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There continues to be some discussion and rejection of the idea that terrorists would be able to exploit new technology platforms such as social networking and virtual worlds. In a recent post the blogger Abu Aardvark (aka Marc Lynch from GW University) goes some way in debunking ideas surrounding terrorist use of social networking, Wiki’s and virtual worlds. He further states that Al Qaeda is now behind the curve in using the area of user-generated content and interactivity. While, the aardvark’s media analysis relating to ‘al-Qaeda outreach’ appears to be sound I think he misses a fundamental point about terrorists and technology.

The defining feature of terrorism and technology is its adaptive quality. It is highly unlikely that individual terrorists or terrorist groups would exactly replicate the mainstream functions of the technology abu aardvark highlights in his post. It is more likely they would take certain elements from the various innovations and mesh them together or otherwise distort them. So an al-Qaeda Facebook isn’t going to happen anytime soon but using the system to identify IDF soldiers for possible assassination already has. Similarly an ‘AQThirdlife’, which replicates the virtual world Second Life seems unlikely but using some of its key features still seems probable. The virtual money transfer aspect continues to be a high on most peoples list of concerns (this is discussed in a recent SSRN paper written by Stephen Landman, Funding Bin Laden’s Avatar: A proposal for the regulation of Virtual Hawalas, which he has kind enough to share with me). Aardvark’s point about an AQThird life also fails to account for phenomena such as the virtual caliphate, which is running in the UK, where users log into areas to see and hear sermons by dead or expelled radical preachers — there continues to be a market for extremism and virtual exposure to it is potentially more powerful than real exposure.

As ever the central point is that given rapid and increasing virtualization flexible thinking and planning is required to conceptualize the next form of terrorist threat — blogs appear to be a great enabler of this practice.

Here I would like to suggest readers a quotation from my book “Structure of the global catastrophe” (http://www.scribd.com/doc/7529531/-) there I discuss problems of preventing catastrophes.

