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Category: chemistry

In a recent study led by the University of Bristol, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies.

Engineered microbes are increasingly being used to enable the sustainable and clean production of chemicals, medicines and much more. To make this possible, bioengineers must control when specific sets of genes are turned on and off to allow for careful regulation of the biochemical processes involved.

Their findings are reported in the journal Nature Communications.

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Circa 2017

When surgeons complete a successful lung operation, everyone should breathe a sigh of relief. But real relief may not come until weeks or even months later, when doctors remove the patient’s lingering sutures or staples. And that’s assuming there were no leakages, which can send a patient right back to the hospital.

Nasim Annabi, assistant professor of chemical engineering, has a better solution: a new type of surgical glue that could replace the need for staples and sutures altogether. Annabi is leading the research, which she and her colleagues from the University of Sydney and Harvard Medical School described in a paper published Wednesday in Science Translational Medicine.

The gel-like glue, called MeTro, is made from a human protein that has been modified to react to ultraviolet light. Researchers apply the glue to a wound, place it under UV light for a few seconds, and voilà—the wound is sealed.

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Humanity has come a long way in understanding the universe. We’ve got a physical framework that mostly matches our observations, and new technologies have allowed us to analyze the Big Bang and take photos of black holes. But the hypothetical EmDrive rocket engine threatened to upend what we knew about physics… if it worked. After the latest round of testing, we can say with a high degree of certainty that it doesn’t.

If you have memories from the 90s, you probably remember the interest in cold fusion, a supposed chemical process that could produce energy from fusion at room temperature instead of millions of degrees (pick your favorite scale, the numbers are all huge). The EmDrive is basically cold fusion for the 21st century. First proposed in 2001, the EmDrive uses an asymmetrical resonator cavity inside which electromagnetic energy can bounce around. There’s no exhaust, but proponents claim the EmDrive generates thrust.

The idea behind the EmDrive is that the tapered shape of the cavity would reflect radiation in such a way that there was a larger net force exerted on the resonator at one end. Thus, an object could use this “engine” for hyper-efficient propulsion. That would be a direct violation of the conservation of momentum. Interest in the EmDrive was scattered until 2016 when NASA’s Eagelworks lab built a prototype and tested it. According to the team, they detected a small but measurable net force, and that got people interested.

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Summary: Dopamine neurons largely rely on their own discharge to determine release rates of the hormone, researchers report.

Source: NYU Langone.

In addition to smoothing out wrinkles, researchers have found that the drug Botox can reveal the inner workings of the brain. A new study used it to show that feedback from individual nerve cells controls the release of dopamine, a chemical messenger involved in motivation, memory, and movement.

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Glass, rubber and plastics all belong to a class of matter called amorphous solids. And in spite of how common they are in our everyday lives, amorphous solids have long posed a challenge to scientists.

Since the 1910s, scientists have been able to map in 3D the atomic structures of crystals, the other major class of solids, which has led to myriad advances in physics, chemistry, biology, , geology, nanoscience, drug discovery and more. But because aren’t assembled in rigid, repetitive atomic structures like crystals are, they have defied researchers’ ability to determine their with the same level of precision.

Until now, that is.

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Bipolar disorder affects millions of Americans, causing dramatic swings in mood and, in some people, additional effects such as memory problems.

While bipolar disorder is linked to many genes, each one making small contributions to the disease, scientists don’t know just how those genes ultimately give rise to the disorder’s effects.

However, in new research, scientists at the University of Wisconsin-Madison have found for the first time that disruptions to a particular protein called Akt can lead to the brain changes characteristic of bipolar disorder. The results offer a foundation for research into treating the often-overlooked cognitive impairments of bipolar disorder, such as memory loss, and add to a growing understanding of how the biochemistry of the brain affects health and disease.

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The companies attempting to avoid transparency.

Jerry Lehnert.

· 1tSpohntsnorted ·

In just over a month, the state’s largest business lobby has filed another lawsuit against the Wisconsin Department of Natural Resources over so-called “forever chemicals” known as PFAS — this time for conducting PFAS sampling in wastewater.

Wisconsin Manufacturers and Commerce (WMC) filed a complaint on Monday in Jefferson County Circuit Court against the DNR, claiming the agency is unlawfully seeking to sample wastewater for PFAS that’s released from industrial and municipal facilities. The business group argues the DNR lacks explicit authority to conduct such sampling among facilities that operate under wastewater discharge permits.

WMC wants to prevent the DNR from collecting samples and releasing the data to the public. Jefferson County Judge William F. Hue granted a temporary restraining order on Monday to bar the agency from sampling for PFAS.

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SYNTHETIC cells made by combining components of Mycoplasma bacteria with a chemically synthesised genome can grow and divide into cells of uniform shape and size, just like most natural bacterial cells.

In 2016, researchers led by Craig Venter at the J. Craig Venter Institute in San Diego, California, announced that they had created synthetic “minimal” cells. The genome in each cell contained just 473 key genes thought to be essential for life.

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For the first time, a team of scientists has created a synthetic single-celled organism that can divide and grow like a regular living cell. This breakthrough could lead to designer cells that can produce useful chemicals on demand or treat disease from inside the body.

This new study, by scientists from the J. Craig Venter Institute (JCVI), the National Institute of Standards and Technology (NIST) and MIT, builds on over a decade’s work in creating synthetic lifeforms. In 2010 a JCVI team created the world’s first cell with a synthetic genome, which they dubbed JCVI-syn1.0.

In 2016, the researchers followed that up with JCVI-syn3.0, a version where the goal was to make the organism as simple as possible. With only 473 genes, it was the simplest living cell ever known – by comparison, an E. coli bacterium has well over 4000 genes. But perhaps it was too simple, because the cells weren’t all that effective at dividing. Rather than uniform shapes and sizes, some of them would form filaments and others wouldn’t fully separate.

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CLEVELAND, Ohio — The Cleveland Clinic and IBM have entered a 10-year partnership that will install a quantum computer — which can handle large amounts of data at lightning speeds — at the Clinic next year to speed up medical innovations.

The Discovery Accelerator, a joint Clinic-IBM center, will feature artificial intelligence, hybrid cloud data storage and quantum computing technologies. A hybrid cloud is a data storage technology that allows for faster storage and analysis of large amounts of data.

The partnership will allow Clinic researchers to use the advanced tech in its new Global Center for Pathogen Research and Human Health for research into genomics, population health, clinical applications, and chemical and drug discovery.

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