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Scientists say they have discovered the first evidence of a “significant” mutation of the coronavirus — raising concerns that strides made toward a vaccine so far could become “futile,” according to a new study.

The researchers, who isolated a strain of the virus from a sample collected in India in January, said the mutation appeared to make the bug less able to bind to a receptor on human cells called ACE2, an enzyme found in the lungs.

The discovery of this mutation “raises the alarm that the ongoing vaccine development may become futile in future epidemic if more mutations were identified,” the researchers said, according to Newsweek. The study, which was published on biorxiv.org on Saturday, has not yet been peer-reviewed.