Refuges and bunkers

Different sort of a refuge and bunkers can increase chances of survival of the mankind in case of global catastrophe, however the situation with them is not simple. Separate independent refuges can exist for decades, but the more they are independent and long-time, the more efforts are necessary for their preparation in advance. Refuges should provide ability for the mankind to the further self-reproduction. Hence, they should contain not only enough of capable to reproduction people, but also a stock of technologies which will allow to survive and breed in territory which is planned to render habitable after an exit from the refuge. The more this territory will be polluted, the higher level of technologies is required for a reliable survival.
Very big bunker will appear capable to continue in itself development of technologies and after catastrophe. However in this case it will be vulnerable to the same risks, as all terrestrial civilisation — there can be internal terrorists, AI, nanorobots, leaks etc. If the bunker is not capable to continue itself development of technologies it, more likely, is doomed to degradation.
Further, the bunker can be or «civilizational», that is keep the majority of cultural and technological achievements of the civilisation, or “specific”, that is keep only human life. For “long” bunkers (which are prepared for long-term stay) the problem of formation and education of children and risks of degradation will rise. The bunker can or live for the account of the resources which have been saved up before catastrophe, or be engaged in own manufacture. In last case it will be simply underground civilisation on the infected planet.
The more a bunker is constructed on modern technologies and independent cultural and technically, the higher ammount of people should live there (but in the future it will be not so: the bunker on the basis of advanced nanotechnology can be even at all deserted, — only with the frozen human embryos). To provide simple reproduction by means of training to the basic human trades, thousand people are required. These people should be selected and be in the bunker before final catastrophe, and, it is desirable, on a constant basis. However it is improbable, that thousand intellectually and physically excellent people would want to sit in the bunker “just in case”. In this case they can be in the bunker in two or three changes and receive for it a salary. (Now in Russia begins experiment «Mars 500» in which 6 humans will be in completely independent — on water, to meal, air — for 500 days. Possibly, it is the best result which we now have. In the early nineties in the USA there was also a project «Biosphera-2» in which people should live two years on full self-maintenance under a dome in desert. The project has ended with partial failure as oxygen level in system began to fall because of unforeseen reproduction of microorganisms and insects.) As additional risk for bunkers it is necessary to note fact of psychology of the small groups closed in one premise widely known on the Antarctic expeditions — namely, the increase of animosities fraught with destructive actions, reducing survival rate.
The bunker can be either unique, or one of many. In the first case it is vulnerable to different catastrophes, and in the second is possible struggle between different bunkers for the resources which have remained outside. Or is possible war continuation if catastrophe has resulted from war.
The bunker, most likely, will be either underground, or in the sea, or in space. But the space bunker too can be underground of asteroids or the Moon. For the space bunker it will be more difficult to use the rests of resources on the Earth. The bunker can be completely isolated, or to allow “excursion” in the external hostile environment.
As model of the sea bunker can serve the nuclear submarine possessing high reserve, autonomy, manoeuvrability and stability to negative influences. Besides, it can easily be cooled at ocean (the problem of cooling of the underground closed bunkers is not simple), to extract from it water, oxygen and even food. Besides, already there are ready boats and technical decisions. The boat is capable to sustain shock and radiating influence. However the resource of independent swimming of modern submarines makes at the best 1 year, and in them there is no place for storage of stocks.
Modern space station ISS could support independently life of several humans within approximately year though there are problems of independent landing and adaptation. Not clearly, whether the certain dangerous agent, capable to get into all cracks on the Earth could dissipate for so short term.
There is a difference between gaso — and bio — refuges which can be on a surface, but are divided into many sections for maintenance of a mode of quarantine, and refuges which are intended as a shelter from in the slightest degree intelligent opponent (including other people who did not manage to get a place in a refuge). In case of biodanger island with rigid quarantine can be a refuge if illness is not transferred by air.
A bunker can possess different vulnerabilities. For example, in case of biological threat, is enough insignificant penetration to destroy it. Only hi-tech bunker can be the completely independent. Energy and oxygen are necessary to the bunker. The system on a nuclear reactor can give energy, but modern machines hardly can possess durability more than 30–50 years. The bunker cannot be universal — it should assume protection against the certain kinds of threats known in advance — radiating, biological etc.
The more reinforced is a bunker, the smaller number of bunkers can prepare mankind in advance, and it will be more difficult to hide such bunker. If after a certain catastrophe there was a limited number of the bunkers which site is known, the secondary nuclear war can terminate mankind through countable number of strikes in known places.
The larger is the bunker, the less amount of such bunkers is possible to construct. However any bunker is vulnerable to accidental destruction or contamination. Therefore the limited number of bunkers with certain probability of contamination unequivocally defines the maximum survival time of mankind. If bunkers are connected among themselves by trade and other material distribution, contamination between them is more probable. If bunkers are not connected, they will degrade faster. The more powerfully and more expensively is the bunker, the more difficult is to create it imperceptibly for the probable opponent and so it easeir becomes the goal for an attack. The more cheaply the bunker, the less it is durable.
Casual shelters — the people who have escaped in the underground, mines, submarines — are possible. They will suffer from absence of the central power and struggle for resources. The people, in case of exhaustion of resources in one bunker, can undertake the armed attempts to break in other next bunker. Also the people who have escaped casually (or under the threat of the comong catastrophe), can attack those who was locked in the bunker.
Bunkers will suffer from necessity of an exchange of heat, energy, water and air with an external world. The more independent is the bunker, the less time it can exist in full isolation. Bunkers being in the Earth will deeply suffer from an overheating. Any nuclear reactors and other complex machines will demand external cooling. Cooling by external water will unmask them, and it is impossible to have energy sources lost-free in the form of heat, while on depth of earth there are always high temperatures. Temperature growth, in process of deepening in the Earth, limits depth of possible bunkers. (The geothermal gradient on the average makes 30 degrees C/kilometers. It means, that bunkers on depth more than 1 kilometre are impossible — or demand huge cooling installations on a surface, as gold mines in the republic of South Africa. There can be deeper bunkers in ices of Antarctica.)
The more durable, more universal and more effective, should be a bunker, the earlier it is necessary to start to build it. But in this case it is difficult to foresee the future risks. For example, in 1930th years in Russia was constructed many anti-gase bombproof shelters which have appeared useless and vulnerable to bombardments by heavy demolition bombs.
Efficiency of the bunker which can create the civilisation, corresponds to a technological level of development of this civilisation. But it means that it possesses and corresponding means of destruction. So, especially powerful bunker is necessary. The more independently and more absolutely is the bunker (for example, equipped with AI, nanorobots and biotechnologies), the easier it can do without, eventually, people, having given rise to purely computer civilisation.
People from different bunkers will compete for that who first leaves on a surface and who, accordingly, will own it — therefore will develop the temptation for them to go out to still infected sites of the Earth.
There are possible automatic robotic bunkers: in them the frozen human embryos are stored in a certain artificial uterus and through hundreds or thousand years start to be grown up. (Technology of cryonics of embryos already exists, and works on an artificial uterus are forbidden for bioethics reasons, but basically such device is possible.) With embryos it is possible to send such installations in travel to other planets. However, if such bunkers are possible, the Earth hardly remains empty — most likely it will be populated with robots. Besides, if the human cub who has been brought up by wolves, considers itself as a wolf as whom human who has been brought up by robots will consider itself?
So, the idea about a survival in bunkers contains many reefs which reduce its utility and probability of success. It is necessary to build long-term bunkers for many years, but they can become outdated for this time as the situation will change and it is not known to what to prepare. Probably, that there is a number of powerful bunkers which have been constructed in days of cold war. A limit of modern technical possibilities the bunker of an order of a 30-year-old autonomy, however it would take long time for building — decade, and it will demand billions dollars of investments.
Independently there are information bunkers, which are intended to inform to the possible escaped descendants about our knowledge, technologies and achievements. For example, in Norway, on Spitsbergen have been created a stock of samples of seeds and grain with these purposes (Doomsday Vault). Variants with preservation of a genetic variety of people by means of the frozen sperm are possible. Digital carriers steady against long storage, for example, compact discs on which the text which can be read through a magnifier is etched are discussed and implemented by Long Now Foundation. This knowledge can be crucial for not repeating our errors.

