Urolithin A, a metabolite of biomolecules found in pomegranates and other fruits, could help slow certain aging processes. EPFL spin-off Amazentis, in conjunction with EPFL and the Swiss Institute of Bioinformatics, has published a paper Metabolism outlining the results of their clinical trial.
It is a fact of life that skeletal muscles begin to lose strength and mass once a person reaches the age of 50. A recent clinical trial involving two EPFL entities — spin-off Amazentis and the Laboratory of Integrative Systems Physiology (LISP) — showed that urolithin A, a compound derived from biomolecules found in fruits such as pomegranates, could slow down this process by improving the functioning of mitochondria — the cells’ powerhouses. A joint paper presenting the results of the trial also demonstrates that ingesting the compound poses no risk to human health.
In a recent study, a group of researchers from Hebrew University-Hadassah Medical School, Feinberg School of Medicine, and Tel Aviv University examined astrocytes in mice and found that these cells exhibited a senescent phenotype that led to neurodegeneration and neurotoxicity [1].
Age-dependent increase in senescent astrocytes adjacent to Aβ plaques
Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells senescent… These cells are caused primarily by telomere shortening and DNA damage, they are known to contribute to many diseases, and this is not the first study that links them to neurodegeneration.
The three-hour event was part marketing spectacle and part dry technical explainer. Musk and his team members described the brain-machine interface design they’re betting on, which will employ dozens of thin wires to collect signals in the brain, and which they want to try out on paralyzed people soon, so they can type with their minds. Their eventual aim is to connect those wires to a thought transmitter which tucks behind your ear like a hearing aid.
Well, it’s pretty cool. It seemed like maybe it will work the way they want down the road, but it probably doesn’t work that way now. A couple of years ago, when I heard he was working with a neural interface, I said I would be there in a heartbeat. I was joking, but it’s interesting to think about what I am going to do when I get explanted. I am coming up on my five years. Then the FDA says my implants may have to come out. Neuralink talked about longevity of the implant and also a large number of electrodes. I always say I wish they had put more electrodes into me.
Basically, the more electrodes you have, the more neurons you record from, so I would imagine higher-degree tasks would be easier. I am limited to thinking about my right arm and hand. I thought it would be good to have more control. I always want to play more video games.
I was going to school at Penn State, Fayette, for nanofabrication, so I didn’t have a job, I was in school.
My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself. I read the books and do all the research and share my findings with you!
This video is an interview of Dr. Aubrey de Grey @ SENS on July 17, 2019. My wife, Lauren Nally, was our camerawoman.
- Please consider a donation so I can continue to keep my YouTube ads off: My Bitcoin Cash (BCH) address: qr9gcfv92pzwfwa5hj9sqk3ptcnr5jss2g78n7w6f2 or https://www.paypal.me/BrentNally - Please consider a donation to SENS: https://www.sens.org/
SHOW NOTES:
- Aubrey’s wikipedia: https://en.wikipedia.org/wiki/Aubrey_de_Grey - SENS wikipedia: https://en.wikipedia.org/wiki/SENS_Research_Foundation - like & follow SENS on Facebook: https://www.facebook.com/sensf/?ref=br_rs - subscribe to Undoing Aging’s YouTube channel: https://www.youtube.com/channel/UCAwxbQhlE6qcTXmKcxkaCGA/videos - follow Aubrey on Twitter: https://twitter.com/aubreydegrey - follow SENS on Twitter: https://twitter.com/senstweet - follow Aubrey on LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/ - follow SENS on Instagram: https://www.instagram.com/sensresearchfoundation/ 0:55 Type “Aubrey de Grey” into YouTube for lots of his lectures & interviews. 1:50 Update on the state of the anti-aging industry & explosion of private sector interest. 5:05 Intro for Aubrey 5:35 My May 30, 2019 interview with Sierra Sciences CEO Dr. Bill Andrews: https://www.youtube.com/watch?v=Tx9yG6iTROQ 6:25 diversity of messaging in anti-aging is increasing. 7:10 My July 10, 2019 interview with BioViva CEO Liz Parrish: https://www.youtube.com/watch?v=oBFTwGPaPr4 8:28 Aubrey shares his updated thoughts on the role of telomerase in cancer in humans. 