Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension

Isaac Asimov referred to a 70-old man as an old individual who is unlikely to live much longer. Yet, given the present pace of discovery in the ageing field, the pace of ageing could be slowed within our lifetime, with science surpassing science fiction.

Thus, genetic studies have now firmly established that aging is regulated by specific genes conserved from yeast to mice [23,30–34].

Independently of discoveries of AP genes in model organisms, research in cellular senescence yielded complementary results. Cellular senescence is now widely recognized as an essential tumor suppressor mechanisms, and is not a decline due to cellular degeneration. In contrast, the senescence response is an active process caused by activation of both DNA-damage responses (DDR) and mitogen-activated pathways. Senescent fibroblasts acquire phenotypes that include hyper-secretion of inflammatory cytokines and other tissue-altering molecules and hypertrophic morphologies [35–42]. Senescent cells can alter the behavior of neighboring cells [35], and may drive aging and age-related diseases [43]. Cellular senescence can be prevented by knocking out cell cycle inhibitors such as p53, pRb, p21 and p16 [44–48].

Read more

Liz in this video is speaking to the mormons. THE MORMONS do not care a lot for me. Mostly due to when they push their thoughts that are wrong I push back. {I dealt with one of their prophets Years ago} and some of the minds of this day, their wrong-thoughts are the same as in 2003–4. When one is adjusting their comments, they then freak out and begin attacking your truth that moved their comments-thoughts out of the way. The truth will cut you loose. Respect r.p.berry & AEWR wherein the many causes of aging have been found and a cure located by our Data research. We search for partners-investors to now join us in agings end…

At the 2018 Conference of the Mormon Transhumanist Association, held 7 Apr 2018 at the Marriott Hotel and Conference Center in Provo, UT, speakers addressed the themes of Mormonism, Transhumanism and Transfigurism, with particular attention to topics at the intersection of technology, spirituality, science and religion. Members, friends and critics of the association have many views. This is one of them. It is not necessarily shared by others.

Read more

This week, UK-based futurologist Ian Pearson announced humanity will achieve immortality by the year 2050. Is he right?

According to the former rocket scientist and IT engineer – who claims to have an 85 percent success rate “when looking 10–15 years ahead” – recent advances in biomedical and computing technology will inevitably lead to victory over death via one of three means:

Read more

Elizabeth Parris, the CEO of Bioviva USA Inc, has become the very first human being to successfully, from a biological standpoint, reverse the age of her white blood cells, thanks to her own company’s experimental therapies. Bioviva utilizes intramural and extramural peer-reviewed research to create therapies for age-related diseases (Parkinson’s, Alzheimer’s, cancer, heart-disease), and now, they have reversed 20 years of ‘telomere shortening’ in a human for the first time.

Telomeres are short segments of DNA that cap the ends of every chromosome and act as a protective feature against wear and tear, which occurs naturally as the human body ages. As we age, these telomeres become shorter and shorter as our cells continue to divide more and more. Eventually they become too short to protect the chromosome, which is what causes our cells to malfunction and age related diseases to start setting in.

In September of last year, the 44 year old volunteered to partake in two of her own company’s experimental gene therapies; one intended to battle stem cell depletion, which happens when we age and leads to various age related diseases, and the other intended to protect against loss of muscle mass with age.

Read more

As we age, the reduced turnover of our cells means we can lose control over how our skin ages. Epidermal stem cells needed to create healthy new skin are significantly reduced and function less efficiently. A discovery based on promising plant stem cell research may allow you to regain control.

Scientists have found that a novel extract derived from the stem cells of a rare apple tree cultivated for its extraordinary longevity shows tremendous ability to rejuvenate aging skin. By stimulating aging skin stem cells, this plant extract has been shown to lessen the appearance of unsightly wrinkles. Clinical trials show that this unique formulation increases the longevity of skin cells, resulting in skin that has a more youthful and radiant appearance.

Read more

A new publication highlights how the complex interaction of NAD+ and cellular senescence pathways may complicate proposed anti-aging therapies that boost NAD+ using precursors.

What are epigenetic alterations?

One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations. These alterations harm the fundamental functions of our cells and can increase the risk of cancer and other age-related diseases.

Read more