November 14, 2008
Computer History Museum, Mountain View, CA

http://ieet.org/index.php/IEET/eventinfo/ieet20081114/

Organized by: Institute for Ethics and Emerging Technologies, the Center for Responsible Nanotechnology and the Lifeboat Foundation

A day-long seminar on threats to the future of humanity, natural and man-made, and the pro-active steps we can take to reduce these risks and build a more resilient civilization. Seminar participants are strongly encouraged to pre-order and review the Global Catastrophic Risks volume edited by Nick Bostrom and Milan Cirkovic, and contributed to by some of the faculty for this seminar.

This seminar will precede the futurist mega-gathering Convergence 08, November 15–16 at the same venue, which is co-sponsored by the IEET, Humanity Plus (World Transhumanist Association), the Singularity Institute for Artificial Intelligence, the Immortality Institute, the Foresight Institute, the Long Now Foundation, the Methuselah Foundation, the Millenium Project, Reason Foundation and the Accelerating Studies Foundation.

SEMINAR FACULTY

  • Nick Bostrom Ph.D., Director, Future of Humanity Institute, Oxford University
  • Jamais Cascio, research affiliate, Institute for the Future
  • James J. Hughes Ph.D., Exec. Director, Institute for Ethics and Emerging Technologies
  • Mike Treder, Executive Director, Center for Responsible Nanotechnology
  • Eliezer Yudkowsky, Research Associate. Singularity Institute for Artificial Intelligence
  • William Potter Ph.D., Director, James Martin Center for Nonproliferation Studies

REGISTRATION:
Before Nov 1: $100
After Nov 1 and at the door: $150

1. Language and cultural isolation lead to the situation then Russian researches are not known in West and vice versa. I spent a lot of time translating into Russian and promoting works of Bostrom, Yudkowsky, Circovic, D.Brin, Freitas, A.Kent and other writers on global risks. Here I would like to tell you about some Russian researchers. Though I can’t prove validity of their ideas I think they should be checked internationally in order to roll out them or to take preventive measures. A. V. Karnauhov created a theory of “green house” catastrophe. He shows that climate is non linear system this many positive feedbacks and one of them is often missed – it is that water vapor is also greenhouse gas and growing temperatures would lead to injection of more and more water vapor into atmosphere. Also current level of carbon dioxid should lead to much more temperature increase, but inertia of ocean temperature makes current temperature smaller. But ocean temperature will rise, especially in Arctic, where large amounts of methane stored under seebed on the low shallow waters. This would lead to clarhat gun explosion of metane. Cumulative effect of water vapor, CO2, Metane and surmounting of ocean inertia will lead to very quick exponential global warming, which could have devastating effects as early as in 2020th and make global temperature higher not on 6 degrees but on several tens to the end of the century – which would mean human extinction, and after 200 years all life extinction on Earth Some his ideas you could see in the article: http://www.poteplenie.ru/doc/role.pdf Karnaukhov A.V. Role of the biosphere in the formation of the Earth’s Climate: The Greenhouse Catastrophe, Biophysics, Vol.46, No 6, 2001, pp. 1078-1088. Also I should mention works of Drobishevsky “Danger of the explosion of Callisto and the priority of space missions” http://www.springerlink.com/content/584mw0407824nt72/ He thinks that Jovian satellite Callisto could soon explode because of H and O reaction in its ice. Such explosion will lead to bombardment of the earth by comets and “nuclear winter” for 60 years. He suggested to send there a space mission. But I wrote him that, if he is write, it is very dangerous to send where mission, because it could trigger the explosion by drilling the ice crust. And the last man, about whom I would like to tell you, is a reviewer of my book “the Structure of the global catastrophe” Aranowich, who told me by way that his group has created much more effective way to penetrate the earth crust the Stevenson’s probe. Stevenson’s probe require 10 million ton of melted iron. His probe will weight only 10 tons and will use an energy of radioactive decay. It could reach 1000 km depth by one month – and the main danger is creation of supervolcano. Then I asked him, was any safety analysis done – he said not. But this is only theoretical work and no practical realization is planned.
2. I have wrote a book “The structure of global catastrophe” which aim was to investigate how different scenarios of global risks could interact in time, because all of them could realize in the XXI century. This book is sponsored by Russian Transhumanist movemet. Nick Bostrom wrote short preface to it. The book is mostly ready, but some editorial and organizational problems still persists. I hope it will be published by the end of the year.
3. I am started to translate this book into English. I have translated it by computer and then edit the result – now I am on the page 27 of 390. I need someone with native English who could help me to edit this translation. The book is here: http://avturchin.narod.ru/sgkengl2.doc I hope to finish English translation (in readable, but not high literature quality:) of the book until winter.
4. The shorter version of this book is already published on the name “War and 25 other scenarios of the End of the world”. This name was suggested by editorial house, the original name was: “Gnoseology of catastrophes”. The main idea of the book is that our inability to predict the future is equal to the end of the world.
5. I have translated the most part of Lifeboat site on Russian and I expect it will appear in the Net soon.
6. I have wrote several articles on the theme of global catastrophe: “Is SETI dangerous? English translation — http://www.proza.ru/texts/2008/04/12/55.html, “Atrophic principle and natural catastrophes” http://www.proza.ru/texts/2007/04/12-13.html and “About possibilities of manmade ignition of giant planets and other objects of Solar system” http://www.proza.ru/texts/2008/07/19/466.html which are in Russian.
7. I have created “Global catastrophic risks and human extinction library” there you could find many interesting literature on English and Russian. http://avturchin.narod.ru/Global.htm
8. I think that it is provable that if humanity will unite, it will have a chance to resist global risks, but if it will be divided on military competing parts, it almost doomed. Resent events on Caucasus put again in agenda the question of New cold war. Here we should ask what is the worst outcome of possible Cold war? Common answer is that Nuclear war is that worst outcome. But Nuclear war will not terminate all human population in most realistic scenarios. Much worse outcome is, I think, new arm race, which could lead to quick creation of much more destructive weapons, than nuclear. And the worst outcome of arm race is creation of Doomsday machine. Doomsday machine (DM) is ultimate defense weaponry. The example of such strategy was depicted by Kubrick in his genius movie “Dr. Strangelove”. Here we should say that DM-strategy is more suitable for a weaker state, which is in danger of aggression (or feels so). Quality of Russian nuclear forces is continue to deteriorating and minimum is expected around the year 2010 then most of old soviets rockets should be out of order. Simultaneously after the year 2010 US will rich a peak of their supremacy (because of thousand non nuclear cruise missiles, unique GPS system and antimissile shield it will have ability to make first strike without answer.), but later could lose supremacy because of economic crisis in US and growing arsenal of new Russian missiles. This situation looks dangerous, because from chess we know the principle: “Someone must attack under threat of losing his supremacy”. And antiballistic missile shield (ABM), which is developing now by NATO is very dangerous because it makes direct way to the creation of Doomsday Machine. Before ABM rockets were good as a mean of defense. But now only large underground bomb (gigaton order and with cobalt shield) could be a strategic defense. Such ideas is not only my creation but they are circulating in the air. Of course nobody is going to actually use such weapon, but it could be lunched accidentally. It should not be nuclear – it could be also large stockpile of anthrax, manmade supervulcano-threat or something more sophisticated. DM also could be used as a offensive mean. If Osama get it, he could say: everybody should convert in Islam, or I detonate it. The really big problem arise if in answer someone Catholic say: if anyone convert in Islam I will detonate my own Doomsday machine. In this case we finally doomed. But worst case scenarios are low probability ones, so I hope we have a chance to unite.

