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Papers referenced in the video:
Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a.

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial.

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.

Forget all the nanotechnology devoted to fighting cancer, and just consider that nanoparticles have invaded makeup, anti-odor socks, sunscreen, plastic beer bottles and home pregnancy tests. Now scientists have developed a way to assess the health and environmental impact of such nanoparticles: a tiny microresonator that can detect and measure individual particles smaller than a single virus.

The microresonator is a lab-on-a-chip that harnesses the “whispering gallery” concept that’s displayed by buildings such as St. Paul’s Cathedral in London. The cathedral’s domed gallery can carry whispers easily across to the other side, but normal-volume voices end up garbled after bouncing around the dome multiple times.

Similarly, microresonators can bounce laser light many times around a circular “waveguide,” such as a glass ring. A laser frequency must perfectly fit the circumference of a ring to achieve this whispering-gallery mode.

Apple has been talking for years about the role it wants to play in human health, led by the Apple Watch and its array of health-related features. With the Apple Watch maturing and Apple increasing its integration of health-focused hardware and software, several pieces of evidence suggest the company is positioning itself for an even bigger expansion in that direction.

According to trends compiled by Linkedin and seen by MacRumors, over the past year, Apple’s open job listings in health-related fields have increased by over 220%, with a significant portion of the increase coming in just the last several months. Apple’s health-focused hiring has been the fastest-growing segment for the company over the past year, followed most closely by sales and IT specialists, such as in cloud computing and security, according to the data.

The nutrient content of our vegetables is down 40% over the last two decades and our soil health is suffering due to increasingly harsh herbicide use, according to Carbon Robotics founder Paul Mikesell. And farmers are increasingly concerned about the long-term health impacts of continually spraying chemicals on their fields.

But not weeding will cost half your crop, killing profitability.

The solution?

The path that led Jennifer Doudna, PhD, and her colleagues to the development of CRISPR, the gene-editing tool that has revolutionized science and earned her a Nobel Prize, started with their deep curiosity and drive to understand how the most basic building blocks of life function.

When Doudna first decided to investigate precisely what systems bacteria use to adapt their immune systems to fight off viral infections, she had little expectation that the findings would ultimately provide the key to technology that could be used to safely alter genetic code.

“All of us [on the research team] realized that what had started as a fundamental research question was morphing into a very different kind of project; namely, one with enormous technical potential and also risks and opportunities that we had not appreciated when we started the work,” Doudna explained during a conversation with J. Larry Jameson, MD, PhD, chair of the AAMC Board of Directors and executive vice president of the University of Pennsylvania Health System, at the opening plenary of Learn Serve Lead 2021: The Virtual Experience, on Monday, Nov. 8.

A CNS 2021 provided an incredible opportunity to learn more how the anatomy and integrity of brain networks impact higher-level cognition.

In the 19th and 20th century, cases of individuals with brain injury, such as Phineas Gage or Henry Molaison, have advanced our understanding of the relationship between the anatomy of the brain and its function. Back then, methods were limited to investigate whole-brain structure and function. Now, cognitive neuroscientists have some ability to visualize and measure activity of the whole brain at once, as well as the computational tools to investigate complex network-level relationships between brain structure, brain function, and behavior.

As a doctoral student working on stroke recovery, attending the CNS 2021 symposium led by Danielle Bassett was an incredible opportunity to learn more about some of the most recent methods that have been developed to understand how the anatomy and integrity of brain networks impact higher-level cognition. Strokes highly disrupt anatomical and functional connectivity, leading to cognitive and motor impairments. In individuals with post-stroke language impairments, namely aphasia, evidence shows that the more functional brain networks recover an organization similar to healthy individuals the better the recovery (Kiran et al., 2019). Understanding the relationship between brain structure and function in health and disease is therefore essential to develop appropriate treatments.

At this CNS symposium, the speakers showed how different models can help us better understand brain structural organization and how this particular organization constrains cognitive processes. They also showed direct relationships between alteration of anatomical networks, caused by disease or behavioral training, and changes in behavioral performance.

China’s zero-COVID-19 policy is showing strain as health authorities struggle to contain the growing spread of the Delta variant.
At least 1,000 locally-transmitted infections have been reported since mid-October in 20 provinces, prompting strict quarantine periods and area-specific lockdowns.
The onset of winter in China’s north is also helping disperse the disease.
Al Jazeera’s Katrina Yu reports from Beijing, China.

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A decade ago, a London cancer prevention researcher predicted that the United Kingdom’s national HPV vaccination campaign would take more than 15 years to prevent a majority of cervical cancers. So when he analyzed the data this year, he was stunned to find that the vaccine may already have nearly eliminated cervical cancer in the U.K. among young women.

“If this is right,” Peter Sasieni of King’s College London said of his findings, cervical cancers “could be reduced to about 50 – just 50 cancers in the whole of the U.K. for women under 30. It’s really quite exciting to see that day come – excitement and just joy.”

That joy was tempered with envy in the United States, where some of Sasieni’s peers lamented that the HPV vaccination rate for teenage girls lags far behind — about 59% in the U.S. vs. more than 85% in the U.K. The analysis, published last week in the Lancet, suggests the U.K. has notched a major public health victory against cancer through vaccinating the vast majority of young women against HPV, said Allison Kempe, a pediatrics professor at the University of Colorado School of Medicine who did not work on the study.

Health Canada is updating the labels for the AstraZeneca and Johnson & Johnson COVID-19 vaccines to add immune thrombocytopenia (ITP), an autoimmune condition, as a potential side effect.

In a statement on Tuesday, the agency said very rare cases of ITP have been reported internationally after receiving the Vaxzevria (AstraZeneca) and Janssen (J&J) COVID-19 vaccines.

ITP is a disorder that can cause easy or excessive bruising and bleeding, which results from unusually low blood platelet levels.