Sputnik’s interlocutor has a medallion with a phone number and instructions for what to do if he dies. So it’s highly likely that if he dies he will end up where he and Sputnik have come.
Freeze Your Own Grandma
Danila Medvedev is a 38-year-old futurist, transhumanist and Chairman of the board of the Russian company KrioRus. The company was founded in 2006 and, as you can guess from its name, deals with the question of how to preserve the bodies of dead people for a future awakening.
https://youtube.com/watch?v=6A1knkZiysQ
Senolytics are the first therapies that directly target the aging process to delay or prevent age-related diseases and are now in human trials. Today we thought it was the ideal time to have a look at how they work and the companies involved.
Senescent cells and aging
As we get older, more and more of our the cells in our bodies become dysfunctional and enter into a state known as senescence. These senescent cells no longer divide or support the tissues and organs of which they are part; instead, they secrete a range of harmful inflammatory chemical signals, which are known as the senescence-associated secretory phenotype (SASP).
As we get older, more and more of our the cells in our bodies become dysfunctional and enter into a state known as senescence. These senescent cells no longer divide or support the tissues and organs of which they are part; instead, they secrete a range of harmful inflammatory chemical signals, which are known as the senescence-associated secretory phenotype (SASP).
For more aging research news visit: https://www.leafscience.org/
1st conference upcoming in Nov. 2018, in Spain.
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Today, we have a talk by Dr. Alvaro Macieira-Coelho, who discusses how aging is a consequence of thermodynamics and entropy. Quite simply, aging is the default for most species.
Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. The event was focused on bringing the worlds of research and investment in the rejuvenation biotechnology field together and saw a number of talks and panels focused on research and investment.
Dr. Alvaro Macieira-Coelho is a research director at the French National Institute of Health and Medical Research – INSERM. His talk was about how aging is the default behavior and that life is a balance between entropy and the availability of free energy. Essentially, due to the second law, all species progress through changes, and they age as their ability to resist entropy declines.
Here at LEAF, we engage in a wide range of activities in support of the development of rejuvenation biotechnology in order to end age-related diseases. We report the latest news in aging research, attend conferences and give talks, educate, advocate, and fundraise for research projects on Lifespan.io; recently, we implemented the Longevity Investor Network in order to bring startup companies and investors together.
The Longevity Investor Network
The Longevity Investor Network is a group of investors who meet every month and invite young biotech companies working on aging to pitch their ideas. A successful pitch can often mean funding for a new startup company, helping to get its product developed and into clinical trials.
Scientists found out that nonclassical monocites can become senescent.
Scientists from the A*STAR Singapore Immunology Network have discovered that immune cells called nonclassical monocytes undergo cellular senescence, contradicting what was previously thought of them [1].
Abstract
Human primary monocytes comprise a heterogeneous population that can be classified into three subsets based on CD14 and CD16 expression: classical (CD14high/CD16−), intermediate (CD14high/CD16+), and non-classical (CD14low/CD16+). The non-classical monocytes are the most pro-inflammatory in response to TLR stimulation in vitro, yet they express a remarkably high basal level of miR-146a, a microRNA known to negatively regulate the TLR pathway. This concurrence of a pro-inflammatory status and a high miR-146a level has been associated with cellular senescence in other cell types. Hence, we assessed the three monocyte subsets for evidence of senescence, including proliferative status, telomere length, cellular ROS levels, and mitochondrial membrane potential. Indeed, the non-classical subset exhibited the clearest hallmarks of senescence, followed by the intermediate and then the classical subset. In addition, the non-classical subset secreted pro-inflammatory cytokines basally in vitro.
Today, we are going to be taking a look at GAIM and what it might mean for treating amyloid-based diseases, such as Alzheimer’s, Parkinson’s, and amyloidosis. This approach has the potential to treat multiple age-related diseases at once by targeting a common characteristic that they all share.
Misfolded proteins cause multiple age-related diseases
Proteins are large, complex molecules that regulate almost everything in our bodies, either directly or indirectly. They do the majority of the work in cells and are critical for the function, regulation, and structure of tissues and organs.