The UK’s Guardian today published details of a report produced by Britain’s Security Service (MI5) entitled, ‘Understanding radicalization and violent extremism in the UK’. The report is from MI5’s internal behavioral analysis unit and contains within it some interesting and surprising conclusions. The Guardian report covers many of these in depth (so no need to go over here) but one point, which is worth highlighting is the claim made within the report that religion is and was not a contributory factor in the radicalization of the home-grown terrorist threat that the UK faces. In fact, the report goes on to state that a strong religious faith protects individuals from the effects of extremism.This viewpoint is one that is gathering strength and coincides with an article written by Martin Amis in the Wall Street Journal, which also argues that ‘terrorism’s new structure’ is about the quest for fame and thirst for power, with religion simply acting as a “means of mobilization”.

All of this also tends to agree with the assertion made by Philip Bobbit in ‘Terror and Consent’, that al-Qaeda is simply version 1.0 of a new type of terrorism for the 21st century. This type of terrorism is attuned to the advantages and pressures of a market based world and acts more like a Silicon Valley start-up company than the Red Brigades — being flexible, fast moving and wired — taking advantage of globalization to pursue a violent agenda.

This all somewhat begs the question of, what next? If al-Qaeda is version 1.0 what is 2.0? This of course is hard to discern but looking at the two certain trends, which will shape humanity over the next 20 years — urbanization and virtualization — throws up some interesting potential opponents who are operating today. The road to mass urbanization is currently being highlighted by the 192021 project (19 cities, 20 million people in the 21st century) and amongst other things, points to the large use of slum areas to grow the cities of the 21st century. Slum areas are today being globally exploited from Delhi to Sao Paulo by Nigerian drug organizations that are able to recruit the indigenous people to build their own cities within cities. This kind of highly profitable criminal activity in areas beyond the vision of government is a disturbing incubator.

150px-anonymousdemotivator.jpg
Increased global virtualization complements urbanization as well as standing alone. Virtual environments provide a useful platform for any kind of real-life extremist (as is now widely accepted) but it is the formation of groups within virtual spaces that then spill-out into real-space that could become a significant feature of the 21st century security picture. This is happening with, ‘Project Chanology’ a group that was formed virtually with some elements of the Anonymous movement in order to disrupt the Church of Scientology. While Project Chanology (WhyWeProtest Website)began as a series of cyber actions directed at Scientology’s website, it is now organizing legal protests of Scientology buildings. A shift from the virtual to the real. A more sinister take on this is the alleged actions of the Patriotic Nigras — a group dedicated to the disruption of Second Life, which has reportedly taken to using the tactic of ‘swatting’ — which is the misdirection of armed police officers to a victim’s home address. A disturbing spill-over into real-space. Therefore, whatever pattern future terrorist movements follow, there are signs that religion will play a peripheral rather than central role.

