists in general. Scientists are the unsung superheros of our society! Also, scroll down to the bottom to see the breadth of his work. I felt like it should be put here in it’s entirety. Hyperlinked show notes will go up tonight for this episode and the previous ones that are lacking them!

“George Church, professor at Harvard & MIT, co-author of 480 papers, 130 patent publications & the book ”Regenesis”, developed methods used for the first genome sequence (1994) & million-fold cost reductions since (via NGS and nanopores), plus barcoding, DNA assembly from chips, genome editing, writing & recoding. He co-initiated the BRAIN Initiative (2011) & Genome Projects (1984, 2005) to provide & interpret the world’s only open-access personal precision medicine datasets.

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Today, we want to point out a new publication that dives into the world of senolytics, which are drugs or therapies that seek and destroy harmful non-dividing cells that resist the programmed cell death known as apoptosis.

These cells linger in the body, and, as we age, more and more of them accumulate and contribute to the chronic age-related inflammation known as “inflammaging” while reducing tissue regeneration and repair and contributing to the development of various age-related diseases.

One approach to dealing with these problem cells is to tip them over the edge and cause them to self-destruct, thus removing them and the inflammation they cause. A new class of drugs known as senolytics was discovered a few years ago, and the interest in developing them to potentially combat age-related diseases has been growing rapidly.

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An in depth print cover story out on life extension by Forbes Africa—probably destined to become one of the main go-to articles for people on the continent seeking info on the topic. Myself, Aubrey de Grey, and others are featured in it. Excited to see #Africa join the race to overcome death and disease:

Science is pumping in billions searching for solutions that will help humans live longer – and better – and one day even indefinitely.

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