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Synthetic protocells can be made to move toward and away from chemical signals, an important step for the development of new drug-delivery systems that could target specific locations in the body. By coating the surface of the protocells with enzymes—proteins that catalyze chemical reactions—a team of researchers at Penn State was able to control the direction of the protocell’s movement in a chemical gradient in a microfluidic device. A paper describing the research appears November 18, 2019 in the journal Nature Nanotechnology.

“The is to have drugs delivered by tiny ‘bots’ that can transport the drug to the specific location where it is needed,” said Ayusman Sen, the Verne M. Willaman Professor of Chemistry at Penn State and the leader of the research team. “Currently, if you take an antibiotic for an infection in your leg, it diffuses throughout your entire body. So, you have to take a higher dose in order to get enough of the antibiotic to your leg where it is needed. If we can control the directional movement of a drug-delivery system, we not only reduce the amount of the drug required but also can increase its speed of delivery.”

One way to address controlling direction is for the drug-delivery system to recognize and move towards specific emanating from the infection site, a phenomenon called chemotaxis. Many organisms use chemotaxis as a survival strategy, to find food or escape toxins. Previous work had shown that enzymes undergo chemotactic movement because the reactions they catalyze produce energy that can be harnessed. However, most of that work had focused on positive chemotaxis, movement towards a . Until now, little work had been done looking at negative chemotaxis. “Tunable” chemotaxis—the ability to control movement direction, towards and away from different chemical signals—had never been demonstrated.

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View full lesson: http://ed.ted.com/lessons/can-we-eat-to-starve-cancer-william-li

William Li presents a new way to think about treating cancer and other diseases: anti-angiogenesis, preventing the growth of blood vessels that feed a tumor. The crucial first (and best) step: Eating cancer-fighting foods that cut off the supply lines and beat cancer at its own game.

Talk by WIlliam Li.

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The danger of artificial intelligence isn’t that it’s going to rebel against us, but that it’s going to do exactly what we ask it to do, says AI researcher Janelle Shane. Sharing the weird, sometimes alarming antics of AI algorithms as they try to solve human problems — like creating new ice cream flavors or recognizing cars on the road — Shane shows why AI doesn’t yet measure up to real brains.
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On November 2, 12 bottles of Bordeaux wine were launched to the International Space Station (ISS). These bottles are not intended for holiday celebrations by the crew, however (consumption of alcohol is officially prohibited in space.) Instead. the bottles are part of an experiment conducted by the University of Bordeaux’s Institute of Vine and Wine Science (ISVV) and a company called Space Cargo Unlimited to investigate if the aging process of wine is affected by microgravity conditions.

As novel as this experiment sounds, the Bordeaux team is not the first group to examine how alcoholic beverages age in space. That distinction is held by two whisky producers, one in Scotland, the other in Japan. In 2011, Scotch whisky producer Ardbeg partnered with Nanoracks to launch the first whisky aging experiment in orbit. When the samples were returned to Earth in 2014, a clear difference was readily apparent from the control samples that remained on Earth—and not for the better. According to an Ardbeg white paper, the aftertaste was “pungent, intense and long, with hints of wood, antiseptic lozenges and rubbery smoke.” However, Ardbeg was not certain if this was a result of the aging process or other extreme factors that the samples encountered.

In 2015, Japanese whisky producer Suntory also launched whisky samples to be aged on the ISS. One batch of these samples returned to Earth for analysis after a year in orbit, but another batch still remains on the station. Thus far, Suntory has not released any data from these experiments.

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The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with ‘Western’ diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched ‘Western’ diets can reprogram maternal bodily metabolism with maternal nutrient supply precipitating the body-wide imprinting of molecular and cellular adaptations at the level of long-range intercellular signaling networks in the unborn fetus. Even though unfavorable neurological outcomes are amongst the most common complications of intrauterine ω-6 PUFA excess, cellular underpinnings of life-long modifications to brain architecture remain unknown. Here, we show that nutritional ω-6 PUFA-derived endocannabinoids desensitize CB1 cannabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory networks controlling neuronal differentiation. We found that cortical neurons lose their positional identity and axonal selectivity when mouse fetuses are exposed to excess ω-6 PUFAs in utero. Conversion of ω-6 PUFAs into endocannabinoids disrupted the temporal precision of signaling at neuronal CB1 cannabinoid receptors, chiefly deregulating Stat3-dependent transcriptional cascades otherwise required to execute neuronal differentiation programs. Global proteomics identified the immunoglobulin family of cell adhesion molecules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramming at 1400 sites in neurons after prolonged cannabinoid exposure. We found anxiety and depression-like behavioral traits to manifest in adult offspring, which is consistent with genetic models of reduced IgCAM expression, to suggest causality for cortical wiring defects. Overall, our data uncover a regulatory mechanism whose disruption by maternal food choices could limit an offspring’s brain function for life.

  • Immediate Communication
  • Published: 18 November 2019
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Insect farming is a small – but growing – industry globally, with bugs touted as a sustainable and cheap food that is high in protein, vitamins, fibre and minerals. Their cultivation, meanwhile, has much less environmental impact than meat.

With predictions that the insect market could grow significantly, it is not just scientists cooking up ways to put bugs on the menu but also some of the world’s largest food and agricultural companies.

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In a classic episode of an old-school TV comedy called I Love Lucy, we see Lucille Ball stepping into an assembly line job at a candy factory. As the pace of the conveyor belt exceeds her ability to wrap the candy, the frenzy gets the best of her. She shoves candy into her pockets, into her hat, into her mouth—it’s a job fail.

As we know, faster doesn’t always mean better. And precision can take a big bite out of speed.

Sometimes, though, innovative minds come up with a new strategy that improves both efficiency and precision.

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Think about it. Your brain is always “on.” It takes care of your thoughts and movements, your breathing and heartbeat, your senses — it works hard 24/7, even while you’re asleep. This means your brain requires a constant supply of fuel. That “fuel” comes from the foods you eat — and what’s in that fuel makes all the difference. Put simply, what you eat directly affects the structure and function of your brain and, ultimately, your mood.

Like an expensive car, your brain functions best when it gets only premium fuel. Eating high-quality foods that contain lots of vitamins, minerals, and antioxidants nourishes the brain and protects it from oxidative stress — the “waste” (free radicals) produced when the body uses oxygen, which can damage cells.

Unfortunately, just like an expensive car, your brain can be damaged if you ingest anything other than premium fuel. If substances from “low-premium” fuel (such as what you get from processed or refined foods) get to the brain, it has little ability to get rid of them. Diets high in refined sugars, for example, are harmful to the brain. In addition to worsening your body’s regulation of insulin, they also promote inflammation and oxidative stress. Multiple studies have found a correlation between a diet high in refined sugars and impaired brain function — and even a worsening of symptoms of mood disorders, such as depression.

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