Originally posted on the Counterterrorism blog.

Researchers have devised a rapid and efficient method for generating protein sentinels of the immune system, called monoclonal antibodies, which mark and neutralize foreign invaders.

For both ethical and practical reasons, monoclonals are usually made in mice. And that’s a problem, because the human immune system recognizes the mouse proteins as foreign and sometimes attacks them instead. The result can be an allergic reaction, and sometimes even death.

To get around that problem, researchers now “humanize” the antibodies, replacing some or all of mouse-derived pieces with human ones.

Wilson and Ahmed were interested in the immune response to vaccination. Conventional wisdom held that the B-cell response would be dominated by “memory” B cells. But as the study authors monitored individuals vaccinated against influenza, they found that a different population of B cells peaked about one week after vaccination, and then disappeared, before the memory cells kicked in. This population of cells, called antibody-secreting plasma cells (ASCs), is highly enriched for cells that target the vaccine, with vaccine-specific cells accounting for nearly 70 percent of all ASCs.

“That’s the trick,” said Wilson. “So instead of one cell in 1,000 binding to the vaccines, now it is seven in 10 cells.”

All of a sudden, the researchers had access to a highly enriched pool of antibody-secreting cells, something that is relatively easy to produce in mice, but hard to come by for human B cells.

To ramp up the production and cloning of these antibodies, the researchers added a second twist. Mouse monoclonal antibodies are traditionally produced in the lab from hybridomas, which are cell lines made by fusing the antibody-producing cell with a cancer cell. But human cells don’t respond well to this treatment. So Wilson and his colleagues isolated the ASC antibody genes and transferred them into an “immortalized” cell line. The result was the generation of more than 100 different monoclonals in less than a year, with each taking just a few weeks to produce.

In the event of an emerging flu pandemic, for instance, this approach could lead to faster production of human monoclonals to both diagnose and protect against the disease.

Journal Nature article: Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

Nature 453, 667–671 (29 May 2008) | doi:10.1038/nature06890; Received 16 October 2007; Accepted 4 March 2008; Published online 30 April 2008

Pre-existing neutralizing antibody provides the first line of defence against pathogens in general. For influenza virus, annual vaccinations are given to maintain protective levels of antibody against the currently circulating strains. Here we report that after booster vaccination there was a rapid and robust influenza-specific IgG+ antibody-secreting plasma cell (ASC) response that peaked at approximately day 7 and accounted for up to 6% of peripheral blood B cells. These ASCs could be distinguished from influenza-specific IgG+ memory B cells that peaked 14–21 days after vaccination and averaged 1% of all B cells. Importantly, as much as 80% of ASCs purified at the peak of the response were influenza specific. This ASC response was characterized by a highly restricted B-cell receptor (BCR) repertoire that in some donors was dominated by only a few B-cell clones. This pauci-clonal response, however, showed extensive intraclonal diversification from accumulated somatic mutations. We used the immunoglobulin variable regions isolated from sorted single ASCs to produce over 50 human monoclonal antibodies (mAbs) that bound to the three influenza vaccine strains with high affinity. This strategy demonstrates that we can generate multiple high-affinity mAbs from humans within a month after vaccination. The panel of influenza-virus-specific human mAbs allowed us to address the issue of original antigenic sin (OAS): the phenomenon where the induced antibody shows higher affinity to a previously encountered influenza virus strain compared with the virus strain present in the vaccine1. However, we found that most of the influenza-virus-specific mAbs showed the highest affinity for the current vaccine strain. Thus, OAS does not seem to be a common occurrence in normal, healthy adults receiving influenza vaccination.

Researchers from Imperial College in London, England, isolated the receptor in the lungs that triggers the immune overreaction to flu.

With the receptor identified, a therapy can be developed that will bind to the receptor, preventing the deadly immune response. Also, by targeting a receptor in humans rather than a particular strain of flu, therapies developed to exploit this discovery would work regardless of the rapid mutations that beguile flu vaccine producers every year.

The flu kills 250,000 to 500,000 people in an average year with epidemics reaching 1 to 2 million deaths (other than the spanish flu which was more severe

This discovery could lead to treatments which turn off the inflammation in the lungs caused by influenza and other infections, according to a study published today in the journal Nature Immunology. The virus is often cleared from the body by the time symptoms appear and yet symptoms can last for many days, because the immune system continues to fight the damaged lung. The immune system is essential for clearing the virus, but it can damage the body when it overreacts if it is not quickly contained.

The immune overreaction accounts for the high percentage of young, healthy people who died in the vicious 1918 flu pandemic. While the flu usually kills the very young or the sickly and old, the pandemic flu provoked healthy people’s stronger immune systems to react even more profoundly than usual, exacerbating the symptoms and ultimately causing between 50 and 100 million deaths world wide. These figures from the past make the new discovery that much more important, as new therapies based on this research could prevent a future H5N1 bird flu pandemic from turning into a repeat of the 1918 Spanish flu.

In the new study, the researchers gave mice infected with influenza a mimic of CD200, or an antibody to stimulate CD200R, to see if these would enable CD200R to bring the immune system under control and reduce inflammation.

