New research has revealed that fisetin – a natural flavonoid found in many fruits and vegetables – functions as an effective senolytic agent by clearing out damaged aging cells, improving health and extending lifespan.
Category: life extension
Recently, we have shown that by administering the NAD+ precursor NMN (Nicotinamide Mononucleotide)in normal drinking water to older mice, NAD+ levels were restored to those normally associated with younger healthy animals. By administering NMN to mice for just one week, our lab demonstrated a robust correction in age-associated metabolic dysfunction and restored muscle mitochondrial function in old mice to levels seen in younger control mice (Gomes et al. 2013).
https://www.lifespan.io/campaigns/can-nmn-increase-longevity/?mc_cid=9f24c0f697&mc_eid=019dfcda6c
Dr. Aubrey De Grey, SENS Foundation, Co-Founder, talks of species that live hundreds of years. We have to understand metabolism and postpone old age.
How can reverse aging by improving repair mechanism. Cells die, and the waste as well as energy byproducts to avoid tissue breakdown with methyl donors.
Cellular senescence is one phenomenon by which normal cells cease to divide. In their seminal experiments from the early 1960’s, Leonard Hayflick.
Senescent cells increase in many tissues with aging; they also occur in organs associated with many chronic diseases and after radiation or chemotherapy. Senolytics are a class of drugs that selectively eliminate senescent cells.
Cancer cells are immortal, why?
Celebrate Unlimited Life Spans and a presentation by Bill Faloon on Human Age Reversal.
Bill Faloon will give an update on Age Reversal, similar to a presentation that he shared at RAAD Fest 2018!
Bill Faloon compiled the 1,500-page medical reference book Disease Prevention and Treatment, and his latest book is Pharmocracy: How Corrupt Deals and Misguided Medical Regulations Are Bankrupting America—and What to Do About It. He is also Director and Co-founder of the Life Extension Foundation.
To promote Life Extension’s innovative medical concepts, Bill has been featured in hundreds of media appearances including The Phil Donahue Show, The Joan Rivers Show, Tony Brown’s Journal, ABC News Day One, and Newsweek magazine.
Church of Perpetual Life, a science-based church is open to people of all faiths & belief systems. We are non-denominational & non-judgmental and a central gathering place of Transhumans. What unites us is our common faith, belief, and desire in Unlimited Life Spans.
Sometimes, people say that around 80 years of life will be enough for them, but have they thought it through?
When asked how long they want to live, people often say no more than ten years above their country’s average lifespan. This, mind you, is in a world where aging is still inevitable; people know they won’t be in top shape during those ten extra years, and yet, perhaps hoping they might be an exception to that rule, they still wish they could get that little extra time. Even when told that they will live these extra years in complete health, the most common choice is the current maximum recorded human lifespan, which is roughly 120 years.
If we assume that no rejuvenation therapies are available to extend the time you spend in youthful health, then it is somewhat understandable if you don’t feel up for a very long life, because the odds are that its final decades will be increasingly miserable ; however, if rejuvenation therapies were available, and you could be fully healthy for an indefinite time, why stop at 120 years? Life extension advocates have probably all had their fair share of conversations with people who insist that 80-odd years will be more than enough for them, health or no health—worse still, some don’t care about preserving their health precisely because they think that 80 years is a sufficiently long time to live.
How long one wants to live is only his or her business; just like no one should have the right to force other people to live no longer than the current maximum (an imposition that would indirectly result from a hypothetical ban on life extension therapies), no one should have the right to force anyone else to live longer than 80 years, if that’s what he or she wishes for whatever reason. Indeed, it’s not the right to die when you see fit that’s at issue here; the question is whether people who claim that 80 years are enough have seriously thought the matter through before making their minds up or are simply parroting what others typically say out of social pressure.
Today, we want to bring your attention to a recent mouse study on fisetin, a commonly available supplement that has proven effective at destroying senescent cells.
What are senescent cells?
As we age, increasing amounts of our cells enter into a state known as senescence. Normally, these cells destroy themselves by a self-destruct process known as apoptosis and are disposed of by the immune system. Unfortunately, as we age, the immune system declines, and increasing numbers of senescent cells escape apoptosis and accumulate in the body.
Previous research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life. They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.
https://www.youtube.com/watch?v=EX1PiRyIOis
Today, we have another video from our Ending Age-Related Diseases 2018 conference, which was held earlier this year at the Cooper Union in New York City. The conference was designed to bring the worlds of research and investment together in one place and explore the progress and challenges that the industry faces in developing and funding therapies to end age-related disease.
This was the second panel during the conference and featured Dr. Aubrey de Grey of the SENS Research Foundation, Keith Comito of Lifespan.io, Dr. James Peyer of Apollo Ventures, Dr. Mark Hammond of Deep Science Ventures, Joe Betts Lacroix of Y Combinator and Vium, Dr. Oliver Medvedik of Lifespan.io and The Cooper Union, and Ramphis Castro of ScienceVest.