12:00 Liz had here telomeres tested by SpectraCell Laboratories: https://www.spectracell.com/clinicians/products/telomere-testing/ & LifeLength: https://lifelength.com/ 14:10 there has recently been more testing on humans in the field of the biology of aging. 15:44 It’s obvious to Aubrey & I that aging is a big problem but most people still don’t understand this. 18:40 profound difference between how scientists & technologists think. 22:11 Watch the documentary “The Immortalists” about Dr. Aubrey de Grey & Dr. Bill Andrews: https://www.theimmortalists.com/watch/? 22:58 updates on anti-aging investments & research projects. 30:01 stem cell therapy is intended to repair cell loss. 30:50: we have a massive funding problem to reverse human aging. 32:53 we must educate the public that aging is causing 100,000 deaths per day and funding biological age reversal research can change this. 36:52 Is human aging a disease? 44:10 FDA progress to treat age-related diseases/conditions. 47:38 World Health Organization ICD code progress to treat age-related diseases/conditions. 50:02 Trans-NIH Geroscience Interest Group (GSIG) 54:40 “triangular log jam” of funding with governments, scientists and public opinion. 56:30 Aubrey shares why SENS still exists. 1:00:38 Ethereum cryptocurrency founder Vitalik Buterin & other SENS donors. 1:01:55 Undoing Aging is a conference held every spring in Berlin, Germany. 1:04:53 July 2019 is Aubrey’s 2-year anniversary at AgeX as the VP of New Technology Discovery. 1:08:44 Jeff Bezos donated $100 million to Unity Biotechnology, Inc. (not Human Longevity Inc.) in 2018. 1:11:02 (Larry) Ellison Medical Foundation failure in reversing human aging. 1:14:15 Google co-founders creating Calico rather than investing in or donating to SENS 1:21: Aubrey shares details about his lifestyle as well as his recommendations for a healthy lifestyle. 1:24:25 Aubrey looks up to the longevity “foot soldiers“ 1:28:42 do what you love as much as you can to avoid excess mental, physical and emotional stress. 1:30:40 Aubrey is following all longevity therapies to determine their safety & effectiveness. 1:32:20 my stem cells story & Aubrey’s feedback. 1:34:58 EmCell in Kyiv, Ukraine is the only company doing fetal stem cells therapy. 1:39:20 exosomes 1:41:00 I’ve had no reply from Ambrosia founder Jesse Karmazin since October 2018. 1:42:51 My March 26, 2019 interview with Dr. Ed Park at Recharge Biomedical: https://www.youtube.com/watch?v=xHgfYKsH0uw&list=UUCwpkla04tVxHJUds2J2aqA&index=6 1:44:31 NAD+ 1:47:39 gene therapy 1:53:37 please network on the internet & in person with other longevity enthusiasts to help grow this movement faster. 1:58:48 mitochondria 2:00:48 long lived animals 2:01:49 consider a donation to SENS
Researchers from Johns Hopkins University have published a new study that sheds light on skin rejuvenation, and it shares a link with what some cosmetic companies are doing using laser therapy.
A link between cosmetics and regeneration
During their study, the researchers found that the laser treatments used by cosmetic companies and retinoic acid, which is produced by the skin and sold commercially to treat wrinkles and sun damage, also target the same pathway. In addition, they also found that the activity of this pathway is increased in mice when they regenerate their hair follicles [1].
Vice President for Research Technology and Innovation and Chair of the Department of Cell Stress Biology Roswell Park Comprehensive Cancer Center (Buffalo, NY) on systemic DNA damage and anti-aging therapies.
It might sound crazy to the masses, but life extension is a real thing. The science, also known as anti-aging medicine, indefinite life extension, experimental gerontology, and biomedical gerontology, is the study of slowing down or reversing the processes that create aging. The result? Maximum and average lifespan extended. The question is, do we need tech? Or should we begin to look at why our life spans aren’t already longer?
If you try to envision it, you might find yourself lost in a futuristic sci-fi film you’ve already seen. But it’s more than a concept fit for the silver screen. Life extension is a very real science, and is currently being worked on as you read this.
According to some scientists, we are mere decades away from moving into life extension, which could change life as we know it forever.