The mice that received treatment had less weight loss than control mice and less inflammation in their airways and lung tissue. The influenza virus was still cleared from the lungs within seven days and so this strategy did not appear to affect the immune system’s ability to fight the virus itself.

The researchers hope that in the event of a flu pandemic, such as a pandemic of H5N1 avian flu that had mutated to be transmissible between humans, the new treatment would add to the current arsenal of anti-viral medications and vaccines. One key advantage of this type of therapy is that it would be effective even if the flu virus mutated, because it targets the body’s overreaction to the virus rather than the virus itself.

In addition to the possible applications for treating influenza, the researchers also hope their findings could lead to new treatments for other conditions where excessive immunity can be a problem, including other infectious diseases, autoimmune diseases and allergy.

On April 16, 2008, NASA News Release 08–103 reaffirmed that its estimation of a 1 in 45,000 chance of impact in 2036 remains valid.

The B612 Foundation is working towardcs the goal of of significantly altering the orbit of an asteroid in a controlled manner by 2015.

the B612 Foundation made estimates of Apophis path if a 2036 Earth impact were to occur.

The impact result is a narrow corridor called the ‘risk corrider’ which would be a few miles wide. Countries estimated to be in the direct path:

- southern Russia,
- across the north Pacific Ocean (relatively close to the coastlines of the California and Mexico), then
- right between Nicaragua and Costa Rica,
- crossing northern Colombia and
- Venezuela and over the Caribbean islands of Trinidad and Tobago,
- over the Atlantic Ocean to the west coast of Africa.


Earth’s Path of Risk for the 99942 Apophis Asteroid that is suspected to be on track for a collision course with earth in the year 2036. This image is self-made from data estimated by the B612 Foundation, this is why it is just an approximation. Credit: Mario Roberto Duran Ortiz Mariordo and the re-use of this image is based on ‘Fair use’ of public domain info by the B612 Foundation work on Apophis.

The hypothetical impact of Apophis along the path of risk could have more than 10 million casualties, however the threatened zones would be evacuated [as per B612 foundation comment. The threat of casualties would be for a similar sized object, if it was not detected.].

Spaceworks Engineering had an award winning plan to send a spacecraft to shadow the Apophis asteroid

A video Foresight: A Radio Beacon Mission to Asteroid Apophis is on Youtube.

The Foresight final report is here

As of October 19, 2006 [and also April 16, 2008′, the impact probability for April 13, 2036, was calculated as 1 in 45,000. An additional impact date in 2037 was also identified; the impact probability for that encounter was calculated as 1 in 12.3 million.

Cross posted from Nextbigfuture

Click for larger image

I had previously looked at making two large concrete or nanomaterial monolithic or geodesic domes over cities which could protect a city from nuclear bombs.

Now Alexander Bolonkin has come up with a cheaper, technological easy and more practical approach with thin film inflatable domes. It not only would provide protection form nuclear devices it could be used to place high communication devices, windmill power and a lot of other money generating uses. The film mass covered of 1 km**2 of ground area is M1 = 2×10**6 mc = 600 tons/km**2 and film cost is $60,000/km**2.
The area of big city diameter 20 km is 314 km**2. Area of semi-spherical dome is 628 km2. The cost of Dome cover is 62.8 millions $US. We can take less the overpressure (p = 0.001atm) and decrease the cover cost in 5 – 7 times. The total cost of installation is about 30–90 million $US. Not only is it only about $153 million to protect a city it is cheaper than a geosynchronous satellite for high speed communications. Alexander Bolonkin’s website

The author suggests a cheap closed AB-Dome which protects the densely populated cities from nuclear, chemical, biological weapon (bombs) delivered by warheads, strategic missiles, rockets, and various incarnations of aviation technology. The offered AB-Dome is also very useful in peacetime because it shields a city from exterior weather and creates a fine climate within the ABDome. The hemispherical AB-Dome is the inflatable, thin transparent film, located at altitude up to as much as 15 km, which converts the city into a closed-loop system. The film may be armored the stones which destroy the rockets and nuclear warhead. AB-Dome protects the city in case the World nuclear war and total poisoning the Earth’s atmosphere by radioactive fallout (gases and dust). Construction of the AB-Dome is easy; the enclosure’s film is spread upon the ground, the air pump is turned on, and the cover rises to its planned altitude and supported by a small air overpressure. The offered method is cheaper by thousand times than protection of city by current antirocket systems. The AB-Dome may be also used (height up to 15 and more kilometers) for TV, communication, telescope, long distance location, tourism, high placed windmills (energy), illumination and entertainments. The author developed theory of AB-Dome, made estimation, computation and computed a typical project.

His idea is a thin dome covering a city with that is a very transparent film 2 (Fig.1). The film has thickness 0.05 – 0.3 mm. One is located at high altitude (5 — 20 km). The film is supported at this altitude by a small additional air pressure produced by ground ventilators. That is connected to Earth’s ground by managed cables 3. The film may have a controlled transparency option. The system can have the second lower film 6 with controlled reflectivity, a further option.

The offered protection defends in the following way. The smallest space warhead has a
minimum cross-section area 1 m2 and a huge speed 3 – 5 km/s. The warhead gets a blow and overload from film (mass about 0.5 kg). This overload is 500 – 1500g and destroys the warhead (see computation below). Warhead also gets an overpowering blow from 2 −5 (every mass is 0.5 — 1 kg) of the strong stones. Relative (about warhead) kinetic energy of every stone is about 8 millions of Joules! (It is in 2–3 more than energy of 1 kg explosive!). The film destroys the high speed warhead (aircraft, bomber, wing missile) especially if the film will be armored by stone.

Our dome cover (film) has 2 layers: top transparant layer 2, located at a maximum altitude (up 5 −20 km), and lower transparant layer 4 having control reflectivity, located at altitude of 1–3 km (option). Upper transparant cover has thickness about 0.05 – 0.3 mm and supports the protection strong stones (rebbles) 8. The stones have a mass 0.2 – 1 kg and locate the step about 0.5 m.

If we want to control temperature in city, the top film must have some layers: transparant dielectric layer, conducting layer (about 1 — 3 microns), liquid crystal layer (about 10 — 100 microns), conducting layer (for example, SnO2), and transparant dielectric layer. Common thickness is 0.05 — 0.5 mm. Control voltage is 5 — 10 V. This film may be produced by industry relatively cheaply.

If some level of light control is needed materials can be incorporated to control transparency. Also, some transparent solar cells can be used to gather wide area solar power.


As you see the 10 kt bomb exploded at altitude 10 km decreases the air blast effect about in 1000
times and thermal radiation effect without the second cover film in 500 times, with the second reflected film about 5000 times. The hydrogen 100kt bomb exploded at altitude 10 km decreases the air blast effect about in 10 times and thermal radiation effect without the second cover film in 20 times, with the second reflected film about 200 times. Only power 1000kt thermonuclear (hydrogen) bomb can damage city. But this damage will be in 10 times less from air blast and in 10 times less from thermal radiation. If the film located at altitude 15 km, the
damage will be in 85 times less from the air blast and in 65 times less from the thermal radiation.
For protection from super thermonuclear (hydrogen) bomb we need in higher dome altitudes (20−30 km and more). We can cover by AB-Dome the important large region and full country.

Because the Dome is light weight it could be to stay in place even with very large holes. Multiple shells of domes could still be made for more protection.

Better climate inside a dome can make for more productive farming.

AB-Dome is cheaper in hundreds times then current anti-rocket systems.
2. AB-Dome does not need in high technology and can build by poor country.
3. It is easy for building.
4. Dome is used in peacetime; it creates the fine climate (weather) into Dome.
5. AB-Dome protects from nuclear, chemical, biological weapon.
6. Dome produces the autonomous existence of the city population after total World nuclear war
and total confinement (infection) all planet and its atmosphere.
7. Dome may be used for high region TV, for communication, for long distance locator, for
astronomy (telescope).
8. Dome may be used for high altitude tourism.
9. Dome may be used for the high altitude windmills (getting of cheap renewable wind energy).
10. Dome may be used for a night illumination and entertainment

Cross posted from Next big future by Brian Wang, Lifeboat foundation director of Research

I am presenting disruption events for humans and also for biospheres and planets and where I can correlating them with historical frequency and scale.

There has been previous work on categorizing and classifying extinction events. There is Bostroms paper and there is also the work by Jamais Cascio and Michael Anissimov on classification and identifying risks (presented below).

A recent article discusses the inevtiable “end of societies” (it refers to civilizations but it seems to be referring more to things like the end of the roman empire, which still ends up later with Italy, Austria Hungary etc… emerging)

The theories around complexity seem me that to be that core developments along connected S curves of technology and societal processes cap out (around key areas of energy, transportation, governing efficiency, agriculture, production) and then a society falls back (soft or hard dark age, reconstitutes and starts back up again).

Here is a wider range of disruption. Which can also be correlated to frequency that they have occurred historically.

High growth drop to Low growth (short business cycles, every few years)
Recession (soft or deep) Every five to fifteen years.
Depressions (50−100 years, can be more frequent)

List of recessions for the USA (includes depressions)

Differences recession/depression

Good rule of thumb for determining the difference between a recession and a depression is to look at the changes in GNP. A depression is any economic downturn where real GDP declines by more than 10 percent. A recession is an economic downturn that is less severe. By this yardstick, the last depression in the United States was from May 1937 to June 1938, where real GDP declined by 18.2 percent. Great Depression of the 1930s can be seen as two separate events: an incredibly severe depression lasting from August 1929 to March 1933 where real GDP declined by almost 33 percent, a period of recovery, then another less severe depression of 1937–38. (Depressions every 50–100 years. Were more frequent in the past).

Dark age (period of societal collapse, soft/light or regular)
I would say the difference between a long recession and a dark age has to do with breakdown of societal order and some level of population decline / dieback, loss of knowledge/education breakdown. (Once per thousand years.)

I would say that a soft dark age is also something like what China had from the 1400’s to 1970.
Basically a series of really bad societal choices. Maybe something between depressions and dark age or something that does not categorize as neatly but an underperformance by twenty times versus competing groups. Perhaps there should be some kind of societal disorder, levels and categories of major society wide screw ups — historic level mistakes. The Chinese experience I think was triggered by the renunciation of the ocean going fleet, outside ideas and tech, and a lot of other follow on screw ups.

Plagues played a part in weakening the Roman and Han empires.

Societal collapse talk which includes Toynbee analysis.

Toynbee argues that the breakdown of civilizations is not caused by loss of control over the environment, over the human environment, or attacks from outside. Rather, it comes from the deterioration of the “Creative Minority,” which eventually ceases to be creative and degenerates into merely a “Dominant Minority” (who forces the majority to obey without meriting obedience). He argues that creative minorities deteriorate due to a worship of their “former self,” by which they become prideful, and fail to adequately address the next challenge they face.

My take is that the Enlightenment would strengthened with a larger creative majority, where everyone has a stake and capability to creatively advance society. I have an article about who the elite are now.

Many now argue about how dark the dark ages were not as completely bad as commonly believed.
The dark ages is also called the Middle Ages

Population during the middle ages

Between dark age/social collapse and extinction. There are levels of decimation/devastation. (use orders of magnitude 90+%, 99%, 99.9%, 99.99%)

Level 1 decimation = 90% population loss
Level 2 decimation = 99% population loss
Level 3 decimation = 99.9% population loss

Level 9 population loss (would pretty much be extinction for current human civilization). Only 6–7 people left or less which would not be a viable population.

Can be regional or global, some number of species (for decimation)

Categorizations of Extinctions, end of world categories

Can be regional or global, some number of species (for extinctions)

== The Mass extinction events have occurred in the past (to other species. For each species there can only be one extinction event). Dinosaurs, and many others.

Unfortunately Michael’s accelerating future blog is having some issues so here is a cached link.

Michael was identifying manmade risks
The Easier-to-Explain Existential Risks (remember an existential risk
is something that can set humanity way back, not necessarily killing
everyone):

1. neoviruses
2. neobacteria
3. cybernetic biota
4. Drexlerian nanoweapons

The hardest to explain is probably #4. My proposal here is that, if
someone has never heard of the concept of existential risk, it’s
easier to focus on these first four before even daring to mention the
latter ones. But here they are anyway:

5. runaway self-replicating machines (“grey goo” not recommended
because this is too narrow of a term)
6. destructive takeoff initiated by intelligence-amplified human
7. destructive takeoff initiated by mind upload
8. destructive takeoff initiated by artificial intelligence

Another classification scheme: the eschatological taxonomy by Jamais
Cascio on Open the Future. His classification scheme has seven
categories, one with two sub-categories. These are:

0:Regional Catastrophe (examples: moderate-case global warming,
minor asteroid impact, local thermonuclear war)
1: Human Die-Back (examples: extreme-case global warming,
moderate asteroid impact, global thermonuclear war)
2: Civilization Extinction (examples: worst-case global warming,
significant asteroid impact, early-era molecular nanotech warfare)
3a: Human Extinction-Engineered (examples: targeted nano-plague,
engineered sterility absent radical life extension)
3b: Human Extinction-Natural (examples: major asteroid impact,
methane clathrates melt)
4: Biosphere Extinction (examples: massive asteroid impact,
“iceball Earth” reemergence, late-era molecular nanotech warfare)
5: Planetary Extinction (examples: dwarf-planet-scale asteroid
impact, nearby gamma-ray burst)
X: Planetary Elimination (example: post-Singularity beings
disassemble planet to make computronium)

A couple of interesting posts about historical threats to civilization and life by Howard Bloom.

Natural climate shifts and from space (not asteroids but interstellar gases).

Humans are not the most successful life, bacteria is the most successful. Bacteria has survived for 3.85 billion years. Humans for 100,000 years. All other kinds of life lasted no more than 160 million years. [Other species have only managed to hang in there for anywhere from 1.6 million years to 160 million. We humans are one of the shortest-lived natural experiments around. We’ve been here in one form or another for a paltry two and a half million years.] If your numbers are not big enough and you are not diverse enough then something in nature eventually wipes you out.

Following the bacteria survival model could mean using transhumanism as a survival strategy. Creating more diversity to allow for better survival. Humans adapted to living under the sea, deep in the earth, in various niches in space, more radiation resistance,non-biological forms etc… It would also mean spreading into space (panspermia). Individually using technology we could become very successful at life extension, but it will take more than that for a good plan for human (civilization, society, species) long term survival planning.

Other periodic challenges:
142 mass extinctions, 80 glaciations in the last two million years, a planet that may have once been a frozen iceball, and a klatch of global warmings in which the temperature has soared by 18 degrees in ten years or less.

In the last 120,000 years there were 20 interludes in which the temperature of the planet shot up 10 to 18 degrees within a decade. Until just 10,000 years ago, the Gulf Stream shifted its route every 1,500 years or so. This would melt mega-islands of ice, put out our coastal cities beneath the surface of the sea, and strip our farmlands of the conditions they need to produce the food that feeds us.

The solar system has a 240-million-year-long-orbit around the center of our galaxy, an orbit that takes us through interstellar gas clusters called local fluff, interstellar clusters that strip our planet of its protective heliosphere, interstellar clusters that bombard the earth with cosmic radiation and interstellar clusters that trigger giant climate change.